Drug Repurposing Hub

How a lung injury study helped inspire new COVID-19 drug trials

Corie Lok — Tue, 17 Nov 2020 16:39:16 +0000

How ӳ��ý scientists are bridging the gap between biological insights and new therapies

By Allessandra DiCorato February 16, 2022

How ӳ��ý scientists are bridging the gap between biological insights and new therapies

At ӳ��ý’s Center for the Development of Therapeutics, biologists collaborate with drug-development experts to bring novel therapies to the clinic.

By Allessandra DiCorato

February 16, 2022

Our role in CDoT is to help find those ideas that might have the potential to make it to the clinic.

Alex Burgin, CDoT

From bench to bedside

Reflecting on her time at ӳ��ý, Wagner said, “It’s been 13 years and I’m still as excited to be a part of CDoT.”

“Throughout my career, I’ve been back and forth between academia and industry,” he said. “I’ve seen both worlds. ӳ��ý is the perfect place for me.”

Alex Burgin and Flo Wagner share their perspectives on how drug discovery works at CDoT.

Journey of a drug at CDoT

Then, they work to optimize the potency and selectivity of the molecule, testing it in cells, animals, and ultimately humans, with the aim of gaining FDA approval.

All this work is arduous, expensive, and far beyond the scope of any academic lab.

Alex Burgin and Flo Wagner observe as Elyse Petrunak, a research scientist in CDoT, works in the lab.

Credit: Gretchen Ertl

To determine the best approach for each project, Burgin attends research meetings and talks with scientists across the institute.

Burgin and Wagner point to three projects as representative of the center’s collaborative approach, ones they hope offer new models for drug development.

Searching for cancer cell killers

With help from Timothy Lewis, a medicinal chemist then at CDoT, the scientists tweaked the chemical structure of one velcrin to improve its stability.

Tackling rare disease

Burgin and Wagner say that among the key ingredients of CDoT is its proximity to academic labs. In one case, that proximity is literal.

Credit: Erik Jacobs

Now Greka already has her sights set on the next therapeutic target.

Targeting schizophrenia and neurodegeneration

Each year, on the first Friday in October, CDoT team members eagerly participate in Plaidurday and sport their favorite plaid shirts at work.
Credit: CDoT

Participants in the 2019 CDoT Push-up Contest compete as judges and onlookers observe.
Credit: CDoT

CDoT members participate in social events organized by “houses” named for famous scientists.
Credit: CDoT

The next generation

Scientists at the Center for the Development of Therapeutics (CDoT) talk about what it's like to work in drug discovery.

Tags:

Researchers discover new member of novel drug family for ‘undruggable’ targets

Corie Lok — Thu, 04 Jun 2020 12:47:59 +0000

How ӳ��ý scientists are bridging the gap between biological insights and new therapies

By Allessandra DiCorato February 16, 2022

How ӳ��ý scientists are bridging the gap between biological insights and new therapies

At ӳ��ý’s Center for the Development of Therapeutics, biologists collaborate with drug-development experts to bring novel therapies to the clinic.

By Allessandra DiCorato

February 16, 2022

Our role in CDoT is to help find those ideas that might have the potential to make it to the clinic.

Alex Burgin, CDoT

From bench to bedside

Reflecting on her time at ӳ��ý, Wagner said, “It’s been 13 years and I’m still as excited to be a part of CDoT.”

“Throughout my career, I’ve been back and forth between academia and industry,” he said. “I’ve seen both worlds. ӳ��ý is the perfect place for me.”

Alex Burgin and Flo Wagner share their perspectives on how drug discovery works at CDoT.

Journey of a drug at CDoT

Then, they work to optimize the potency and selectivity of the molecule, testing it in cells, animals, and ultimately humans, with the aim of gaining FDA approval.

All this work is arduous, expensive, and far beyond the scope of any academic lab.

Alex Burgin and Flo Wagner observe as Elyse Petrunak, a research scientist in CDoT, works in the lab.

Credit: Gretchen Ertl

To determine the best approach for each project, Burgin attends research meetings and talks with scientists across the institute.

Burgin and Wagner point to three projects as representative of the center’s collaborative approach, ones they hope offer new models for drug development.

Searching for cancer cell killers

With help from Timothy Lewis, a medicinal chemist then at CDoT, the scientists tweaked the chemical structure of one velcrin to improve its stability.

Tackling rare disease

Burgin and Wagner say that among the key ingredients of CDoT is its proximity to academic labs. In one case, that proximity is literal.

