/ en /news/first-large-genetic-study-bipolar-disorder-asian-populations-launches <span class="field field--name-title field--type-string field--label-hidden"><h1>First large genetic study of bipolar disorder in Asian populations launches</h1> </span> <span class="field field--name-uid field--type-entity-reference field--label-hidden"> <span>By Alex Viveros</span> </span> <span class="field field--name-created field--type-created field--label-hidden"><time datetime="2022-10-31T12:53:52-04:00" class="datetime">October 31, 2022</time> </span> <div class="hero-section container"> <div class="hero-section__row row"> <div class="hero-section__content hero-section__content_left col-6"> <div class="hero-section__breadcrumbs"> <div class="block block-layout-builder block-extra-field-blocknodenewsbreadcrumbs"> <nav class="breadcrumb" role="navigation" aria-labelledby="system-breadcrumb"> <h2 id="system-breadcrumb" class="visually-hidden">Breadcrumb</h2> <ol> <li> <a href="/">Home</a> </li> <li> <a href="/news">News</a> </li> </ol> </nav> </div> </div> <div class="hero-section__title"> <div class="block block-layout-builder block-field-blocknodenewstitle"> <span class="field field--name-title field--type-string field--label-hidden"><h1>First large genetic study of bipolar disorder in Asian populations launches</h1> </span> </div> </div> <div class="hero-section__description"> <div class="block block-layout-builder block-field-blocknodenewsbody"> <div class="clearfix text-formatted field field--name-body field--type-text-with-summary field--label-hidden field__item"><div class="summary-only"> <p>Researchers will analyze the DNA of tens of thousands of people from five countries in East and South Asia to find genetic markers for the psychiatric condition.&nbsp;</p> </div> </div> </div> </div> <div class="hero-section__author"> <div class="block block-layout-builder block-extra-field-blocknodenewsextra-field-author-custom"> By Alex Viveros </div> </div> <div class="hero-section__date"> <div class="block block-layout-builder block-field-blocknodenewscreated"> <span class="field field--name-created field--type-created field--label-hidden"><time datetime="2022-10-31T12:53:52-04:00" class="datetime">October 31, 2022</time> </span> </div> </div> </div> <div class="hero-section__right col-6"> <div class="hero-section__image"> <div class="block block-layout-builder block-field-blocknodenewsfield-image"> <div class="field field--name-field-image field--type-entity-reference field--label-hidden field__item"> <article class="media media--type-image media--view-mode-multiple-content-types-header"> <div class="field field--name-field-media-image field--type-image field--label-hidden field__item"> <picture> <source srcset="/files/styles/multiple_ct_header_desktop_xl/public/news/images/2022/1022%20Bipolar%20Disorder%20Study_Main_557x415_02%20%282%29.png?h=9423a5c0&amp;itok=P3u1Cpvw 1x" media="all and (min-width: 1921px)" type="image/png" width="754" height="503"> <source srcset="/files/styles/multiple_ct_header_desktop_xl/public/news/images/2022/1022%20Bipolar%20Disorder%20Study_Main_557x415_02%20%282%29.png?h=9423a5c0&amp;itok=P3u1Cpvw 1x" media="all and (min-width: 1601px) and (max-width: 1920px)" type="image/png" width="754" height="503"> <source srcset="/files/styles/multiple_ct_header_desktop/public/news/images/2022/1022%20Bipolar%20Disorder%20Study_Main_557x415_02%20%282%29.png?h=9423a5c0&amp;itok=Fvvhxxtr 1x" media="all and (min-width: 1340px) and (max-width: 1600px)" type="image/png" width="736" height="520"> <source srcset="/files/styles/multiple_ct_header_laptop/public/news/images/2022/1022%20Bipolar%20Disorder%20Study_Main_557x415_02%20%282%29.png?h=9423a5c0&amp;itok=oYYe6sIs 1x" media="all and (min-width: 800px) and (max-width: 1339px)" type="image/png" width="641" height="451"> <source srcset="/files/styles/multiple_ct_header_tablet/public/news/images/2022/1022%20Bipolar%20Disorder%20Study_Main_557x415_02%20%282%29.png?h=9423a5c0&amp;itok=wqUDzIyM 1x" media="all and (min-width: 540px) and (max-width: 799px)" type="image/png" width="706" height="417"> <source srcset="/files/styles/multiple_ct_header_phone/public/news/images/2022/1022%20Bipolar%20Disorder%20Study_Main_557x415_02%20%282%29.png?h=9423a5c0&amp;itok=oydp084j 1x" media="all and (max-width: 539px)" type="image/png" width="499" height="294"> <img loading="eager" width="499" height="294" src="/files/styles/multiple_ct_header_phone/public/news/images/2022/1022%20Bipolar%20Disorder%20Study_Main_557x415_02%20%282%29.png?h=9423a5c0&amp;itok=oydp084j" alt="Ricardo Job-Reese, ӳ����ý Communications" typeof="foaf:Image"> </picture> </div> <div class="media-caption"> <div class="media-caption__credit"> Credit: Ricardo Job-Reese, ӳ����ý Communications </div> <div class="media-caption__description"> </div> </div> </article> </div> </div> </div> </div> </div> </div> <div class="content-section content-section_with-sidebars container"> <div class="row"> <div class="content-section__left col-2"> <div class="block block-better-social-sharing-buttons block-social-sharing-buttons-block"> <div style="display: none"><link rel="preload" href="/modules/contrib/better_social_sharing_buttons/assets/dist/sprites/social-icons--no-color.svg" as="image" type="image/svg+xml" crossorigin="anonymous"></div> <div class="social-sharing-buttons"> <a href="https://www.facebook.com/sharer/sharer.php?u=/taxonomy/term/1166/feed&amp;title=" target="_blank" title="Share to Facebook" aria-label="Share to Facebook" class="social-sharing-buttons-button share-facebook" rel="noopener"> <svg aria-hidden="true" width="32px" height="32px" style="border-radius:100%;"> <use href="/modules/contrib/better_social_sharing_buttons/assets/dist/sprites/social-icons--no-color.svg#facebook" /> </svg> </a> <a href="https://twitter.com/intent/tweet?text=+/taxonomy/term/1166/feed" target="_blank" title="Share to X" aria-label="Share to X" class="social-sharing-buttons-button share-x" rel="noopener"> <svg aria-hidden="true" width="32px" height="32px" style="border-radius:100%;"> <use href="/modules/contrib/better_social_sharing_buttons/assets/dist/sprites/social-icons--no-color.svg#x" /> </svg> </a> <a href="mailto:?subject=&amp;body=/taxonomy/term/1166/feed" title="Share to Email" aria-label="Share to Email" class="social-sharing-buttons-button share-email" target="_blank" rel="noopener"> <svg aria-hidden="true" width="32px" height="32px" style="border-radius:100%;"> <use href="/modules/contrib/better_social_sharing_buttons/assets/dist/sprites/social-icons--no-color.svg#email" /> </svg> </a> </div> </div> </div> <div class="content-section__main col-8"> <div class="block block-layout-builder block-field-blocknodenewsbody"> <div class="clearfix text-formatted field field--name-body field--type-text-with-summary field--label-hidden field__item"><p>Nearly 60 percent of the world’s population resides in Asian countries, but only 10 percent of participants of genetic studies are of Asian descent. And that disparity is even greater in studies of psychiatric conditions, where participants are almost all of European ancestry, even though serious mental illness affects all human populations evenly. This lack of representation of the world’s population in genetic datasets leaves out a huge amount of genomic variation, limiting what scientists can learn about the biological basis of mental disorders.&nbsp;</p> <p>A global team of scientists is now trying to tackle this problem by launching a genetic study of bipolar disorder in people from India, Pakistan, Singapore, South Korea, and Taiwan. The study, called the Asian Bipolar Genetics Network (A-BIG-NET), will collect and analyze DNA and demographic, environmental, and medical information from 27,500 patients diagnosed with the psychiatric condition and 15,000 controls.&nbsp;</p> <p>The project is a collaboration between experts from the ӳ����ý of MIT and Harvard (led by Hailiang Huang), Virginia Commonwealth University (led by Kenneth Kendler), Johns Hopkins University (led by Peter Zandi), National Institute of Mental Health and NeuroSciences in India (NIMHANS, led by Biju Viswanath), Indian Institute of Science (led by Bratati Kahali), Institute of Mental Health in Singapore (led by Jimmy Lee), Korea University College of Medicine (led by Heon-Jeong Lee), and National Taiwan University (led by Po-Hsiu Kuo). They will work together to recruit the participants, sequence the genomes, analyze the data, and build a network for rapid data-sharing.&nbsp;</p> <p>The team hopes to uncover genetic markers of bipolar disorder, which may point towards the biological causes and mechanisms underlying this condition that affects 1-2 percent of the world’s population. By focusing on Asian populations, the scientists aim to find markers that are more common in these groups than in others, which may highlight genetic roots of the disorder that are shared across other populations around the world. Better insight into the causes of bipolar disorder from this research could one day lead to new and better treatments.</p> <p>“There haven’t been any sizable bipolar genetic studies from Asian populations,” said Hailiang Huang, the project’s leader, Director of the Stanley Global Asia Initiatives at the Stanley Center for Psychiatric Research at the ӳ����ý, and an Assistant Professor at Massachusetts General Hospital and Harvard Medical School. “If this were to continue, we risk the possibility that therapeutic innovations might exclude large segments of the global population which are under-represented in psychiatric genetics. This is a major unsolved challenge for everyone in the world, including people from South and East Asia.”</p> <p>The new project extends Stanley Global, an initiative launched in 2014 by the Stanley Center to diversify genetic research and include underrepresented populations worldwide. One Stanley Global project, NeuroGAP-Psychosis, launched in 2018 to study the genetics of schizophrenia in four African countries, while another project, NeuroMex, is doing the same in Mexico. NeuroDev is studying neurodevelopmental differences in people in Kenya and South Africa.</p> <p>“Studies like A-BIG-NET have potential to discover rare variant risk genes, which should have a big impact on the mechanistic understanding of bipolar disorder,&nbsp; like the SCHEMA study did for schizophrenia. Because Asian populations have different genetic variants, their inclusion in A-BIG-NET will enhance the diversity and richness of gene discovery for bipolar,” said Morgan Sheng, co-director of the Stanley Center.</p> <h3>Global partnerships</h3> <p>A-BIG-NET was inspired by NeuroGAP-Psychosis and NeuroMex to expand this kind of genetics research to Asian countries. Though Stanley Global has sequenced genomic samples from East Asian populations before, A-BIG-NET expands that effort to include bipolar disorder and will study a much larger cohort. It will also be the first known large-scale study to explore the genetics of bipolar disorder in South Asian countries, and will build on recent discoveries from the Stanley Center including the <a href="/news/researchers-find-first-strong-genetic-risk-factor-bipolar-disorder">first strong genetic signal for bipolar disorder</a>.</p> <p>“The most important finding I would hope would emerge from this project is to find the direct causal genes underlying bipolar disorder,” Huang said. “This study gives us the chance to actually identify the causal genes for bipolar disorder in the Asian population.”</p> <p>“By taking a deep phenotyping approach, we will be collecting information which will allow us to explore a number of clinical subtypes of bipolar illness from a molecular genetic perspective to detect potential differences in their genetic substrate,” said Kendler, a Professor of Psychiatry and Human and Molecular Genetics at Virginia Commonwealth University and Co-Principal Investigator of the project. “Furthermore, studying a range of environmental risk factors will permit us to further clarify how genes and environment jointly act or interact to produce bipolar disorder.”</p> <p>“This study will be an important step in increasing equity in research, especially in the area of psychiatric genetics, ” said Biju Viswanath, Professor of Psychiatry at NIMHANS in India and the lead on the Indian arm of the study. Viswanath has established the India Consortium on Mental Illness And Genetics In the Clinic (IC-MAGIC), which conducts large genetic studies on mental health. Participants from India will make up the largest cohort of the study.&nbsp;</p> <p>“The project will allow advanced training in psychiatric genetics, and engage more researchers and participants. This will allow greater community engagement and expand research capacity in the region. We will then be able to contribute both globally, and importantly, locally to understand these complex disorders,” said Sanjeev Jain, a NIMHANS Professor and senior co-investigator of the study.</p> <p>About a third of A-BIG-NET’s genetic samples will be sequenced at the ӳ����ý by the Genomics Platform, with the rest being analyzed in their home countries. The scientists will use a recently developed sequencing technology called <a href="/blog/perspective-uncovering-genetic-basis-mental-illness-requires-diverse-datasets-and-better">Blended Genome Exome (BGE)</a>, which deeply sequences the exome — the 2 percent of human DNA that translates into proteins — and more broadly decodes the rest of the genome. This approach was designed to increase the chances of finding new genetic variation from global samples in a cost-effective manner, allowing for a large number of samples to be sequenced.&nbsp;</p> <p>The team will publicly share A-BIG-NET data through the <a href="https://nda.nih.gov/" target="_blank">National Institute of Mental Health Data Archive (NDA)</a> and the <a href="https://bipex.broadinstitute.org/">Bipolar Exomes Browser</a>. They will also contribute their data to the Psychiatric Genomics Consortium Bipolar Workgroup and the Bipolar Sequencing Project, which will allow them to compare their results to those from other studies focused on European populations.</p> <p>“This study puts together a strong team from Asia to work at understanding the biology of bipolar disorder,” said Jimmy Lee, a Senior Consultant at Singapore’s Institute of Mental Health, an associate professor at the Lee Kong Chian School of Medicine at Nanyang Technological University, and a co-senior investigator of the study. “Singapore is glad to be a part of this coordinated effort. I am confident the team will make important and impactful scientific discoveries, which will eventually translate into improved clinical care and recovery outcomes in people living with bipolar disorder. Additionally, I hope this effort will catalyze the growth of psychiatric genetics in Asia to address the gap in ethnic representation and knowledge.”</p> <p>“Taiwan is often excluded from a number of major international organizations and actions. We’re very glad to be part of the global diversity initiative and to contribute to enhancing our understanding of a severe psychiatric disorder and reducing health inequity in the long run,” said the project’s co-lead, Po-Hsiu Kuo, Associate Dean of College of Public Health, and a Professor at Institute of Epidemiology and Preventive Medicine, National Taiwan University.</p> <p>“In South Korea, no large-scale genomic study has been conducted on mental illness. Recently, however, psychiatric genetic researchers have reached a consensus on the need for large-scale collaborative genomic study on major mental illnesses, and formed the Korean Mood Disorder Genomics Consortium (KOMOGEN) with about 40 organizations to move the team to succeed in the project,” said the South Korea site leader, Heon-Jeong Lee, Professor of Psychiatry, Korea University College of Medicine.</p> <p><em>Funding for this research is provided by the National Institute of Mental Health.</em></p> </div> </div> <div class="block-node-broad-tags block block-layout-builder block-field-blocknodenewsfield-broad-tags"> <div class="block-node-broad-tags__row"> <div class="block-node-broad-tags__title">Tags:</div> <div class="field field--name-field-broad-tags field--type-entity-reference field--label-hidden field__items"> <div class="field__item"><a href="/broad-tags/neurogap" hreflang="en">NeuroGap</a></div> <div class="field__item"><a href="/broad-tags/stanley-center-psychiatric-research" hreflang="en">Stanley Center for Psychiatric Research</a></div> <div class="field__item"><a href="/broad-tags/psychiatric-disease-0" hreflang="en">Psychiatric disease</a></div> <div class="field__item"><a href="/broad-tags/psychiatric-disease" hreflang="en">Brain Health</a></div> <div class="field__item"><a href="/broad-tags/steven-hyman" hreflang="en">Steven Hyman</a></div> <div class="field__item"><a href="/broad-tags/news-and-media" hreflang="en">News and Media</a></div> </div> </div> </div> </div> <div class="content-section__right col-2"> <div class="block block-ctools block-entity-viewnode"> <article about="/news/first-large-genetic-study-bipolar-disorder-asian-populations-launches" class="node node--type-news node--view-mode-sidebar"> <div class="node__content"> <div class="sidebar-group"> <div class="sidebar-group__content"> <div class="block block-layout-builder block-field-blocknodenewsfield-news-extra-info"> <div class="clearfix text-formatted field field--name-field-news-extra-info field--type-text-long field--label-hidden field__item"><h2>&nbsp;</h2> <h2>Related News</h2> <p><img alt src="/files/styles/blog__557x415_/public/news/images/2022/Bipolar_story.png?itok=OnjsAk-j" style="width: 212px; height: 162px;"></p> <p><a href="/node/1130671">Researchers find first strong genetic risk factor for bipolar disorder</a></p> <p><img alt src="/files/styles/blog__557x415_/public/news/images/2022/Singh_Daly_Neale-Graphic.png?itok=5P7iYe2D" style="width: 212px; height: 162px;"></p> <p><a href="/node/1130626">Two large studies reveal genes and genome regions that influence schizophrenia risk</a></p> <p><img alt src="/files/styles/pt_ls_image_tablet/public/long_story/Fullwidth_NDev-Team-Photo.png" style="width: 219px; height: 138px;"></p> <p><a href="/node/1130881">A genetics study in Africa is helping to destigmatize neurodevelopmental differences in children</a></p> <p>&nbsp;</p> <h2>Related Programs</h2> <p><a href="/node/145111">Stanley Global</a></p> <p>&nbsp;</p> <p>&nbsp;</p> <h2>Related Projects</h2> <p><a href="/node/221261">NeuroGAP</a></p> <p><a href="/node/221976">NeuroGAP-Psychosis</a></p> <p><a href="/node/699091">NeuroDev</a></p> <p><a href="/node/1003656">NeuroMex</a></p> <p>&nbsp;</p> <h2>Related People</h2> <p><img alt src="/files/styles/biosketch__413x315_/public/bios/photos/Steve%20Hyman.jpg?itok=Oc4iJDp1" style="width: 212px; height: 162px;"></p> <p><a href="/node/7576">Steven Hyman</a></p> <p><img alt src="/files/styles/biosketch__413x315_/public/bios/photos/MorganSheng-bio.png?itok=BB66CSnx" style="width: 212px; height: 162px;"></p> <p><a href="/node/515316">Morgan Sheng</a></p> </div> </div> </div> </div> </div> </article> </div> </div> </div> </div> Mon, 31 Oct 2022 16:53:52 +0000 aviveros@broadinstitute.org 1238511 at /news/broad-discovery-center-cambridge-opens-public-october <span class="field field--name-title field--type-string field--label-hidden"><h1>First large genetic study of bipolar disorder in Asian populations launches</h1> </span> <span class="field field--name-uid field--type-entity-reference field--label-hidden"> <span>By Alex Viveros</span> </span> <span class="field field--name-created field--type-created field--label-hidden"><time datetime="2022-10-31T12:53:52-04:00" class="datetime">October 31, 2022</time> </span> <div class="hero-section container"> <div class="hero-section__row row"> <div class="hero-section__content hero-section__content_left col-6"> <div class="hero-section__breadcrumbs"> <div class="block block-layout-builder block-extra-field-blocknodenewsbreadcrumbs"> <nav class="breadcrumb" role="navigation" aria-labelledby="system-breadcrumb"> <h2 id="system-breadcrumb" class="visually-hidden">Breadcrumb</h2> <ol> <li> <a href="/">Home</a> </li> <li> <a href="/news">News</a> </li> </ol> </nav> </div> </div> <div class="hero-section__title"> <div class="block block-layout-builder block-field-blocknodenewstitle"> <span class="field field--name-title field--type-string field--label-hidden"><h1>First large genetic study of bipolar disorder in Asian populations launches</h1> </span> </div> </div> <div class="hero-section__description"> <div class="block block-layout-builder block-field-blocknodenewsbody"> <div class="clearfix text-formatted field field--name-body field--type-text-with-summary field--label-hidden field__item"><div class="summary-only"> <p>Researchers will analyze the DNA of tens of thousands of people from five countries in East and South Asia to find genetic markers for the psychiatric condition.