Credit: Erik Jacobs

Now Greka already has her sights set on the next therapeutic target.

Targeting schizophrenia and neurodegeneration

Each year, on the first Friday in October, CDoT team members eagerly participate in Plaidurday and sport their favorite plaid shirts at work.
Credit: CDoT

Participants in the 2019 CDoT Push-up Contest compete as judges and onlookers observe.
Credit: CDoT

CDoT members participate in social events organized by “houses” named for famous scientists.
Credit: CDoT

The next generation

Scientists at the Center for the Development of Therapeutics (CDoT) talk about what it's like to work in drug discovery.

Tags:

Combing through old drugs to find new ones for COVID-19

Namrata Sengupta — Tue, 12 May 2020 13:48:25 +0000

How ӳ��ý scientists are bridging the gap between biological insights and new therapies

By Allessandra DiCorato February 16, 2022

How ӳ��ý scientists are bridging the gap between biological insights and new therapies

At ӳ��ý’s Center for the Development of Therapeutics, biologists collaborate with drug-development experts to bring novel therapies to the clinic.

By Allessandra DiCorato

February 16, 2022

Our role in CDoT is to help find those ideas that might have the potential to make it to the clinic.

Alex Burgin, CDoT

From bench to bedside

Reflecting on her time at ӳ��ý, Wagner said, “It’s been 13 years and I’m still as excited to be a part of CDoT.”

“Throughout my career, I’ve been back and forth between academia and industry,” he said. “I’ve seen both worlds. ӳ��ý is the perfect place for me.”

Alex Burgin and Flo Wagner share their perspectives on how drug discovery works at CDoT.

Journey of a drug at CDoT

Then, they work to optimize the potency and selectivity of the molecule, testing it in cells, animals, and ultimately humans, with the aim of gaining FDA approval.

All this work is arduous, expensive, and far beyond the scope of any academic lab.

Alex Burgin and Flo Wagner observe as Elyse Petrunak, a research scientist in CDoT, works in the lab.

Credit: Gretchen Ertl

To determine the best approach for each project, Burgin attends research meetings and talks with scientists across the institute.

Burgin and Wagner point to three projects as representative of the center’s collaborative approach, ones they hope offer new models for drug development.

Searching for cancer cell killers

With help from Timothy Lewis, a medicinal chemist then at CDoT, the scientists tweaked the chemical structure of one velcrin to improve its stability.

Tackling rare disease

Burgin and Wagner say that among the key ingredients of CDoT is its proximity to academic labs. In one case, that proximity is literal.

Credit: Erik Jacobs

Now Greka already has her sights set on the next therapeutic target.

Targeting schizophrenia and neurodegeneration

Each year, on the first Friday in October, CDoT team members eagerly participate in Plaidurday and sport their favorite plaid shirts at work.
Credit: CDoT

Participants in the 2019 CDoT Push-up Contest compete as judges and onlookers observe.
Credit: CDoT

CDoT members participate in social events organized by “houses” named for famous scientists.
Credit: CDoT

The next generation

Scientists at the Center for the Development of Therapeutics (CDoT) talk about what it's like to work in drug discovery.

Tags:

Dozens of non-oncology drugs can kill cancer cells

leah@broadinstitute.org — Mon, 20 Jan 2020 16:00:00 +0000

How ӳ��ý scientists are bridging the gap between biological insights and new therapies

By Allessandra DiCorato February 16, 2022

How ӳ��ý scientists are bridging the gap between biological insights and new therapies

At ӳ��ý’s Center for the Development of Therapeutics, biologists collaborate with drug-development experts to bring novel therapies to the clinic.

By Allessandra DiCorato

February 16, 2022

Our role in CDoT is to help find those ideas that might have the potential to make it to the clinic.

Alex Burgin, CDoT

From bench to bedside

Reflecting on her time at ӳ��ý, Wagner said, “It’s been 13 years and I’m still as excited to be a part of CDoT.”

“Throughout my career, I’ve been back and forth between academia and industry,” he said. “I’ve seen both worlds. ӳ��ý is the perfect place for me.”

Alex Burgin and Flo Wagner share their perspectives on how drug discovery works at CDoT.

Journey of a drug at CDoT

Then, they work to optimize the potency and selectivity of the molecule, testing it in cells, animals, and ultimately humans, with the aim of gaining FDA approval.

All this work is arduous, expensive, and far beyond the scope of any academic lab.

Alex Burgin and Flo Wagner observe as Elyse Petrunak, a research scientist in CDoT, works in the lab.

Credit: Gretchen Ertl

To determine the best approach for each project, Burgin attends research meetings and talks with scientists across the institute.

Burgin and Wagner point to three projects as representative of the center’s collaborative approach, ones they hope offer new models for drug development.

Searching for cancer cell killers

With help from Timothy Lewis, a medicinal chemist then at CDoT, the scientists tweaked the chemical structure of one velcrin to improve its stability.

Tackling rare disease

Burgin and Wagner say that among the key ingredients of CDoT is its proximity to academic labs. In one case, that proximity is literal.

Credit: Erik Jacobs

Now Greka already has her sights set on the next therapeutic target.

Targeting schizophrenia and neurodegeneration

Each year, on the first Friday in October, CDoT team members eagerly participate in Plaidurday and sport their favorite plaid shirts at work.
Credit: CDoT

Participants in the 2019 CDoT Push-up Contest compete as judges and onlookers observe.
Credit: CDoT

CDoT members participate in social events organized by “houses” named for famous scientists.
Credit: CDoT

The next generation

Scientists at the Center for the Development of Therapeutics (CDoT) talk about what it's like to work in drug discovery.

Tags:

Drug Repurposing Hub

mnemchuk@broadinstitute.org — Mon, 06 May 2019 22:11:00 +0000

How ӳ��ý scientists are bridging the gap between biological insights and new therapies

By Allessandra DiCorato February 16, 2022

How ӳ��ý scientists are bridging the gap between biological insights and new therapies

At ӳ��ý’s Center for the Development of Therapeutics, biologists collaborate with drug-development experts to bring novel therapies to the clinic.

By Allessandra DiCorato

February 16, 2022

Our role in CDoT is to help find those ideas that might have the potential to make it to the clinic.

Alex Burgin, CDoT

From bench to bedside

Reflecting on her time at ӳ��ý, Wagner said, “It’s been 13 years and I’m still as excited to be a part of CDoT.”

“Throughout my career, I’ve been back and forth between academia and industry,” he said. “I’ve seen both worlds. ӳ��ý is the perfect place for me.”

Alex Burgin and Flo Wagner share their perspectives on how drug discovery works at CDoT.

Journey of a drug at CDoT

Then, they work to optimize the potency and selectivity of the molecule, testing it in cells, animals, and ultimately humans, with the aim of gaining FDA approval.

All this work is arduous, expensive, and far beyond the scope of any academic lab.

Alex Burgin and Flo Wagner observe as Elyse Petrunak, a research scientist in CDoT, works in the lab.

Credit: Gretchen Ertl

To determine the best approach for each project, Burgin attends research meetings and talks with scientists across the institute.

Burgin and Wagner point to three projects as representative of the center’s collaborative approach, ones they hope offer new models for drug development.

Searching for cancer cell killers

With help from Timothy Lewis, a medicinal chemist then at CDoT, the scientists tweaked the chemical structure of one velcrin to improve its stability.

Tackling rare disease

Burgin and Wagner say that among the key ingredients of CDoT is its proximity to academic labs. In one case, that proximity is literal.

Credit: Erik Jacobs

Now Greka already has her sights set on the next therapeutic target.

Targeting schizophrenia and neurodegeneration

Each year, on the first Friday in October, CDoT team members eagerly participate in Plaidurday and sport their favorite plaid shirts at work.
Credit: CDoT

Participants in the 2019 CDoT Push-up Contest compete as judges and onlookers observe.
Credit: CDoT

CDoT members participate in social events organized by “houses” named for famous scientists.
Credit: CDoT

The next generation

Scientists at the Center for the Development of Therapeutics (CDoT) talk about what it's like to work in drug discovery.

Tags:

The Center for the Development of Therapeutics (CDoT)

mnemchuk@broadinstitute.org — Thu, 21 Mar 2019 19:44:57 +0000

How ӳ��ý scientists are bridging the gap between biological insights and new therapies

By Allessandra DiCorato February 16, 2022

How ӳ��ý scientists are bridging the gap between biological insights and new therapies

At ӳ��ý’s Center for the Development of Therapeutics, biologists collaborate with drug-development experts to bring novel therapies to the clinic.

By Allessandra DiCorato

February 16, 2022

Our role in CDoT is to help find those ideas that might have the potential to make it to the clinic.