&nbsp;</p> </div> </div> </div> </div> <div class="hero-section__author"> <div class="block block-layout-builder block-extra-field-blocknodenewsextra-field-author-custom"> By Alex Viveros </div> </div> <div class="hero-section__date"> <div class="block block-layout-builder block-field-blocknodenewscreated"> <span class="field field--name-created field--type-created field--label-hidden"><time datetime="2022-10-31T12:53:52-04:00" class="datetime">October 31, 2022</time> </span> </div> </div> </div> <div class="hero-section__right col-6"> <div class="hero-section__image"> <div class="block block-layout-builder block-field-blocknodenewsfield-image"> <div class="field field--name-field-image field--type-entity-reference field--label-hidden field__item"> <article class="media media--type-image media--view-mode-multiple-content-types-header"> <div class="field field--name-field-media-image field--type-image field--label-hidden field__item"> <picture> <source srcset="/files/styles/multiple_ct_header_desktop_xl/public/news/images/2022/1022%20Bipolar%20Disorder%20Study_Main_557x415_02%20%282%29.png?h=9423a5c0&amp;itok=P3u1Cpvw 1x" media="all and (min-width: 1921px)" type="image/png" width="754" height="503"> <source srcset="/files/styles/multiple_ct_header_desktop_xl/public/news/images/2022/1022%20Bipolar%20Disorder%20Study_Main_557x415_02%20%282%29.png?h=9423a5c0&amp;itok=P3u1Cpvw 1x" media="all and (min-width: 1601px) and (max-width: 1920px)" type="image/png" width="754" height="503"> <source srcset="/files/styles/multiple_ct_header_desktop/public/news/images/2022/1022%20Bipolar%20Disorder%20Study_Main_557x415_02%20%282%29.png?h=9423a5c0&amp;itok=Fvvhxxtr 1x" media="all and (min-width: 1340px) and (max-width: 1600px)" type="image/png" width="736" height="520"> <source srcset="/files/styles/multiple_ct_header_laptop/public/news/images/2022/1022%20Bipolar%20Disorder%20Study_Main_557x415_02%20%282%29.png?h=9423a5c0&amp;itok=oYYe6sIs 1x" media="all and (min-width: 800px) and (max-width: 1339px)" type="image/png" width="641" height="451"> <source srcset="/files/styles/multiple_ct_header_tablet/public/news/images/2022/1022%20Bipolar%20Disorder%20Study_Main_557x415_02%20%282%29.png?h=9423a5c0&amp;itok=wqUDzIyM 1x" media="all and (min-width: 540px) and (max-width: 799px)" type="image/png" width="706" height="417"> <source srcset="/files/styles/multiple_ct_header_phone/public/news/images/2022/1022%20Bipolar%20Disorder%20Study_Main_557x415_02%20%282%29.png?h=9423a5c0&amp;itok=oydp084j 1x" media="all and (max-width: 539px)" type="image/png" width="499" height="294"> <img loading="eager" width="499" height="294" src="/files/styles/multiple_ct_header_phone/public/news/images/2022/1022%20Bipolar%20Disorder%20Study_Main_557x415_02%20%282%29.png?h=9423a5c0&amp;itok=oydp084j" alt="Ricardo Job-Reese, ӳ����ý Communications" typeof="foaf:Image"> </picture> </div> <div class="media-caption"> <div class="media-caption__credit"> Credit: Ricardo Job-Reese, ӳ����ý Communications </div> <div class="media-caption__description"> </div> </div> </article> </div> </div> </div> </div> </div> </div> <div class="content-section content-section_with-sidebars container"> <div class="row"> <div class="content-section__left col-2"> <div class="block block-better-social-sharing-buttons block-social-sharing-buttons-block"> <div style="display: none"><link rel="preload" href="/modules/contrib/better_social_sharing_buttons/assets/dist/sprites/social-icons--no-color.svg" as="image" type="image/svg+xml" crossorigin="anonymous"></div> <div class="social-sharing-buttons"> <a href="https://www.facebook.com/sharer/sharer.php?u=/taxonomy/term/1166/feed&amp;title=" target="_blank" title="Share to Facebook" aria-label="Share to Facebook" class="social-sharing-buttons-button share-facebook" rel="noopener"> <svg aria-hidden="true" width="32px" height="32px" style="border-radius:100%;"> <use href="/modules/contrib/better_social_sharing_buttons/assets/dist/sprites/social-icons--no-color.svg#facebook" /> </svg> </a> <a href="https://twitter.com/intent/tweet?text=+/taxonomy/term/1166/feed" target="_blank" title="Share to X" aria-label="Share to X" class="social-sharing-buttons-button share-x" rel="noopener"> <svg aria-hidden="true" width="32px" height="32px" style="border-radius:100%;"> <use href="/modules/contrib/better_social_sharing_buttons/assets/dist/sprites/social-icons--no-color.svg#x" /> </svg> </a> <a href="mailto:?subject=&amp;body=/taxonomy/term/1166/feed" title="Share to Email" aria-label="Share to Email" class="social-sharing-buttons-button share-email" target="_blank" rel="noopener"> <svg aria-hidden="true" width="32px" height="32px" style="border-radius:100%;"> <use href="/modules/contrib/better_social_sharing_buttons/assets/dist/sprites/social-icons--no-color.svg#email" /> </svg> </a> </div> </div> </div> <div class="content-section__main col-8"> <div class="block block-layout-builder block-field-blocknodenewsbody"> <div class="clearfix text-formatted field field--name-body field--type-text-with-summary field--label-hidden field__item"><p>Nearly 60 percent of the world’s population resides in Asian countries, but only 10 percent of participants of genetic studies are of Asian descent. And that disparity is even greater in studies of psychiatric conditions, where participants are almost all of European ancestry, even though serious mental illness affects all human populations evenly. This lack of representation of the world’s population in genetic datasets leaves out a huge amount of genomic variation, limiting what scientists can learn about the biological basis of mental disorders.&nbsp;</p> <p>A global team of scientists is now trying to tackle this problem by launching a genetic study of bipolar disorder in people from India, Pakistan, Singapore, South Korea, and Taiwan. The study, called the Asian Bipolar Genetics Network (A-BIG-NET), will collect and analyze DNA and demographic, environmental, and medical information from 27,500 patients diagnosed with the psychiatric condition and 15,000 controls.&nbsp;</p> <p>The project is a collaboration between experts from the ӳ����ý of MIT and Harvard (led by Hailiang Huang), Virginia Commonwealth University (led by Kenneth Kendler), Johns Hopkins University (led by Peter Zandi), National Institute of Mental Health and NeuroSciences in India (NIMHANS, led by Biju Viswanath), Indian Institute of Science (led by Bratati Kahali), Institute of Mental Health in Singapore (led by Jimmy Lee), Korea University College of Medicine (led by Heon-Jeong Lee), and National Taiwan University (led by Po-Hsiu Kuo). They will work together to recruit the participants, sequence the genomes, analyze the data, and build a network for rapid data-sharing.&nbsp;</p> <p>The team hopes to uncover genetic markers of bipolar disorder, which may point towards the biological causes and mechanisms underlying this condition that affects 1-2 percent of the world’s population. By focusing on Asian populations, the scientists aim to find markers that are more common in these groups than in others, which may highlight genetic roots of the disorder that are shared across other populations around the world. Better insight into the causes of bipolar disorder from this research could one day lead to new and better treatments.</p> <p>“There haven’t been any sizable bipolar genetic studies from Asian populations,” said Hailiang Huang, the project’s leader, Director of the Stanley Global Asia Initiatives at the Stanley Center for Psychiatric Research at the ӳ����ý, and an Assistant Professor at Massachusetts General Hospital and Harvard Medical School. “If this were to continue, we risk the possibility that therapeutic innovations might exclude large segments of the global population which are under-represented in psychiatric genetics. This is a major unsolved challenge for everyone in the world, including people from South and East Asia.”</p> <p>The new project extends Stanley Global, an initiative launched in 2014 by the Stanley Center to diversify genetic research and include underrepresented populations worldwide. One Stanley Global project, NeuroGAP-Psychosis, launched in 2018 to study the genetics of schizophrenia in four African countries, while another project, NeuroMex, is doing the same in Mexico. NeuroDev is studying neurodevelopmental differences in people in Kenya and South Africa.</p> <p>“Studies like A-BIG-NET have potential to discover rare variant risk genes, which should have a big impact on the mechanistic understanding of bipolar disorder,&nbsp; like the SCHEMA study did for schizophrenia. Because Asian populations have different genetic variants, their inclusion in A-BIG-NET will enhance the diversity and richness of gene discovery for bipolar,” said Morgan Sheng, co-director of the Stanley Center.</p> <h3>Global partnerships</h3> <p>A-BIG-NET was inspired by NeuroGAP-Psychosis and NeuroMex to expand this kind of genetics research to Asian countries. Though Stanley Global has sequenced genomic samples from East Asian populations before, A-BIG-NET expands that effort to include bipolar disorder and will study a much larger cohort. It will also be the first known large-scale study to explore the genetics of bipolar disorder in South Asian countries, and will build on recent discoveries from the Stanley Center including the <a href="/news/researchers-find-first-strong-genetic-risk-factor-bipolar-disorder">first strong genetic signal for bipolar disorder</a>.</p> <p>“The most important finding I would hope would emerge from this project is to find the direct causal genes underlying bipolar disorder,” Huang said. “This study gives us the chance to actually identify the causal genes for bipolar disorder in the Asian population.”</p> <p>“By taking a deep phenotyping approach, we will be collecting information which will allow us to explore a number of clinical subtypes of bipolar illness from a molecular genetic perspective to detect potential differences in their genetic substrate,” said Kendler, a Professor of Psychiatry and Human and Molecular Genetics at Virginia Commonwealth University and Co-Principal Investigator of the project. “Furthermore, studying a range of environmental risk factors will permit us to further clarify how genes and environment jointly act or interact to produce bipolar disorder.”</p> <p>“This study will be an important step in increasing equity in research, especially in the area of psychiatric genetics, ” said Biju Viswanath, Professor of Psychiatry at NIMHANS in India and the lead on the Indian arm of the study. Viswanath has established the India Consortium on Mental Illness And Genetics In the Clinic (IC-MAGIC), which conducts large genetic studies on mental health. Participants from India will make up the largest cohort of the study.&nbsp;</p> <p>“The project will allow advanced training in psychiatric genetics, and engage more researchers and participants. This will allow greater community engagement and expand research capacity in the region. We will then be able to contribute both globally, and importantly, locally to understand these complex disorders,” said Sanjeev Jain, a NIMHANS Professor and senior co-investigator of the study.</p> <p>About a third of A-BIG-NET’s genetic samples will be sequenced at the ӳ����ý by the Genomics Platform, with the rest being analyzed in their home countries. The scientists will use a recently developed sequencing technology called <a href="/blog/perspective-uncovering-genetic-basis-mental-illness-requires-diverse-datasets-and-better">Blended Genome Exome (BGE)</a>, which deeply sequences the exome — the 2 percent of human DNA that translates into proteins — and more broadly decodes the rest of the genome. This approach was designed to increase the chances of finding new genetic variation from global samples in a cost-effective manner, allowing for a large number of samples to be sequenced.&nbsp;</p> <p>The team will publicly share A-BIG-NET data through the <a href="https://nda.nih.gov/" target="_blank">National Institute of Mental Health Data Archive (NDA)</a> and the <a href="https://bipex.broadinstitute.org/">Bipolar Exomes Browser</a>. They will also contribute their data to the Psychiatric Genomics Consortium Bipolar Workgroup and the Bipolar Sequencing Project, which will allow them to compare their results to those from other studies focused on European populations.</p> <p>“This study puts together a strong team from Asia to work at understanding the biology of bipolar disorder,” said Jimmy Lee, a Senior Consultant at Singapore’s Institute of Mental Health, an associate professor at the Lee Kong Chian School of Medicine at Nanyang Technological University, and a co-senior investigator of the study. “Singapore is glad to be a part of this coordinated effort. I am confident the team will make important and impactful scientific discoveries, which will eventually translate into improved clinical care and recovery outcomes in people living with bipolar disorder. Additionally, I hope this effort will catalyze the growth of psychiatric genetics in Asia to address the gap in ethnic representation and knowledge.”</p> <p>“Taiwan is often excluded from a number of major international organizations and actions. We’re very glad to be part of the global diversity initiative and to contribute to enhancing our understanding of a severe psychiatric disorder and reducing health inequity in the long run,” said the project’s co-lead, Po-Hsiu Kuo, Associate Dean of College of Public Health, and a Professor at Institute of Epidemiology and Preventive Medicine, National Taiwan University.</p> <p>“In South Korea, no large-scale genomic study has been conducted on mental illness. Recently, however, psychiatric genetic researchers have reached a consensus on the need for large-scale collaborative genomic study on major mental illnesses, and formed the Korean Mood Disorder Genomics Consortium (KOMOGEN) with about 40 organizations to move the team to succeed in the project,” said the South Korea site leader, Heon-Jeong Lee, Professor of Psychiatry, Korea University College of Medicine.</p> <p><em>Funding for this research is provided by the National Institute of Mental Health.</em></p> </div> </div> <div class="block-node-broad-tags block block-layout-builder block-field-blocknodenewsfield-broad-tags"> <div class="block-node-broad-tags__row"> <div class="block-node-broad-tags__title">Tags:</div> <div class="field field--name-field-broad-tags field--type-entity-reference field--label-hidden field__items"> <div class="field__item"><a href="/broad-tags/neurogap" hreflang="en">NeuroGap</a></div> <div class="field__item"><a href="/broad-tags/stanley-center-psychiatric-research" hreflang="en">Stanley Center for Psychiatric Research</a></div> <div class="field__item"><a href="/broad-tags/psychiatric-disease-0" hreflang="en">Psychiatric disease</a></div> <div class="field__item"><a href="/broad-tags/psychiatric-disease" hreflang="en">Brain Health</a></div> <div class="field__item"><a href="/broad-tags/steven-hyman" hreflang="en">Steven Hyman</a></div> <div class="field__item"><a href="/broad-tags/news-and-media" hreflang="en">News and Media</a></div> </div> </div> </div> </div> <div class="content-section__right col-2"> <div class="block block-ctools block-entity-viewnode"> <article about="/news/first-large-genetic-study-bipolar-disorder-asian-populations-launches" class="node node--type-news node--view-mode-sidebar"> <div class="node__content"> <div class="sidebar-group"> <div class="sidebar-group__content"> <div class="block block-layout-builder block-field-blocknodenewsfield-news-extra-info"> <div class="clearfix text-formatted field field--name-field-news-extra-info field--type-text-long field--label-hidden field__item"><h2>&nbsp;</h2> <h2>Related News</h2> <p><img alt src="/files/styles/blog__557x415_/public/news/images/2022/Bipolar_story.png?itok=OnjsAk-j" style="width: 212px; height: 162px;"></p> <p><a href="/node/1130671">Researchers find first strong genetic risk factor for bipolar disorder</a></p> <p><img alt src="/files/styles/blog__557x415_/public/news/images/2022/Singh_Daly_Neale-Graphic.png?itok=5P7iYe2D" style="width: 212px; height: 162px;"></p> <p><a href="/node/1130626">Two large studies reveal genes and genome regions that influence schizophrenia risk</a></p> <p><img alt src="/files/styles/pt_ls_image_tablet/public/long_story/Fullwidth_NDev-Team-Photo.png" style="width: 219px; height: 138px;"></p> <p><a href="/node/1130881">A genetics study in Africa is helping to destigmatize neurodevelopmental differences in children</a></p> <p>&nbsp;</p> <h2>Related Programs</h2> <p><a href="/node/145111">Stanley Global</a></p> <p>&nbsp;</p> <p>&nbsp;</p> <h2>Related Projects</h2> <p><a href="/node/221261">NeuroGAP</a></p> <p><a href="/node/221976">NeuroGAP-Psychosis</a></p> <p><a href="/node/699091">NeuroDev</a></p> <p><a href="/node/1003656">NeuroMex</a></p> <p>&nbsp;</p> <h2>Related People</h2> <p><img alt src="/files/styles/biosketch__413x315_/public/bios/photos/Steve%20Hyman.jpg?itok=Oc4iJDp1" style="width: 212px; height: 162px;"></p> <p><a href="/node/7576">Steven Hyman</a></p> <p><img alt src="/files/styles/biosketch__413x315_/public/bios/photos/MorganSheng-bio.png?itok=BB66CSnx" style="width: 212px; height: 162px;"></p> <p><a href="/node/515316">Morgan Sheng</a></p> </div> </div> </div> </div> </div> </article> </div> </div> </div> </div> Mon, 19 Sep 2022 14:53:09 +0000 kzusi@broadinstitute.org 1195701 at /autonomy-equity-and-cultural-considerations-bioethicists-discuss-mental-health-genetics-africa <span class="field field--name-title field--type-string field--label-hidden"><h1>First large genetic study of bipolar disorder in Asian populations launches</h1> </span> <span class="field field--name-uid field--type-entity-reference field--label-hidden"> <span>By Alex Viveros</span> </span> <span class="field field--name-created field--type-created field--label-hidden"><time datetime="2022-10-31T12:53:52-04:00" class="datetime">October 31, 2022</time> </span> <div class="hero-section container"> <div class="hero-section__row row"> <div class="hero-section__content hero-section__content_left col-6"> <div class="hero-section__breadcrumbs"> <div class="block block-layout-builder block-extra-field-blocknodenewsbreadcrumbs"> <nav class="breadcrumb" role="navigation" aria-labelledby="system-breadcrumb"> <h2 id="system-breadcrumb" class="visually-hidden">Breadcrumb</h2> <ol> <li> <a href="/">Home</a> </li> <li> <a href="/news">News</a> </li> </ol> </nav> </div> </div> <div class="hero-section__title"> <div class="block block-layout-builder block-field-blocknodenewstitle"> <span class="field field--name-title field--type-string field--label-hidden"><h1>First large genetic study of bipolar disorder in Asian populations launches</h1> </span> </div> </div> <div class="hero-section__description"> <div class="block block-layout-builder block-field-blocknodenewsbody"> <div class="clearfix text-formatted field field--name-body field--type-text-with-summary field--label-hidden field__item"><div class="summary-only"> <p>Researchers will analyze the DNA of tens of thousands of people from five countries in East and South Asia to find genetic markers for the psychiatric condition.&nbsp;</p> </div> </div> </div> </div> <div class="hero-section__author"> <div class="block block-layout-builder block-extra-field-blocknodenewsextra-field-author-custom"> By Alex Viveros </div> </div> <div class="hero-section__date"> <div class="block block-layout-builder block-field-blocknodenewscreated"> <span class="field field--name-created field--type-created field--label-hidden"><time datetime="2022-10-31T12:53:52-04:00" class="datetime">October 31, 2022</time> </span> </div> </div> </div> <div class="hero-section__right col-6"> <div class="hero-section__image"> <div class="block block-layout-builder block-field-blocknodenewsfield-image"> <div class="field field--name-field-image field--type-entity-reference field--label-hidden field__item"> <article class="media media--type-image media--view-mode-multiple-content-types-header"> <div class="field field--name-field-media-image field--type-image field--label-hidden field__item"> <picture> <source srcset="/files/styles/multiple_ct_header_desktop_xl/public/news/images/2022/1022%20Bipolar%20Disorder%20Study_Main_557x415_02%20%282%29.png?h=9423a5c0&amp;itok=P3u1Cpvw 1x" media="all and (min-width: 1921px)" type="image/png" width="754" height="503"> <source srcset="/files/styles/multiple_ct_header_desktop_xl/public/news/images/2022/1022%20Bipolar%20Disorder%20Study_Main_557x415_02%20%282%29.png?h=9423a5c0&amp;itok=P3u1Cpvw 1x" media="all and (min-width: 1601px) and (max-width: 1920px)" type="image/png" width="754" height="503"> <source srcset="/files/styles/multiple_ct_header_desktop/public/news/images/2022/1022%20Bipolar%20Disorder%20Study_Main_557x415_02%20%282%29.png?h=9423a5c0&amp;itok=Fvvhxxtr 1x" media="all and (min-width: 1340px) and (max-width: 1600px)" type="image/png" width="736" height="520"> <source srcset="/files/styles/multiple_ct_header_laptop/public/news/images/2022/1022%20Bipolar%20Disorder%20Study_Main_557x415_02%20%282%29.png?h=9423a5c0&amp;itok=oYYe6sIs 1x" media="all and (min-width: 800px) and (max-width: 1339px)" type="image/png" width="641" height="451"> <source srcset="/files/styles/multiple_ct_header_tablet/public/news/images/2022/1022%20Bipolar%20Disorder%20Study_Main_557x415_02%20%282%29.png?h=9423a5c0&amp;itok=wqUDzIyM 1x" media="all and (min-width: 540px) and (max-width: 799px)" type="image/png" width="706" height="417"> <source srcset="/files/styles/multiple_ct_header_phone/public/news/images/2022/1022%20Bipolar%20Disorder%20Study_Main_557x415_02%20%282%29.png?h=9423a5c0&amp;itok=oydp084j 1x" media="all and (max-width: 539px)" type="image/png" width="499" height="294"> <img loading="eager" width="499" height="294" src="/files/styles/multiple_ct_header_phone/public/news/images/2022/1022%20Bipolar%20Disorder%20Study_Main_557x415_02%20%282%29.png?h=9423a5c0&amp;itok=oydp084j" alt="Ricardo Job-Reese, ӳ����ý Communications" typeof="foaf:Image"> </picture> </div> <div class="media-caption"> <div class="media-caption__credit"> Credit: Ricardo Job-Reese, ӳ����ý Communications </div> <div class="media-caption__description"> </div> </div> </article> </div> </div> </div> </div> </div> </div> <div class="content-section content-section_with-sidebars container"> <div class="row"> <div class="content-section__left col-2"> <div class="block block-better-social-sharing-buttons block-social-sharing-buttons-block"> <div style="display: none"><link rel="preload" href="/modules/contrib/better_social_sharing_buttons/assets/dist/sprites/social-icons--no-color.svg" as="image" type="image/svg+xml" crossorigin="anonymous"></div> <div class="social-sharing-buttons"> <a href="https://www.facebook.com/sharer/sharer.php?u=/taxonomy/term/1166/feed&amp;title=" target="_blank" title="Share to Facebook" aria-label="Share to Facebook" class="social-sharing-buttons-button share-facebook" rel="noopener"> <svg aria-hidden="true" width="32px" height="32px" style="border-radius:100%;"> <use href="/modules/contrib/better_social_sharing_buttons/assets/dist/sprites/social-icons--no-color.svg#facebook" /> </svg> </a> <a href="https://twitter.com/intent/tweet?text=+/taxonomy/term/1166/feed" target="_blank" title="Share to X" aria-label="Share to X" class="social-sharing-buttons-button share-x" rel="noopener"> <svg aria-hidden="true" width="32px" height="32px" style="border-radius:100%;"> <use href="/modules/contrib/better_social_sharing_buttons/assets/dist/sprites/social-icons--no-color.svg#x" /> </svg> </a> <a href="mailto:?subject=&amp;body=/taxonomy/term/1166/feed" title="Share to Email" aria-label="Share to Email" class="social-sharing-buttons-button share-email" target="_blank" rel="noopener"> <svg aria-hidden="true" width="32px" height="32px" style="border-radius:100%;"> <use href="/modules/contrib/better_social_sharing_buttons/assets/dist/sprites/social-icons--no-color.svg#email" /> </svg> </a> </div> </div> </div> <div class="content-section__main col-8"> <div class="block block-layout-builder block-field-blocknodenewsbody"> <div class="clearfix text-formatted field field--name-body field--type-text-with-summary field--label-hidden field__item"><p>Nearly 60 percent of the world’s population resides in Asian countries, but only 10 percent of participants of genetic studies are of Asian descent. And that disparity is even greater in studies of psychiatric conditions, where participants are almost all of European ancestry, even though serious mental illness affects all human populations evenly. This lack of representation of the world’s population in genetic datasets leaves out a huge amount of genomic variation, limiting what scientists can learn about the biological basis of mental disorders.&nbsp;</p> <p>A global team of scientists is now trying to tackle this problem by launching a genetic study of bipolar disorder in people from India, Pakistan, Singapore, South Korea, and Taiwan. The study, called the Asian Bipolar Genetics Network (A-BIG-NET), will collect and analyze DNA and demographic, environmental, and medical information from 27,500 patients diagnosed with the psychiatric condition and 15,000 controls.&nbsp;</p> <p>The project is a collaboration between experts from the ӳ����ý of MIT and Harvard (led by Hailiang Huang), Virginia Commonwealth University (led by Kenneth Kendler), Johns Hopkins University (led by Peter Zandi), National Institute of Mental Health and NeuroSciences in India (NIMHANS, led by Biju Viswanath), Indian Institute of Science (led by Bratati Kahali), Institute of Mental Health in Singapore (led by Jimmy Lee), Korea University College of Medicine (led by Heon-Jeong Lee), and National Taiwan University (led by Po-Hsiu Kuo). They will work together to recruit the participants, sequence the genomes, analyze the data, and build a network for rapid data-sharing.&nbsp;</p> <p>The team hopes to uncover genetic markers of bipolar disorder, which may point towards the biological causes and mechanisms underlying this condition that affects 1-2 percent of the world’s population. By focusing on Asian populations, the scientists aim to find markers that are more common in these groups than in others, which may highlight genetic roots of the disorder that are shared across other populations around the world. Better insight into the causes of bipolar disorder from this research could one day lead to new and better treatments.</p> <p>“There haven’t been any sizable bipolar genetic studies from Asian populations,” said Hailiang Huang, the project’s leader, Director of the Stanley Global Asia Initiatives at the Stanley Center for Psychiatric Research at the ӳ����ý, and an Assistant Professor at Massachusetts General Hospital and Harvard Medical School. “If this were to continue, we risk the possibility that therapeutic innovations might exclude large segments of the global population which are under-represented in psychiatric genetics. This is a major unsolved challenge for everyone in the world, including people from South and East Asia.”</p> <p>The new project extends Stanley Global, an initiative launched in 2014 by the Stanley Center to diversify genetic research and include underrepresented populations worldwide. One Stanley Global project, NeuroGAP-Psychosis, launched in 2018 to study the genetics of schizophrenia in four African countries, while another project, NeuroMex, is doing the same in Mexico. NeuroDev is studying neurodevelopmental differences in people in Kenya and South Africa.</p> <p>“Studies like A-BIG-NET have potential to discover rare variant risk genes, which should have a big impact on the mechanistic understanding of bipolar disorder,&nbsp; like the SCHEMA study did for schizophrenia. Because Asian populations have different genetic variants, their inclusion in A-BIG-NET will enhance the diversity and richness of gene discovery for bipolar,” said Morgan Sheng, co-director of the Stanley Center.</p> <h3>Global partnerships</h3> <p>A-BIG-NET was inspired by NeuroGAP-Psychosis and NeuroMex to expand this kind of genetics research to Asian countries. Though Stanley Global has sequenced genomic samples from East Asian populations before, A-BIG-NET expands that effort to include bipolar disorder and will study a much larger cohort. It will also be the first known large-scale study to explore the genetics of bipolar disorder in South Asian countries, and will build on recent discoveries from the Stanley Center including the <a href="/news/researchers-find-first-strong-genetic-risk-factor-bipolar-disorder">first strong genetic signal for bipolar disorder</a>.</p> <p>“The most important finding I would hope would emerge from this project is to find the direct causal genes underlying bipolar disorder,” Huang said. “This study gives us the chance to actually identify the causal genes for bipolar disorder in the Asian population.”</p> <p>“By taking a deep phenotyping approach, we will be collecting information which will allow us to explore a number of clinical subtypes of bipolar illness from a molecular genetic perspective to detect potential differences in their genetic substrate,” said Kendler, a Professor of Psychiatry and Human and Molecular Genetics at Virginia Commonwealth University and Co-Principal Investigator of the project. “Furthermore, studying a range of environmental risk factors will permit us to further clarify how genes and environment jointly act or interact to produce bipolar disorder.”</p> <p>“This study will be an important step in increasing equity in research, especially in the area of psychiatric genetics, ” said Biju Viswanath, Professor of Psychiatry at NIMHANS in India and the lead on the Indian arm of the study. Viswanath has established the India Consortium on Mental Illness And Genetics In the Clinic (IC-MAGIC), which conducts large genetic studies on mental health. Participants from India will make up the largest cohort of the study.&nbsp;</p> <p>“The project will allow advanced training in psychiatric genetics, and engage more researchers and participants. This will allow greater community engagement and expand research capacity in the region. We will then be able to contribute both globally, and importantly, locally to understand these complex disorders,” said Sanjeev Jain, a NIMHANS Professor and senior co-investigator of the study.</p> <p>About a third of A-BIG-NET’s genetic samples will be sequenced at the ӳ����ý by the Genomics Platform, with the rest being analyzed in their home countries. The scientists will use a recently developed sequencing technology called <a href="/blog/perspective-uncovering-genetic-basis-mental-illness-requires-diverse-datasets-and-better">Blended Genome Exome (BGE)</a>, which deeply sequences the exome — the 2 percent of human DNA that translates into proteins — and more broadly decodes the rest of the genome. This approach was designed to increase the chances of finding new genetic variation from global samples in a cost-effective manner, allowing for a large number of samples to be sequenced.&nbsp;</p> <p>The team will publicly share A-BIG-NET data through the <a href="https://nda.nih.gov/" target="_blank">National Institute of Mental Health Data Archive (NDA)</a> and the <a href="https://bipex.broadinstitute.org/">Bipolar Exomes Browser</a>. They will also contribute their data to the Psychiatric Genomics Consortium Bipolar Workgroup and the Bipolar Sequencing Project, which will allow them to compare their results to those from other studies focused on European populations.</p> <p>“This study puts together a strong team from Asia to work at understanding the biology of bipolar disorder,” said Jimmy Lee, a Senior Consultant at Singapore’s Institute of Mental Health, an associate professor at the Lee Kong Chian School of Medicine at Nanyang Technological University, and a co-senior investigator of the study. “Singapore is glad to be a part of this coordinated effort. I am confident the team will make important and impactful scientific discoveries, which will eventually translate into improved clinical care and recovery outcomes in people living with bipolar disorder. Additionally, I hope this effort will catalyze the growth of psychiatric genetics in Asia to address the gap in ethnic representation and knowledge.”</p> <p>“Taiwan is often excluded from a number of major international organizations and actions. We’re very glad to be part of the global diversity initiative and to contribute to enhancing our understanding of a severe psychiatric disorder and reducing health inequity in the long run,” said the project’s co-lead, Po-Hsiu Kuo, Associate Dean of College of Public Health, and a Professor at Institute of Epidemiology and Preventive Medicine, National Taiwan University.</p> <p>“In South Korea, no large-scale genomic study has been conducted on mental illness. Recently, however, psychiatric genetic researchers have reached a consensus on the need for large-scale collaborative genomic study on major mental illnesses, and formed the Korean Mood Disorder Genomics Consortium (KOMOGEN) with about 40 organizations to move the team to succeed in the project,” said the South Korea site leader, Heon-Jeong Lee, Professor of Psychiatry, Korea University College of Medicine.</p> <p><em>Funding for this research is provided by the National Institute of Mental Health.</em></p> </div> </div> <div class="block-node-broad-tags block block-layout-builder block-field-blocknodenewsfield-broad-tags"> <div class="block-node-broad-tags__row"> <div class="block-node-broad-tags__title">Tags:</div> <div class="field field--name-field-broad-tags field--type-entity-reference field--label-hidden field__items"> <div class="field__item"><a href="/broad-tags/neurogap" hreflang="en">NeuroGap</a></div> <div class="field__item"><a href="/broad-tags/stanley-center-psychiatric-research" hreflang="en">Stanley Center for Psychiatric Research</a></div> <div class="field__item"><a href="/broad-tags/psychiatric-disease-0" hreflang="en">Psychiatric disease</a></div> <div class="field__item"><a href="/broad-tags/psychiatric-disease" hreflang="en">Brain Health</a></div> <div class="field__item"><a href="/broad-tags/steven-hyman" hreflang="en">Steven Hyman</a></div> <div class="field__item"><a href="/broad-tags/news-and-media" hreflang="en">News and Media</a></div> </div> </div> </div> </div> <div class="content-section__right col-2"> <div class="block block-ctools block-entity-viewnode"> <article about="/news/first-large-genetic-study-bipolar-disorder-asian-populations-launches" class="node node--type-news node--view-mode-sidebar"> <div class="node__content"> <div class="sidebar-group"> <div class="sidebar-group__content"> <div class="block block-layout-builder block-field-blocknodenewsfield-news-extra-info"> <div class="clearfix text-formatted field field--name-field-news-extra-info field--type-text-long field--label-hidden field__item"><h2>&nbsp;</h2> <h2>Related News</h2> <p><img alt src="/files/styles/blog__557x415_/public/news/images/2022/Bipolar_story.png?itok=OnjsAk-j" style="width: 212px; height: 162px;"></p> <p><a href="/node/1130671">Researchers find first strong genetic risk factor for bipolar disorder</a></p> <p><img alt src="/files/styles/blog__557x415_/public/news/images/2022/Singh_Daly_Neale-Graphic.png?itok=5P7iYe2D" style="width: 212px; height: 162px;"></p> <p><a href="/node/1130626">Two large studies reveal genes and genome regions that influence schizophrenia risk</a></p> <p><img alt src="/files/styles/pt_ls_image_tablet/public/long_story/Fullwidth_NDev-Team-Photo.png" style="width: 219px; height: 138px;"></p> <p><a href="/node/1130881">A genetics study in Africa is helping to destigmatize neurodevelopmental differences in children</a></p> <p>&nbsp;</p> <h2>Related Programs</h2> <p><a href="/node/145111">Stanley Global</a></p> <p>&nbsp;</p> <p>&nbsp;</p> <h2>Related Projects</h2> <p><a href="/node/221261">NeuroGAP</a></p> <p><a href="/node/221976">NeuroGAP-Psychosis</a></p> <p><a href="/node/699091">NeuroDev</a></p> <p><a href="/node/1003656">NeuroMex</a></p> <p>&nbsp;</p> <h2>Related People</h2> <p><img alt src="/files/styles/biosketch__413x315_/public/bios/photos/Steve%20Hyman.jpg?itok=Oc4iJDp1" style="width: 212px; height: 162px;"></p> <p><a href="/node/7576">Steven Hyman</a></p> <p><img alt src="/files/styles/biosketch__413x315_/public/bios/photos/MorganSheng-bio.png?itok=BB66CSnx" style="width: 212px; height: 162px;"></p> <p><a href="/node/515316">Morgan Sheng</a></p> </div> </div> </div> </div> </div> </article> </div> </div> </div> </div> Thu, 08 Oct 2020 04:00:00 +0000 tulrich@broadinstitute.org 661246 at /meet-members-next-generation-psychiatric-genetics-researchers-kenya-and-uganda <span class="field field--name-title field--type-string field--label-hidden"><h1>First large genetic study of bipolar disorder in Asian populations launches</h1> </span> <span class="field field--name-uid field--type-entity-reference field--label-hidden"> <span>By Alex Viveros</span> </span> <span class="field field--name-created field--type-created field--label-hidden"><time datetime="2022-10-31T12:53:52-04:00" class="datetime">October 31, 2022</time> </span> <div class="hero-section container"> <div class="hero-section__row row"> <div class="hero-section__content hero-section__content_left col-6"> <div class="hero-section__breadcrumbs"> <div class="block block-layout-builder block-extra-field-blocknodenewsbreadcrumbs"> <nav class="breadcrumb" role="navigation" aria-labelledby="system-breadcrumb"> <h2 id="system-breadcrumb" class="visually-hidden">Breadcrumb</h2> <ol> <li> <a href="/">Home</a> </li> <li> <a href="/news">News</a> </li> </ol> </nav> </div> </div> <div class="hero-section__title"> <div class="block block-layout-builder block-field-blocknodenewstitle"> <span class="field field--name-title field--type-string field--label-hidden"><h1>First large genetic study of bipolar disorder in Asian populations launches</h1> </span> </div> </div> <div class="hero-section__description"> <div class="block block-layout-builder block-field-blocknodenewsbody"> <div class="clearfix text-formatted field field--name-body field--type-text-with-summary field--label-hidden field__item"><div class="summary-only"> <p>Researchers will analyze the DNA of tens of thousands of people from five countries in East and South Asia to find genetic markers for the psychiatric condition.&nbsp;</p> </div> </div> </div> </div> <div class="hero-section__author"> <div class="block block-layout-builder block-extra-field-blocknodenewsextra-field-author-custom"> By Alex Viveros </div> </div> <div class="hero-section__date"> <div class="block block-layout-builder block-field-blocknodenewscreated"> <span class="field field--name-created field--type-created field--label-hidden"><time datetime="2022-10-31T12:53:52-04:00" class="datetime">October 31, 2022</time> </span> </div> </div> </div> <div class="hero-section__right col-6"> <div class="hero-section__image"> <div class="block block-layout-builder block-field-blocknodenewsfield-image"> <div class="field field--name-field-image field--type-entity-reference field--label-hidden field__item"> <article class="media media--type-image media--view-mode-multiple-content-types-header"> <div class="field field--name-field-media-image field--type-image field--label-hidden field__item"> <picture> <source srcset="/files/styles/multiple_ct_header_desktop_xl/public/news/images/2022/1022%20Bipolar%20Disorder%20Study_Main_557x415_02%20%282%29.png?h=9423a5c0&amp;itok=P3u1Cpvw 1x" media="all and (min-width: 1921px)" type="image/png" width="754" height="503"> <source srcset="/files/styles/multiple_ct_header_desktop_xl/public/news/images/2022/1022%20Bipolar%20Disorder%20Study_Main_557x415_02%20%282%29.png?h=9423a5c0&amp;itok=P3u1Cpvw 1x" media="all and (min-width: 1601px) and (max-width: 1920px)" type="image/png" width="754" height="503"> <source srcset="/files/styles/multiple_ct_header_desktop/public/news/images/2022/1022%20Bipolar%20Disorder%20Study_Main_557x415_02%20%282%29.png?h=9423a5c0&amp;itok=Fvvhxxtr 1x" media="all and (min-width: 1340px) and (max-width: 1600px)" type="image/png" width="736" height="520"> <source srcset="/files/styles/multiple_ct_header_laptop/public/news/images/2022/1022%20Bipolar%20Disorder%20Study_Main_557x415_02%20%282%29.png?h=9423a5c0&amp;itok=oYYe6sIs 1x" media="all and (min-width: 800px) and (max-width: 1339px)" type="image/png" width="641" height="451"> <source srcset="/files/styles/multiple_ct_header_tablet/public/news/images/2022/1022%20Bipolar%20Disorder%20Study_Main_557x415_02%20%282%29.png?h=9423a5c0&amp;itok=wqUDzIyM 1x" media="all and (min-width: 540px) and (max-width: 799px)" type="image/png" width="706" height="417"> <source srcset="/files/styles/multiple_ct_header_phone/public/news/images/2022/1022%20Bipolar%20Disorder%20Study_Main_557x415_02%20%282%29.png?h=9423a5c0&amp;itok=oydp084j 1x" media="all and (max-width: 539px)" type="image/png" width="499" height="294"> <img loading="eager" width="499" height="294" src="/files/styles/multiple_ct_header_phone/public/news/images/2022/1022%20Bipolar%20Disorder%20Study_Main_557x415_02%20%282%29.png?h=9423a5c0&amp;itok=oydp084j" alt="Ricardo Job-Reese, ӳ����ý Communications" typeof="foaf:Image"> </picture> </div> <div class="media-caption"> <div class="media-caption__credit"> Credit: Ricardo Job-Reese, ӳ����ý Communications </div> <div class="media-caption__description"> </div> </div> </article> </div> </div> </div> </div> </div> </div> <div class="content-section content-section_with-sidebars container"> <div class="row"> <div class="content-section__left col-2"> <div class="block block-better-social-sharing-buttons block-social-sharing-buttons-block"> <div style="display: none"><link rel="preload" href="/modules/contrib/better_social_sharing_buttons/assets/dist/sprites/social-icons--no-color.svg" as="image" type="image/svg+xml" crossorigin="anonymous"></div> <div class="social-sharing-buttons"> <a href="https://www.facebook.com/sharer/sharer.php?u=/taxonomy/term/1166/feed&amp;title=" target="_blank" title="Share to Facebook" aria-label="Share to Facebook" class="social-sharing-buttons-button share-facebook" rel="noopener"> <svg aria-hidden="true" width="32px" height="32px" style="border-radius:100%;"> <use href="/modules/contrib/better_social_sharing_buttons/assets/dist/sprites/social-icons--no-color.svg#facebook" /> </svg> </a> <a href="https://twitter.com/intent/tweet?text=+/taxonomy/term/1166/feed" target="_blank" title="Share to X" aria-label="Share to X" class="social-sharing-buttons-button share-x" rel="noopener"> <svg aria-hidden="true" width="32px" height="32px" style="border-radius:100%;"> <use href="/modules/contrib/better_social_sharing_buttons/assets/dist/sprites/social-icons--no-color.svg#x" /> </svg> </a> <a href="mailto:?subject=&amp;body=/taxonomy/term/1166/feed" title="Share to Email" aria-label="Share to Email" class="social-sharing-buttons-button share-email" target="_blank" rel="noopener"> <svg aria-hidden="true" width="32px" height="32px" style="border-radius:100%;"> <use href="/modules/contrib/better_social_sharing_buttons/assets/dist/sprites/social-icons--no-color.svg#email" /> </svg> </a> </div> </div> </div> <div class="content-section__main col-8"> <div class="block block-layout-builder block-field-blocknodenewsbody"> <div class="clearfix text-formatted field field--name-body field--type-text-with-summary field--label-hidden field__item"><p>Nearly 60 percent of the world’s population resides in Asian countries, but only 10 percent of participants of genetic studies are of Asian descent. And that disparity is even greater in studies of psychiatric conditions, where participants are almost all of European ancestry, even though serious mental illness affects all human populations evenly. This lack of representation of the world’s population in genetic datasets leaves out a huge amount of genomic variation, limiting what scientists can learn about the biological basis of mental disorders.&nbsp;</p> <p>A global team of scientists is now trying to tackle this problem by launching a genetic study of bipolar disorder in people from India, Pakistan, Singapore, South Korea, and Taiwan. The study, called the Asian Bipolar Genetics Network (A-BIG-NET), will collect and analyze DNA and demographic, environmental, and medical information from 27,500 patients diagnosed with the psychiatric condition and 15,000 controls.&nbsp;</p> <p>The project is a collaboration between experts from the ӳ����ý of MIT and Harvard (led by Hailiang Huang), Virginia Commonwealth University (led by Kenneth Kendler), Johns Hopkins University (led by Peter Zandi), National Institute of Mental Health and NeuroSciences in India (NIMHANS, led by Biju Viswanath), Indian Institute of Science (led by Bratati Kahali), Institute of Mental Health in Singapore (led by Jimmy Lee), Korea University College of Medicine (led by Heon-Jeong Lee), and National Taiwan University (led by Po-Hsiu Kuo). They will work together to recruit the participants, sequence the genomes, analyze the data, and build a network for rapid data-sharing.&nbsp;</p> <p>The team hopes to uncover genetic markers of bipolar disorder, which may point towards the biological causes and mechanisms underlying this condition that affects 1-2 percent of the world’s population. By focusing on Asian populations, the scientists aim to find markers that are more common in these groups than in others, which may highlight genetic roots of the disorder that are shared across other populations around the world. Better insight into the causes of bipolar disorder from this research could one day lead to new and better treatments.</p> <p>“There haven’t been any sizable bipolar genetic studies from Asian populations,” said Hailiang Huang, the project’s leader, Director of the Stanley Global Asia Initiatives at the Stanley Center for Psychiatric Research at the ӳ����ý, and an Assistant Professor at Massachusetts General Hospital and Harvard Medical School. “If this were to continue, we risk the possibility that therapeutic innovations might exclude large segments of the global population which are under-represented in psychiatric genetics. This is a major unsolved challenge for everyone in the world, including people from South and East Asia.”</p> <p>The new project extends Stanley Global, an initiative launched in 2014 by the Stanley Center to diversify genetic research and include underrepresented populations worldwide. One Stanley Global project, NeuroGAP-Psychosis, launched in 2018 to study the genetics of schizophrenia in four African countries, while another project, NeuroMex, is doing the same in Mexico. NeuroDev is studying neurodevelopmental differences in people in Kenya and South Africa.</p> <p>“Studies like A-BIG-NET have potential to discover rare variant risk genes, which should have a big impact on the mechanistic understanding of bipolar disorder,&nbsp; like the SCHEMA study did for schizophrenia. Because Asian populations have different genetic variants, their inclusion in A-BIG-NET will enhance the diversity and richness of gene discovery for bipolar,” said Morgan Sheng, co-director of the Stanley Center.</p> <h3>Global partnerships</h3> <p>A-BIG-NET was inspired by NeuroGAP-Psychosis and NeuroMex to expand this kind of genetics research to Asian countries. Though Stanley Global has sequenced genomic samples from East Asian populations before, A-BIG-NET expands that effort to include bipolar disorder and will study a much larger cohort. It will also be the first known large-scale study to explore the genetics of bipolar disorder in South Asian countries, and will build on recent discoveries from the Stanley Center including the <a href="/news/researchers-find-first-strong-genetic-risk-factor-bipolar-disorder">first strong genetic signal for bipolar disorder</a>.</p> <p>“The most important finding I would hope would emerge from this project is to find the direct causal genes underlying bipolar disorder,” Huang said. “This study gives us the chance to actually identify the causal genes for bipolar disorder in the Asian population.”</p> <p>“By taking a deep phenotyping approach, we will be collecting information which will allow us to explore a number of clinical subtypes of bipolar illness from a molecular genetic perspective to detect potential differences in their genetic substrate,” said Kendler, a Professor of Psychiatry and Human and Molecular Genetics at Virginia Commonwealth University and Co-Principal Investigator of the project. “Furthermore, studying a range of environmental risk factors will permit us to further clarify how genes and environment jointly act or interact to produce bipolar disorder.”</p> <p>“This study will be an important step in increasing equity in research, especially in the area of psychiatric genetics, ” said Biju Viswanath, Professor of Psychiatry at NIMHANS in India and the lead on the Indian arm of the study. Viswanath has established the India Consortium on Mental Illness And Genetics In the Clinic (IC-MAGIC), which conducts large genetic studies on mental health. Participants from India will make up the largest cohort of the study.&nbsp;</p> <p>“The project will allow advanced training in psychiatric genetics, and engage more researchers and participants. This will allow greater community engagement and expand research capacity in the region. We will then be able to contribute both globally, and importantly, locally to understand these complex disorders,” said Sanjeev Jain, a NIMHANS Professor and senior co-investigator of the study.</p> <p>About a third of A-BIG-NET’s genetic samples will be sequenced at the ӳ����ý by the Genomics Platform, with the rest being analyzed in their home countries. The scientists will use a recently developed sequencing technology called <a href="/blog/perspective-uncovering-genetic-basis-mental-illness-requires-diverse-datasets-and-better">Blended Genome Exome (BGE)</a>, which deeply sequences the exome — the 2 percent of human DNA that translates into proteins — and more broadly decodes the rest of the genome. This approach was designed to increase the chances of finding new genetic variation from global samples in a cost-effective manner, allowing for a large number of samples to be sequenced.&nbsp;</p> <p>The team will publicly share A-BIG-NET data through the <a href="https://nda.nih.gov/" target="_blank">National Institute of Mental Health Data Archive (NDA)</a> and the <a href="https://bipex.broadinstitute.org/">Bipolar Exomes Browser</a>. They will also contribute their data to the Psychiatric Genomics Consortium Bipolar Workgroup and the Bipolar Sequencing Project, which will allow them to compare their results to those from other studies focused on European populations.</p> <p>“This study puts together a strong team from Asia to work at understanding the biology of bipolar disorder,” said Jimmy Lee, a Senior Consultant at Singapore’s Institute of Mental Health, an associate professor at the Lee Kong Chian School of Medicine at Nanyang Technological University, and a co-senior investigator of the study. “Singapore is glad to be a part of this coordinated effort. I am confident the team will make important and impactful scientific discoveries, which will eventually translate into improved clinical care and recovery outcomes in people living with bipolar disorder. Additionally, I hope this effort will catalyze the growth of psychiatric genetics in Asia to address the gap in ethnic representation and knowledge.”</p> <p>“Taiwan is often excluded from a number of major international organizations and actions. We’re very glad to be part of the global diversity initiative and to contribute to enhancing our understanding of a severe psychiatric disorder and reducing health inequity in the long run,” said the project’s co-lead, Po-Hsiu Kuo, Associate Dean of College of Public Health, and a Professor at Institute of Epidemiology and Preventive Medicine, National Taiwan University.</p> <p>“In South Korea, no large-scale genomic study has been conducted on mental illness. Recently, however, psychiatric genetic researchers have reached a consensus on the need for large-scale collaborative genomic study on major mental illnesses, and formed the Korean Mood Disorder Genomics Consortium (KOMOGEN) with about 40 organizations to move the team to succeed in the project,” said the South Korea site leader, Heon-Jeong Lee, Professor of Psychiatry, Korea University College of Medicine.</p> <p><em>Funding for this research is provided by the National Institute of Mental Health.</em></p> </div> </div> <div class="block-node-broad-tags block block-layout-builder block-field-blocknodenewsfield-broad-tags"> <div class="block-node-broad-tags__row"> <div class="block-node-broad-tags__title">Tags:</div> <div class="field field--name-field-broad-tags field--type-entity-reference field--label-hidden field__items"> <div class="field__item"><a href="/broad-tags/neurogap" hreflang="en">NeuroGap</a></div> <div class="field__item"><a href="/broad-tags/stanley-center-psychiatric-research" hreflang="en">Stanley Center for Psychiatric Research</a></div> <div class="field__item"><a href="/broad-tags/psychiatric-disease-0" hreflang="en">Psychiatric disease</a></div> <div class="field__item"><a href="/broad-tags/psychiatric-disease" hreflang="en">Brain Health</a></div> <div class="field__item"><a href="/broad-tags/steven-hyman" hreflang="en">Steven Hyman</a></div> <div class="field__item"><a href="/broad-tags/news-and-media" hreflang="en">News and Media</a></div> </div> </div> </div> </div> <div class="content-section__right col-2"> <div class="block block-ctools block-entity-viewnode"> <article about="/news/first-large-genetic-study-bipolar-disorder-asian-populations-launches" class="node node--type-news node--view-mode-sidebar"> <div class="node__content"> <div class="sidebar-group"> <div class="sidebar-group__content"> <div class="block block-layout-builder block-field-blocknodenewsfield-news-extra-info"> <div class="clearfix text-formatted field field--name-field-news-extra-info field--type-text-long field--label-hidden field__item"><h2>&nbsp;</h2> <h2>Related News</h2> <p><img alt src="/files/styles/blog__557x415_/public/news/images/2022/Bipolar_story.png?itok=OnjsAk-j" style="width: 212px; height: 162px;"></p> <p><a href="/node/1130671">Researchers find first strong genetic risk factor for bipolar disorder</a></p> <p><img alt src="/files/styles/blog__557x415_/public/news/images/2022/Singh_Daly_Neale-Graphic.png?itok=5P7iYe2D" style="width: 212px; height: 162px;"></p> <p><a href="/node/1130626">Two large studies reveal genes and genome regions that influence schizophrenia risk</a></p> <p><img alt src="/files/styles/pt_ls_image_tablet/public/long_story/Fullwidth_NDev-Team-Photo.png" style="width: 219px; height: 138px;"></p> <p><a href="/node/1130881">A genetics study in Africa is helping to destigmatize neurodevelopmental differences in children</a></p> <p>&nbsp;</p> <h2>Related Programs</h2> <p><a href="/node/145111">Stanley Global</a></p> <p>&nbsp;</p> <p>&nbsp;</p> <h2>Related Projects</h2> <p><a href="/node/221261">NeuroGAP</a></p> <p><a href="/node/221976">NeuroGAP-Psychosis</a></p> <p><a href="/node/699091">NeuroDev</a></p> <p><a href="/node/1003656">NeuroMex</a></p> <p>&nbsp;</p> <h2>Related People</h2> <p><img alt src="/files/styles/biosketch__413x315_/public/bios/photos/Steve%20Hyman.jpg?itok=Oc4iJDp1" style="width: 212px; height: 162px;"></p> <p><a href="/node/7576">Steven Hyman</a></p> <p><img alt src="/files/styles/biosketch__413x315_/public/bios/photos/MorganSheng-bio.png?itok=BB66CSnx" style="width: 212px; height: 162px;"></p> <p><a href="/node/515316">Morgan Sheng</a></p> </div> </div> </div> </div> </div> </article> </div> </div> </div> </div> Thu, 08 Oct 2020 04:00:00 +0000 Corie Lok 660721 at /schizophrenia-study-africa-boosting-equity-global-genetics-research <span class="field field--name-title field--type-string field--label-hidden"><h1>First large genetic study of bipolar disorder in Asian populations launches</h1> </span> <span class="field field--name-uid field--type-entity-reference field--label-hidden"> <span>By Alex Viveros</span> </span> <span class="field field--name-created field--type-created field--label-hidden"><time datetime="2022-10-31T12:53:52-04:00" class="datetime">October 31, 2022</time> </span> <div class="hero-section container"> <div class="hero-section__row row"> <div class="hero-section__content hero-section__content_left col-6"> <div class="hero-section__breadcrumbs"> <div class="block block-layout-builder block-extra-field-blocknodenewsbreadcrumbs"> <nav class="breadcrumb" role="navigation" aria-labelledby="system-breadcrumb"> <h2 id="system-breadcrumb" class="visually-hidden">Breadcrumb</h2> <ol> <li> <a href="/">Home</a> </li> <li> <a href="/news">News</a> </li> </ol> </nav> </div> </div> <div class="hero-section__title"> <div class="block block-layout-builder block-field-blocknodenewstitle"> <span class="field field--name-title field--type-string field--label-hidden"><h1>First large genetic study of bipolar disorder in Asian populations launches</h1> </span> </div> </div> <div class="hero-section__description"> <div class="block block-layout-builder block-field-blocknodenewsbody"> <div class="clearfix text-formatted field field--name-body field--type-text-with-summary field--label-hidden field__item"><div class="summary-only"> <p>Researchers will analyze the DNA of tens of thousands of people from five countries in East and South Asia to find genetic markers for the psychiatric condition.&nbsp;</p> </div> </div> </div> </div> <div class="hero-section__author"> <div class="block block-layout-builder block-extra-field-blocknodenewsextra-field-author-custom"> By Alex Viveros </div> </div> <div class="hero-section__date"> <div class="block block-layout-builder block-field-blocknodenewscreated"> <span class="field field--name-created field--type-created field--label-hidden"><time datetime="2022-10-31T12:53:52-04:00" class="datetime">October 31, 2022</time> </span> </div> </div> </div> <div class="hero-section__right col-6"> <div class="hero-section__image"> <div class="block block-layout-builder block-field-blocknodenewsfield-image"> <div class="field field--name-field-image field--type-entity-reference field--label-hidden field__item"> <article class="media media--type-image media--view-mode-multiple-content-types-header"> <div class="field field--name-field-media-image field--type-image field--label-hidden field__item"> <picture> <source srcset="/files/styles/multiple_ct_header_desktop_xl/public/news/images/2022/1022%20Bipolar%20Disorder%20Study_Main_557x415_02%20%282%29.png?h=9423a5c0&amp;itok=P3u1Cpvw 1x" media="all and (min-width: 1921px)" type="image/png" width="754" height="503"> <source srcset="/files/styles/multiple_ct_header_desktop_xl/public/news/images/2022/1022%20Bipolar%20Disorder%20Study_Main_557x415_02%20%282%29.png?h=9423a5c0&amp;itok=P3u1Cpvw 1x" media="all and (min-width: 1601px) and (max-width: 1920px)" type="image/png" width="754" height="503"> <source srcset="/files/styles/multiple_ct_header_desktop/public/news/images/2022/1022%20Bipolar%20Disorder%20Study_Main_557x415_02%20%282%29.png?h=9423a5c0&amp;itok=Fvvhxxtr 1x" media="all and (min-width: 1340px) and (max-width: 1600px)" type="image/png" width="736" height="520"> <source srcset="/files/styles/multiple_ct_header_laptop/public/news/images/2022/1022%20Bipolar%20Disorder%20Study_Main_557x415_02%20%282%29.png?h=9423a5c0&amp;itok=oYYe6sIs 1x" media="all and (min-width: 800px) and (max-width: 1339px)" type="image/png" width="641" height="451"> <source srcset="/files/styles/multiple_ct_header_tablet/public/news/images/2022/1022%20Bipolar%20Disorder%20Study_Main_557x415_02%20%282%29.png?h=9423a5c0&amp;itok=wqUDzIyM 1x" media="all and (min-width: 540px) and (max-width: 799px)" type="image/png" width="706" height="417"> <source srcset="/files/styles/multiple_ct_header_phone/public/news/images/2022/1022%20Bipolar%20Disorder%20Study_Main_557x415_02%20%282%29.png?h=9423a5c0&amp;itok=oydp084j 1x" media="all and (max-width: 539px)" type="image/png" width="499" height="294"> <img loading="eager" width="499" height="294" src="/files/styles/multiple_ct_header_phone/public/news/images/2022/1022%20Bipolar%20Disorder%20Study_Main_557x415_02%20%282%29.png?h=9423a5c0&amp;itok=oydp084j" alt="Ricardo Job-Reese, ӳ����ý Communications" typeof="foaf:Image"> </picture> </div> <div class="media-caption"> <div class="media-caption__credit"> Credit: Ricardo Job-Reese, ӳ����ý Communications </div> <div class="media-caption__description"> </div> </div> </article> </div> </div> </div> </div> </div> </div> <div class="content-section content-section_with-sidebars container"> <div class="row"> <div class="content-section__left col-2"> <div class="block block-better-social-sharing-buttons block-social-sharing-buttons-block"> <div style="display: none"><link rel="preload" href="/modules/contrib/better_social_sharing_buttons/assets/dist/sprites/social-icons--no-color.svg" as="image" type="image/svg+xml" crossorigin="anonymous"></div> <div class="social-sharing-buttons"> <a href="https://www.facebook.com/sharer/sharer.php?u=/taxonomy/term/1166/feed&amp;title=" target="_blank" title="Share to Facebook" aria-label="Share to Facebook" class="social-sharing-buttons-button share-facebook" rel="noopener"> <svg aria-hidden="true" width="32px" height="32px" style="border-radius:100%;"> <use href="/modules/contrib/better_social_sharing_buttons/assets/dist/sprites/social-icons--no-color.svg#facebook" /> </svg> </a> <a href="https://twitter.com/intent/tweet?text=+/taxonomy/term/1166/feed" target="_blank" title="Share to X" aria-label="Share to X" class="social-sharing-buttons-button share-x" rel="noopener"> <svg aria-hidden="true" width="32px" height="32px" style="border-radius:100%;"> <use href="/modules/contrib/better_social_sharing_buttons/assets/dist/sprites/social-icons--no-color.svg#x" /> </svg> </a> <a href="mailto:?subject=&amp;body=/taxonomy/term/1166/feed" title="Share to Email" aria-label="Share to Email" class="social-sharing-buttons-button share-email" target="_blank" rel="noopener"> <svg aria-hidden="true" width="32px" height="32px" style="border-radius:100%;"> <use href="/modules/contrib/better_social_sharing_buttons/assets/dist/sprites/social-icons--no-color.svg#email" /> </svg> </a> </div> </div> </div> <div class="content-section__main col-8"> <div class="block block-layout-builder block-field-blocknodenewsbody"> <div class="clearfix text-formatted field field--name-body field--type-text-with-summary field--label-hidden field__item"><p>Nearly 60 percent of the world’s population resides in Asian countries, but only 10 percent of participants of genetic studies are of Asian descent. And that disparity is even greater in studies of psychiatric conditions, where participants are almost all of European ancestry, even though serious mental illness affects all human populations evenly. This lack of representation of the world’s population in genetic datasets leaves out a huge amount of genomic variation, limiting what scientists can learn about the biological basis of mental disorders.&nbsp;</p> <p>A global team of scientists is now trying to tackle this problem by launching a genetic study of bipolar disorder in people from India, Pakistan, Singapore, South Korea, and Taiwan. The study, called the Asian Bipolar Genetics Network (A-BIG-NET), will collect and analyze DNA and demographic, environmental, and medical information from 27,500 patients diagnosed with the psychiatric condition and 15,000 controls.&nbsp;</p> <p>The project is a collaboration between experts from the ӳ����ý of MIT and Harvard (led by Hailiang Huang), Virginia Commonwealth University (led by Kenneth Kendler), Johns Hopkins University (led by Peter Zandi), National Institute of Mental Health and NeuroSciences in India (NIMHANS, led by Biju Viswanath), Indian Institute of Science (led by Bratati Kahali), Institute of Mental Health in Singapore (led by Jimmy Lee), Korea University College of Medicine (led by Heon-Jeong Lee), and National Taiwan University (led by Po-Hsiu Kuo). They will work together to recruit the participants, sequence the genomes, analyze the data, and build a network for rapid data-sharing.&nbsp;</p> <p>The team hopes to uncover genetic markers of bipolar disorder, which may point towards the biological causes and mechanisms underlying this condition that affects 1-2 percent of the world’s population. By focusing on Asian populations, the scientists aim to find markers that are more common in these groups than in others, which may highlight genetic roots of the disorder that are shared across other populations around the world. Better insight into the causes of bipolar disorder from this research could one day lead to new and better treatments.</p> <p>“There haven’t been any sizable bipolar genetic studies from Asian populations,” said Hailiang Huang, the project’s leader, Director of the Stanley Global Asia Initiatives at the Stanley Center for Psychiatric Research at the ӳ����ý, and an Assistant Professor at Massachusetts General Hospital and Harvard Medical School. “If this were to continue, we risk the possibility that therapeutic innovations might exclude large segments of the global population which are under-represented in psychiatric genetics. This is a major unsolved challenge for everyone in the world, including people from South and East Asia.”</p> <p>The new project extends Stanley Global, an initiative launched in 2014 by the Stanley Center to diversify genetic research and include underrepresented populations worldwide. One Stanley Global project, NeuroGAP-Psychosis, launched in 2018 to study the genetics of schizophrenia in four African countries, while another project, NeuroMex, is doing the same in Mexico. NeuroDev is studying neurodevelopmental differences in people in Kenya and South Africa.</p> <p>“Studies like A-BIG-NET have potential to discover rare variant risk genes, which should have a big impact on the mechanistic understanding of bipolar disorder,&nbsp; like the SCHEMA study did for schizophrenia. Because Asian populations have different genetic variants, their inclusion in A-BIG-NET will enhance the diversity and richness of gene discovery for bipolar,” said Morgan Sheng, co-director of the Stanley Center.</p> <h3>Global partnerships</h3> <p>A-BIG-NET was inspired by NeuroGAP-Psychosis and NeuroMex to expand this kind of genetics research to Asian countries. Though Stanley Global has sequenced genomic samples from East Asian populations before, A-BIG-NET expands that effort to include bipolar disorder and will study a much larger cohort. It will also be the first known large-scale study to explore the genetics of bipolar disorder in South Asian countries, and will build on recent discoveries from the Stanley Center including the <a href="/news/researchers-find-first-strong-genetic-risk-factor-bipolar-disorder">first strong genetic signal for bipolar disorder</a>.</p> <p>“The most important finding I would hope would emerge from this project is to find the direct causal genes underlying bipolar disorder,” Huang said. “This study gives us the chance to actually identify the causal genes for bipolar disorder in the Asian population.”</p> <p>“By taking a deep phenotyping approach, we will be collecting information which will allow us to explore a number of clinical subtypes of bipolar illness from a molecular genetic perspective to detect potential differences in their genetic substrate,” said Kendler, a Professor of Psychiatry and Human and Molecular Genetics at Virginia Commonwealth University and Co-Principal Investigator of the project. “Furthermore, studying a range of environmental risk factors will permit us to further clarify how genes and environment jointly act or interact to produce bipolar disorder.”</p> <p>“This study will be an important step in increasing equity in research, especially in the area of psychiatric genetics, ” said Biju Viswanath, Professor of Psychiatry at NIMHANS in India and the lead on the Indian arm of the study. Viswanath has established the India Consortium on Mental Illness And Genetics In the Clinic (IC-MAGIC), which conducts large genetic studies on mental health. Participants from India will make up the largest cohort of the study.&nbsp;</p> <p>“The project will allow advanced training in psychiatric genetics, and engage more researchers and participants. This will allow greater community engagement and expand research capacity in the region. We will then be able to contribute both globally, and importantly, locally to understand these complex disorders,” said Sanjeev Jain, a NIMHANS Professor and senior co-investigator of the study.</p> <p>About a third of A-BIG-NET’s genetic samples will be sequenced at the ӳ����ý by the Genomics Platform, with the rest being analyzed in their home countries. The scientists will use a recently developed sequencing technology called <a href="/blog/perspective-uncovering-genetic-basis-mental-illness-requires-diverse-datasets-and-better">Blended Genome Exome (BGE)</a>, which deeply sequences the exome — the 2 percent of human DNA that translates into proteins — and more broadly decodes the rest of the genome. This approach was designed to increase the chances of finding new genetic variation from global samples in a cost-effective manner, allowing for a large number of samples to be sequenced.&nbsp;</p> <p>The team will publicly share A-BIG-NET data through the <a href="https://nda.nih.gov/" target="_blank">National Institute of Mental Health Data Archive (NDA)</a> and the <a href="https://bipex.broadinstitute.org/">Bipolar Exomes Browser</a>. They will also contribute their data to the Psychiatric Genomics Consortium Bipolar Workgroup and the Bipolar Sequencing Project, which will allow them to compare their results to those from other studies focused on European populations.</p> <p>“This study puts together a strong team from Asia to work at understanding the biology of bipolar disorder,” said Jimmy Lee, a Senior Consultant at Singapore’s Institute of Mental Health, an associate professor at the Lee Kong Chian School of Medicine at Nanyang Technological University, and a co-senior investigator of the study. “Singapore is glad to be a part of this coordinated effort. I am confident the team will make important and impactful scientific discoveries, which will eventually translate into improved clinical care and recovery outcomes in people living with bipolar disorder. Additionally, I hope this effort will catalyze the growth of psychiatric genetics in Asia to address the gap in ethnic representation and knowledge.”</p> <p>“Taiwan is often excluded from a number of major international organizations and actions. We’re very glad to be part of the global diversity initiative and to contribute to enhancing our understanding of a severe psychiatric disorder and reducing health inequity in the long run,” said the project’s co-lead, Po-Hsiu Kuo, Associate Dean of College of Public Health, and a Professor at Institute of Epidemiology and Preventive Medicine, National Taiwan University.</p> <p>“In South Korea, no large-scale genomic study has been conducted on mental illness. Recently, however, psychiatric genetic researchers have reached a consensus on the need for large-scale collaborative genomic study on major mental illnesses, and formed the Korean Mood Disorder Genomics Consortium (KOMOGEN) with about 40 organizations to move the team to succeed in the project,” said the South Korea site leader, Heon-Jeong Lee, Professor of Psychiatry, Korea University College of Medicine.</p> <p><em>Funding for this research is provided by the National Institute of Mental Health.</em></p> </div> </div> <div class="block-node-broad-tags block block-layout-builder block-field-blocknodenewsfield-broad-tags"> <div class="block-node-broad-tags__row"> <div class="block-node-broad-tags__title">Tags:</div> <div class="field field--name-field-broad-tags field--type-entity-reference field--label-hidden field__items"> <div class="field__item"><a href="/broad-tags/neurogap" hreflang="en">NeuroGap</a></div> <div class="field__item"><a href="/broad-tags/stanley-center-psychiatric-research" hreflang="en">Stanley Center for Psychiatric Research</a></div> <div class="field__item"><a href="/broad-tags/psychiatric-disease-0" hreflang="en">Psychiatric disease</a></div> <div class="field__item"><a href="/broad-tags/psychiatric-disease" hreflang="en">Brain Health</a></div> <div class="field__item"><a href="/broad-tags/steven-hyman" hreflang="en">Steven Hyman</a></div> <div class="field__item"><a href="/broad-tags/news-and-media" hreflang="en">News and Media</a></div> </div> </div> </div> </div> <div class="content-section__right col-2"> <div class="block block-ctools block-entity-viewnode"> <article about="/news/first-large-genetic-study-bipolar-disorder-asian-populations-launches" class="node node--type-news node--view-mode-sidebar"> <div class="node__content"> <div class="sidebar-group"> <div class="sidebar-group__content"> <div class="block block-layout-builder block-field-blocknodenewsfield-news-extra-info"> <div class="clearfix text-formatted field field--name-field-news-extra-info field--type-text-long field--label-hidden field__item"><h2>&nbsp;</h2> <h2>Related News</h2> <p><img alt src="/files/styles/blog__557x415_/public/news/images/2022/Bipolar_story.png?itok=OnjsAk-j" style="width: 212px; height: 162px;"></p> <p><a href="/node/1130671">Researchers find first strong genetic risk factor for bipolar disorder</a></p> <p><img alt src="/files/styles/blog__557x415_/public/news/images/2022/Singh_Daly_Neale-Graphic.png?itok=5P7iYe2D" style="width: 212px; height: 162px;"></p> <p><a href="/node/1130626">Two large studies reveal genes and genome regions that influence schizophrenia risk</a></p> <p><img alt src="/files/styles/pt_ls_image_tablet/public/long_story/Fullwidth_NDev-Team-Photo.png" style="width: 219px; height: 138px;"></p> <p><a href="/node/1130881">A genetics study in Africa is helping to destigmatize neurodevelopmental differences in children</a></p> <p>&nbsp;</p> <h2>Related Programs</h2> <p><a href="/node/145111">Stanley Global</a></p> <p>&nbsp;</p> <p>&nbsp;</p> <h2>Related Projects</h2> <p><a href="/node/221261">NeuroGAP</a></p> <p><a href="/node/221976">NeuroGAP-Psychosis</a></p> <p><a href="/node/699091">NeuroDev</a></p> <p><a href="/node/1003656">NeuroMex</a></p> <p>&nbsp;</p> <h2>Related People</h2> <p><img alt src="/files/styles/biosketch__413x315_/public/bios/photos/Steve%20Hyman.jpg?itok=Oc4iJDp1" style="width: 212px; height: 162px;"></p> <p><a href="/node/7576">Steven Hyman</a></p> <p><img alt src="/files/styles/biosketch__413x315_/public/bios/photos/MorganSheng-bio.png?itok=BB66CSnx" style="width: 212px; height: 162px;"></p> <p><a href="/node/515316">Morgan Sheng</a></p> </div> </div> </div> </div> </div> </article> </div> </div> </div> </div> Thu, 08 Oct 2020 04:00:00 +0000 tulrich@broadinstitute.org 660191 at /blog/whyiscience-qa-rocky-stroud-ii-helping-lead-largest-psychiatric-genetics-study-africa <span class="field field--name-title field--type-string field--label-hidden"><h1>First large genetic study of bipolar disorder in Asian populations launches</h1> </span> <span class="field field--name-uid field--type-entity-reference field--label-hidden"> <span>By Alex Viveros</span> </span> <span class="field field--name-created field--type-created field--label-hidden"><time datetime="2022-10-31T12:53:52-04:00" class="datetime">October 31, 2022</time> </span> <div class="hero-section container"> <div class="hero-section__row row"> <div class="hero-section__content hero-section__content_left col-6"> <div class="hero-section__breadcrumbs"> <div class="block block-layout-builder block-extra-field-blocknodenewsbreadcrumbs"> <nav class="breadcrumb" role="navigation" aria-labelledby="system-breadcrumb"> <h2 id="system-breadcrumb" class="visually-hidden">Breadcrumb</h2> <ol> <li> <a href="/">Home</a> </li> <li> <a href="/news">News</a> </li> </ol> </nav> </div> </div> <div class="hero-section__title"> <div class="block block-layout-builder block-field-blocknodenewstitle"> <span class="field field--name-title field--type-string field--label-hidden"><h1>First large genetic study of bipolar disorder in Asian populations launches</h1> </span> </div> </div> <div class="hero-section__description"> <div class="block block-layout-builder block-field-blocknodenewsbody"> <div class="clearfix text-formatted field field--name-body field--type-text-with-summary field--label-hidden field__item"><div class="summary-only"> <p>Researchers will analyze the DNA of tens of thousands of people from five countries in East and South Asia to find genetic markers for the psychiatric condition.&nbsp;</p> </div> </div> </div> </div> <div class="hero-section__author"> <div class="block block-layout-builder block-extra-field-blocknodenewsextra-field-author-custom"> By Alex Viveros </div> </div> <div class="hero-section__date"> <div class="block block-layout-builder block-field-blocknodenewscreated"> <span class="field field--name-created field--type-created field--label-hidden"><time datetime="2022-10-31T12:53:52-04:00" class="datetime">October 31, 2022</time> </span> </div> </div> </div> <div class="hero-section__right col-6"> <div class="hero-section__image"> <div class="block block-layout-builder block-field-blocknodenewsfield-image"> <div class="field field--name-field-image field--type-entity-reference field--label-hidden field__item"> <article class="media media--type-image media--view-mode-multiple-content-types-header"> <div class="field field--name-field-media-image field--type-image field--label-hidden field__item"> <picture> <source srcset="/files/styles/multiple_ct_header_desktop_xl/public/news/images/2022/1022%20Bipolar%20Disorder%20Study_Main_557x415_02%20%282%29.png?h=9423a5c0&amp;itok=P3u1Cpvw 1x" media="all and (min-width: 1921px)" type="image/png" width="754" height="503"> <source srcset="/files/styles/multiple_ct_header_desktop_xl/public/news/images/2022/1022%20Bipolar%20Disorder%20Study_Main_557x415_02%20%282%29.png?h=9423a5c0&amp;itok=P3u1Cpvw 1x" media="all and (min-width: 1601px) and (max-width: 1920px)" type="image/png" width="754" height="503"> <source srcset="/files/styles/multiple_ct_header_desktop/public/news/images/2022/1022%20Bipolar%20Disorder%20Study_Main_557x415_02%20%282%29.png?h=9423a5c0&amp;itok=Fvvhxxtr 1x" media="all and (min-width: 1340px) and (max-width: 1600px)" type="image/png" width="736" height="520"> <source srcset="/files/styles/multiple_ct_header_laptop/public/news/images/2022/1022%20Bipolar%20Disorder%20Study_Main_557x415_02%20%282%29.png?h=9423a5c0&amp;itok=oYYe6sIs 1x" media="all and (min-width: 800px) and (max-width: 1339px)" type="image/png" width="641" height="451"> <source srcset="/files/styles/multiple_ct_header_tablet/public/news/images/2022/1022%20Bipolar%20Disorder%20Study_Main_557x415_02%20%282%29.png?h=9423a5c0&amp;itok=wqUDzIyM 1x" media="all and (min-width: 540px) and (max-width: 799px)" type="image/png" width="706" height="417"> <source srcset="/files/styles/multiple_ct_header_phone/public/news/images/2022/1022%20Bipolar%20Disorder%20Study_Main_557x415_02%20%282%29.png?h=9423a5c0&amp;itok=oydp084j 1x" media="all and (max-width: 539px)" type="image/png" width="499" height="294"> <img loading="eager" width="499" height="294" src="/files/styles/multiple_ct_header_phone/public/news/images/2022/1022%20Bipolar%20Disorder%20Study_Main_557x415_02%20%282%29.png?h=9423a5c0&amp;itok=oydp084j" alt="Ricardo Job-Reese, ӳ����ý Communications" typeof="foaf:Image"> </picture> </div> <div class="media-caption"> <div class="media-caption__credit"> Credit: Ricardo Job-Reese, ӳ����ý Communications </div> <div class="media-caption__description"> </div> </div> </article> </div> </div> </div> </div> </div> </div> <div class="content-section content-section_with-sidebars container"> <div class="row"> <div class="content-section__left col-2"> <div class="block block-better-social-sharing-buttons block-social-sharing-buttons-block"> <div style="display: none"><link rel="preload" href="/modules/contrib/better_social_sharing_buttons/assets/dist/sprites/social-icons--no-color.svg" as="image" type="image/svg+xml" crossorigin="anonymous"></div> <div class="social-sharing-buttons"> <a href="https://www.facebook.com/sharer/sharer.php?u=/taxonomy/term/1166/feed&amp;title=" target="_blank" title="Share to Facebook" aria-label="Share to Facebook" class="social-sharing-buttons-button share-facebook" rel="noopener"> <svg aria-hidden="true" width="32px" height="32px" style="border-radius:100%;"> <use href="/modules/contrib/better_social_sharing_buttons/assets/dist/sprites/social-icons--no-color.svg#facebook" /> </svg> </a> <a href="https://twitter.com/intent/tweet?text=+/taxonomy/term/1166/feed" target="_blank" title="Share to X" aria-label="Share to X" class="social-sharing-buttons-button share-x" rel="noopener"> <svg aria-hidden="true" width="32px" height="32px" style="border-radius:100%;"> <use href="/modules/contrib/better_social_sharing_buttons/assets/dist/sprites/social-icons--no-color.svg#x" /> </svg> </a> <a href="mailto:?subject=&amp;body=/taxonomy/term/1166/feed" title="Share to Email" aria-label="Share to Email" class="social-sharing-buttons-button share-email" target="_blank" rel="noopener"> <svg aria-hidden="true" width="32px" height="32px" style="border-radius:100%;"> <use href="/modules/contrib/better_social_sharing_buttons/assets/dist/sprites/social-icons--no-color.svg#email" /> </svg> </a> </div> </div> </div> <div class="content-section__main col-8"> <div class="block block-layout-builder block-field-blocknodenewsbody"> <div class="clearfix text-formatted field field--name-body field--type-text-with-summary field--label-hidden field__item"><p>Nearly 60 percent of the world’s population resides in Asian countries, but only 10 percent of participants of genetic studies are of Asian descent. And that disparity is even greater in studies of psychiatric conditions, where participants are almost all of European ancestry, even though serious mental illness affects all human populations evenly. This lack of representation of the world’s population in genetic datasets leaves out a huge amount of genomic variation, limiting what scientists can learn about the biological basis of mental disorders.&nbsp;</p> <p>A global team of scientists is now trying to tackle this problem by launching a genetic study of bipolar disorder in people from India, Pakistan, Singapore, South Korea, and Taiwan. The study, called the Asian Bipolar Genetics Network (A-BIG-NET), will collect and analyze DNA and demographic, environmental, and medical information from 27,500 patients diagnosed with the psychiatric condition and 15,000 controls.&nbsp;</p> <p>The project is a collaboration between experts from the ӳ����ý of MIT and Harvard (led by Hailiang Huang), Virginia Commonwealth University (led by Kenneth Kendler), Johns Hopkins University (led by Peter Zandi), National Institute of Mental Health and NeuroSciences in India (NIMHANS, led by Biju Viswanath), Indian Institute of Science (led by Bratati Kahali), Institute of Mental Health in Singapore (led by Jimmy Lee), Korea University College of Medicine (led by Heon-Jeong Lee), and National Taiwan University (led by Po-Hsiu Kuo). They will work together to recruit the participants, sequence the genomes, analyze the data, and build a network for rapid data-sharing.&nbsp;</p> <p>The team hopes to uncover genetic markers of bipolar disorder, which may point towards the biological causes and mechanisms underlying this condition that affects 1-2 percent of the world’s population. By focusing on Asian populations, the scientists aim to find markers that are more common in these groups than in others, which may highlight genetic roots of the disorder that are shared across other populations around the world. Better insight into the causes of bipolar disorder from this research could one day lead to new and better treatments.</p> <p>“There haven’t been any sizable bipolar genetic studies from Asian populations,” said Hailiang Huang, the project’s leader, Director of the Stanley Global Asia Initiatives at the Stanley Center for Psychiatric Research at the ӳ����ý, and an Assistant Professor at Massachusetts General Hospital and Harvard Medical School. “If this were to continue, we risk the possibility that therapeutic innovations might exclude large segments of the global population which are under-represented in psychiatric genetics. This is a major unsolved challenge for everyone in the world, including people from South and East Asia.”</p> <p>The new project extends Stanley Global, an initiative launched in 2014 by the Stanley Center to diversify genetic research and include underrepresented populations worldwide. One Stanley Global project, NeuroGAP-Psychosis, launched in 2018 to study the genetics of schizophrenia in four African countries, while another project, NeuroMex, is doing the same in Mexico. NeuroDev is studying neurodevelopmental differences in people in Kenya and South Africa.</p> <p>“Studies like A-BIG-NET have potential to discover rare variant risk genes, which should have a big impact on the mechanistic understanding of bipolar disorder,&nbsp; like the SCHEMA study did for schizophrenia. Because Asian populations have different genetic variants, their inclusion in A-BIG-NET will enhance the diversity and richness of gene discovery for bipolar,” said Morgan Sheng, co-director of the Stanley Center.</p> <h3>Global partnerships</h3> <p>A-BIG-NET was inspired by NeuroGAP-Psychosis and NeuroMex to expand this kind of genetics research to Asian countries. Though Stanley Global has sequenced genomic samples from East Asian populations before, A-BIG-NET expands that effort to include bipolar disorder and will study a much larger cohort. It will also be the first known large-scale study to explore the genetics of bipolar disorder in South Asian countries, and will build on recent discoveries from the Stanley Center including the <a href="/news/researchers-find-first-strong-genetic-risk-factor-bipolar-disorder">first strong genetic signal for bipolar disorder</a>.</p> <p>“The most important finding I would hope would emerge from this project is to find the direct causal genes underlying bipolar disorder,” Huang said. “This study gives us the chance to actually identify the causal genes for bipolar disorder in the Asian population.”</p> <p>“By taking a deep phenotyping approach, we will be collecting information which will allow us to explore a number of clinical subtypes of bipolar illness from a molecular genetic perspective to detect potential differences in their genetic substrate,” said Kendler, a Professor of Psychiatry and Human and Molecular Genetics at Virginia Commonwealth University and Co-Principal Investigator of the project. “Furthermore, studying a range of environmental risk factors will permit us to further clarify how genes and environment jointly act or interact to produce bipolar disorder.”</p> <p>“This study will be an important step in increasing equity in research, especially in the area of psychiatric genetics, ” said Biju Viswanath, Professor of Psychiatry at NIMHANS in India and the lead on the Indian arm of the study. Viswanath has established the India Consortium on Mental Illness And Genetics In the Clinic (IC-MAGIC), which conducts large genetic studies on mental health. Participants from India will make up the largest cohort of the study.&nbsp;</p> <p>“The project will allow advanced training in psychiatric genetics, and engage more researchers and participants. This will allow greater community engagement and expand research capacity in the region. We will then be able to contribute both globally, and importantly, locally to understand these complex disorders,” said Sanjeev Jain, a NIMHANS Professor and senior co-investigator of the study.</p> <p>About a third of A-BIG-NET’s genetic samples will be sequenced at the ӳ����ý by the Genomics Platform, with the rest being analyzed in their home countries. The scientists will use a recently developed sequencing technology called <a href="/blog/perspective-uncovering-genetic-basis-mental-illness-requires-diverse-datasets-and-better">Blended Genome Exome (BGE)</a>, which deeply sequences the exome — the 2 percent of human DNA that translates into proteins — and more broadly decodes the rest of the genome. This approach was designed to increase the chances of finding new genetic variation from global samples in a cost-effective manner, allowing for a large number of samples to be sequenced.&nbsp;</p> <p>The team will publicly share A-BIG-NET data through the <a href="https://nda.nih.gov/" target="_blank">National Institute of Mental Health Data Archive (NDA)</a> and the <a href="https://bipex.broadinstitute.org/">Bipolar Exomes Browser</a>. They will also contribute their data to the Psychiatric Genomics Consortium Bipolar Workgroup and the Bipolar Sequencing Project, which will allow them to compare their results to those from other studies focused on European populations.</p> <p>“This study puts together a strong team from Asia to work at understanding the biology of bipolar disorder,” said Jimmy Lee, a Senior Consultant at Singapore’s Institute of Mental Health, an associate professor at the Lee Kong Chian School of Medicine at Nanyang Technological University, and a co-senior investigator of the study. “Singapore is glad to be a part of this coordinated effort. I am confident the team will make important and impactful scientific discoveries, which will eventually translate into improved clinical care and recovery outcomes in people living with bipolar disorder. Additionally, I hope this effort will catalyze the growth of psychiatric genetics in Asia to address the gap in ethnic representation and knowledge.”</p> <p>“Taiwan is often excluded from a number of major international organizations and actions. We’re very glad to be part of the global diversity initiative and to contribute to enhancing our understanding of a severe psychiatric disorder and reducing health inequity in the long run,” said the project’s co-lead, Po-Hsiu Kuo, Associate Dean of College of Public Health, and a Professor at Institute of Epidemiology and Preventive Medicine, National Taiwan University.</p> <p>“In South Korea, no large-scale genomic study has been conducted on mental illness. Recently, however, psychiatric genetic researchers have reached a consensus on the need for large-scale collaborative genomic study on major mental illnesses, and formed the Korean Mood Disorder Genomics Consortium (KOMOGEN) with about 40 organizations to move the team to succeed in the project,” said the South Korea site leader, Heon-Jeong Lee, Professor of Psychiatry, Korea University College of Medicine.</p> <p><em>Funding for this research is provided by the National Institute of Mental Health.</em></p> </div> </div> <div class="block-node-broad-tags block block-layout-builder block-field-blocknodenewsfield-broad-tags"> <div class="block-node-broad-tags__row"> <div class="block-node-broad-tags__title">Tags:</div> <div class="field field--name-field-broad-tags field--type-entity-reference field--label-hidden field__items"> <div class="field__item"><a href="/broad-tags/neurogap" hreflang="en">NeuroGap</a></div> <div class="field__item"><a href="/broad-tags/stanley-center-psychiatric-research" hreflang="en">Stanley Center for Psychiatric Research</a></div> <div class="field__item"><a href="/broad-tags/psychiatric-disease-0" hreflang="en">Psychiatric disease</a></div> <div class="field__item"><a href="/broad-tags/psychiatric-disease" hreflang="en">Brain Health</a></div> <div class="field__item"><a href="/broad-tags/steven-hyman" hreflang="en">Steven Hyman</a></div> <div class="field__item"><a href="/broad-tags/news-and-media" hreflang="en">News and Media</a></div> </div> </div> </div> </div> <div class="content-section__right col-2"> <div class="block block-ctools block-entity-viewnode"> <article about="/news/first-large-genetic-study-bipolar-disorder-asian-populations-launches" class="node node--type-news node--view-mode-sidebar"> <div class="node__content"> <div class="sidebar-group"> <div class="sidebar-group__content"> <div class="block block-layout-builder block-field-blocknodenewsfield-news-extra-info"> <div class="clearfix text-formatted field field--name-field-news-extra-info field--type-text-long field--label-hidden field__item"><h2>&nbsp;</h2> <h2>Related News</h2> <p><img alt src="/files/styles/blog__557x415_/public/news/images/2022/Bipolar_story.png?itok=OnjsAk-j" style="width: 212px; height: 162px;"></p> <p><a href="/node/1130671">Researchers find first strong genetic risk factor for bipolar disorder</a></p> <p><img alt src="/files/styles/blog__557x415_/public/news/images/2022/Singh_Daly_Neale-Graphic.png?itok=5P7iYe2D" style="width: 212px; height: 162px;"></p> <p><a href="/node/1130626">Two large studies reveal genes and genome regions that influence schizophrenia risk</a></p> <p><img alt src="/files/styles/pt_ls_image_tablet/public/long_story/Fullwidth_NDev-Team-Photo.png" style="width: 219px; height: 138px;"></p> <p><a href="/node/1130881">A genetics study in Africa is helping to destigmatize neurodevelopmental differences in children</a></p> <p>&nbsp;</p> <h2>Related Programs</h2> <p><a href="/node/145111">Stanley Global</a></p> <p>&nbsp;</p> <p>&nbsp;</p> <h2>Related Projects</h2> <p><a href="/node/221261">NeuroGAP</a></p> <p><a href="/node/221976">NeuroGAP-Psychosis</a></p> <p><a href="/node/699091">NeuroDev</a></p> <p><a href="/node/1003656">NeuroMex</a></p> <p>&nbsp;</p> <h2>Related People</h2> <p><img alt src="/files/styles/biosketch__413x315_/public/bios/photos/Steve%20Hyman.jpg?itok=Oc4iJDp1" style="width: 212px; height: 162px;"></p> <p><a href="/node/7576">Steven Hyman</a></p> <p><img alt src="/files/styles/biosketch__413x315_/public/bios/photos/MorganSheng-bio.png?itok=BB66CSnx" style="width: 212px; height: 162px;"></p> <p><a href="/node/515316">Morgan Sheng</a></p> </div> </div> </div> </div> </div> </article> </div> </div> </div> </div> Thu, 21 Feb 2019 05:02:43 +0000 veronica@broadinstitute.org 465861 at /stanley-center-psychiatric-research/stanley-global/neuropsychiatric-genetics-african-populations-neurogap <span class="field field--name-title field--type-string field--label-hidden"><h1>First large genetic study of bipolar disorder in Asian populations launches</h1> </span> <span class="field field--name-uid field--type-entity-reference field--label-hidden"> <span>By Alex Viveros</span> </span> <span class="field field--name-created field--type-created field--label-hidden"><time datetime="2022-10-31T12:53:52-04:00" class="datetime">October 31, 2022</time> </span> <div class="hero-section container"> <div class="hero-section__row row"> <div class="hero-section__content hero-section__content_left col-6"> <div class="hero-section__breadcrumbs"> <div class="block block-layout-builder block-extra-field-blocknodenewsbreadcrumbs"> <nav class="breadcrumb" role="navigation" aria-labelledby="system-breadcrumb"> <h2 id="system-breadcrumb" class="visually-hidden">Breadcrumb</h2> <ol> <li> <a href="/">Home</a> </li> <li> <a href="/news">News</a> </li> </ol> </nav> </div> </div> <div class="hero-section__title"> <div class="block block-layout-builder block-field-blocknodenewstitle"> <span class="field field--name-title field--type-string field--label-hidden"><h1>First large genetic study of bipolar disorder in Asian populations launches</h1> </span> </div> </div> <div class="hero-section__description"> <div class="block block-layout-builder block-field-blocknodenewsbody"> <div class="clearfix text-formatted field field--name-body field--type-text-with-summary field--label-hidden field__item"><div class="summary-only"> <p>Researchers will analyze the DNA of tens of thousands of people from five countries in East and South Asia to find genetic markers for the psychiatric condition.&nbsp;</p> </div> </div> </div> </div> <div class="hero-section__author"> <div class="block block-layout-builder block-extra-field-blocknodenewsextra-field-author-custom"> By Alex Viveros </div> </div> <div class="hero-section__date"> <div class="block block-layout-builder block-field-blocknodenewscreated"> <span class="field field--name-created field--type-created field--label-hidden"><time datetime="2022-10-31T12:53:52-04:00" class="datetime">October 31, 2022</time> </span> </div> </div> </div> <div class="hero-section__right col-6"> <div class="hero-section__image"> <div class="block block-layout-builder block-field-blocknodenewsfield-image"> <div class="field field--name-field-image field--type-entity-reference field--label-hidden field__item"> <article class="media media--type-image media--view-mode-multiple-content-types-header"> <div class="field field--name-field-media-image field--type-image field--label-hidden field__item"> <picture> <source srcset="/files/styles/multiple_ct_header_desktop_xl/public/news/images/2022/1022%20Bipolar%20Disorder%20Study_Main_557x415_02%20%282%29.png?h=9423a5c0&amp;itok=P3u1Cpvw 1x" media="all and (min-width: 1921px)" type="image/png" width="754" height="503"> <source srcset="/files/styles/multiple_ct_header_desktop_xl/public/news/images/2022/1022%20Bipolar%20Disorder%20Study_Main_557x415_02%20%282%29.png?h=9423a5c0&amp;itok=P3u1Cpvw 1x" media="all and (min-width: 1601px) and (max-width: 1920px)" type="image/png" width="754" height="503"> <source srcset="/files/styles/multiple_ct_header_desktop/public/news/images/2022/1022%20Bipolar%20Disorder%20Study_Main_557x415_02%20%282%29.png?h=9423a5c0&amp;itok=Fvvhxxtr 1x" media="all and (min-width: 1340px) and (max-width: 1600px)" type="image/png" width="736" height="520"> <source srcset="/files/styles/multiple_ct_header_laptop/public/news/images/2022/1022%20Bipolar%20Disorder%20Study_Main_557x415_02%20%282%29.png?h=9423a5c0&amp;itok=oYYe6sIs 1x" media="all and (min-width: 800px) and (max-width: 1339px)" type="image/png" width="641" height="451"> <source srcset="/files/styles/multiple_ct_header_tablet/public/news/images/2022/1022%20Bipolar%20Disorder%20Study_Main_557x415_02%20%282%29.png?h=9423a5c0&amp;itok=wqUDzIyM 1x" media="all and (min-width: 540px) and (max-width: 799px)" type="image/png" width="706" height="417"> <source srcset="/files/styles/multiple_ct_header_phone/public/news/images/2022/1022%20Bipolar%20Disorder%20Study_Main_557x415_02%20%282%29.png?h=9423a5c0&amp;itok=oydp084j 1x" media="all and (max-width: 539px)" type="image/png" width="499" height="294"> <img loading="eager" width="499" height="294" src="/files/styles/multiple_ct_header_phone/public/news/images/2022/1022%20Bipolar%20Disorder%20Study_Main_557x415_02%20%282%29.png?h=9423a5c0&amp;itok=oydp084j" alt="Ricardo Job-Reese, ӳ����ý Communications" typeof="foaf:Image"> </picture> </div> <div class="media-caption"> <div class="media-caption__credit"> Credit: Ricardo Job-Reese, ӳ����ý Communications </div> <div class="media-caption__description"> </div> </div> </article> </div> </div> </div> </div> </div> </div> <div class="content-section content-section_with-sidebars container"> <div class="row"> <div class="content-section__left col-2"> <div class="block block-better-social-sharing-buttons block-social-sharing-buttons-block"> <div style="display: none"><link rel="preload" href="/modules/contrib/better_social_sharing_buttons/assets/dist/sprites/social-icons--no-color.svg" as="image" type="image/svg+xml" crossorigin="anonymous"></div> <div class="social-sharing-buttons"> <a href="https://www.facebook.com/sharer/sharer.php?u=/taxonomy/term/1166/feed&amp;title=" target="_blank" title="Share to Facebook" aria-label="Share to Facebook" class="social-sharing-buttons-button share-facebook" rel="noopener"> <svg aria-hidden="true" width="32px" height="32px" style="border-radius:100%;"> <use href="/modules/contrib/better_social_sharing_buttons/assets/dist/sprites/social-icons--no-color.svg#facebook" /> </svg> </a> <a href="https://twitter.com/intent/tweet?text=+/taxonomy/term/1166/feed" target="_blank" title="Share to X" aria-label="Share to X" class="social-sharing-buttons-button share-x" rel="noopener"> <svg aria-hidden="true" width="32px" height="32px" style="border-radius:100%;"> <use href="/modules/contrib/better_social_sharing_buttons/assets/dist/sprites/social-icons--no-color.svg#x" /> </svg> </a> <a href="mailto:?subject=&amp;body=/taxonomy/term/1166/feed" title="Share to Email" aria-label="Share to Email" class="social-sharing-buttons-button share-email" target="_blank" rel="noopener"> <svg aria-hidden="true" width="32px" height="32px" style="border-radius:100%;"> <use href="/modules/contrib/better_social_sharing_buttons/assets/dist/sprites/social-icons--no-color.svg#email" /> </svg> </a> </div> </div> </div> <div class="content-section__main col-8"> <div class="block block-layout-builder block-field-blocknodenewsbody"> <div class="clearfix text-formatted field field--name-body field--type-text-with-summary field--label-hidden field__item"><p>Nearly 60 percent of the world’s population resides in Asian countries, but only 10 percent of participants of genetic studies are of Asian descent. And that disparity is even greater in studies of psychiatric conditions, where participants are almost all of European ancestry, even though serious mental illness affects all human populations evenly. This lack of representation of the world’s population in genetic datasets leaves out a huge amount of genomic variation, limiting what scientists can learn about the biological basis of mental disorders.&nbsp;</p> <p>A global team of scientists is now trying to tackle this problem by launching a genetic study of bipolar disorder in people from India, Pakistan, Singapore, South Korea, and Taiwan. The study, called the Asian Bipolar Genetics Network (A-BIG-NET), will collect and analyze DNA and demographic, environmental, and medical information from 27,500 patients diagnosed with the psychiatric condition and 15,000 controls.&nbsp;</p> <p>The project is a collaboration between experts from the ӳ����ý of MIT and Harvard (led by Hailiang Huang), Virginia Commonwealth University (led by Kenneth Kendler), Johns Hopkins University (led by Peter Zandi), National Institute of Mental Health and NeuroSciences in India (NIMHANS, led by Biju Viswanath), Indian Institute of Science (led by Bratati Kahali), Institute of Mental Health in Singapore (led by Jimmy Lee), Korea University College of Medicine (led by Heon-Jeong Lee), and National Taiwan University (led by Po-Hsiu Kuo). They will work together to recruit the participants, sequence the genomes, analyze the data, and build a network for rapid data-sharing.&nbsp;</p> <p>The team hopes to uncover genetic markers of bipolar disorder, which may point towards the biological causes and mechanisms underlying this condition that affects 1-2 percent of the world’s population. By focusing on Asian populations, the scientists aim to find markers that are more common in these groups than in others, which may highlight genetic roots of the disorder that are shared across other populations around the world. Better insight into the causes of bipolar disorder from this research could one day lead to new and better treatments.</p> <p>“There haven’t been any sizable bipolar genetic studies from Asian populations,” said Hailiang Huang, the project’s leader, Director of the Stanley Global Asia Initiatives at the Stanley Center for Psychiatric Research at the ӳ����ý, and an Assistant Professor at Massachusetts General Hospital and Harvard Medical School. “If this were to continue, we risk the possibility that therapeutic innovations might exclude large segments of the global population which are under-represented in psychiatric genetics. This is a major unsolved challenge for everyone in the world, including people from South and East Asia.”</p> <p>The new project extends Stanley Global, an initiative launched in 2014 by the Stanley Center to diversify genetic research and include underrepresented populations worldwide. One Stanley Global project, NeuroGAP-Psychosis, launched in 2018 to study the genetics of schizophrenia in four African countries, while another project, NeuroMex, is doing the same in Mexico. NeuroDev is studying neurodevelopmental differences in people in Kenya and South Africa.</p> <p>“Studies like A-BIG-NET have potential to discover rare variant risk genes, which should have a big impact on the mechanistic understanding of bipolar disorder,&nbsp; like the SCHEMA study did for schizophrenia. Because Asian populations have different genetic variants, their inclusion in A-BIG-NET will enhance the diversity and richness of gene discovery for bipolar,” said Morgan Sheng, co-director of the Stanley Center.</p> <h3>Global partnerships</h3> <p>A-BIG-NET was inspired by NeuroGAP-Psychosis and NeuroMex to expand this kind of genetics research to Asian countries. Though Stanley Global has sequenced genomic samples from East Asian populations before, A-BIG-NET expands that effort to include bipolar disorder and will study a much larger cohort. It will also be the first known large-scale study to explore the genetics of bipolar disorder in South Asian countries, and will build on recent discoveries from the Stanley Center including the <a href="/news/researchers-find-first-strong-genetic-risk-factor-bipolar-disorder">first strong genetic signal for bipolar disorder</a>.</p> <p>“The most important finding I would hope would emerge from this project is to find the direct causal genes underlying bipolar disorder,” Huang said. “This study gives us the chance to actually identify the causal genes for bipolar disorder in the Asian population.”</p> <p>“By taking a deep phenotyping approach, we will be collecting information which will allow us to explore a number of clinical subtypes of bipolar illness from a molecular genetic perspective to detect potential differences in their genetic substrate,” said Kendler, a Professor of Psychiatry and Human and Molecular Genetics at Virginia Commonwealth University and Co-Principal Investigator of the project. “Furthermore, studying a range of environmental risk factors will permit us to further clarify how genes and environment jointly act or interact to produce bipolar disorder.”</p> <p>“This study will be an important step in increasing equity in research, especially in the area of psychiatric genetics, ” said Biju Viswanath, Professor of Psychiatry at NIMHANS in India and the lead on the Indian arm of the study. Viswanath has established the India Consortium on Mental Illness And Genetics In the Clinic (IC-MAGIC), which conducts large genetic studies on mental health. Participants from India will make up the largest cohort of the study.&nbsp;</p> <p>“The project will allow advanced training in psychiatric genetics, and engage more researchers and participants. This will allow greater community engagement and expand research capacity in the region. We will then be able to contribute both globally, and importantly, locally to understand these complex disorders,” said Sanjeev Jain, a NIMHANS Professor and senior co-investigator of the study.</p> <p>About a third of A-BIG-NET’s genetic samples will be sequenced at the ӳ����ý by the Genomics Platform, with the rest being analyzed in their home countries. The scientists will use a recently developed sequencing technology called <a href="/blog/perspective-uncovering-genetic-basis-mental-illness-requires-diverse-datasets-and-better">Blended Genome Exome (BGE)</a>, which deeply sequences the exome — the 2 percent of human DNA that translates into proteins — and more broadly decodes the rest of the genome. This approach was designed to increase the chances of finding new genetic variation from global samples in a cost-effective manner, allowing for a large number of samples to be sequenced.&nbsp;</p> <p>The team will publicly share A-BIG-NET data through the <a href="https://nda.nih.gov/" target="_blank">National Institute of Mental Health Data Archive (NDA)</a> and the <a href="https://bipex.broadinstitute.org/">Bipolar Exomes Browser</a>. They will also contribute their data to the Psychiatric Genomics Consortium Bipolar Workgroup and the Bipolar Sequencing Project, which will allow them to compare their results to those from other studies focused on European populations.</p> <p>“This study puts together a strong team from Asia to work at understanding the biology of bipolar disorder,” said Jimmy Lee, a Senior Consultant at Singapore’s Institute of Mental Health, an associate professor at the Lee Kong Chian School of Medicine at Nanyang Technological University, and a co-senior investigator of the study. “Singapore is glad to be a part of this coordinated effort. I am confident the team will make important and impactful scientific discoveries, which will eventually translate into improved clinical care and recovery outcomes in people living with bipolar disorder. Additionally, I hope this effort will catalyze the growth of psychiatric genetics in Asia to address the gap in ethnic representation and knowledge.”</p> <p>“Taiwan is often excluded from a number of major international organizations and actions. We’re very glad to be part of the global diversity initiative and to contribute to enhancing our understanding of a severe psychiatric disorder and reducing health inequity in the long run,” said the project’s co-lead, Po-Hsiu Kuo, Associate Dean of College of Public Health, and a Professor at Institute of Epidemiology and Preventive Medicine, National Taiwan University.</p> <p>“In South Korea, no large-scale genomic study has been conducted on mental illness. Recently, however, psychiatric genetic researchers have reached a consensus on the need for large-scale collaborative genomic study on major mental illnesses, and formed the Korean Mood Disorder Genomics Consortium (KOMOGEN) with about 40 organizations to move the team to succeed in the project,” said the South Korea site leader, Heon-Jeong Lee, Professor of Psychiatry, Korea University College of Medicine.</p> <p><em>Funding for this research is provided by the National Institute of Mental Health.</em></p> </div> </div> <div class="block-node-broad-tags block block-layout-builder block-field-blocknodenewsfield-broad-tags"> <div class="block-node-broad-tags__row"> <div class="block-node-broad-tags__title">Tags:</div> <div class="field field--name-field-broad-tags field--type-entity-reference field--label-hidden field__items"> <div class="field__item"><a href="/broad-tags/neurogap" hreflang="en">NeuroGap</a></div> <div class="field__item"><a href="/broad-tags/stanley-center-psychiatric-research" hreflang="en">Stanley Center for Psychiatric Research</a></div> <div class="field__item"><a href="/broad-tags/psychiatric-disease-0" hreflang="en">Psychiatric disease</a></div> <div class="field__item"><a href="/broad-tags/psychiatric-disease" hreflang="en">Brain Health</a></div> <div class="field__item"><a href="/broad-tags/steven-hyman" hreflang="en">Steven Hyman</a></div> <div class="field__item"><a href="/broad-tags/news-and-media" hreflang="en">News and Media</a></div> </div> </div> </div> </div> <div class="content-section__right col-2"> <div class="block block-ctools block-entity-viewnode"> <article about="/news/first-large-genetic-study-bipolar-disorder-asian-populations-launches" class="node node--type-news node--view-mode-sidebar"> <div class="node__content"> <div class="sidebar-group"> <div class="sidebar-group__content"> <div class="block block-layout-builder block-field-blocknodenewsfield-news-extra-info"> <div class="clearfix text-formatted field field--name-field-news-extra-info field--type-text-long field--label-hidden field__item"><h2>&nbsp;</h2> <h2>Related News</h2> <p><img alt src="/files/styles/blog__557x415_/public/news/images/2022/Bipolar_story.png?itok=OnjsAk-j" style="width: 212px; height: 162px;"></p> <p><a href="/node/1130671">Researchers find first strong genetic risk factor for bipolar disorder</a></p> <p><img alt src="/files/styles/blog__557x415_/public/news/images/2022/Singh_Daly_Neale-Graphic.png?itok=5P7iYe2D" style="width: 212px; height: 162px;"></p> <p><a href="/node/1130626">Two large studies reveal genes and genome regions that influence schizophrenia risk</a></p> <p><img alt src="/files/styles/pt_ls_image_tablet/public/long_story/Fullwidth_NDev-Team-Photo.png" style="width: 219px; height: 138px;"></p> <p><a href="/node/1130881">A genetics study in Africa is helping to destigmatize neurodevelopmental differences in children</a></p> <p>&nbsp;</p> <h2>Related Programs</h2> <p><a href="/node/145111">Stanley Global</a></p> <p>&nbsp;</p> <p>&nbsp;</p> <h2>Related Projects</h2> <p><a href="/node/221261">NeuroGAP</a></p> <p><a href="/node/221976">NeuroGAP-Psychosis</a></p> <p><a href="/node/699091">NeuroDev</a></p> <p><a href="/node/1003656">NeuroMex</a></p> <p>&nbsp;</p> <h2>Related People</h2> <p><img alt src="/files/styles/biosketch__413x315_/public/bios/photos/Steve%20Hyman.jpg?itok=Oc4iJDp1" style="width: 212px; height: 162px;"></p> <p><a href="/node/7576">Steven Hyman</a></p> <p><img alt src="/files/styles/biosketch__413x315_/public/bios/photos/MorganSheng-bio.png?itok=BB66CSnx" style="width: 212px; height: 162px;"></p> <p><a href="/node/515316">Morgan Sheng</a></p> </div> </div> </div> </div> </div> </article> </div> </div> </div> </div> Tue, 06 Mar 2018 23:06:51 +0000 mnemchuk@broadinstitute.org 221261 at /blog/africa-should-not-be-left-behind-addressing-diversity-gaps-psychiatric-genetic-data <span class="field field--name-title field--type-string field--label-hidden"><h1>First large genetic study of bipolar disorder in Asian populations launches</h1> </span> <span class="field field--name-uid field--type-entity-reference field--label-hidden"> <span>By Alex Viveros</span> </span> <span class="field field--name-created field--type-created field--label-hidden"><time datetime="2022-10-31T12:53:52-04:00" class="datetime">October 31, 2022</time> </span> <div class="hero-section container"> <div class="hero-section__row row"> <div class="hero-section__content hero-section__content_left col-6"> <div class="hero-section__breadcrumbs"> <div class="block block-layout-builder block-extra-field-blocknodenewsbreadcrumbs"> <nav class="breadcrumb" role="navigation" aria-labelledby="system-breadcrumb"> <h2 id="system-breadcrumb" class="visually-hidden">Breadcrumb</h2> <ol> <li> <a href="/">Home</a> </li> <li> <a href="/news">News</a> </li> </ol> </nav> </div> </div> <div class="hero-section__title"> <div class="block block-layout-builder block-field-blocknodenewstitle"> <span class="field field--name-title field--type-string field--label-hidden"><h1>First large genetic study of bipolar disorder in Asian populations launches</h1> </span> </div> </div> <div class="hero-section__description"> <div class="block block-layout-builder block-field-blocknodenewsbody"> <div class="clearfix text-formatted field field--name-body field--type-text-with-summary field--label-hidden field__item"><div class="summary-only"> <p>Researchers will analyze the DNA of tens of thousands of people from five countries in East and South Asia to find genetic markers for the psychiatric condition.&nbsp;</p> </div> </div> </div> </div> <div class="hero-section__author"> <div class="block block-layout-builder block-extra-field-blocknodenewsextra-field-author-custom"> By Alex Viveros </div> </div> <div class="hero-section__date"> <div class="block block-layout-builder block-field-blocknodenewscreated"> <span class="field field--name-created field--type-created field--label-hidden"><time datetime="2022-10-31T12:53:52-04:00" class="datetime">October 31, 2022</time> </span> </div> </div> </div> <div class="hero-section__right col-6"> <div class="hero-section__image"> <div class="block block-layout-builder block-field-blocknodenewsfield-image"> <div class="field field--name-field-image field--type-entity-reference field--label-hidden field__item"> <article class="media media--type-image media--view-mode-multiple-content-types-header"> <div class="field field--name-field-media-image field--type-image field--label-hidden field__item"> <picture> <source srcset="/files/styles/multiple_ct_header_desktop_xl/public/news/images/2022/1022%20Bipolar%20Disorder%20Study_Main_557x415_02%20%282%29.png?h=9423a5c0&amp;itok=P3u1Cpvw 1x" media="all and (min-width: 1921px)" type="image/png" width="754" height="503"> <source srcset="/files/styles/multiple_ct_header_desktop_xl/public/news/images/2022/1022%20Bipolar%20Disorder%20Study_Main_557x415_02%20%282%29.png?h=9423a5c0&amp;itok=P3u1Cpvw 1x" media="all and (min-width: 1601px) and (max-width: 1920px)" type="image/png" width="754" height="503"> <source srcset="/files/styles/multiple_ct_header_desktop/public/news/images/2022/1022%20Bipolar%20Disorder%20Study_Main_557x415_02%20%282%29.png?h=9423a5c0&amp;itok=Fvvhxxtr 1x" media="all and (min-width: 1340px) and (max-width: 1600px)" type="image/png" width="736" height="520"> <source srcset="/files/styles/multiple_ct_header_laptop/public/news/images/2022/1022%20Bipolar%20Disorder%20Study_Main_557x415_02%20%282%29.png?h=9423a5c0&amp;itok=oYYe6sIs 1x" media="all and (min-width: 800px) and (max-width: 1339px)" type="image/png" width="641" height="451"> <source srcset="/files/styles/multiple_ct_header_tablet/public/news/images/2022/1022%20Bipolar%20Disorder%20Study_Main_557x415_02%20%282%29.png?h=9423a5c0&amp;itok=wqUDzIyM 1x" media="all and (min-width: 540px) and (max-width: 799px)" type="image/png" width="706" height="417"> <source srcset="/files/styles/multiple_ct_header_phone/public/news/images/2022/1022%20Bipolar%20Disorder%20Study_Main_557x415_02%20%282%29.png?h=9423a5c0&amp;itok=oydp084j 1x" media="all and (max-width: 539px)" type="image/png" width="499" height="294"> <img loading="eager" width="499" height="294" src="/files/styles/multiple_ct_header_phone/public/news/images/2022/1022%20Bipolar%20Disorder%20Study_Main_557x415_02%20%282%29.png?h=9423a5c0&amp;itok=oydp084j" alt="Ricardo Job-Reese, ӳ����ý Communications" typeof="foaf:Image"> </picture> </div> <div class="media-caption"> <div class="media-caption__credit"> Credit: Ricardo Job-Reese, ӳ����ý Communications </div> <div class="media-caption__description"> </div> </div> </article> </div> </div> </div> </div> </div> </div> <div class="content-section content-section_with-sidebars container"> <div class="row"> <div class="content-section__left col-2"> <div class="block block-better-social-sharing-buttons block-social-sharing-buttons-block"> <div style="display: none"><link rel="preload" href="/modules/contrib/better_social_sharing_buttons/assets/dist/sprites/social-icons--no-color.svg" as="image" type="image/svg+xml" crossorigin="anonymous"></div> <div class="social-sharing-buttons"> <a href="https://www.facebook.com/sharer/sharer.php?u=/taxonomy/term/1166/feed&amp;title=" target="_blank" title="Share to Facebook" aria-label="Share to Facebook" class="social-sharing-buttons-button share-facebook" rel="noopener"> <svg aria-hidden="true" width="32px" height="32px" style="border-radius:100%;"> <use href="/modules/contrib/better_social_sharing_buttons/assets/dist/sprites/social-icons--no-color.svg#facebook" /> </svg> </a> <a href="https://twitter.com/intent/tweet?text=+/taxonomy/term/1166/feed" target="_blank" title="Share to X" aria-label="Share to X" class="social-sharing-buttons-button share-x" rel="noopener"> <svg aria-hidden="true" width="32px" height="32px" style="border-radius:100%;"> <use href="/modules/contrib/better_social_sharing_buttons/assets/dist/sprites/social-icons--no-color.svg#x" /> </svg> </a> <a href="mailto:?subject=&amp;body=/taxonomy/term/1166/feed" title="Share to Email" aria-label="Share to Email" class="social-sharing-buttons-button share-email" target="_blank" rel="noopener"> <svg aria-hidden="true" width="32px" height="32px" style="border-radius:100%;"> <use href="/modules/contrib/better_social_sharing_buttons/assets/dist/sprites/social-icons--no-color.svg#email" /> </svg> </a> </div> </div> </div> <div class="content-section__main col-8"> <div class="block block-layout-builder block-field-blocknodenewsbody"> <div class="clearfix text-formatted field field--name-body field--type-text-with-summary field--label-hidden field__item"><p>Nearly 60 percent of the world’s population resides in Asian countries, but only 10 percent of participants of genetic studies are of Asian descent. And that disparity is even greater in studies of psychiatric conditions, where participants are almost all of European ancestry, even though serious mental illness affects all human populations evenly. This lack of representation of the world’s population in genetic datasets leaves out a huge amount of genomic variation, limiting what scientists can learn about the biological basis of mental disorders.&nbsp;</p> <p>A global team of scientists is now trying to tackle this problem by launching a genetic study of bipolar disorder in people from India, Pakistan, Singapore, South Korea, and Taiwan. The study, called the Asian Bipolar Genetics Network (A-BIG-NET), will collect and analyze DNA and demographic, environmental, and medical information from 27,500 patients diagnosed with the psychiatric condition and 15,000 controls.&nbsp;</p> <p>The project is a collaboration between experts from the ӳ����ý of MIT and Harvard (led by Hailiang Huang), Virginia Commonwealth University (led by Kenneth Kendler), Johns Hopkins University (led by Peter Zandi), National Institute of Mental Health and NeuroSciences in India (NIMHANS, led by Biju Viswanath), Indian Institute of Science (led by Bratati Kahali), Institute of Mental Health in Singapore (led by Jimmy Lee), Korea University College of Medicine (led by Heon-Jeong Lee), and National Taiwan University (led by Po-Hsiu Kuo). They will work together to recruit the participants, sequence the genomes, analyze the data, and build a network for rapid data-sharing.&nbsp;</p> <p>The team hopes to uncover genetic markers of bipolar disorder, which may point towards the biological causes and mechanisms underlying this condition that affects 1-2 percent of the world’s population. By focusing on Asian populations, the scientists aim to find markers that are more common in these groups than in others, which may highlight genetic roots of the disorder that are shared across other populations around the world. Better insight into the causes of bipolar disorder from this research could one day lead to new and better treatments.</p> <p>“There haven’t been any sizable bipolar genetic studies from Asian populations,” said Hailiang Huang, the project’s leader, Director of the Stanley Global Asia Initiatives at the Stanley Center for Psychiatric Research at the ӳ����ý, and an Assistant Professor at Massachusetts General Hospital and Harvard Medical School. “If this were to continue, we risk the possibility that therapeutic innovations might exclude large segments of the global population which are under-represented in psychiatric genetics. This is a major unsolved challenge for everyone in the world, including people from South and East Asia.”</p> <p>The new project extends Stanley Global, an initiative launched in 2014 by the Stanley Center to diversify genetic research and include underrepresented populations worldwide. One Stanley Global project, NeuroGAP-Psychosis, launched in 2018 to study the genetics of schizophrenia in four African countries, while another project, NeuroMex, is doing the same in Mexico. NeuroDev is studying neurodevelopmental differences in people in Kenya and South Africa.</p> <p>“Studies like A-BIG-NET have potential to discover rare variant risk genes, which should have a big impact on the mechanistic understanding of bipolar disorder,&nbsp; like the SCHEMA study did for schizophrenia. Because Asian populations have different genetic variants, their inclusion in A-BIG-NET will enhance the diversity and richness of gene discovery for bipolar,” said Morgan Sheng, co-director of the Stanley Center.</p> <h3>Global partnerships</h3> <p>A-BIG-NET was inspired by NeuroGAP-Psychosis and NeuroMex to expand this kind of genetics research to Asian countries. Though Stanley Global has sequenced genomic samples from East Asian populations before, A-BIG-NET expands that effort to include bipolar disorder and will study a much larger cohort. It will also be the first known large-scale study to explore the genetics of bipolar disorder in South Asian countries, and will build on recent discoveries from the Stanley Center including the <a href="/news/researchers-find-first-strong-genetic-risk-factor-bipolar-disorder">first strong genetic signal for bipolar disorder</a>.</p> <p>“The most important finding I would hope would emerge from this project is to find the direct causal genes underlying bipolar disorder,” Huang said. “This study gives us the chance to actually identify the causal genes for bipolar disorder in the Asian population.”</p> <p>“By taking a deep phenotyping approach, we will be collecting information which will allow us to explore a number of clinical subtypes of bipolar illness from a molecular genetic perspective to detect potential differences in their genetic substrate,” said Kendler, a Professor of Psychiatry and Human and Molecular Genetics at Virginia Commonwealth University and Co-Principal Investigator of the project. “Furthermore, studying a range of environmental risk factors will permit us to further clarify how genes and environment jointly act or interact to produce bipolar disorder.”</p> <p>“This study will be an important step in increasing equity in research, especially in the area of psychiatric genetics, ” said Biju Viswanath, Professor of Psychiatry at NIMHANS in India and the lead on the Indian arm of the study. Viswanath has established the India Consortium on Mental Illness And Genetics In the Clinic (IC-MAGIC), which conducts large genetic studies on mental health. Participants from India will make up the largest cohort of the study.&nbsp;</p> <p>“The project will allow advanced training in psychiatric genetics, and engage more researchers and participants. This will allow greater community engagement and expand research capacity in the region. We will then be able to contribute both globally, and importantly, locally to understand these complex disorders,” said Sanjeev Jain, a NIMHANS Professor and senior co-investigator of the study.</p> <p>About a third of A-BIG-NET’s genetic samples will be sequenced at the ӳ����ý by the Genomics Platform, with the rest being analyzed in their home countries. The scientists will use a recently developed sequencing technology called <a href="/blog/perspective-uncovering-genetic-basis-mental-illness-requires-diverse-datasets-and-better">Blended Genome Exome (BGE)</a>, which deeply sequences the exome — the 2 percent of human DNA that translates into proteins — and more broadly decodes the rest of the genome. This approach was designed to increase the chances of finding new genetic variation from global samples in a cost-effective manner, allowing for a large number of samples to be sequenced.&nbsp;</p> <p>The team will publicly share A-BIG-NET data through the <a href="https://nda.nih.gov/" target="_blank">National Institute of Mental Health Data Archive (NDA)</a> and the <a href="https://bipex.broadinstitute.org/">Bipolar Exomes Browser</a>. They will also contribute their data to the Psychiatric Genomics Consortium Bipolar Workgroup and the Bipolar Sequencing Project, which will allow them to compare their results to those from other studies focused on European populations.</p> <p>“This study puts together a strong team from Asia to work at understanding the biology of bipolar disorder,” said Jimmy Lee, a Senior Consultant at Singapore’s Institute of Mental Health, an associate professor at the Lee Kong Chian School of Medicine at Nanyang Technological University, and a co-senior investigator of the study. “Singapore is glad to be a part of this coordinated effort. I am confident the team will make important and impactful scientific discoveries, which will eventually translate into improved clinical care and recovery outcomes in people living with bipolar disorder. Additionally, I hope this effort will catalyze the growth of psychiatric genetics in Asia to address the gap in ethnic representation and knowledge.”</p> <p>“Taiwan is often excluded from a number of major international organizations and actions. We’re very glad to be part of the global diversity initiative and to contribute to enhancing our understanding of a severe psychiatric disorder and reducing health inequity in the long run,” said the project’s co-lead, Po-Hsiu Kuo, Associate Dean of College of Public Health, and a Professor at Institute of Epidemiology and Preventive Medicine, National Taiwan University.</p> <p>“In South Korea, no large-scale genomic study has been conducted on mental illness. Recently, however, psychiatric genetic researchers have reached a consensus on the need for large-scale collaborative genomic study on major mental illnesses, and formed the Korean Mood Disorder Genomics Consortium (KOMOGEN) with about 40 organizations to move the team to succeed in the project,” said the South Korea site leader, Heon-Jeong Lee, Professor of Psychiatry, Korea University College of Medicine.</p> <p><em>Funding for this research is provided by the National Institute of Mental Health.</em></p> </div> </div> <div class="block-node-broad-tags block block-layout-builder block-field-blocknodenewsfield-broad-tags"> <div class="block-node-broad-tags__row"> <div class="block-node-broad-tags__title">Tags:</div> <div class="field field--name-field-broad-tags field--type-entity-reference field--label-hidden field__items"> <div class="field__item"><a href="/broad-tags/neurogap" hreflang="en">NeuroGap</a></div> <div class="field__item"><a href="/broad-tags/stanley-center-psychiatric-research" hreflang="en">Stanley Center for Psychiatric Research</a></div> <div class="field__item"><a href="/broad-tags/psychiatric-disease-0" hreflang="en">Psychiatric disease</a></div> <div class="field__item"><a href="/broad-tags/psychiatric-disease" hreflang="en">Brain Health</a></div> <div class="field__item"><a href="/broad-tags/steven-hyman" hreflang="en">Steven Hyman</a></div> <div class="field__item"><a href="/broad-tags/news-and-media" hreflang="en">News and Media</a></div> </div> </div> </div> </div> <div class="content-section__right col-2"> <div class="block block-ctools block-entity-viewnode"> <article about="/news/first-large-genetic-study-bipolar-disorder-asian-populations-launches" class="node node--type-news node--view-mode-sidebar"> <div class="node__content"> <div class="sidebar-group"> <div class="sidebar-group__content"> <div class="block block-layout-builder block-field-blocknodenewsfield-news-extra-info"> <div class="clearfix text-formatted field field--name-field-news-extra-info field--type-text-long field--label-hidden field__item"><h2>&nbsp;</h2> <h2>Related News</h2> <p><img alt src="/files/styles/blog__557x415_/public/news/images/2022/Bipolar_story.png?itok=OnjsAk-j" style="width: 212px; height: 162px;"></p> <p><a href="/node/1130671">Researchers find first strong genetic risk factor for bipolar disorder</a></p> <p><img alt src="/files/styles/blog__557x415_/public/news/images/2022/Singh_Daly_Neale-Graphic.png?itok=5P7iYe2D" style="width: 212px; height: 162px;"></p> <p><a href="/node/1130626">Two large studies reveal genes and genome regions that influence schizophrenia risk</a></p> <p><img alt src="/files/styles/pt_ls_image_tablet/public/long_story/Fullwidth_NDev-Team-Photo.png" style="width: 219px; height: 138px;"></p> <p><a href="/node/1130881">A genetics study in Africa is helping to destigmatize neurodevelopmental differences in children</a></p> <p>&nbsp;</p> <h2>Related Programs</h2> <p><a href="/node/145111">Stanley Global</a></p> <p>&nbsp;</p> <p>&nbsp;</p> <h2>Related Projects</h2> <p><a href="/node/221261">NeuroGAP</a></p> <p><a href="/node/221976">NeuroGAP-Psychosis</a></p> <p><a href="/node/699091">NeuroDev</a></p> <p><a href="/node/1003656">NeuroMex</a></p> <p>&nbsp;</p> <h2>Related People</h2> <p><img alt src="/files/styles/biosketch__413x315_/public/bios/photos/Steve%20Hyman.jpg?itok=Oc4iJDp1" style="width: 212px; height: 162px;"></p> <p><a href="/node/7576">Steven Hyman</a></p> <p><img alt src="/files/styles/biosketch__413x315_/public/bios/photos/MorganSheng-bio.png?itok=BB66CSnx" style="width: 212px; height: 162px;"></p> <p><a href="/node/515316">Morgan Sheng</a></p> </div> </div> </div> </div> </div> </article> </div> </div> </div> </div> Tue, 06 Mar 2018 15:30:51 +0000 tulrich@broadinstitute.org 216281 at /news/psychiatric-genetics-push-think-globally-act-locally <span class="field field--name-title field--type-string field--label-hidden"><h1>First large genetic study of bipolar disorder in Asian populations launches</h1> </span> <span class="field field--name-uid field--type-entity-reference field--label-hidden"> <span>By Alex Viveros</span> </span> <span class="field field--name-created field--type-created field--label-hidden"><time datetime="2022-10-31T12:53:52-04:00" class="datetime">October 31, 2022</time> </span> <div class="hero-section container"> <div class="hero-section__row row"> <div class="hero-section__content hero-section__content_left col-6"> <div class="hero-section__breadcrumbs"> <div class="block block-layout-builder block-extra-field-blocknodenewsbreadcrumbs"> <nav class="breadcrumb" role="navigation" aria-labelledby="system-breadcrumb"> <h2 id="system-breadcrumb" class="visually-hidden">Breadcrumb</h2> <ol> <li> <a href="/">Home</a> </li> <li> <a href="/news">News</a> </li> </ol> </nav> </div> </div> <div class="hero-section__title"> <div class="block block-layout-builder block-field-blocknodenewstitle"> <span class="field field--name-title field--type-string field--label-hidden"><h1>First large genetic study of bipolar disorder in Asian populations launches</h1> </span> </div> </div> <div class="hero-section__description"> <div class="block block-layout-builder block-field-blocknodenewsbody"> <div class="clearfix text-formatted field field--name-body field--type-text-with-summary field--label-hidden field__item"><div class="summary-only"> <p>Researchers will analyze the DNA of tens of thousands of people from five countries in East and South Asia to find genetic markers for the psychiatric condition.&nbsp;</p> </div> </div> </div> </div> <div class="hero-section__author"> <div class="block block-layout-builder block-extra-field-blocknodenewsextra-field-author-custom"> By Alex Viveros </div> </div> <div class="hero-section__date"> <div class="block block-layout-builder block-field-blocknodenewscreated"> <span class="field field--name-created field--type-created field--label-hidden"><time datetime="2022-10-31T12:53:52-04:00" class="datetime">October 31, 2022</time> </span> </div> </div> </div> <div class="hero-section__right col-6"> <div class="hero-section__image"> <div class="block block-layout-builder block-field-blocknodenewsfield-image"> <div class="field field--name-field-image field--type-entity-reference field--label-hidden field__item"> <article class="media media--type-image media--view-mode-multiple-content-types-header"> <div class="field field--name-field-media-image field--type-image field--label-hidden field__item"> <picture> <source srcset="/files/styles/multiple_ct_header_desktop_xl/public/news/images/2022/1022%20Bipolar%20Disorder%20Study_Main_557x415_02%20%282%29.png?h=9423a5c0&amp;itok=P3u1Cpvw 1x" media="all and (min-width: 1921px)" type="image/png" width="754" height="503"> <source srcset="/files/styles/multiple_ct_header_desktop_xl/public/news/images/2022/1022%20Bipolar%20Disorder%20Study_Main_557x415_02%20%282%29.png?h=9423a5c0&amp;itok=P3u1Cpvw 1x" media="all and (min-width: 1601px) and (max-width: 1920px)" type="image/png" width="754" height="503"> <source srcset="/files/styles/multiple_ct_header_desktop/public/news/images/2022/1022%20Bipolar%20Disorder%20Study_Main_557x415_02%20%282%29.png?h=9423a5c0&amp;itok=Fvvhxxtr 1x" media="all and (min-width: 1340px) and (max-width: 1600px)" type="image/png" width="736" height="520"> <source srcset="/files/styles/multiple_ct_header_laptop/public/news/images/2022/1022%20Bipolar%20Disorder%20Study_Main_557x415_02%20%282%29.png?h=9423a5c0&amp;itok=oYYe6sIs 1x" media="all and (min-width: 800px) and (max-width: 1339px)" type="image/png" width="641" height="451"> <source srcset="/files/styles/multiple_ct_header_tablet/public/news/images/2022/1022%20Bipolar%20Disorder%20Study_Main_557x415_02%20%282%29.png?h=9423a5c0&amp;itok=wqUDzIyM 1x" media="all and (min-width: 540px) and (max-width: 799px)" type="image/png" width="706" height="417"> <source srcset="/files/styles/multiple_ct_header_phone/public/news/images/2022/1022%20Bipolar%20Disorder%20Study_Main_557x415_02%20%282%29.png?h=9423a5c0&amp;itok=oydp084j 1x" media="all and (max-width: 539px)" type="image/png" width="499" height="294"> <img loading="eager" width="499" height="294" src="/files/styles/multiple_ct_header_phone/public/news/images/2022/1022%20Bipolar%20Disorder%20Study_Main_557x415_02%20%282%29.png?h=9423a5c0&amp;itok=oydp084j" alt="Ricardo Job-Reese, ӳ����ý Communications" typeof="foaf:Image"> </picture> </div> <div class="media-caption"> <div class="media-caption__credit"> Credit: Ricardo Job-Reese, ӳ����ý Communications </div> <div class="media-caption__description"> </div> </div> </article> </div> </div> </div> </div> </div> </div> <div class="content-section content-section_with-sidebars container"> <div class="row"> <div class="content-section__left col-2"> <div class="block block-better-social-sharing-buttons block-social-sharing-buttons-block"> <div style="display: none"><link rel="preload" href="/modules/contrib/better_social_sharing_buttons/assets/dist/sprites/social-icons--no-color.svg" as="image" type="image/svg+xml" crossorigin="anonymous"></div> <div class="social-sharing-buttons"> <a href="https://www.facebook.com/sharer/sharer.php?u=/taxonomy/term/1166/feed&amp;title=" target="_blank" title="Share to Facebook" aria-label="Share to Facebook" class="social-sharing-buttons-button share-facebook" rel="noopener"> <svg aria-hidden="true" width="32px" height="32px" style="border-radius:100%;"> <use href="/modules/contrib/better_social_sharing_buttons/assets/dist/sprites/social-icons--no-color.svg#facebook" /> </svg> </a> <a href="https://twitter.com/intent/tweet?text=+/taxonomy/term/1166/feed" target="_blank" title="Share to X" aria-label="Share to X" class="social-sharing-buttons-button share-x" rel="noopener"> <svg aria-hidden="true" width="32px" height="32px" style="border-radius:100%;"> <use href="/modules/contrib/better_social_sharing_buttons/assets/dist/sprites/social-icons--no-color.svg#x" /> </svg> </a> <a href="mailto:?subject=&amp;body=/taxonomy/term/1166/feed" title="Share to Email" aria-label="Share to Email" class="social-sharing-buttons-button share-email" target="_blank" rel="noopener"> <svg aria-hidden="true" width="32px" height="32px" style="border-radius:100%;"> <use href="/modules/contrib/better_social_sharing_buttons/assets/dist/sprites/social-icons--no-color.svg#email" /> </svg> </a> </div> </div> </div> <div class="content-section__main col-8"> <div class="block block-layout-builder block-field-blocknodenewsbody"> <div class="clearfix text-formatted field field--name-body field--type-text-with-summary field--label-hidden field__item"><p>Nearly 60 percent of the world’s population resides in Asian countries, but only 10 percent of participants of genetic studies are of Asian descent. And that disparity is even greater in studies of psychiatric conditions, where participants are almost all of European ancestry, even though serious mental illness affects all human populations evenly. This lack of representation of the world’s population in genetic datasets leaves out a huge amount of genomic variation, limiting what scientists can learn about the biological basis of mental disorders.&nbsp;</p> <p>A global team of scientists is now trying to tackle this problem by launching a genetic study of bipolar disorder in people from India, Pakistan, Singapore, South Korea, and Taiwan. The study, called the Asian Bipolar Genetics Network (A-BIG-NET), will collect and analyze DNA and demographic, environmental, and medical information from 27,500 patients diagnosed with the psychiatric condition and 15,000 controls.&nbsp;</p> <p>The project is a collaboration between experts from the ӳ����ý of MIT and Harvard (led by Hailiang Huang), Virginia Commonwealth University (led by Kenneth Kendler), Johns Hopkins University (led by Peter Zandi), National Institute of Mental Health and NeuroSciences in India (NIMHANS, led by Biju Viswanath), Indian Institute of Science (led by Bratati Kahali), Institute of Mental Health in Singapore (led by Jimmy Lee), Korea University College of Medicine (led by Heon-Jeong Lee), and National Taiwan University (led by Po-Hsiu Kuo). They will work together to recruit the participants, sequence the genomes, analyze the data, and build a network for rapid data-sharing.&nbsp;</p> <p>The team hopes to uncover genetic markers of bipolar disorder, which may point towards the biological causes and mechanisms underlying this condition that affects 1-2 percent of the world’s population. By focusing on Asian populations, the scientists aim to find markers that are more common in these groups than in others, which may highlight genetic roots of the disorder that are shared across other populations around the world. Better insight into the causes of bipolar disorder from this research could one day lead to new and better treatments.</p> <p>“There haven’t been any sizable bipolar genetic studies from Asian populations,” said Hailiang Huang, the project’s leader, Director of the Stanley Global Asia Initiatives at the Stanley Center for Psychiatric Research at the ӳ����ý, and an Assistant Professor at Massachusetts General Hospital and Harvard Medical School. “If this were to continue, we risk the possibility that therapeutic innovations might exclude large segments of the global population which are under-represented in psychiatric genetics. This is a major unsolved challenge for everyone in the world, including people from South and East Asia.”</p> <p>The new project extends Stanley Global, an initiative launched in 2014 by the Stanley Center to diversify genetic research and include underrepresented populations worldwide. One Stanley Global project, NeuroGAP-Psychosis, launched in 2018 to study the genetics of schizophrenia in four African countries, while another project, NeuroMex, is doing the same in Mexico. NeuroDev is studying neurodevelopmental differences in people in Kenya and South Africa.</p> <p>“Studies like A-BIG-NET have potential to discover rare variant risk genes, which should have a big impact on the mechanistic understanding of bipolar disorder,&nbsp; like the SCHEMA study did for schizophrenia. Because Asian populations have different genetic variants, their inclusion in A-BIG-NET will enhance the diversity and richness of gene discovery for bipolar,” said Morgan Sheng, co-director of the Stanley Center.</p> <h3>Global partnerships</h3> <p>A-BIG-NET was inspired by NeuroGAP-Psychosis and NeuroMex to expand this kind of genetics research to Asian countries. Though Stanley Global has sequenced genomic samples from East Asian populations before, A-BIG-NET expands that effort to include bipolar disorder and will study a much larger cohort. It will also be the first known large-scale study to explore the genetics of bipolar disorder in South Asian countries, and will build on recent discoveries from the Stanley Center including the <a href="/news/researchers-find-first-strong-genetic-risk-factor-bipolar-disorder">first strong genetic signal for bipolar disorder</a>.</p> <p>“The most important finding I would hope would emerge from this project is to find the direct causal genes underlying bipolar disorder,” Huang said. “This study gives us the chance to actually identify the causal genes for bipolar disorder in the Asian population.”</p> <p>“By taking a deep phenotyping approach, we will be collecting information which will allow us to explore a number of clinical subtypes of bipolar illness from a molecular genetic perspective to detect potential differences in their genetic substrate,” said Kendler, a Professor of Psychiatry and Human and Molecular Genetics at Virginia Commonwealth University and Co-Principal Investigator of the project. “Furthermore, studying a range of environmental risk factors will permit us to further clarify how genes and environment jointly act or interact to produce bipolar disorder.”</p> <p>“This study will be an important step in increasing equity in research, especially in the area of psychiatric genetics, ” said Biju Viswanath, Professor of Psychiatry at NIMHANS in India and the lead on the Indian arm of the study. Viswanath has established the India Consortium on Mental Illness And Genetics In the Clinic (IC-MAGIC), which conducts large genetic studies on mental health. Participants from India will make up the largest cohort of the study.&nbsp;</p> <p>“The project will allow advanced training in psychiatric genetics, and engage more researchers and participants. This will allow greater community engagement and expand research capacity in the region. We will then be able to contribute both globally, and importantly, locally to understand these complex disorders,” said Sanjeev Jain, a NIMHANS Professor and senior co-investigator of the study.</p> <p>About a third of A-BIG-NET’s genetic samples will be sequenced at the ӳ����ý by the Genomics Platform, with the rest being analyzed in their home countries. The scientists will use a recently developed sequencing technology called <a href="/blog/perspective-uncovering-genetic-basis-mental-illness-requires-diverse-datasets-and-better">Blended Genome Exome (BGE)</a>, which deeply sequences the exome — the 2 percent of human DNA that translates into proteins — and more broadly decodes the rest of the genome. This approach was designed to increase the chances of finding new genetic variation from global samples in a cost-effective manner, allowing for a large number of samples to be sequenced.&nbsp;</p> <p>The team will publicly share A-BIG-NET data through the <a href="https://nda.nih.gov/" target="_blank">National Institute of Mental Health Data Archive (NDA)</a> and the <a href="https://bipex.broadinstitute.org/">Bipolar Exomes Browser</a>. They will also contribute their data to the Psychiatric Genomics Consortium Bipolar Workgroup and the Bipolar Sequencing Project, which will allow them to compare their results to those from other studies focused on European populations.</p> <p>“This study puts together a strong team from Asia to work at understanding the biology of bipolar disorder,” said Jimmy Lee, a Senior Consultant at Singapore’s Institute of Mental Health, an associate professor at the Lee Kong Chian School of Medicine at Nanyang Technological University, and a co-senior investigator of the study. “Singapore is glad to be a part of this coordinated effort. I am confident the team will make important and impactful scientific discoveries, which will eventually translate into improved clinical care and recovery outcomes in people living with bipolar disorder. Additionally, I hope this effort will catalyze the growth of psychiatric genetics in Asia to address the gap in ethnic representation and knowledge.”</p> <p>“Taiwan is often excluded from a number of major international organizations and actions. We’re very glad to be part of the global diversity initiative and to contribute to enhancing our understanding of a severe psychiatric disorder and reducing health inequity in the long run,” said the project’s co-lead, Po-Hsiu Kuo, Associate Dean of College of Public Health, and a Professor at Institute of Epidemiology and Preventive Medicine, National Taiwan University.</p> <p>“In South Korea, no large-scale genomic study has been conducted on mental illness. Recently, however, psychiatric genetic researchers have reached a consensus on the need for large-scale collaborative genomic study on major mental illnesses, and formed the Korean Mood Disorder Genomics Consortium (KOMOGEN) with about 40 organizations to move the team to succeed in the project,” said the South Korea site leader, Heon-Jeong Lee, Professor of Psychiatry, Korea University College of Medicine.</p> <p><em>Funding for this research is provided by the National Institute of Mental Health.</em></p> </div> </div> <div class="block-node-broad-tags block block-layout-builder block-field-blocknodenewsfield-broad-tags"> <div class="block-node-broad-tags__row"> <div class="block-node-broad-tags__title">Tags:</div> <div class="field field--name-field-broad-tags field--type-entity-reference field--label-hidden field__items"> <div class="field__item"><a href="/broad-tags/neurogap" hreflang="en">NeuroGap</a></div> <div class="field__item"><a href="/broad-tags/stanley-center-psychiatric-research" hreflang="en">Stanley Center for Psychiatric Research</a></div> <div class="field__item"><a href="/broad-tags/psychiatric-disease-0" hreflang="en">Psychiatric disease</a></div> <div class="field__item"><a href="/broad-tags/psychiatric-disease" hreflang="en">Brain Health</a></div> <div class="field__item"><a href="/broad-tags/steven-hyman" hreflang="en">Steven Hyman</a></div> <div class="field__item"><a href="/broad-tags/news-and-media" hreflang="en">News and Media</a></div> </div> </div> </div> </div> <div class="content-section__right col-2"> <div class="block block-ctools block-entity-viewnode"> <article about="/news/first-large-genetic-study-bipolar-disorder-asian-populations-launches" class="node node--type-news node--view-mode-sidebar"> <div class="node__content"> <div class="sidebar-group"> <div class="sidebar-group__content"> <div class="block block-layout-builder block-field-blocknodenewsfield-news-extra-info"> <div class="clearfix text-formatted field field--name-field-news-extra-info field--type-text-long field--label-hidden field__item"><h2>&nbsp;</h2> <h2>Related News</h2> <p><img alt src="/files/styles/blog__557x415_/public/news/images/2022/Bipolar_story.png?itok=OnjsAk-j" style="width: 212px; height: 162px;"></p> <p><a href="/node/1130671">Researchers find first strong genetic risk factor for bipolar disorder</a></p> <p><img alt src="/files/styles/blog__557x415_/public/news/images/2022/Singh_Daly_Neale-Graphic.png?itok=5P7iYe2D" style="width: 212px; height: 162px;"></p> <p><a href="/node/1130626">Two large studies reveal genes and genome regions that influence schizophrenia risk</a></p> <p><img alt src="/files/styles/pt_ls_image_tablet/public/long_story/Fullwidth_NDev-Team-Photo.png" style="width: 219px; height: 138px;"></p> <p><a href="/node/1130881">A genetics study in Africa is helping to destigmatize neurodevelopmental differences in children</a></p> <p>&nbsp;</p> <h2>Related Programs</h2> <p><a href="/node/145111">Stanley Global</a></p> <p>&nbsp;</p> <p>&nbsp;</p> <h2>Related Projects</h2> <p><a href="/node/221261">NeuroGAP</a></p> <p><a href="/node/221976">NeuroGAP-Psychosis</a></p> <p><a href="/node/699091">NeuroDev</a></p> <p><a href="/node/1003656">NeuroMex</a></p> <p>&nbsp;</p> <h2>Related People</h2> <p><img alt src="/files/styles/biosketch__413x315_/public/bios/photos/Steve%20Hyman.jpg?itok=Oc4iJDp1" style="width: 212px; height: 162px;"></p> <p><a href="/node/7576">Steven Hyman</a></p> <p><img alt src="/files/styles/biosketch__413x315_/public/bios/photos/MorganSheng-bio.png?itok=BB66CSnx" style="width: 212px; height: 162px;"></p> <p><a href="/node/515316">Morgan Sheng</a></p> </div> </div> </div> </div> </div> </article> </div> </div> </div> </div> Fri, 02 Mar 2018 14:30:01 +0000 tulrich@broadinstitute.org 216276 at