Alex Burgin, CDoT

From bench to bedside

Reflecting on her time at ӳ��ý, Wagner said, “It’s been 13 years and I’m still as excited to be a part of CDoT.”

“Throughout my career, I’ve been back and forth between academia and industry,” he said. “I’ve seen both worlds. ӳ��ý is the perfect place for me.”

Alex Burgin and Flo Wagner share their perspectives on how drug discovery works at CDoT.

Journey of a drug at CDoT

Then, they work to optimize the potency and selectivity of the molecule, testing it in cells, animals, and ultimately humans, with the aim of gaining FDA approval.

All this work is arduous, expensive, and far beyond the scope of any academic lab.

Alex Burgin and Flo Wagner observe as Elyse Petrunak, a research scientist in CDoT, works in the lab.

Credit: Gretchen Ertl

To determine the best approach for each project, Burgin attends research meetings and talks with scientists across the institute.

Burgin and Wagner point to three projects as representative of the center’s collaborative approach, ones they hope offer new models for drug development.

Searching for cancer cell killers

With help from Timothy Lewis, a medicinal chemist then at CDoT, the scientists tweaked the chemical structure of one velcrin to improve its stability.

Tackling rare disease

Burgin and Wagner say that among the key ingredients of CDoT is its proximity to academic labs. In one case, that proximity is literal.

Credit: Erik Jacobs

Now Greka already has her sights set on the next therapeutic target.

Targeting schizophrenia and neurodegeneration

Each year, on the first Friday in October, CDoT team members eagerly participate in Plaidurday and sport their favorite plaid shirts at work.
Credit: CDoT

Participants in the 2019 CDoT Push-up Contest compete as judges and onlookers observe.
Credit: CDoT

CDoT members participate in social events organized by “houses” named for famous scientists.
Credit: CDoT

The next generation

Scientists at the Center for the Development of Therapeutics (CDoT) talk about what it's like to work in drug discovery.

Tags:

A hub for medicines hiding tricks up their sleeves

tulrich@broadinstitute.org — Mon, 14 May 2018 16:00:18 +0000

How ӳ��ý scientists are bridging the gap between biological insights and new therapies

By Allessandra DiCorato February 16, 2022

How ӳ��ý scientists are bridging the gap between biological insights and new therapies

At ӳ��ý’s Center for the Development of Therapeutics, biologists collaborate with drug-development experts to bring novel therapies to the clinic.

By Allessandra DiCorato

February 16, 2022

Our role in CDoT is to help find those ideas that might have the potential to make it to the clinic.

Alex Burgin, CDoT

From bench to bedside

Reflecting on her time at ӳ��ý, Wagner said, “It’s been 13 years and I’m still as excited to be a part of CDoT.”

“Throughout my career, I’ve been back and forth between academia and industry,” he said. “I’ve seen both worlds. ӳ��ý is the perfect place for me.”

Alex Burgin and Flo Wagner share their perspectives on how drug discovery works at CDoT.

Journey of a drug at CDoT

Then, they work to optimize the potency and selectivity of the molecule, testing it in cells, animals, and ultimately humans, with the aim of gaining FDA approval.

All this work is arduous, expensive, and far beyond the scope of any academic lab.

Alex Burgin and Flo Wagner observe as Elyse Petrunak, a research scientist in CDoT, works in the lab.

Credit: Gretchen Ertl

To determine the best approach for each project, Burgin attends research meetings and talks with scientists across the institute.

Burgin and Wagner point to three projects as representative of the center’s collaborative approach, ones they hope offer new models for drug development.

Searching for cancer cell killers

With help from Timothy Lewis, a medicinal chemist then at CDoT, the scientists tweaked the chemical structure of one velcrin to improve its stability.

Tackling rare disease

Burgin and Wagner say that among the key ingredients of CDoT is its proximity to academic labs. In one case, that proximity is literal.

Credit: Erik Jacobs

Now Greka already has her sights set on the next therapeutic target.

Targeting schizophrenia and neurodegeneration

Each year, on the first Friday in October, CDoT team members eagerly participate in Plaidurday and sport their favorite plaid shirts at work.
Credit: CDoT

Participants in the 2019 CDoT Push-up Contest compete as judges and onlookers observe.
Credit: CDoT

CDoT members participate in social events organized by “houses” named for famous scientists.
Credit: CDoT

The next generation

Scientists at the Center for the Development of Therapeutics (CDoT) talk about what it's like to work in drug discovery.

Tags: