/ en /news/potential-alzheimers-disease-therapeutic-target-identified-brain-immune-cells <span class="field field--name-title field--type-string field--label-hidden"><h1>Potential Alzheimer’s disease therapeutic target identified in brain immune cells</h1> </span> <span class="field field--name-uid field--type-entity-reference field--label-hidden"> <span>By Corie Lok</span> </span> <span class="field field--name-created field--type-created field--label-hidden"><time datetime="2025-04-09T09:36:41-04:00" class="datetime">April 9, 2025</time> </span> <div class="hero-section container"> <div class="hero-section__row row"> <div class="hero-section__content hero-section__content_left col-6"> <div class="hero-section__breadcrumbs"> <div class="block block-system block-system-breadcrumb-block"> <nav class="breadcrumb" role="navigation" aria-labelledby="system-breadcrumb"> <h2 id="system-breadcrumb" class="visually-hidden">Breadcrumb</h2> <ol> <li> <a href="/">Home</a> </li> <li> <a href="/news">News</a> </li> </ol> </nav> </div> </div> <div class="hero-section__title"> <div class="block block-layout-builder block-field-blocknodelong-storytitle"> <span class="field field--name-title field--type-string field--label-hidden"><h1>Potential Alzheimer’s disease therapeutic target identified in brain immune cells</h1> </span> </div> </div> <div class="hero-section__description"> <div class="block block-layout-builder block-field-blocknodelong-storybody"> <div class="clearfix text-formatted field field--name-body field--type-text-with-summary field--label-hidden field__item"><p>Scientists discover possible way to harness immune cells in the brain to remove plaques associated with Alzheimer's.&nbsp;</p> </div> </div> </div> <div class="hero-section__author"> <div class="block block-layout-builder block-extra-field-blocknodelong-storyextra-field-author-custom"> By Anna McTigue, Mass General Brigham Communications </div> </div> <div class="hero-section__date"> <div class="block block-layout-builder block-field-blocknodelong-storycreated"> <span class="field field--name-created field--type-created field--label-hidden"><time datetime="2025-04-09T09:36:41-04:00" title="Wednesday, April 9, 2025 - 09:36" class="datetime">April 9, 2025</time> </span> </div> </div> </div> <div class="hero-section__right col-6"> <div class="hero-section__image"> <div class="block block-layout-builder block-field-blocknodelong-storyfield-image"> <div class="field field--name-field-image field--type-entity-reference field--label-hidden field__item"> <article class="media media--type-image media--view-mode-multiple-content-types-header"> <div class="field field--name-field-media-image field--type-image field--label-hidden field__item"> <picture> <source srcset="/files/styles/multiple_ct_header_desktop_xl/public/longstory/26709211161_956113bf3e_c.jpg?itok=Ti1GJfAc 1x" media="all and (min-width: 1921px)" type="image/jpeg" width="754" height="503"> <source srcset="/files/styles/multiple_ct_header_desktop_xl/public/longstory/26709211161_956113bf3e_c.jpg?itok=Ti1GJfAc 1x" media="all and (min-width: 1601px) and (max-width: 1920px)" type="image/jpeg" width="754" height="503"> <source srcset="/files/styles/multiple_ct_header_desktop/public/longstory/26709211161_956113bf3e_c.jpg?itok=nu30mWVf 1x" media="all and (min-width: 1340px) and (max-width: 1600px)" type="image/jpeg" width="736" height="520"> <source srcset="/files/styles/multiple_ct_header_laptop/public/longstory/26709211161_956113bf3e_c.jpg?itok=SrnEVHSE 1x" media="all and (min-width: 800px) and (max-width: 1339px)" type="image/jpeg" width="641" height="451"> <source srcset="/files/styles/multiple_ct_header_tablet/public/longstory/26709211161_956113bf3e_c.jpg?itok=uR_vA2Q5 1x" media="all and (min-width: 540px) and (max-width: 799px)" type="image/jpeg" width="706" height="417"> <source srcset="/files/styles/multiple_ct_header_phone/public/longstory/26709211161_956113bf3e_c.jpg?itok=Y1c99wkP 1x" media="all and (max-width: 539px)" type="image/jpeg" width="499" height="294"> <img loading="eager" width="499" height="294" src="/files/styles/multiple_ct_header_phone/public/longstory/26709211161_956113bf3e_c.jpg?itok=Y1c99wkP" alt="Microscopy image showing mouse brain with nerve cells, blood vessels, and plaques from Alzheimer's disease." title="Microscopy image showing mouse brain with nerve cells, blood vessels, and plaques from Alzheimer's disease." typeof="foaf:Image"> </picture> </div> <div class="media-caption"> <div class="media-caption__credit"> Credit: Alvin Gogineni, Genentech </div> <div class="media-caption__description"> This mouse brain shows hallmarks of Alzheimer’s disease (plaques in blue), along with blood vessels (red) and nerve cells (green). </div> </div> </article> </div> </div> </div> </div> </div> </div> <div class="content-section container"> <div class="content-section__main"> <div class="block block-better-social-sharing-buttons block-social-sharing-buttons-block"> <div style="display: none"><link rel="preload" href="/modules/contrib/better_social_sharing_buttons/assets/dist/sprites/social-icons--no-color.svg" as="image" type="image/svg+xml" crossorigin="anonymous"></div> <div class="social-sharing-buttons"> <a href="https://www.facebook.com/sharer/sharer.php?u=/taxonomy/term/2311/feed&amp;title=" target="_blank" title="Share to Facebook" aria-label="Share to Facebook" class="social-sharing-buttons-button share-facebook" rel="noopener"> <svg aria-hidden="true" width="32px" height="32px" style="border-radius:100%;"> <use href="/modules/contrib/better_social_sharing_buttons/assets/dist/sprites/social-icons--no-color.svg#facebook" /> </svg> </a> <a href="https://twitter.com/intent/tweet?text=+/taxonomy/term/2311/feed" target="_blank" title="Share to X" aria-label="Share to X" class="social-sharing-buttons-button share-x" rel="noopener"> <svg aria-hidden="true" width="32px" height="32px" style="border-radius:100%;"> <use href="/modules/contrib/better_social_sharing_buttons/assets/dist/sprites/social-icons--no-color.svg#x" /> </svg> </a> <a href="mailto:?subject=&amp;body=/taxonomy/term/2311/feed" title="Share to Email" aria-label="Share to Email" class="social-sharing-buttons-button share-email" target="_blank" rel="noopener"> <svg aria-hidden="true" width="32px" height="32px" style="border-radius:100%;"> <use href="/modules/contrib/better_social_sharing_buttons/assets/dist/sprites/social-icons--no-color.svg#email" /> </svg> </a> </div> </div> <div class="block block-layout-builder block-field-blocknodelong-storyfield-content-paragraphs"> <div class="field field--name-field-content-paragraphs field--type-entity-reference-revisions field--label-hidden field__items"> <div class="field__item"> <div class="paragraph paragraph--type--text-with-sidebar text-with-sidebar"> <div class="field field--name-field-sidebar field--type-entity-reference-revisions field--label-hidden field__items"> <div class="field__item"> <div class="paragraph paragraph--type--sidebar-articles sidebar-articles"> <div class="sidebar-articles__col"> <div class="clearfix text-formatted field field--name-field-heading field--type-text field--label-hidden field__item"><p>Related News</p> </div> <div class="field field--name-field-content-reference field--type-entity-reference field--label-hidden field__items"> <div class="field__item"><article about="/news/scientists-reveal-cellular-changes-unique-early-alzheimers-disease" class="node"> <div class="field field--name-field-image field--type-entity-reference field--label-hidden field__item"><article class="media media--type-image media--view-mode-multiple-ct-sidebar-link-with-image"> <div class="field field--name-field-media-image field--type-image field--label-hidden field__item"> <a href="/news/scientists-reveal-cellular-changes-unique-early-alzheimers-disease"><picture> <source srcset="/files/styles/multiple_ct_sidebar_link_with_image_desktop_xl/public/longstory/24746155619_b586852fe9_o_main.png?h=035871dd&amp;itok=3nYqiEZV 1x" media="all and (min-width: 1921px)" type="image/png" width="104" height="104"> <source srcset="/files/styles/multiple_ct_sidebar_link_with_image_desktop_xl/public/longstory/24746155619_b586852fe9_o_main.png?h=035871dd&amp;itok=3nYqiEZV 1x" media="all and (min-width: 1601px) and (max-width: 1920px)" type="image/png" width="104" height="104"> <source srcset="/files/styles/multiple_ct_sidebar_link_with_image_desktop/public/longstory/24746155619_b586852fe9_o_main.png?h=035871dd&amp;itok=wU17IzF- 1x" media="all and (min-width: 1340px) and (max-width: 1600px)" type="image/png" width="87" height="104"> <source srcset="/files/styles/multiple_ct_sidebar_link_with_image_desktop/public/longstory/24746155619_b586852fe9_o_main.png?h=035871dd&amp;itok=wU17IzF- 1x" media="all and (min-width: 800px) and (max-width: 1339px)" type="image/png" width="87" height="104"> <source srcset="/files/styles/multiple_ct_sidebar_link_with_image_tablet/public/longstory/24746155619_b586852fe9_o_main.png?h=035871dd&amp;itok=03Z2hZpL 1x" media="all and (min-width: 540px) and (max-width: 799px)" type="image/png" width="285" height="186"> <source srcset="/files/styles/multiple_ct_sidebar_link_with_image_phone/public/longstory/24746155619_b586852fe9_o_main.png?h=035871dd&amp;itok=WE7B6Ds0 1x" media="all and (max-width: 539px)" type="image/png" width="220" height="186"> <img loading="eager" width="220" height="186" src="/files/styles/multiple_ct_sidebar_link_with_image_phone/public/longstory/24746155619_b586852fe9_o_main.png?h=035871dd&amp;itok=WE7B6Ds0" alt="A fluorescence microscopy image showing buildup of amyloid beta clusters among neurons in a mouse model of Alzheimer’s disease." title="A fluorescence microscopy image showing buildup of amyloid beta clusters among neurons in a mouse model of Alzheimer’s disease." typeof="foaf:Image"> </picture></a> </div> </article> </div> <div class="node__content"> <a href="/news/scientists-reveal-cellular-changes-unique-early-alzheimers-disease" class="node__title"><span class="field field--name-title field--type-string field--label-hidden">Scientists reveal cellular changes unique to early Alzheimer’s disease</span> </a> </div> </article> </div> <div class="field__item"><article about="/news/researchers-map-brain-cell-changes-alzheimers-disease" class="node"> <div class="field field--name-field-image field--type-entity-reference field--label-hidden field__item"><article class="media media--type-image media--view-mode-multiple-ct-sidebar-link-with-image"> <div class="field field--name-field-media-image field--type-image field--label-hidden field__item"> <a href="/news/researchers-map-brain-cell-changes-alzheimers-disease"><picture> <source srcset="/files/styles/multiple_ct_sidebar_link_with_image_desktop_xl/public/longstory/main_mAD-Figure-1_20221206-01.png?h=93c99ee8&amp;itok=YbcVyrou 1x" media="all and (min-width: 1921px)" type="image/png" width="104" height="104"> <source srcset="/files/styles/multiple_ct_sidebar_link_with_image_desktop_xl/public/longstory/main_mAD-Figure-1_20221206-01.png?h=93c99ee8&amp;itok=YbcVyrou 1x" media="all and (min-width: 1601px) and (max-width: 1920px)" type="image/png" width="104" height="104"> <source srcset="/files/styles/multiple_ct_sidebar_link_with_image_desktop/public/longstory/main_mAD-Figure-1_20221206-01.png?h=93c99ee8&amp;itok=_khBWxft 1x" media="all and (min-width: 1340px) and (max-width: 1600px)" type="image/png" width="87" height="104"> <source srcset="/files/styles/multiple_ct_sidebar_link_with_image_desktop/public/longstory/main_mAD-Figure-1_20221206-01.png?h=93c99ee8&amp;itok=_khBWxft 1x" media="all and (min-width: 800px) and (max-width: 1339px)" type="image/png" width="87" height="104"> <source srcset="/files/styles/multiple_ct_sidebar_link_with_image_tablet/public/longstory/main_mAD-Figure-1_20221206-01.png?h=93c99ee8&amp;itok=0DsI2w5k 1x" media="all and (min-width: 540px) and (max-width: 799px)" type="image/png" width="285" height="186"> <source srcset="/files/styles/multiple_ct_sidebar_link_with_image_phone/public/longstory/main_mAD-Figure-1_20221206-01.png?h=93c99ee8&amp;itok=rIgOybCw 1x" media="all and (max-width: 539px)" type="image/png" width="220" height="186"> <img loading="eager" width="220" height="186" src="/files/styles/multiple_ct_sidebar_link_with_image_phone/public/longstory/main_mAD-Figure-1_20221206-01.png?h=93c99ee8&amp;itok=rIgOybCw" alt="Fluorescence microscopy image of brain tissue from a mouse model of Alzheimer’s, showing tau tangles (red), amyloid plaques (white), RNA (green), and cell nuclei (blue)." title="Fluorescence microscopy image of brain tissue from a mouse model of Alzheimer’s, showing tau tangles (red), amyloid plaques (white), RNA (green), and cell nuclei (blue)." typeof="foaf:Image"> </picture></a> </div> </article> </div> <div class="node__content"> <a href="/news/researchers-map-brain-cell-changes-alzheimers-disease" class="node__title"><span class="field field--name-title field--type-string field--label-hidden">Researchers map brain cell changes in Alzheimer’s disease</span> </a> </div> </article> </div> </div> </div> </div> </div> </div> <div class="clearfix text-formatted field field--name-field-text field--type-text-long field--label-hidden field__item"><p>Since the 1990s, researchers have found several immune system molecules that act like “brakes” on immune responses, leading to a new class of cancer drugs. One of these “immune checkpoint” molecules, called Tim-3 has recently been linked to late-onset Alzheimer’s disease (AD), but its role in the brain was unknown until now. In a paper published in <a href="https://www.nature.com/articles/s41586-025-08852-z"><em>Nature</em></a>, researchers from Mass General Brigham and the ӳ����ý used preclinical models to uncover Tim-3’s role in microglia, the brain's resident immune cells, and have identified it as a promising therapeutic target for Alzheimer’s disease.</p> <p>“Immune checkpoint inhibitors have revolutionized cancer immunotherapy, and it is exciting that we might be able to repurpose them to treat Alzheimer’s disease,” said senior author <a href="/bios/vijay-k-kuchroo">Vijay Kuchroo</a>&nbsp;of the Gene Lay Institute of Immunology and Inflammation at Brigham and Women’s Hospital and Massachusetts General Hospital, founding members of the Mass General Brigham healthcare system. Kuchroo is also an institute member at the ӳ����ý. “Microglia are pivotal in neuroinflammation and neurodegeneration, and therapeutic targeting of Tim-3 in microglia may alter them to an optimal state to fight the disease pathology in AD."</p> <p>Using a mouse model of AD, the Kuchroo lab together with Oleg Butovsky lab, at the Ann Romney Center for Neurologic Diseases at BWH, determined that Tim-3 is only expressed in microglia in the central nervous system, where it helps the cells maintain a healthy state of homeostasis. Tim-3 can also, however, prevent the brain from effectively clearing out the toxic plaques that accumulate during AD. The researchers found that deleting Tim-3 helped kickstart plaque removal by prompting the microglia to eat up more of the plaques, while also producing anti-inflammatory proteins to reduce neuroinflammation, and limiting cognitive impairment.<br> &nbsp;<br> Over a half-dozen clinical trials are currently testing therapeutics that target Tim-3 to treat patients with immunotherapy-resistant cancers. According to the authors, the new study highlights the therapeutic potential of adapting these treatments to enhance plaque clearance and mitigate neurodegeneration in Alzheimer’s disease.</p> <p><em><a href="https://www.massgeneralbrigham.org/en/about/newsroom/press-releases/potential-alzheimers-target-in-brain-immune-cells" target="_blank">Adapted from a Mass General Brigham story</a>.</em></p> </div> </div> </div> <div class="field__item"> <div class="paragraph paragraph--type--table-outro paragraph--view-mode--default"> <div class="field field--name-field-paragraph field--type-entity-reference-revisions field--label-hidden field__items"> <div class="field__item"> <div class="paragraph paragraph--type--table-outro-row paragraph--view-mode--default"> <div class="clearfix text-formatted field field--name-field-heading field--type-text field--label-hidden field__item"><p>Funding</p> </div> <div class="clearfix text-formatted field field--name-field-text field--type-text-long field--label-hidden field__item"><p>This work was supported by the National Institutes of Health, Cure Alzheimer’s Fund, and the BrightFocus Foundation.</p> </div> </div> </div> <div class="field__item"> <div class="paragraph paragraph--type--table-outro-row paragraph--view-mode--default"> <div class="clearfix text-formatted field field--name-field-heading field--type-text field--label-hidden field__item"><p>Paper cited</p> </div> <div class="clearfix text-formatted field field--name-field-text field--type-text-long field--label-hidden field__item"><p>Kimura, K, et al. “<a href="https://www.nature.com/articles/s41586-025-08852-z">Tim-3 immune checkpoint regulates microglial function and Alzheimer's disease</a>” <em>Nature. </em>Online April 9, 2025.<em>&nbsp;</em>DOI: 10.1038/s41586-025-08852-z</p> </div> </div> </div> </div> </div> </div> </div> </div> </div> </div> <div class="content-section container"> <div class="content-section__main"> <div class="block-node-broad-tags block block-layout-builder block-field-blocknodelong-storyfield-broad-tags"> <div class="block-node-broad-tags__row"> <div class="block-node-broad-tags__title">Tags:</div> <div class="field field--name-field-broad-tags field--type-entity-reference field--label-hidden field__items"> <div class="field__item"><a href="/broad-tags/neurodegeneration" hreflang="en">Neurodegeneration</a></div> </div> </div> </div> </div> </div> Wed, 09 Apr 2025 13:36:41 +0000 Corie Lok 5558456 at /news/study-finds-surprising-way-genetic-mutation-causes-huntingtons-disease-transforming <span class="field field--name-title field--type-string field--label-hidden"><h1>Potential Alzheimer’s disease therapeutic target identified in brain immune cells</h1> </span> <span class="field field--name-uid field--type-entity-reference field--label-hidden"> <span>By Corie Lok</span> </span> <span class="field field--name-created field--type-created field--label-hidden"><time datetime="2025-04-09T09:36:41-04:00" class="datetime">April 9, 2025</time> </span> <div class="hero-section container"> <div class="hero-section__row row"> <div class="hero-section__content hero-section__content_left col-6"> <div class="hero-section__breadcrumbs"> <div class="block block-system block-system-breadcrumb-block"> <nav class="breadcrumb" role="navigation" aria-labelledby="system-breadcrumb"> <h2 id="system-breadcrumb" class="visually-hidden">Breadcrumb</h2> <ol> <li> <a href="/">Home</a> </li> <li> <a href="/news">News</a> </li> </ol> </nav> </div> </div> <div class="hero-section__title"> <div class="block block-layout-builder block-field-blocknodelong-storytitle"> <span class="field field--name-title field--type-string field--label-hidden"><h1>Potential Alzheimer’s disease therapeutic target identified in brain immune cells</h1> </span> </div> </div> <div class="hero-section__description"> <div class="block block-layout-builder block-field-blocknodelong-storybody"> <div class="clearfix text-formatted field field--name-body field--type-text-with-summary field--label-hidden field__item"><p>Scientists discover possible way to harness immune cells in the brain to remove plaques associated with Alzheimer's.&nbsp;</p> </div> </div> </div> <div class="hero-section__author"> <div class="block block-layout-builder block-extra-field-blocknodelong-storyextra-field-author-custom"> By Anna McTigue, Mass General Brigham Communications </div> </div> <div class="hero-section__date"> <div class="block block-layout-builder block-field-blocknodelong-storycreated"> <span class="field field--name-created field--type-created field--label-hidden"><time datetime="2025-04-09T09:36:41-04:00" title="Wednesday, April 9, 2025 - 09:36" class="datetime">April 9, 2025</time> </span> </div> </div> </div> <div class="hero-section__right col-6"> <div class="hero-section__image"> <div class="block block-layout-builder block-field-blocknodelong-storyfield-image"> <div class="field field--name-field-image field--type-entity-reference field--label-hidden field__item"> <article class="media media--type-image media--view-mode-multiple-content-types-header"> <div class="field field--name-field-media-image field--type-image field--label-hidden field__item"> <picture> <source srcset="/files/styles/multiple_ct_header_desktop_xl/public/longstory/26709211161_956113bf3e_c.jpg?itok=Ti1GJfAc 1x" media="all and (min-width: 1921px)" type="image/jpeg" width="754" height="503"> <source srcset="/files/styles/multiple_ct_header_desktop_xl/public/longstory/26709211161_956113bf3e_c.jpg?itok=Ti1GJfAc 1x" media="all and (min-width: 1601px) and (max-width: 1920px)" type="image/jpeg" width="754" height="503"> <source srcset="/files/styles/multiple_ct_header_desktop/public/longstory/26709211161_956113bf3e_c.jpg?itok=nu30mWVf 1x" media="all and (min-width: 1340px) and (max-width: 1600px)" type="image/jpeg" width="736" height="520"> <source srcset="/files/styles/multiple_ct_header_laptop/public/longstory/26709211161_956113bf3e_c.jpg?itok=SrnEVHSE 1x" media="all and (min-width: 800px) and (max-width: 1339px)" type="image/jpeg" width="641" height="451"> <source srcset="/files/styles/multiple_ct_header_tablet/public/longstory/26709211161_956113bf3e_c.jpg?itok=uR_vA2Q5 1x" media="all and (min-width: 540px) and (max-width: 799px)" type="image/jpeg" width="706" height="417"> <source srcset="/files/styles/multiple_ct_header_phone/public/longstory/26709211161_956113bf3e_c.jpg?itok=Y1c99wkP 1x" media="all and (max-width: 539px)" type="image/jpeg" width="499" height="294"> <img loading="eager" width="499" height="294" src="/files/styles/multiple_ct_header_phone/public/longstory/26709211161_956113bf3e_c.jpg?itok=Y1c99wkP" alt="Microscopy image showing mouse brain with nerve cells, blood vessels, and plaques from Alzheimer's disease." title="Microscopy image showing mouse brain with nerve cells, blood vessels, and plaques from Alzheimer's disease." typeof="foaf:Image"> </picture> </div> <div class="media-caption"> <div class="media-caption__credit"> Credit: Alvin Gogineni, Genentech </div> <div class="media-caption__description"> This mouse brain shows hallmarks of Alzheimer’s disease (plaques in blue), along with blood vessels (red) and nerve cells (green). </div> </div> </article> </div> </div> </div> </div> </div> </div> <div class="content-section container"> <div class="content-section__main"> <div class="block block-better-social-sharing-buttons block-social-sharing-buttons-block"> <div style="display: none"><link rel="preload" href="/modules/contrib/better_social_sharing_buttons/assets/dist/sprites/social-icons--no-color.svg" as="image" type="image/svg+xml" crossorigin="anonymous"></div> <div class="social-sharing-buttons"> <a href="https://www.facebook.com/sharer/sharer.php?u=/taxonomy/term/2311/feed&amp;title=" target="_blank" title="Share to Facebook" aria-label="Share to Facebook" class="social-sharing-buttons-button share-facebook" rel="noopener"> <svg aria-hidden="true" width="32px" height="32px" style="border-radius:100%;"> <use href="/modules/contrib/better_social_sharing_buttons/assets/dist/sprites/social-icons--no-color.svg#facebook" /> </svg> </a> <a href="https://twitter.com/intent/tweet?text=+/taxonomy/term/2311/feed" target="_blank" title="Share to X" aria-label="Share to X" class="social-sharing-buttons-button share-x" rel="noopener"> <svg aria-hidden="true" width="32px" height="32px" style="border-radius:100%;"> <use href="/modules/contrib/better_social_sharing_buttons/assets/dist/sprites/social-icons--no-color.svg#x" /> </svg> </a> <a href="mailto:?subject=&amp;body=/taxonomy/term/2311/feed" title="Share to Email" aria-label="Share to Email" class="social-sharing-buttons-button share-email" target="_blank" rel="noopener"> <svg aria-hidden="true" width="32px" height="32px" style="border-radius:100%;"> <use href="/modules/contrib/better_social_sharing_buttons/assets/dist/sprites/social-icons--no-color.svg#email" /> </svg> </a> </div> </div> <div class="block block-layout-builder block-field-blocknodelong-storyfield-content-paragraphs"> <div class="field field--name-field-content-paragraphs field--type-entity-reference-revisions field--label-hidden field__items"> <div class="field__item"> <div class="paragraph paragraph--type--text-with-sidebar text-with-sidebar"> <div class="field field--name-field-sidebar field--type-entity-reference-revisions field--label-hidden field__items"> <div class="field__item"> <div class="paragraph paragraph--type--sidebar-articles sidebar-articles"> <div class="sidebar-articles__col"> <div class="clearfix text-formatted field field--name-field-heading field--type-text field--label-hidden field__item"><p>Related News</p> </div> <div class="field field--name-field-content-reference field--type-entity-reference field--label-hidden field__items"> <div class="field__item"><article about="/news/scientists-reveal-cellular-changes-unique-early-alzheimers-disease" class="node"> <div class="field field--name-field-image field--type-entity-reference field--label-hidden field__item"><article class="media media--type-image media--view-mode-multiple-ct-sidebar-link-with-image"> <div class="field field--name-field-media-image field--type-image field--label-hidden field__item"> <a href="/news/scientists-reveal-cellular-changes-unique-early-alzheimers-disease"><picture> <source srcset="/files/styles/multiple_ct_sidebar_link_with_image_desktop_xl/public/longstory/24746155619_b586852fe9_o_main.png?h=035871dd&amp;itok=3nYqiEZV 1x" media="all and (min-width: 1921px)" type="image/png" width="104" height="104"> <source srcset="/files/styles/multiple_ct_sidebar_link_with_image_desktop_xl/public/longstory/24746155619_b586852fe9_o_main.png?h=035871dd&amp;itok=3nYqiEZV 1x" media="all and (min-width: 1601px) and (max-width: 1920px)" type="image/png" width="104" height="104"> <source srcset="/files/styles/multiple_ct_sidebar_link_with_image_desktop/public/longstory/24746155619_b586852fe9_o_main.png?h=035871dd&amp;itok=wU17IzF- 1x" media="all and (min-width: 1340px) and (max-width: 1600px)" type="image/png" width="87" height="104"> <source srcset="/files/styles/multiple_ct_sidebar_link_with_image_desktop/public/longstory/24746155619_b586852fe9_o_main.png?h=035871dd&amp;itok=wU17IzF- 1x" media="all and (min-width: 800px) and (max-width: 1339px)" type="image/png" width="87" height="104"> <source srcset="/files/styles/multiple_ct_sidebar_link_with_image_tablet/public/longstory/24746155619_b586852fe9_o_main.png?h=035871dd&amp;itok=03Z2hZpL 1x" media="all and (min-width: 540px) and (max-width: 799px)" type="image/png" width="285" height="186"> <source srcset="/files/styles/multiple_ct_sidebar_link_with_image_phone/public/longstory/24746155619_b586852fe9_o_main.png?h=035871dd&amp;itok=WE7B6Ds0 1x" media="all and (max-width: 539px)" type="image/png" width="220" height="186"> <img loading="eager" width="220" height="186" src="/files/styles/multiple_ct_sidebar_link_with_image_phone/public/longstory/24746155619_b586852fe9_o_main.png?h=035871dd&amp;itok=WE7B6Ds0" alt="A fluorescence microscopy image showing buildup of amyloid beta clusters among neurons in a mouse model of Alzheimer’s disease." title="A fluorescence microscopy image showing buildup of amyloid beta clusters among neurons in a mouse model of Alzheimer’s disease." typeof="foaf:Image"> </picture></a> </div> </article> </div> <div class="node__content"> <a href="/news/scientists-reveal-cellular-changes-unique-early-alzheimers-disease" class="node__title"><span class="field field--name-title field--type-string field--label-hidden">Scientists reveal cellular changes unique to early Alzheimer’s disease</span> </a> </div> </article> </div> <div class="field__item"><article about="/news/researchers-map-brain-cell-changes-alzheimers-disease" class="node"> <div class="field field--name-field-image field--type-entity-reference field--label-hidden field__item"><article class="media media--type-image media--view-mode-multiple-ct-sidebar-link-with-image"> <div class="field field--name-field-media-image field--type-image field--label-hidden field__item"> <a href="/news/researchers-map-brain-cell-changes-alzheimers-disease"><picture> <source srcset="/files/styles/multiple_ct_sidebar_link_with_image_desktop_xl/public/longstory/main_mAD-Figure-1_20221206-01.png?h=93c99ee8&amp;itok=YbcVyrou 1x" media="all and (min-width: 1921px)" type="image/png" width="104" height="104"> <source srcset="/files/styles/multiple_ct_sidebar_link_with_image_desktop_xl/public/longstory/main_mAD-Figure-1_20221206-01.png?h=93c99ee8&amp;itok=YbcVyrou 1x" media="all and (min-width: 1601px) and (max-width: 1920px)" type="image/png" width="104" height="104"> <source srcset="/files/styles/multiple_ct_sidebar_link_with_image_desktop/public/longstory/main_mAD-Figure-1_20221206-01.png?h=93c99ee8&amp;itok=_khBWxft 1x" media="all and (min-width: 1340px) and (max-width: 1600px)" type="image/png" width="87" height="104"> <source srcset="/files/styles/multiple_ct_sidebar_link_with_image_desktop/public/longstory/main_mAD-Figure-1_20221206-01.png?h=93c99ee8&amp;itok=_khBWxft 1x" media="all and (min-width: 800px) and (max-width: 1339px)" type="image/png" width="87" height="104"> <source srcset="/files/styles/multiple_ct_sidebar_link_with_image_tablet/public/longstory/main_mAD-Figure-1_20221206-01.png?h=93c99ee8&amp;itok=0DsI2w5k 1x" media="all and (min-width: 540px) and (max-width: 799px)" type="image/png" width="285" height="186"> <source srcset="/files/styles/multiple_ct_sidebar_link_with_image_phone/public/longstory/main_mAD-Figure-1_20221206-01.png?h=93c99ee8&amp;itok=rIgOybCw 1x" media="all and (max-width: 539px)" type="image/png" width="220" height="186"> <img loading="eager" width="220" height="186" src="/files/styles/multiple_ct_sidebar_link_with_image_phone/public/longstory/main_mAD-Figure-1_20221206-01.png?h=93c99ee8&amp;itok=rIgOybCw" alt="Fluorescence microscopy image of brain tissue from a mouse model of Alzheimer’s, showing tau tangles (red), amyloid plaques (white), RNA (green), and cell nuclei (blue)." title="Fluorescence microscopy image of brain tissue from a mouse model of Alzheimer’s, showing tau tangles (red), amyloid plaques (white), RNA (green), and cell nuclei (blue)." typeof="foaf:Image"> </picture></a> </div> </article> </div> <div class="node__content"> <a href="/news/researchers-map-brain-cell-changes-alzheimers-disease" class="node__title"><span class="field field--name-title field--type-string field--label-hidden">Researchers map brain cell changes in Alzheimer’s disease</span> </a> </div> </article> </div> </div> </div> </div> </div> </div> <div class="clearfix text-formatted field field--name-field-text field--type-text-long field--label-hidden field__item"><p>Since the 1990s, researchers have found several immune system molecules that act like “brakes” on immune responses, leading to a new class of cancer drugs. One of these “immune checkpoint” molecules, called Tim-3 has recently been linked to late-onset Alzheimer’s disease (AD), but its role in the brain was unknown until now. In a paper published in <a href="https://www.nature.com/articles/s41586-025-08852-z"><em>Nature</em></a>, researchers from Mass General Brigham and the ӳ����ý used preclinical models to uncover Tim-3’s role in microglia, the brain's resident immune cells, and have identified it as a promising therapeutic target for Alzheimer’s disease.</p> <p>“Immune checkpoint inhibitors have revolutionized cancer immunotherapy, and it is exciting that we might be able to repurpose them to treat Alzheimer’s disease,” said senior author <a href="/bios/vijay-k-kuchroo">Vijay Kuchroo</a>&nbsp;of the Gene Lay Institute of Immunology and Inflammation at Brigham and Women’s Hospital and Massachusetts General Hospital, founding members of the Mass General Brigham healthcare system. Kuchroo is also an institute member at the ӳ����ý. “Microglia are pivotal in neuroinflammation and neurodegeneration, and therapeutic targeting of Tim-3 in microglia may alter them to an optimal state to fight the disease pathology in AD."</p> <p>Using a mouse model of AD, the Kuchroo lab together with Oleg Butovsky lab, at the Ann Romney Center for Neurologic Diseases at BWH, determined that Tim-3 is only expressed in microglia in the central nervous system, where it helps the cells maintain a healthy state of homeostasis. Tim-3 can also, however, prevent the brain from effectively clearing out the toxic plaques that accumulate during AD. The researchers found that deleting Tim-3 helped kickstart plaque removal by prompting the microglia to eat up more of the plaques, while also producing anti-inflammatory proteins to reduce neuroinflammation, and limiting cognitive impairment.<br> &nbsp;<br> Over a half-dozen clinical trials are currently testing therapeutics that target Tim-3 to treat patients with immunotherapy-resistant cancers. According to the authors, the new study highlights the therapeutic potential of adapting these treatments to enhance plaque clearance and mitigate neurodegeneration in Alzheimer’s disease.</p> <p><em><a href="https://www.massgeneralbrigham.org/en/about/newsroom/press-releases/potential-alzheimers-target-in-brain-immune-cells" target="_blank">Adapted from a Mass General Brigham story</a>.</em></p> </div> </div> </div> <div class="field__item"> <div class="paragraph paragraph--type--table-outro paragraph--view-mode--default"> <div class="field field--name-field-paragraph field--type-entity-reference-revisions field--label-hidden field__items"> <div class="field__item"> <div class="paragraph paragraph--type--table-outro-row paragraph--view-mode--default"> <div class="clearfix text-formatted field field--name-field-heading field--type-text field--label-hidden field__item"><p>Funding</p> </div> <div class="clearfix text-formatted field field--name-field-text field--type-text-long field--label-hidden field__item"><p>This work was supported by the National Institutes of Health, Cure Alzheimer’s Fund, and the BrightFocus Foundation.</p> </div> </div> </div> <div class="field__item"> <div class="paragraph paragraph--type--table-outro-row paragraph--view-mode--default"> <div class="clearfix text-formatted field field--name-field-heading field--type-text field--label-hidden field__item"><p>Paper cited</p> </div> <div class="clearfix text-formatted field field--name-field-text field--type-text-long field--label-hidden field__item"><p>Kimura, K, et al. “<a href="https://www.nature.com/articles/s41586-025-08852-z">Tim-3 immune checkpoint regulates microglial function and Alzheimer's disease</a>” <em>Nature. </em>Online April 9, 2025.<em>&nbsp;</em>DOI: 10.1038/s41586-025-08852-z</p> </div> </div> </div> </div> </div> </div> </div> </div> </div> </div> <div class="content-section container"> <div class="content-section__main"> <div class="block-node-broad-tags block block-layout-builder block-field-blocknodelong-storyfield-broad-tags"> <div class="block-node-broad-tags__row"> <div class="block-node-broad-tags__title">Tags:</div> <div class="field field--name-field-broad-tags field--type-entity-reference field--label-hidden field__items"> <div class="field__item"><a href="/broad-tags/neurodegeneration" hreflang="en">Neurodegeneration</a></div> </div> </div> </div> </div> </div> Thu, 16 Jan 2025 16:00:00 +0000 adicorat 5558011 at /news/gene-editing-extends-lifespan-mouse-model-prion-disease <span class="field field--name-title field--type-string field--label-hidden"><h1>Potential Alzheimer’s disease therapeutic target identified in brain immune cells</h1> </span> <span class="field field--name-uid field--type-entity-reference field--label-hidden"> <span>By Corie Lok</span> </span> <span class="field field--name-created field--type-created field--label-hidden"><time datetime="2025-04-09T09:36:41-04:00" class="datetime">April 9, 2025</time> </span> <div class="hero-section container"> <div class="hero-section__row row"> <div class="hero-section__content hero-section__content_left col-6"> <div class="hero-section__breadcrumbs"> <div class="block block-system block-system-breadcrumb-block"> <nav class="breadcrumb" role="navigation" aria-labelledby="system-breadcrumb"> <h2 id="system-breadcrumb" class="visually-hidden">Breadcrumb</h2> <ol> <li> <a href="/">Home</a> </li> <li> <a href="/news">News</a> </li> </ol> </nav> </div> </div> <div class="hero-section__title"> <div class="block block-layout-builder block-field-blocknodelong-storytitle"> <span class="field field--name-title field--type-string field--label-hidden"><h1>Potential Alzheimer’s disease therapeutic target identified in brain immune cells</h1> </span> </div> </div> <div class="hero-section__description"> <div class="block block-layout-builder block-field-blocknodelong-storybody"> <div class="clearfix text-formatted field field--name-body field--type-text-with-summary field--label-hidden field__item"><p>Scientists discover possible way to harness immune cells in the brain to remove plaques associated with Alzheimer's.&nbsp;</p> </div> </div> </div> <div class="hero-section__author"> <div class="block block-layout-builder block-extra-field-blocknodelong-storyextra-field-author-custom"> By Anna McTigue, Mass General Brigham Communications </div> </div> <div class="hero-section__date"> <div class="block block-layout-builder block-field-blocknodelong-storycreated"> <span class="field field--name-created field--type-created field--label-hidden"><time datetime="2025-04-09T09:36:41-04:00" title="Wednesday, April 9, 2025 - 09:36" class="datetime">April 9, 2025</time> </span> </div> </div> </div> <div class="hero-section__right col-6"> <div class="hero-section__image"> <div class="block block-layout-builder block-field-blocknodelong-storyfield-image"> <div class="field field--name-field-image field--type-entity-reference field--label-hidden field__item"> <article class="media media--type-image media--view-mode-multiple-content-types-header"> <div class="field field--name-field-media-image field--type-image field--label-hidden field__item"> <picture> <source srcset="/files/styles/multiple_ct_header_desktop_xl/public/longstory/26709211161_956113bf3e_c.jpg?itok=Ti1GJfAc 1x" media="all and (min-width: 1921px)" type="image/jpeg" width="754" height="503"> <source srcset="/files/styles/multiple_ct_header_desktop_xl/public/longstory/26709211161_956113bf3e_c.jpg?itok=Ti1GJfAc 1x" media="all and (min-width: 1601px) and (max-width: 1920px)" type="image/jpeg" width="754" height="503"> <source srcset="/files/styles/multiple_ct_header_desktop/public/longstory/26709211161_956113bf3e_c.jpg?itok=nu30mWVf 1x" media="all and (min-width: 1340px) and (max-width: 1600px)" type="image/jpeg" width="736" height="520"> <source srcset="/files/styles/multiple_ct_header_laptop/public/longstory/26709211161_956113bf3e_c.jpg?itok=SrnEVHSE 1x" media="all and (min-width: 800px) and (max-width: 1339px)" type="image/jpeg" width="641" height="451"> <source srcset="/files/styles/multiple_ct_header_tablet/public/longstory/26709211161_956113bf3e_c.jpg?itok=uR_vA2Q5 1x" media="all and (min-width: 540px) and (max-width: 799px)" type="image/jpeg" width="706" height="417"> <source srcset="/files/styles/multiple_ct_header_phone/public/longstory/26709211161_956113bf3e_c.jpg?itok=Y1c99wkP 1x" media="all and (max-width: 539px)" type="image/jpeg" width="499" height="294"> <img loading="eager" width="499" height="294" src="/files/styles/multiple_ct_header_phone/public/longstory/26709211161_956113bf3e_c.jpg?itok=Y1c99wkP" alt="Microscopy image showing mouse brain with nerve cells, blood vessels, and plaques from Alzheimer's disease." title="Microscopy image showing mouse brain with nerve cells, blood vessels, and plaques from Alzheimer's disease." typeof="foaf:Image"> </picture> </div> <div class="media-caption"> <div class="media-caption__credit"> Credit: Alvin Gogineni, Genentech </div> <div class="media-caption__description"> This mouse brain shows hallmarks of Alzheimer’s disease (plaques in blue), along with blood vessels (red) and nerve cells (green). </div> </div> </article> </div> </div> </div> </div> </div> </div> <div class="content-section container"> <div class="content-section__main"> <div class="block block-better-social-sharing-buttons block-social-sharing-buttons-block"> <div style="display: none"><link rel="preload" href="/modules/contrib/better_social_sharing_buttons/assets/dist/sprites/social-icons--no-color.svg" as="image" type="image/svg+xml" crossorigin="anonymous"></div> <div class="social-sharing-buttons"> <a href="https://www.facebook.com/sharer/sharer.php?u=/taxonomy/term/2311/feed&amp;title=" target="_blank" title="Share to Facebook" aria-label="Share to Facebook" class="social-sharing-buttons-button share-facebook" rel="noopener"> <svg aria-hidden="true" width="32px" height="32px" style="border-radius:100%;"> <use href="/modules/contrib/better_social_sharing_buttons/assets/dist/sprites/social-icons--no-color.svg#facebook" /> </svg> </a> <a href="https://twitter.com/intent/tweet?text=+/taxonomy/term/2311/feed" target="_blank" title="Share to X" aria-label="Share to X" class="social-sharing-buttons-button share-x" rel="noopener"> <svg aria-hidden="true" width="32px" height="32px" style="border-radius:100%;"> <use href="/modules/contrib/better_social_sharing_buttons/assets/dist/sprites/social-icons--no-color.svg#x" /> </svg> </a> <a href="mailto:?subject=&amp;body=/taxonomy/term/2311/feed" title="Share to Email" aria-label="Share to Email" class="social-sharing-buttons-button share-email" target="_blank" rel="noopener"> <svg aria-hidden="true" width="32px" height="32px" style="border-radius:100%;"> <use href="/modules/contrib/better_social_sharing_buttons/assets/dist/sprites/social-icons--no-color.svg#email" /> </svg> </a> </div> </div> <div class="block block-layout-builder block-field-blocknodelong-storyfield-content-paragraphs"> <div class="field field--name-field-content-paragraphs field--type-entity-reference-revisions field--label-hidden field__items"> <div class="field__item"> <div class="paragraph paragraph--type--text-with-sidebar text-with-sidebar"> <div class="field field--name-field-sidebar field--type-entity-reference-revisions field--label-hidden field__items"> <div class="field__item"> <div class="paragraph paragraph--type--sidebar-articles sidebar-articles"> <div class="sidebar-articles__col"> <div class="clearfix text-formatted field field--name-field-heading field--type-text field--label-hidden field__item"><p>Related News</p> </div> <div class="field field--name-field-content-reference field--type-entity-reference field--label-hidden field__items"> <div class="field__item"><article about="/news/scientists-reveal-cellular-changes-unique-early-alzheimers-disease" class="node"> <div class="field field--name-field-image field--type-entity-reference field--label-hidden field__item"><article class="media media--type-image media--view-mode-multiple-ct-sidebar-link-with-image"> <div class="field field--name-field-media-image field--type-image field--label-hidden field__item"> <a href="/news/scientists-reveal-cellular-changes-unique-early-alzheimers-disease"><picture> <source srcset="/files/styles/multiple_ct_sidebar_link_with_image_desktop_xl/public/longstory/24746155619_b586852fe9_o_main.png?h=035871dd&amp;itok=3nYqiEZV 1x" media="all and (min-width: 1921px)" type="image/png" width="104" height="104"> <source srcset="/files/styles/multiple_ct_sidebar_link_with_image_desktop_xl/public/longstory/24746155619_b586852fe9_o_main.png?h=035871dd&amp;itok=3nYqiEZV 1x" media="all and (min-width: 1601px) and (max-width: 1920px)" type="image/png" width="104" height="104"> <source srcset="/files/styles/multiple_ct_sidebar_link_with_image_desktop/public/longstory/24746155619_b586852fe9_o_main.png?h=035871dd&amp;itok=wU17IzF- 1x" media="all and (min-width: 1340px) and (max-width: 1600px)" type="image/png" width="87" height="104"> <source srcset="/files/styles/multiple_ct_sidebar_link_with_image_desktop/public/longstory/24746155619_b586852fe9_o_main.png?h=035871dd&amp;itok=wU17IzF- 1x" media="all and (min-width: 800px) and (max-width: 1339px)" type="image/png" width="87" height="104"> <source srcset="/files/styles/multiple_ct_sidebar_link_with_image_tablet/public/longstory/24746155619_b586852fe9_o_main.png?h=035871dd&amp;itok=03Z2hZpL 1x" media="all and (min-width: 540px) and (max-width: 799px)" type="image/png" width="285" height="186"> <source srcset="/files/styles/multiple_ct_sidebar_link_with_image_phone/public/longstory/24746155619_b586852fe9_o_main.png?h=035871dd&amp;itok=WE7B6Ds0 1x" media="all and (max-width: 539px)" type="image/png" width="220" height="186"> <img loading="eager" width="220" height="186" src="/files/styles/multiple_ct_sidebar_link_with_image_phone/public/longstory/24746155619_b586852fe9_o_main.png?h=035871dd&amp;itok=WE7B6Ds0" alt="A fluorescence microscopy image showing buildup of amyloid beta clusters among neurons in a mouse model of Alzheimer’s disease." title="A fluorescence microscopy image showing buildup of amyloid beta clusters among neurons in a mouse model of Alzheimer’s disease." typeof="foaf:Image"> </picture></a> </div> </article> </div> <div class="node__content"> <a href="/news/scientists-reveal-cellular-changes-unique-early-alzheimers-disease" class="node__title"><span class="field field--name-title field--type-string field--label-hidden">Scientists reveal cellular changes unique to early Alzheimer’s disease</span> </a> </div> </article> </div> <div class="field__item"><article about="/news/researchers-map-brain-cell-changes-alzheimers-disease" class="node"> <div class="field field--name-field-image field--type-entity-reference field--label-hidden field__item"><article class="media media--type-image media--view-mode-multiple-ct-sidebar-link-with-image"> <div class="field field--name-field-media-image field--type-image field--label-hidden field__item"> <a href="/news/researchers-map-brain-cell-changes-alzheimers-disease"><picture> <source srcset="/files/styles/multiple_ct_sidebar_link_with_image_desktop_xl/public/longstory/main_mAD-Figure-1_20221206-01.png?h=93c99ee8&amp;itok=YbcVyrou 1x" media="all and (min-width: 1921px)" type="image/png" width="104" height="104"> <source srcset="/files/styles/multiple_ct_sidebar_link_with_image_desktop_xl/public/longstory/main_mAD-Figure-1_20221206-01.png?h=93c99ee8&amp;itok=YbcVyrou 1x" media="all and (min-width: 1601px) and (max-width: 1920px)" type="image/png" width="104" height="104"> <source srcset="/files/styles/multiple_ct_sidebar_link_with_image_desktop/public/longstory/main_mAD-Figure-1_20221206-01.png?h=93c99ee8&amp;itok=_khBWxft 1x" media="all and (min-width: 1340px) and (max-width: 1600px)" type="image/png" width="87" height="104"> <source srcset="/files/styles/multiple_ct_sidebar_link_with_image_desktop/public/longstory/main_mAD-Figure-1_20221206-01.png?h=93c99ee8&amp;itok=_khBWxft 1x" media="all and (min-width: 800px) and (max-width: 1339px)" type="image/png" width="87" height="104"> <source srcset="/files/styles/multiple_ct_sidebar_link_with_image_tablet/public/longstory/main_mAD-Figure-1_20221206-01.png?h=93c99ee8&amp;itok=0DsI2w5k 1x" media="all and (min-width: 540px) and (max-width: 799px)" type="image/png" width="285" height="186"> <source srcset="/files/styles/multiple_ct_sidebar_link_with_image_phone/public/longstory/main_mAD-Figure-1_20221206-01.png?h=93c99ee8&amp;itok=rIgOybCw 1x" media="all and (max-width: 539px)" type="image/png" width="220" height="186"> <img loading="eager" width="220" height="186" src="/files/styles/multiple_ct_sidebar_link_with_image_phone/public/longstory/main_mAD-Figure-1_20221206-01.png?h=93c99ee8&amp;itok=rIgOybCw" alt="Fluorescence microscopy image of brain tissue from a mouse model of Alzheimer’s, showing tau tangles (red), amyloid plaques (white), RNA (green), and cell nuclei (blue)." title="Fluorescence microscopy image of brain tissue from a mouse model of Alzheimer’s, showing tau tangles (red), amyloid plaques (white), RNA (green), and cell nuclei (blue)." typeof="foaf:Image"> </picture></a> </div> </article> </div> <div class="node__content"> <a href="/news/researchers-map-brain-cell-changes-alzheimers-disease" class="node__title"><span class="field field--name-title field--type-string field--label-hidden">Researchers map brain cell changes in Alzheimer’s disease</span> </a> </div> </article> </div> </div> </div> </div> </div> </div> <div class="clearfix text-formatted field field--name-field-text field--type-text-long field--label-hidden field__item"><p>Since the 1990s, researchers have found several immune system molecules that act like “brakes” on immune responses, leading to a new class of cancer drugs. One of these “immune checkpoint” molecules, called Tim-3 has recently been linked to late-onset Alzheimer’s disease (AD), but its role in the brain was unknown until now. In a paper published in <a href="https://www.nature.com/articles/s41586-025-08852-z"><em>Nature</em></a>, researchers from Mass General Brigham and the ӳ����ý used preclinical models to uncover Tim-3’s role in microglia, the brain's resident immune cells, and have identified it as a promising therapeutic target for Alzheimer’s disease.</p> <p>“Immune checkpoint inhibitors have revolutionized cancer immunotherapy, and it is exciting that we might be able to repurpose them to treat Alzheimer’s disease,” said senior author <a href="/bios/vijay-k-kuchroo">Vijay Kuchroo</a>&nbsp;of the Gene Lay Institute of Immunology and Inflammation at Brigham and Women’s Hospital and Massachusetts General Hospital, founding members of the Mass General Brigham healthcare system. Kuchroo is also an institute member at the ӳ����ý. “Microglia are pivotal in neuroinflammation and neurodegeneration, and therapeutic targeting of Tim-3 in microglia may alter them to an optimal state to fight the disease pathology in AD."</p> <p>Using a mouse model of AD, the Kuchroo lab together with Oleg Butovsky lab, at the Ann Romney Center for Neurologic Diseases at BWH, determined that Tim-3 is only expressed in microglia in the central nervous system, where it helps the cells maintain a healthy state of homeostasis. Tim-3 can also, however, prevent the brain from effectively clearing out the toxic plaques that accumulate during AD. The researchers found that deleting Tim-3 helped kickstart plaque removal by prompting the microglia to eat up more of the plaques, while also producing anti-inflammatory proteins to reduce neuroinflammation, and limiting cognitive impairment.<br> &nbsp;<br> Over a half-dozen clinical trials are currently testing therapeutics that target Tim-3 to treat patients with immunotherapy-resistant cancers. According to the authors, the new study highlights the therapeutic potential of adapting these treatments to enhance plaque clearance and mitigate neurodegeneration in Alzheimer’s disease.</p> <p><em><a href="https://www.massgeneralbrigham.org/en/about/newsroom/press-releases/potential-alzheimers-target-in-brain-immune-cells" target="_blank">Adapted from a Mass General Brigham story</a>.</em></p> </div> </div> </div> <div class="field__item"> <div class="paragraph paragraph--type--table-outro paragraph--view-mode--default"> <div class="field field--name-field-paragraph field--type-entity-reference-revisions field--label-hidden field__items"> <div class="field__item"> <div class="paragraph paragraph--type--table-outro-row paragraph--view-mode--default"> <div class="clearfix text-formatted field field--name-field-heading field--type-text field--label-hidden field__item"><p>Funding</p> </div> <div class="clearfix text-formatted field field--name-field-text field--type-text-long field--label-hidden field__item"><p>This work was supported by the National Institutes of Health, Cure Alzheimer’s Fund, and the BrightFocus Foundation.</p> </div> </div> </div> <div class="field__item"> <div class="paragraph paragraph--type--table-outro-row paragraph--view-mode--default"> <div class="clearfix text-formatted field field--name-field-heading field--type-text field--label-hidden field__item"><p>Paper cited</p> </div> <div class="clearfix text-formatted field field--name-field-text field--type-text-long field--label-hidden field__item"><p>Kimura, K, et al. “<a href="https://www.nature.com/articles/s41586-025-08852-z">Tim-3 immune checkpoint regulates microglial function and Alzheimer's disease</a>” <em>Nature. </em>Online April 9, 2025.<em>&nbsp;</em>DOI: 10.1038/s41586-025-08852-z</p> </div> </div> </div> </div> </div> </div> </div> </div> </div> </div> <div class="content-section container"> <div class="content-section__main"> <div class="block-node-broad-tags block block-layout-builder block-field-blocknodelong-storyfield-broad-tags"> <div class="block-node-broad-tags__row"> <div class="block-node-broad-tags__title">Tags:</div> <div class="field field--name-field-broad-tags field--type-entity-reference field--label-hidden field__items"> <div class="field__item"><a href="/broad-tags/neurodegeneration" hreflang="en">Neurodegeneration</a></div> </div> </div> </div> </div> </div> Tue, 14 Jan 2025 10:00:00 +0000 adicorat 5558086 at /news/immune-factor-brain-plays-critical-roles-neuron-function-and-aging <span class="field field--name-title field--type-string field--label-hidden"><h1>Potential Alzheimer’s disease therapeutic target identified in brain immune cells</h1> </span> <span class="field field--name-uid field--type-entity-reference field--label-hidden"> <span>By Corie Lok</span> </span> <span class="field field--name-created field--type-created field--label-hidden"><time datetime="2025-04-09T09:36:41-04:00" class="datetime">April 9, 2025</time> </span> <div class="hero-section container"> <div class="hero-section__row row"> <div class="hero-section__content hero-section__content_left col-6"> <div class="hero-section__breadcrumbs"> <div class="block block-system block-system-breadcrumb-block"> <nav class="breadcrumb" role="navigation" aria-labelledby="system-breadcrumb"> <h2 id="system-breadcrumb" class="visually-hidden">Breadcrumb</h2> <ol> <li> <a href="/">Home</a> </li> <li> <a href="/news">News</a> </li> </ol> </nav> </div> </div> <div class="hero-section__title"> <div class="block block-layout-builder block-field-blocknodelong-storytitle"> <span class="field field--name-title field--type-string field--label-hidden"><h1>Potential Alzheimer’s disease therapeutic target identified in brain immune cells</h1> </span> </div> </div> <div class="hero-section__description"> <div class="block block-layout-builder block-field-blocknodelong-storybody"> <div class="clearfix text-formatted field field--name-body field--type-text-with-summary field--label-hidden field__item"><p>Scientists discover possible way to harness immune cells in the brain to remove plaques associated with Alzheimer's.&nbsp;</p> </div> </div> </div> <div class="hero-section__author"> <div class="block block-layout-builder block-extra-field-blocknodelong-storyextra-field-author-custom"> By Anna McTigue, Mass General Brigham Communications </div> </div> <div class="hero-section__date"> <div class="block block-layout-builder block-field-blocknodelong-storycreated"> <span class="field field--name-created field--type-created field--label-hidden"><time datetime="2025-04-09T09:36:41-04:00" title="Wednesday, April 9, 2025 - 09:36" class="datetime">April 9, 2025</time> </span> </div> </div> </div> <div class="hero-section__right col-6"> <div class="hero-section__image"> <div class="block block-layout-builder block-field-blocknodelong-storyfield-image"> <div class="field field--name-field-image field--type-entity-reference field--label-hidden field__item"> <article class="media media--type-image media--view-mode-multiple-content-types-header"> <div class="field field--name-field-media-image field--type-image field--label-hidden field__item"> <picture> <source srcset="/files/styles/multiple_ct_header_desktop_xl/public/longstory/26709211161_956113bf3e_c.jpg?itok=Ti1GJfAc 1x" media="all and (min-width: 1921px)" type="image/jpeg" width="754" height="503"> <source srcset="/files/styles/multiple_ct_header_desktop_xl/public/longstory/26709211161_956113bf3e_c.jpg?itok=Ti1GJfAc 1x" media="all and (min-width: 1601px) and (max-width: 1920px)" type="image/jpeg" width="754" height="503"> <source srcset="/files/styles/multiple_ct_header_desktop/public/longstory/26709211161_956113bf3e_c.jpg?itok=nu30mWVf 1x" media="all and (min-width: 1340px) and (max-width: 1600px)" type="image/jpeg" width="736" height="520"> <source srcset="/files/styles/multiple_ct_header_laptop/public/longstory/26709211161_956113bf3e_c.jpg?itok=SrnEVHSE 1x" media="all and (min-width: 800px) and (max-width: 1339px)" type="image/jpeg" width="641" height="451"> <source srcset="/files/styles/multiple_ct_header_tablet/public/longstory/26709211161_956113bf3e_c.jpg?itok=uR_vA2Q5 1x" media="all and (min-width: 540px) and (max-width: 799px)" type="image/jpeg" width="706" height="417"> <source srcset="/files/styles/multiple_ct_header_phone/public/longstory/26709211161_956113bf3e_c.jpg?itok=Y1c99wkP 1x" media="all and (max-width: 539px)" type="image/jpeg" width="499" height="294"> <img loading="eager" width="499" height="294" src="/files/styles/multiple_ct_header_phone/public/longstory/26709211161_956113bf3e_c.jpg?itok=Y1c99wkP" alt="Microscopy image showing mouse brain with nerve cells, blood vessels, and plaques from Alzheimer's disease." title="Microscopy image showing mouse brain with nerve cells, blood vessels, and plaques from Alzheimer's disease." typeof="foaf:Image"> </picture> </div> <div class="media-caption"> <div class="media-caption__credit"> Credit: Alvin Gogineni, Genentech </div> <div class="media-caption__description"> This mouse brain shows hallmarks of Alzheimer’s disease (plaques in blue), along with blood vessels (red) and nerve cells (green). </div> </div> </article> </div> </div> </div> </div> </div> </div> <div class="content-section container"> <div class="content-section__main"> <div class="block block-better-social-sharing-buttons block-social-sharing-buttons-block"> <div style="display: none"><link rel="preload" href="/modules/contrib/better_social_sharing_buttons/assets/dist/sprites/social-icons--no-color.svg" as="image" type="image/svg+xml" crossorigin="anonymous"></div> <div class="social-sharing-buttons"> <a href="https://www.facebook.com/sharer/sharer.php?u=/taxonomy/term/2311/feed&amp;title=" target="_blank" title="Share to Facebook" aria-label="Share to Facebook" class="social-sharing-buttons-button share-facebook" rel="noopener"> <svg aria-hidden="true" width="32px" height="32px" style="border-radius:100%;"> <use href="/modules/contrib/better_social_sharing_buttons/assets/dist/sprites/social-icons--no-color.svg#facebook" /> </svg> </a> <a href="https://twitter.com/intent/tweet?text=+/taxonomy/term/2311/feed" target="_blank" title="Share to X" aria-label="Share to X" class="social-sharing-buttons-button share-x" rel="noopener"> <svg aria-hidden="true" width="32px" height="32px" style="border-radius:100%;"> <use href="/modules/contrib/better_social_sharing_buttons/assets/dist/sprites/social-icons--no-color.svg#x" /> </svg> </a> <a href="mailto:?subject=&amp;body=/taxonomy/term/2311/feed" title="Share to Email" aria-label="Share to Email" class="social-sharing-buttons-button share-email" target="_blank" rel="noopener"> <svg aria-hidden="true" width="32px" height="32px" style="border-radius:100%;"> <use href="/modules/contrib/better_social_sharing_buttons/assets/dist/sprites/social-icons--no-color.svg#email" /> </svg> </a> </div> </div> <div class="block block-layout-builder block-field-blocknodelong-storyfield-content-paragraphs"> <div class="field field--name-field-content-paragraphs field--type-entity-reference-revisions field--label-hidden field__items"> <div class="field__item"> <div class="paragraph paragraph--type--text-with-sidebar text-with-sidebar"> <div class="field field--name-field-sidebar field--type-entity-reference-revisions field--label-hidden field__items"> <div class="field__item"> <div class="paragraph paragraph--type--sidebar-articles sidebar-articles"> <div class="sidebar-articles__col"> <div class="clearfix text-formatted field field--name-field-heading field--type-text field--label-hidden field__item"><p>Related News</p> </div> <div class="field field--name-field-content-reference field--type-entity-reference field--label-hidden field__items"> <div class="field__item"><article about="/news/scientists-reveal-cellular-changes-unique-early-alzheimers-disease" class="node"> <div class="field field--name-field-image field--type-entity-reference field--label-hidden field__item"><article class="media media--type-image media--view-mode-multiple-ct-sidebar-link-with-image"> <div class="field field--name-field-media-image field--type-image field--label-hidden field__item"> <a href="/news/scientists-reveal-cellular-changes-unique-early-alzheimers-disease"><picture> <source srcset="/files/styles/multiple_ct_sidebar_link_with_image_desktop_xl/public/longstory/24746155619_b586852fe9_o_main.png?h=035871dd&amp;itok=3nYqiEZV 1x" media="all and (min-width: 1921px)" type="image/png" width="104" height="104"> <source srcset="/files/styles/multiple_ct_sidebar_link_with_image_desktop_xl/public/longstory/24746155619_b586852fe9_o_main.png?h=035871dd&amp;itok=3nYqiEZV 1x" media="all and (min-width: 1601px) and (max-width: 1920px)" type="image/png" width="104" height="104"> <source srcset="/files/styles/multiple_ct_sidebar_link_with_image_desktop/public/longstory/24746155619_b586852fe9_o_main.png?h=035871dd&amp;itok=wU17IzF- 1x" media="all and (min-width: 1340px) and (max-width: 1600px)" type="image/png" width="87" height="104"> <source srcset="/files/styles/multiple_ct_sidebar_link_with_image_desktop/public/longstory/24746155619_b586852fe9_o_main.png?h=035871dd&amp;itok=wU17IzF- 1x" media="all and (min-width: 800px) and (max-width: 1339px)" type="image/png" width="87" height="104"> <source srcset="/files/styles/multiple_ct_sidebar_link_with_image_tablet/public/longstory/24746155619_b586852fe9_o_main.png?h=035871dd&amp;itok=03Z2hZpL 1x" media="all and (min-width: 540px) and (max-width: 799px)" type="image/png" width="285" height="186"> <source srcset="/files/styles/multiple_ct_sidebar_link_with_image_phone/public/longstory/24746155619_b586852fe9_o_main.png?h=035871dd&amp;itok=WE7B6Ds0 1x" media="all and (max-width: 539px)" type="image/png" width="220" height="186"> <img loading="eager" width="220" height="186" src="/files/styles/multiple_ct_sidebar_link_with_image_phone/public/longstory/24746155619_b586852fe9_o_main.png?h=035871dd&amp;itok=WE7B6Ds0" alt="A fluorescence microscopy image showing buildup of amyloid beta clusters among neurons in a mouse model of Alzheimer’s disease." title="A fluorescence microscopy image showing buildup of amyloid beta clusters among neurons in a mouse model of Alzheimer’s disease." typeof="foaf:Image"> </picture></a> </div> </article> </div> <div class="node__content"> <a href="/news/scientists-reveal-cellular-changes-unique-early-alzheimers-disease" class="node__title"><span class="field field--name-title field--type-string field--label-hidden">Scientists reveal cellular changes unique to early Alzheimer’s disease</span> </a> </div> </article> </div> <div class="field__item"><article about="/news/researchers-map-brain-cell-changes-alzheimers-disease" class="node"> <div class="field field--name-field-image field--type-entity-reference field--label-hidden field__item"><article class="media media--type-image media--view-mode-multiple-ct-sidebar-link-with-image"> <div class="field field--name-field-media-image field--type-image field--label-hidden field__item"> <a href="/news/researchers-map-brain-cell-changes-alzheimers-disease"><picture> <source srcset="/files/styles/multiple_ct_sidebar_link_with_image_desktop_xl/public/longstory/main_mAD-Figure-1_20221206-01.png?h=93c99ee8&amp;itok=YbcVyrou 1x" media="all and (min-width: 1921px)" type="image/png" width="104" height="104"> <source srcset="/files/styles/multiple_ct_sidebar_link_with_image_desktop_xl/public/longstory/main_mAD-Figure-1_20221206-01.png?h=93c99ee8&amp;itok=YbcVyrou 1x" media="all and (min-width: 1601px) and (max-width: 1920px)" type="image/png" width="104" height="104"> <source srcset="/files/styles/multiple_ct_sidebar_link_with_image_desktop/public/longstory/main_mAD-Figure-1_20221206-01.png?h=93c99ee8&amp;itok=_khBWxft 1x" media="all and (min-width: 1340px) and (max-width: 1600px)" type="image/png" width="87" height="104"> <source srcset="/files/styles/multiple_ct_sidebar_link_with_image_desktop/public/longstory/main_mAD-Figure-1_20221206-01.png?h=93c99ee8&amp;itok=_khBWxft 1x" media="all and (min-width: 800px) and (max-width: 1339px)" type="image/png" width="87" height="104"> <source srcset="/files/styles/multiple_ct_sidebar_link_with_image_tablet/public/longstory/main_mAD-Figure-1_20221206-01.png?h=93c99ee8&amp;itok=0DsI2w5k 1x" media="all and (min-width: 540px) and (max-width: 799px)" type="image/png" width="285" height="186"> <source srcset="/files/styles/multiple_ct_sidebar_link_with_image_phone/public/longstory/main_mAD-Figure-1_20221206-01.png?h=93c99ee8&amp;itok=rIgOybCw 1x" media="all and (max-width: 539px)" type="image/png" width="220" height="186"> <img loading="eager" width="220" height="186" src="/files/styles/multiple_ct_sidebar_link_with_image_phone/public/longstory/main_mAD-Figure-1_20221206-01.png?h=93c99ee8&amp;itok=rIgOybCw" alt="Fluorescence microscopy image of brain tissue from a mouse model of Alzheimer’s, showing tau tangles (red), amyloid plaques (white), RNA (green), and cell nuclei (blue)." title="Fluorescence microscopy image of brain tissue from a mouse model of Alzheimer’s, showing tau tangles (red), amyloid plaques (white), RNA (green), and cell nuclei (blue)." typeof="foaf:Image"> </picture></a> </div> </article> </div> <div class="node__content"> <a href="/news/researchers-map-brain-cell-changes-alzheimers-disease" class="node__title"><span class="field field--name-title field--type-string field--label-hidden">Researchers map brain cell changes in Alzheimer’s disease</span> </a> </div> </article> </div> </div> </div> </div> </div> </div> <div class="clearfix text-formatted field field--name-field-text field--type-text-long field--label-hidden field__item"><p>Since the 1990s, researchers have found several immune system molecules that act like “brakes” on immune responses, leading to a new class of cancer drugs. One of these “immune checkpoint” molecules, called Tim-3 has recently been linked to late-onset Alzheimer’s disease (AD), but its role in the brain was unknown until now. In a paper published in <a href="https://www.nature.com/articles/s41586-025-08852-z"><em>Nature</em></a>, researchers from Mass General Brigham and the ӳ����ý used preclinical models to uncover Tim-3’s role in microglia, the brain's resident immune cells, and have identified it as a promising therapeutic target for Alzheimer’s disease.</p> <p>“Immune checkpoint inhibitors have revolutionized cancer immunotherapy, and it is exciting that we might be able to repurpose them to treat Alzheimer’s disease,” said senior author <a href="/bios/vijay-k-kuchroo">Vijay Kuchroo</a>&nbsp;of the Gene Lay Institute of Immunology and Inflammation at Brigham and Women’s Hospital and Massachusetts General Hospital, founding members of the Mass General Brigham healthcare system. Kuchroo is also an institute member at the ӳ����ý. “Microglia are pivotal in neuroinflammation and neurodegeneration, and therapeutic targeting of Tim-3 in microglia may alter them to an optimal state to fight the disease pathology in AD."</p> <p>Using a mouse model of AD, the Kuchroo lab together with Oleg Butovsky lab, at the Ann Romney Center for Neurologic Diseases at BWH, determined that Tim-3 is only expressed in microglia in the central nervous system, where it helps the cells maintain a healthy state of homeostasis. Tim-3 can also, however, prevent the brain from effectively clearing out the toxic plaques that accumulate during AD. The researchers found that deleting Tim-3 helped kickstart plaque removal by prompting the microglia to eat up more of the plaques, while also producing anti-inflammatory proteins to reduce neuroinflammation, and limiting cognitive impairment.<br> &nbsp;<br> Over a half-dozen clinical trials are currently testing therapeutics that target Tim-3 to treat patients with immunotherapy-resistant cancers. According to the authors, the new study highlights the therapeutic potential of adapting these treatments to enhance plaque clearance and mitigate neurodegeneration in Alzheimer’s disease.</p> <p><em><a href="https://www.massgeneralbrigham.org/en/about/newsroom/press-releases/potential-alzheimers-target-in-brain-immune-cells" target="_blank">Adapted from a Mass General Brigham story</a>.</em></p> </div> </div> </div> <div class="field__item"> <div class="paragraph paragraph--type--table-outro paragraph--view-mode--default"> <div class="field field--name-field-paragraph field--type-entity-reference-revisions field--label-hidden field__items"> <div class="field__item"> <div class="paragraph paragraph--type--table-outro-row paragraph--view-mode--default"> <div class="clearfix text-formatted field field--name-field-heading field--type-text field--label-hidden field__item"><p>Funding</p> </div> <div class="clearfix text-formatted field field--name-field-text field--type-text-long field--label-hidden field__item"><p>This work was supported by the National Institutes of Health, Cure Alzheimer’s Fund, and the BrightFocus Foundation.</p> </div> </div> </div> <div class="field__item"> <div class="paragraph paragraph--type--table-outro-row paragraph--view-mode--default"> <div class="clearfix text-formatted field field--name-field-heading field--type-text field--label-hidden field__item"><p>Paper cited</p> </div> <div class="clearfix text-formatted field field--name-field-text field--type-text-long field--label-hidden field__item"><p>Kimura, K, et al. “<a href="https://www.nature.com/articles/s41586-025-08852-z">Tim-3 immune checkpoint regulates microglial function and Alzheimer's disease</a>” <em>Nature. </em>Online April 9, 2025.<em>&nbsp;</em>DOI: 10.1038/s41586-025-08852-z</p> </div> </div> </div> </div> </div> </div> </div> </div> </div> </div> <div class="content-section container"> <div class="content-section__main"> <div class="block-node-broad-tags block block-layout-builder block-field-blocknodelong-storyfield-broad-tags"> <div class="block-node-broad-tags__row"> <div class="block-node-broad-tags__title">Tags:</div> <div class="field field--name-field-broad-tags field--type-entity-reference field--label-hidden field__items"> <div class="field__item"><a href="/broad-tags/neurodegeneration" hreflang="en">Neurodegeneration</a></div> </div> </div> </div> </div> </div> Fri, 19 Jul 2024 13:42:09 +0000 tulrich@broadinstitute.org 5557141 at /news/therapy-candidate-fatal-prion-diseases-turns-disease-causing-gene <span class="field field--name-title field--type-string field--label-hidden"><h1>Potential Alzheimer’s disease therapeutic target identified in brain immune cells</h1> </span> <span class="field field--name-uid field--type-entity-reference field--label-hidden"> <span>By Corie Lok</span> </span> <span class="field field--name-created field--type-created field--label-hidden"><time datetime="2025-04-09T09:36:41-04:00" class="datetime">April 9, 2025</time> </span> <div class="hero-section container"> <div class="hero-section__row row"> <div class="hero-section__content hero-section__content_left col-6"> <div class="hero-section__breadcrumbs"> <div class="block block-system block-system-breadcrumb-block"> <nav class="breadcrumb" role="navigation" aria-labelledby="system-breadcrumb"> <h2 id="system-breadcrumb" class="visually-hidden">Breadcrumb</h2> <ol> <li> <a href="/">Home</a> </li> <li> <a href="/news">News</a> </li> </ol> </nav> </div> </div> <div class="hero-section__title"> <div class="block block-layout-builder block-field-blocknodelong-storytitle"> <span class="field field--name-title field--type-string field--label-hidden"><h1>Potential Alzheimer’s disease therapeutic target identified in brain immune cells</h1> </span> </div> </div> <div class="hero-section__description"> <div class="block block-layout-builder block-field-blocknodelong-storybody"> <div class="clearfix text-formatted field field--name-body field--type-text-with-summary field--label-hidden field__item"><p>Scientists discover possible way to harness immune cells in the brain to remove plaques associated with Alzheimer's.&nbsp;</p> </div> </div> </div> <div class="hero-section__author"> <div class="block block-layout-builder block-extra-field-blocknodelong-storyextra-field-author-custom"> By Anna McTigue, Mass General Brigham Communications </div> </div> <div class="hero-section__date"> <div class="block block-layout-builder block-field-blocknodelong-storycreated"> <span class="field field--name-created field--type-created field--label-hidden"><time datetime="2025-04-09T09:36:41-04:00" title="Wednesday, April 9, 2025 - 09:36" class="datetime">April 9, 2025</time> </span> </div> </div> </div> <div class="hero-section__right col-6"> <div class="hero-section__image"> <div class="block block-layout-builder block-field-blocknodelong-storyfield-image"> <div class="field field--name-field-image field--type-entity-reference field--label-hidden field__item"> <article class="media media--type-image media--view-mode-multiple-content-types-header"> <div class="field field--name-field-media-image field--type-image field--label-hidden field__item"> <picture> <source srcset="/files/styles/multiple_ct_header_desktop_xl/public/longstory/26709211161_956113bf3e_c.jpg?itok=Ti1GJfAc 1x" media="all and (min-width: 1921px)" type="image/jpeg" width="754" height="503"> <source srcset="/files/styles/multiple_ct_header_desktop_xl/public/longstory/26709211161_956113bf3e_c.jpg?itok=Ti1GJfAc 1x" media="all and (min-width: 1601px) and (max-width: 1920px)" type="image/jpeg" width="754" height="503"> <source srcset="/files/styles/multiple_ct_header_desktop/public/longstory/26709211161_956113bf3e_c.jpg?itok=nu30mWVf 1x" media="all and (min-width: 1340px) and (max-width: 1600px)" type="image/jpeg" width="736" height="520"> <source srcset="/files/styles/multiple_ct_header_laptop/public/longstory/26709211161_956113bf3e_c.jpg?itok=SrnEVHSE 1x" media="all and (min-width: 800px) and (max-width: 1339px)" type="image/jpeg" width="641" height="451"> <source srcset="/files/styles/multiple_ct_header_tablet/public/longstory/26709211161_956113bf3e_c.jpg?itok=uR_vA2Q5 1x" media="all and (min-width: 540px) and (max-width: 799px)" type="image/jpeg" width="706" height="417"> <source srcset="/files/styles/multiple_ct_header_phone/public/longstory/26709211161_956113bf3e_c.jpg?itok=Y1c99wkP 1x" media="all and (max-width: 539px)" type="image/jpeg" width="499" height="294"> <img loading="eager" width="499" height="294" src="/files/styles/multiple_ct_header_phone/public/longstory/26709211161_956113bf3e_c.jpg?itok=Y1c99wkP" alt="Microscopy image showing mouse brain with nerve cells, blood vessels, and plaques from Alzheimer's disease." title="Microscopy image showing mouse brain with nerve cells, blood vessels, and plaques from Alzheimer's disease." typeof="foaf:Image"> </picture> </div> <div class="media-caption"> <div class="media-caption__credit"> Credit: Alvin Gogineni, Genentech </div> <div class="media-caption__description"> This mouse brain shows hallmarks of Alzheimer’s disease (plaques in blue), along with blood vessels (red) and nerve cells (green). </div> </div> </article> </div> </div> </div> </div> </div> </div> <div class="content-section container"> <div class="content-section__main"> <div class="block block-better-social-sharing-buttons block-social-sharing-buttons-block"> <div style="display: none"><link rel="preload" href="/modules/contrib/better_social_sharing_buttons/assets/dist/sprites/social-icons--no-color.svg" as="image" type="image/svg+xml" crossorigin="anonymous"></div> <div class="social-sharing-buttons"> <a href="https://www.facebook.com/sharer/sharer.php?u=/taxonomy/term/2311/feed&amp;title=" target="_blank" title="Share to Facebook" aria-label="Share to Facebook" class="social-sharing-buttons-button share-facebook" rel="noopener"> <svg aria-hidden="true" width="32px" height="32px" style="border-radius:100%;"> <use href="/modules/contrib/better_social_sharing_buttons/assets/dist/sprites/social-icons--no-color.svg#facebook" /> </svg> </a> <a href="https://twitter.com/intent/tweet?text=+/taxonomy/term/2311/feed" target="_blank" title="Share to X" aria-label="Share to X" class="social-sharing-buttons-button share-x" rel="noopener"> <svg aria-hidden="true" width="32px" height="32px" style="border-radius:100%;"> <use href="/modules/contrib/better_social_sharing_buttons/assets/dist/sprites/social-icons--no-color.svg#x" /> </svg> </a> <a href="mailto:?subject=&amp;body=/taxonomy/term/2311/feed" title="Share to Email" aria-label="Share to Email" class="social-sharing-buttons-button share-email" target="_blank" rel="noopener"> <svg aria-hidden="true" width="32px" height="32px" style="border-radius:100%;"> <use href="/modules/contrib/better_social_sharing_buttons/assets/dist/sprites/social-icons--no-color.svg#email" /> </svg> </a> </div> </div> <div class="block block-layout-builder block-field-blocknodelong-storyfield-content-paragraphs"> <div class="field field--name-field-content-paragraphs field--type-entity-reference-revisions field--label-hidden field__items"> <div class="field__item"> <div class="paragraph paragraph--type--text-with-sidebar text-with-sidebar"> <div class="field field--name-field-sidebar field--type-entity-reference-revisions field--label-hidden field__items"> <div class="field__item"> <div class="paragraph paragraph--type--sidebar-articles sidebar-articles"> <div class="sidebar-articles__col"> <div class="clearfix text-formatted field field--name-field-heading field--type-text field--label-hidden field__item"><p>Related News</p> </div> <div class="field field--name-field-content-reference field--type-entity-reference field--label-hidden field__items"> <div class="field__item"><article about="/news/scientists-reveal-cellular-changes-unique-early-alzheimers-disease" class="node"> <div class="field field--name-field-image field--type-entity-reference field--label-hidden field__item"><article class="media media--type-image media--view-mode-multiple-ct-sidebar-link-with-image"> <div class="field field--name-field-media-image field--type-image field--label-hidden field__item"> <a href="/news/scientists-reveal-cellular-changes-unique-early-alzheimers-disease"><picture> <source srcset="/files/styles/multiple_ct_sidebar_link_with_image_desktop_xl/public/longstory/24746155619_b586852fe9_o_main.png?h=035871dd&amp;itok=3nYqiEZV 1x" media="all and (min-width: 1921px)" type="image/png" width="104" height="104"> <source srcset="/files/styles/multiple_ct_sidebar_link_with_image_desktop_xl/public/longstory/24746155619_b586852fe9_o_main.png?h=035871dd&amp;itok=3nYqiEZV 1x" media="all and (min-width: 1601px) and (max-width: 1920px)" type="image/png" width="104" height="104"> <source srcset="/files/styles/multiple_ct_sidebar_link_with_image_desktop/public/longstory/24746155619_b586852fe9_o_main.png?h=035871dd&amp;itok=wU17IzF- 1x" media="all and (min-width: 1340px) and (max-width: 1600px)" type="image/png" width="87" height="104"> <source srcset="/files/styles/multiple_ct_sidebar_link_with_image_desktop/public/longstory/24746155619_b586852fe9_o_main.png?h=035871dd&amp;itok=wU17IzF- 1x" media="all and (min-width: 800px) and (max-width: 1339px)" type="image/png" width="87" height="104"> <source srcset="/files/styles/multiple_ct_sidebar_link_with_image_tablet/public/longstory/24746155619_b586852fe9_o_main.png?h=035871dd&amp;itok=03Z2hZpL 1x" media="all and (min-width: 540px) and (max-width: 799px)" type="image/png" width="285" height="186"> <source srcset="/files/styles/multiple_ct_sidebar_link_with_image_phone/public/longstory/24746155619_b586852fe9_o_main.png?h=035871dd&amp;itok=WE7B6Ds0 1x" media="all and (max-width: 539px)" type="image/png" width="220" height="186"> <img loading="eager" width="220" height="186" src="/files/styles/multiple_ct_sidebar_link_with_image_phone/public/longstory/24746155619_b586852fe9_o_main.png?h=035871dd&amp;itok=WE7B6Ds0" alt="A fluorescence microscopy image showing buildup of amyloid beta clusters among neurons in a mouse model of Alzheimer’s disease." title="A fluorescence microscopy image showing buildup of amyloid beta clusters among neurons in a mouse model of Alzheimer’s disease." typeof="foaf:Image"> </picture></a> </div> </article> </div> <div class="node__content"> <a href="/news/scientists-reveal-cellular-changes-unique-early-alzheimers-disease" class="node__title"><span class="field field--name-title field--type-string field--label-hidden">Scientists reveal cellular changes unique to early Alzheimer’s disease</span> </a> </div> </article> </div> <div class="field__item"><article about="/news/researchers-map-brain-cell-changes-alzheimers-disease" class="node"> <div class="field field--name-field-image field--type-entity-reference field--label-hidden field__item"><article class="media media--type-image media--view-mode-multiple-ct-sidebar-link-with-image"> <div class="field field--name-field-media-image field--type-image field--label-hidden field__item"> <a href="/news/researchers-map-brain-cell-changes-alzheimers-disease"><picture> <source srcset="/files/styles/multiple_ct_sidebar_link_with_image_desktop_xl/public/longstory/main_mAD-Figure-1_20221206-01.png?h=93c99ee8&amp;itok=YbcVyrou 1x" media="all and (min-width: 1921px)" type="image/png" width="104" height="104"> <source srcset="/files/styles/multiple_ct_sidebar_link_with_image_desktop_xl/public/longstory/main_mAD-Figure-1_20221206-01.png?h=93c99ee8&amp;itok=YbcVyrou 1x" media="all and (min-width: 1601px) and (max-width: 1920px)" type="image/png" width="104" height="104"> <source srcset="/files/styles/multiple_ct_sidebar_link_with_image_desktop/public/longstory/main_mAD-Figure-1_20221206-01.png?h=93c99ee8&amp;itok=_khBWxft 1x" media="all and (min-width: 1340px) and (max-width: 1600px)" type="image/png" width="87" height="104"> <source srcset="/files/styles/multiple_ct_sidebar_link_with_image_desktop/public/longstory/main_mAD-Figure-1_20221206-01.png?h=93c99ee8&amp;itok=_khBWxft 1x" media="all and (min-width: 800px) and (max-width: 1339px)" type="image/png" width="87" height="104"> <source srcset="/files/styles/multiple_ct_sidebar_link_with_image_tablet/public/longstory/main_mAD-Figure-1_20221206-01.png?h=93c99ee8&amp;itok=0DsI2w5k 1x" media="all and (min-width: 540px) and (max-width: 799px)" type="image/png" width="285" height="186"> <source srcset="/files/styles/multiple_ct_sidebar_link_with_image_phone/public/longstory/main_mAD-Figure-1_20221206-01.png?h=93c99ee8&amp;itok=rIgOybCw 1x" media="all and (max-width: 539px)" type="image/png" width="220" height="186"> <img loading="eager" width="220" height="186" src="/files/styles/multiple_ct_sidebar_link_with_image_phone/public/longstory/main_mAD-Figure-1_20221206-01.png?h=93c99ee8&amp;itok=rIgOybCw" alt="Fluorescence microscopy image of brain tissue from a mouse model of Alzheimer’s, showing tau tangles (red), amyloid plaques (white), RNA (green), and cell nuclei (blue)." title="Fluorescence microscopy image of brain tissue from a mouse model of Alzheimer’s, showing tau tangles (red), amyloid plaques (white), RNA (green), and cell nuclei (blue)." typeof="foaf:Image"> </picture></a> </div> </article> </div> <div class="node__content"> <a href="/news/researchers-map-brain-cell-changes-alzheimers-disease" class="node__title"><span class="field field--name-title field--type-string field--label-hidden">Researchers map brain cell changes in Alzheimer’s disease</span> </a> </div> </article> </div> </div> </div> </div> </div> </div> <div class="clearfix text-formatted field field--name-field-text field--type-text-long field--label-hidden field__item"><p>Since the 1990s, researchers have found several immune system molecules that act like “brakes” on immune responses, leading to a new class of cancer drugs. One of these “immune checkpoint” molecules, called Tim-3 has recently been linked to late-onset Alzheimer’s disease (AD), but its role in the brain was unknown until now. In a paper published in <a href="https://www.nature.com/articles/s41586-025-08852-z"><em>Nature</em></a>, researchers from Mass General Brigham and the ӳ����ý used preclinical models to uncover Tim-3’s role in microglia, the brain's resident immune cells, and have identified it as a promising therapeutic target for Alzheimer’s disease.</p> <p>“Immune checkpoint inhibitors have revolutionized cancer immunotherapy, and it is exciting that we might be able to repurpose them to treat Alzheimer’s disease,” said senior author <a href="/bios/vijay-k-kuchroo">Vijay Kuchroo</a>&nbsp;of the Gene Lay Institute of Immunology and Inflammation at Brigham and Women’s Hospital and Massachusetts General Hospital, founding members of the Mass General Brigham healthcare system. Kuchroo is also an institute member at the ӳ����ý. “Microglia are pivotal in neuroinflammation and neurodegeneration, and therapeutic targeting of Tim-3 in microglia may alter them to an optimal state to fight the disease pathology in AD."</p> <p>Using a mouse model of AD, the Kuchroo lab together with Oleg Butovsky lab, at the Ann Romney Center for Neurologic Diseases at BWH, determined that Tim-3 is only expressed in microglia in the central nervous system, where it helps the cells maintain a healthy state of homeostasis. Tim-3 can also, however, prevent the brain from effectively clearing out the toxic plaques that accumulate during AD. The researchers found that deleting Tim-3 helped kickstart plaque removal by prompting the microglia to eat up more of the plaques, while also producing anti-inflammatory proteins to reduce neuroinflammation, and limiting cognitive impairment.<br> &nbsp;<br> Over a half-dozen clinical trials are currently testing therapeutics that target Tim-3 to treat patients with immunotherapy-resistant cancers. According to the authors, the new study highlights the therapeutic potential of adapting these treatments to enhance plaque clearance and mitigate neurodegeneration in Alzheimer’s disease.</p> <p><em><a href="https://www.massgeneralbrigham.org/en/about/newsroom/press-releases/potential-alzheimers-target-in-brain-immune-cells" target="_blank">Adapted from a Mass General Brigham story</a>.</em></p> </div> </div> </div> <div class="field__item"> <div class="paragraph paragraph--type--table-outro paragraph--view-mode--default"> <div class="field field--name-field-paragraph field--type-entity-reference-revisions field--label-hidden field__items"> <div class="field__item"> <div class="paragraph paragraph--type--table-outro-row paragraph--view-mode--default"> <div class="clearfix text-formatted field field--name-field-heading field--type-text field--label-hidden field__item"><p>Funding</p> </div> <div class="clearfix text-formatted field field--name-field-text field--type-text-long field--label-hidden field__item"><p>This work was supported by the National Institutes of Health, Cure Alzheimer’s Fund, and the BrightFocus Foundation.</p> </div> </div> </div> <div class="field__item"> <div class="paragraph paragraph--type--table-outro-row paragraph--view-mode--default"> <div class="clearfix text-formatted field field--name-field-heading field--type-text field--label-hidden field__item"><p>Paper cited</p> </div> <div class="clearfix text-formatted field field--name-field-text field--type-text-long field--label-hidden field__item"><p>Kimura, K, et al. “<a href="https://www.nature.com/articles/s41586-025-08852-z">Tim-3 immune checkpoint regulates microglial function and Alzheimer's disease</a>” <em>Nature. </em>Online April 9, 2025.<em>&nbsp;</em>DOI: 10.1038/s41586-025-08852-z</p> </div> </div> </div> </div> </div> </div> </div> </div> </div> </div> <div class="content-section container"> <div class="content-section__main"> <div class="block-node-broad-tags block block-layout-builder block-field-blocknodelong-storyfield-broad-tags"> <div class="block-node-broad-tags__row"> <div class="block-node-broad-tags__title">Tags:</div> <div class="field field--name-field-broad-tags field--type-entity-reference field--label-hidden field__items"> <div class="field__item"><a href="/broad-tags/neurodegeneration" hreflang="en">Neurodegeneration</a></div> </div> </div> </div> </div> </div> Thu, 27 Jun 2024 18:11:10 +0000 Corie Lok 5557021 at /news/calico-and-broad-institute-extend-collaboration-adding-focus-age-related-neurodegeneration <span class="field field--name-title field--type-string field--label-hidden"><h1>Potential Alzheimer’s disease therapeutic target identified in brain immune cells</h1> </span> <span class="field field--name-uid field--type-entity-reference field--label-hidden"> <span>By Corie Lok</span> </span> <span class="field field--name-created field--type-created field--label-hidden"><time datetime="2025-04-09T09:36:41-04:00" class="datetime">April 9, 2025</time> </span> <div class="hero-section container"> <div class="hero-section__row row"> <div class="hero-section__content hero-section__content_left col-6"> <div class="hero-section__breadcrumbs"> <div class="block block-system block-system-breadcrumb-block"> <nav class="breadcrumb" role="navigation" aria-labelledby="system-breadcrumb"> <h2 id="system-breadcrumb" class="visually-hidden">Breadcrumb</h2> <ol> <li> <a href="/">Home</a> </li> <li> <a href="/news">News</a> </li> </ol> </nav> </div> </div> <div class="hero-section__title"> <div class="block block-layout-builder block-field-blocknodelong-storytitle"> <span class="field field--name-title field--type-string field--label-hidden"><h1>Potential Alzheimer’s disease therapeutic target identified in brain immune cells</h1> </span> </div> </div> <div class="hero-section__description"> <div class="block block-layout-builder block-field-blocknodelong-storybody"> <div class="clearfix text-formatted field field--name-body field--type-text-with-summary field--label-hidden field__item"><p>Scientists discover possible way to harness immune cells in the brain to remove plaques associated with Alzheimer's.&nbsp;</p> </div> </div> </div> <div class="hero-section__author"> <div class="block block-layout-builder block-extra-field-blocknodelong-storyextra-field-author-custom"> By Anna McTigue, Mass General Brigham Communications </div> </div> <div class="hero-section__date"> <div class="block block-layout-builder block-field-blocknodelong-storycreated"> <span class="field field--name-created field--type-created field--label-hidden"><time datetime="2025-04-09T09:36:41-04:00" title="Wednesday, April 9, 2025 - 09:36" class="datetime">April 9, 2025</time> </span> </div> </div> </div> <div class="hero-section__right col-6"> <div class="hero-section__image"> <div class="block block-layout-builder block-field-blocknodelong-storyfield-image"> <div class="field field--name-field-image field--type-entity-reference field--label-hidden field__item"> <article class="media media--type-image media--view-mode-multiple-content-types-header"> <div class="field field--name-field-media-image field--type-image field--label-hidden field__item"> <picture> <source srcset="/files/styles/multiple_ct_header_desktop_xl/public/longstory/26709211161_956113bf3e_c.jpg?itok=Ti1GJfAc 1x" media="all and (min-width: 1921px)" type="image/jpeg" width="754" height="503"> <source srcset="/files/styles/multiple_ct_header_desktop_xl/public/longstory/26709211161_956113bf3e_c.jpg?itok=Ti1GJfAc 1x" media="all and (min-width: 1601px) and (max-width: 1920px)" type="image/jpeg" width="754" height="503"> <source srcset="/files/styles/multiple_ct_header_desktop/public/longstory/26709211161_956113bf3e_c.jpg?itok=nu30mWVf 1x" media="all and (min-width: 1340px) and (max-width: 1600px)" type="image/jpeg" width="736" height="520"> <source srcset="/files/styles/multiple_ct_header_laptop/public/longstory/26709211161_956113bf3e_c.jpg?itok=SrnEVHSE 1x" media="all and (min-width: 800px) and (max-width: 1339px)" type="image/jpeg" width="641" height="451"> <source srcset="/files/styles/multiple_ct_header_tablet/public/longstory/26709211161_956113bf3e_c.jpg?itok=uR_vA2Q5 1x" media="all and (min-width: 540px) and (max-width: 799px)" type="image/jpeg" width="706" height="417"> <source srcset="/files/styles/multiple_ct_header_phone/public/longstory/26709211161_956113bf3e_c.jpg?itok=Y1c99wkP 1x" media="all and (max-width: 539px)" type="image/jpeg" width="499" height="294"> <img loading="eager" width="499" height="294" src="/files/styles/multiple_ct_header_phone/public/longstory/26709211161_956113bf3e_c.jpg?itok=Y1c99wkP" alt="Microscopy image showing mouse brain with nerve cells, blood vessels, and plaques from Alzheimer's disease." title="Microscopy image showing mouse brain with nerve cells, blood vessels, and plaques from Alzheimer's disease." typeof="foaf:Image"> </picture> </div> <div class="media-caption"> <div class="media-caption__credit"> Credit: Alvin Gogineni, Genentech </div> <div class="media-caption__description"> This mouse brain shows hallmarks of Alzheimer’s disease (plaques in blue), along with blood vessels (red) and nerve cells (green). </div> </div> </article> </div> </div> </div> </div> </div> </div> <div class="content-section container"> <div class="content-section__main"> <div class="block block-better-social-sharing-buttons block-social-sharing-buttons-block"> <div style="display: none"><link rel="preload" href="/modules/contrib/better_social_sharing_buttons/assets/dist/sprites/social-icons--no-color.svg" as="image" type="image/svg+xml" crossorigin="anonymous"></div> <div class="social-sharing-buttons"> <a href="https://www.facebook.com/sharer/sharer.php?u=/taxonomy/term/2311/feed&amp;title=" target="_blank" title="Share to Facebook" aria-label="Share to Facebook" class="social-sharing-buttons-button share-facebook" rel="noopener"> <svg aria-hidden="true" width="32px" height="32px" style="border-radius:100%;"> <use href="/modules/contrib/better_social_sharing_buttons/assets/dist/sprites/social-icons--no-color.svg#facebook" /> </svg> </a> <a href="https://twitter.com/intent/tweet?text=+/taxonomy/term/2311/feed" target="_blank" title="Share to X" aria-label="Share to X" class="social-sharing-buttons-button share-x" rel="noopener"> <svg aria-hidden="true" width="32px" height="32px" style="border-radius:100%;"> <use href="/modules/contrib/better_social_sharing_buttons/assets/dist/sprites/social-icons--no-color.svg#x" /> </svg> </a> <a href="mailto:?subject=&amp;body=/taxonomy/term/2311/feed" title="Share to Email" aria-label="Share to Email" class="social-sharing-buttons-button share-email" target="_blank" rel="noopener"> <svg aria-hidden="true" width="32px" height="32px" style="border-radius:100%;"> <use href="/modules/contrib/better_social_sharing_buttons/assets/dist/sprites/social-icons--no-color.svg#email" /> </svg> </a> </div> </div> <div class="block block-layout-builder block-field-blocknodelong-storyfield-content-paragraphs"> <div class="field field--name-field-content-paragraphs field--type-entity-reference-revisions field--label-hidden field__items"> <div class="field__item"> <div class="paragraph paragraph--type--text-with-sidebar text-with-sidebar"> <div class="field field--name-field-sidebar field--type-entity-reference-revisions field--label-hidden field__items"> <div class="field__item"> <div class="paragraph paragraph--type--sidebar-articles sidebar-articles"> <div class="sidebar-articles__col"> <div class="clearfix text-formatted field field--name-field-heading field--type-text field--label-hidden field__item"><p>Related News</p> </div> <div class="field field--name-field-content-reference field--type-entity-reference field--label-hidden field__items"> <div class="field__item"><article about="/news/scientists-reveal-cellular-changes-unique-early-alzheimers-disease" class="node"> <div class="field field--name-field-image field--type-entity-reference field--label-hidden field__item"><article class="media media--type-image media--view-mode-multiple-ct-sidebar-link-with-image"> <div class="field field--name-field-media-image field--type-image field--label-hidden field__item"> <a href="/news/scientists-reveal-cellular-changes-unique-early-alzheimers-disease"><picture> <source srcset="/files/styles/multiple_ct_sidebar_link_with_image_desktop_xl/public/longstory/24746155619_b586852fe9_o_main.png?h=035871dd&amp;itok=3nYqiEZV 1x" media="all and (min-width: 1921px)" type="image/png" width="104" height="104"> <source srcset="/files/styles/multiple_ct_sidebar_link_with_image_desktop_xl/public/longstory/24746155619_b586852fe9_o_main.png?h=035871dd&amp;itok=3nYqiEZV 1x" media="all and (min-width: 1601px) and (max-width: 1920px)" type="image/png" width="104" height="104"> <source srcset="/files/styles/multiple_ct_sidebar_link_with_image_desktop/public/longstory/24746155619_b586852fe9_o_main.png?h=035871dd&amp;itok=wU17IzF- 1x" media="all and (min-width: 1340px) and (max-width: 1600px)" type="image/png" width="87" height="104"> <source srcset="/files/styles/multiple_ct_sidebar_link_with_image_desktop/public/longstory/24746155619_b586852fe9_o_main.png?h=035871dd&amp;itok=wU17IzF- 1x" media="all and (min-width: 800px) and (max-width: 1339px)" type="image/png" width="87" height="104"> <source srcset="/files/styles/multiple_ct_sidebar_link_with_image_tablet/public/longstory/24746155619_b586852fe9_o_main.png?h=035871dd&amp;itok=03Z2hZpL 1x" media="all and (min-width: 540px) and (max-width: 799px)" type="image/png" width="285" height="186"> <source srcset="/files/styles/multiple_ct_sidebar_link_with_image_phone/public/longstory/24746155619_b586852fe9_o_main.png?h=035871dd&amp;itok=WE7B6Ds0 1x" media="all and (max-width: 539px)" type="image/png" width="220" height="186"> <img loading="eager" width="220" height="186" src="/files/styles/multiple_ct_sidebar_link_with_image_phone/public/longstory/24746155619_b586852fe9_o_main.png?h=035871dd&amp;itok=WE7B6Ds0" alt="A fluorescence microscopy image showing buildup of amyloid beta clusters among neurons in a mouse model of Alzheimer’s disease." title="A fluorescence microscopy image showing buildup of amyloid beta clusters among neurons in a mouse model of Alzheimer’s disease." typeof="foaf:Image"> </picture></a> </div> </article> </div> <div class="node__content"> <a href="/news/scientists-reveal-cellular-changes-unique-early-alzheimers-disease" class="node__title"><span class="field field--name-title field--type-string field--label-hidden">Scientists reveal cellular changes unique to early Alzheimer’s disease</span> </a> </div> </article> </div> <div class="field__item"><article about="/news/researchers-map-brain-cell-changes-alzheimers-disease" class="node"> <div class="field field--name-field-image field--type-entity-reference field--label-hidden field__item"><article class="media media--type-image media--view-mode-multiple-ct-sidebar-link-with-image"> <div class="field field--name-field-media-image field--type-image field--label-hidden field__item"> <a href="/news/researchers-map-brain-cell-changes-alzheimers-disease"><picture> <source srcset="/files/styles/multiple_ct_sidebar_link_with_image_desktop_xl/public/longstory/main_mAD-Figure-1_20221206-01.png?h=93c99ee8&amp;itok=YbcVyrou 1x" media="all and (min-width: 1921px)" type="image/png" width="104" height="104"> <source srcset="/files/styles/multiple_ct_sidebar_link_with_image_desktop_xl/public/longstory/main_mAD-Figure-1_20221206-01.png?h=93c99ee8&amp;itok=YbcVyrou 1x" media="all and (min-width: 1601px) and (max-width: 1920px)" type="image/png" width="104" height="104"> <source srcset="/files/styles/multiple_ct_sidebar_link_with_image_desktop/public/longstory/main_mAD-Figure-1_20221206-01.png?h=93c99ee8&amp;itok=_khBWxft 1x" media="all and (min-width: 1340px) and (max-width: 1600px)" type="image/png" width="87" height="104"> <source srcset="/files/styles/multiple_ct_sidebar_link_with_image_desktop/public/longstory/main_mAD-Figure-1_20221206-01.png?h=93c99ee8&amp;itok=_khBWxft 1x" media="all and (min-width: 800px) and (max-width: 1339px)" type="image/png" width="87" height="104"> <source srcset="/files/styles/multiple_ct_sidebar_link_with_image_tablet/public/longstory/main_mAD-Figure-1_20221206-01.png?h=93c99ee8&amp;itok=0DsI2w5k 1x" media="all and (min-width: 540px) and (max-width: 799px)" type="image/png" width="285" height="186"> <source srcset="/files/styles/multiple_ct_sidebar_link_with_image_phone/public/longstory/main_mAD-Figure-1_20221206-01.png?h=93c99ee8&amp;itok=rIgOybCw 1x" media="all and (max-width: 539px)" type="image/png" width="220" height="186"> <img loading="eager" width="220" height="186" src="/files/styles/multiple_ct_sidebar_link_with_image_phone/public/longstory/main_mAD-Figure-1_20221206-01.png?h=93c99ee8&amp;itok=rIgOybCw" alt="Fluorescence microscopy image of brain tissue from a mouse model of Alzheimer’s, showing tau tangles (red), amyloid plaques (white), RNA (green), and cell nuclei (blue)." title="Fluorescence microscopy image of brain tissue from a mouse model of Alzheimer’s, showing tau tangles (red), amyloid plaques (white), RNA (green), and cell nuclei (blue)." typeof="foaf:Image"> </picture></a> </div> </article> </div> <div class="node__content"> <a href="/news/researchers-map-brain-cell-changes-alzheimers-disease" class="node__title"><span class="field field--name-title field--type-string field--label-hidden">Researchers map brain cell changes in Alzheimer’s disease</span> </a> </div> </article> </div> </div> </div> </div> </div> </div> <div class="clearfix text-formatted field field--name-field-text field--type-text-long field--label-hidden field__item"><p>Since the 1990s, researchers have found several immune system molecules that act like “brakes” on immune responses, leading to a new class of cancer drugs. One of these “immune checkpoint” molecules, called Tim-3 has recently been linked to late-onset Alzheimer’s disease (AD), but its role in the brain was unknown until now. In a paper published in <a href="https://www.nature.com/articles/s41586-025-08852-z"><em>Nature</em></a>, researchers from Mass General Brigham and the ӳ����ý used preclinical models to uncover Tim-3’s role in microglia, the brain's resident immune cells, and have identified it as a promising therapeutic target for Alzheimer’s disease.</p> <p>“Immune checkpoint inhibitors have revolutionized cancer immunotherapy, and it is exciting that we might be able to repurpose them to treat Alzheimer’s disease,” said senior author <a href="/bios/vijay-k-kuchroo">Vijay Kuchroo</a>&nbsp;of the Gene Lay Institute of Immunology and Inflammation at Brigham and Women’s Hospital and Massachusetts General Hospital, founding members of the Mass General Brigham healthcare system. Kuchroo is also an institute member at the ӳ����ý. “Microglia are pivotal in neuroinflammation and neurodegeneration, and therapeutic targeting of Tim-3 in microglia may alter them to an optimal state to fight the disease pathology in AD."</p> <p>Using a mouse model of AD, the Kuchroo lab together with Oleg Butovsky lab, at the Ann Romney Center for Neurologic Diseases at BWH, determined that Tim-3 is only expressed in microglia in the central nervous system, where it helps the cells maintain a healthy state of homeostasis. Tim-3 can also, however, prevent the brain from effectively clearing out the toxic plaques that accumulate during AD. The researchers found that deleting Tim-3 helped kickstart plaque removal by prompting the microglia to eat up more of the plaques, while also producing anti-inflammatory proteins to reduce neuroinflammation, and limiting cognitive impairment.<br> &nbsp;<br> Over a half-dozen clinical trials are currently testing therapeutics that target Tim-3 to treat patients with immunotherapy-resistant cancers. According to the authors, the new study highlights the therapeutic potential of adapting these treatments to enhance plaque clearance and mitigate neurodegeneration in Alzheimer’s disease.</p> <p><em><a href="https://www.massgeneralbrigham.org/en/about/newsroom/press-releases/potential-alzheimers-target-in-brain-immune-cells" target="_blank">Adapted from a Mass General Brigham story</a>.</em></p> </div> </div> </div> <div class="field__item"> <div class="paragraph paragraph--type--table-outro paragraph--view-mode--default"> <div class="field field--name-field-paragraph field--type-entity-reference-revisions field--label-hidden field__items"> <div class="field__item"> <div class="paragraph paragraph--type--table-outro-row paragraph--view-mode--default"> <div class="clearfix text-formatted field field--name-field-heading field--type-text field--label-hidden field__item"><p>Funding</p> </div> <div class="clearfix text-formatted field field--name-field-text field--type-text-long field--label-hidden field__item"><p>This work was supported by the National Institutes of Health, Cure Alzheimer’s Fund, and the BrightFocus Foundation.</p> </div> </div> </div> <div class="field__item"> <div class="paragraph paragraph--type--table-outro-row paragraph--view-mode--default"> <div class="clearfix text-formatted field field--name-field-heading field--type-text field--label-hidden field__item"><p>Paper cited</p> </div> <div class="clearfix text-formatted field field--name-field-text field--type-text-long field--label-hidden field__item"><p>Kimura, K, et al. “<a href="https://www.nature.com/articles/s41586-025-08852-z">Tim-3 immune checkpoint regulates microglial function and Alzheimer's disease</a>” <em>Nature. </em>Online April 9, 2025.<em>&nbsp;</em>DOI: 10.1038/s41586-025-08852-z</p> </div> </div> </div> </div> </div> </div> </div> </div> </div> </div> <div class="content-section container"> <div class="content-section__main"> <div class="block-node-broad-tags block block-layout-builder block-field-blocknodelong-storyfield-broad-tags"> <div class="block-node-broad-tags__row"> <div class="block-node-broad-tags__title">Tags:</div> <div class="field field--name-field-broad-tags field--type-entity-reference field--label-hidden field__items"> <div class="field__item"><a href="/broad-tags/neurodegeneration" hreflang="en">Neurodegeneration</a></div> </div> </div> </div> </div> </div> Thu, 09 May 2024 12:30:10 +0000 Corie Lok 5556886 at /news/scientists-reveal-cellular-changes-unique-early-alzheimers-disease <span class="field field--name-title field--type-string field--label-hidden"><h1>Potential Alzheimer’s disease therapeutic target identified in brain immune cells</h1> </span> <span class="field field--name-uid field--type-entity-reference field--label-hidden"> <span>By Corie Lok</span> </span> <span class="field field--name-created field--type-created field--label-hidden"><time datetime="2025-04-09T09:36:41-04:00" class="datetime">April 9, 2025</time> </span> <div class="hero-section container"> <div class="hero-section__row row"> <div class="hero-section__content hero-section__content_left col-6"> <div class="hero-section__breadcrumbs"> <div class="block block-system block-system-breadcrumb-block"> <nav class="breadcrumb" role="navigation" aria-labelledby="system-breadcrumb"> <h2 id="system-breadcrumb" class="visually-hidden">Breadcrumb</h2> <ol> <li> <a href="/">Home</a> </li> <li> <a href="/news">News</a> </li> </ol> </nav> </div> </div> <div class="hero-section__title"> <div class="block block-layout-builder block-field-blocknodelong-storytitle"> <span class="field field--name-title field--type-string field--label-hidden"><h1>Potential Alzheimer’s disease therapeutic target identified in brain immune cells</h1> </span> </div> </div> <div class="hero-section__description"> <div class="block block-layout-builder block-field-blocknodelong-storybody"> <div class="clearfix text-formatted field field--name-body field--type-text-with-summary field--label-hidden field__item"><p>Scientists discover possible way to harness immune cells in the brain to remove plaques associated with Alzheimer's.&nbsp;</p> </div> </div> </div> <div class="hero-section__author"> <div class="block block-layout-builder block-extra-field-blocknodelong-storyextra-field-author-custom"> By Anna McTigue, Mass General Brigham Communications </div> </div> <div class="hero-section__date"> <div class="block block-layout-builder block-field-blocknodelong-storycreated"> <span class="field field--name-created field--type-created field--label-hidden"><time datetime="2025-04-09T09:36:41-04:00" title="Wednesday, April 9, 2025 - 09:36" class="datetime">April 9, 2025</time> </span> </div> </div> </div> <div class="hero-section__right col-6"> <div class="hero-section__image"> <div class="block block-layout-builder block-field-blocknodelong-storyfield-image"> <div class="field field--name-field-image field--type-entity-reference field--label-hidden field__item"> <article class="media media--type-image media--view-mode-multiple-content-types-header"> <div class="field field--name-field-media-image field--type-image field--label-hidden field__item"> <picture> <source srcset="/files/styles/multiple_ct_header_desktop_xl/public/longstory/26709211161_956113bf3e_c.jpg?itok=Ti1GJfAc 1x" media="all and (min-width: 1921px)" type="image/jpeg" width="754" height="503"> <source srcset="/files/styles/multiple_ct_header_desktop_xl/public/longstory/26709211161_956113bf3e_c.jpg?itok=Ti1GJfAc 1x" media="all and (min-width: 1601px) and (max-width: 1920px)" type="image/jpeg" width="754" height="503"> <source srcset="/files/styles/multiple_ct_header_desktop/public/longstory/26709211161_956113bf3e_c.jpg?itok=nu30mWVf 1x" media="all and (min-width: 1340px) and (max-width: 1600px)" type="image/jpeg" width="736" height="520"> <source srcset="/files/styles/multiple_ct_header_laptop/public/longstory/26709211161_956113bf3e_c.jpg?itok=SrnEVHSE 1x" media="all and (min-width: 800px) and (max-width: 1339px)" type="image/jpeg" width="641" height="451"> <source srcset="/files/styles/multiple_ct_header_tablet/public/longstory/26709211161_956113bf3e_c.jpg?itok=uR_vA2Q5 1x" media="all and (min-width: 540px) and (max-width: 799px)" type="image/jpeg" width="706" height="417"> <source srcset="/files/styles/multiple_ct_header_phone/public/longstory/26709211161_956113bf3e_c.jpg?itok=Y1c99wkP 1x" media="all and (max-width: 539px)" type="image/jpeg" width="499" height="294"> <img loading="eager" width="499" height="294" src="/files/styles/multiple_ct_header_phone/public/longstory/26709211161_956113bf3e_c.jpg?itok=Y1c99wkP" alt="Microscopy image showing mouse brain with nerve cells, blood vessels, and plaques from Alzheimer's disease." title="Microscopy image showing mouse brain with nerve cells, blood vessels, and plaques from Alzheimer's disease." typeof="foaf:Image"> </picture> </div> <div class="media-caption"> <div class="media-caption__credit"> Credit: Alvin Gogineni, Genentech </div> <div class="media-caption__description"> This mouse brain shows hallmarks of Alzheimer’s disease (plaques in blue), along with blood vessels (red) and nerve cells (green). </div> </div> </article> </div> </div> </div> </div> </div> </div> <div class="content-section container"> <div class="content-section__main"> <div class="block block-better-social-sharing-buttons block-social-sharing-buttons-block"> <div style="display: none"><link rel="preload" href="/modules/contrib/better_social_sharing_buttons/assets/dist/sprites/social-icons--no-color.svg" as="image" type="image/svg+xml" crossorigin="anonymous"></div> <div class="social-sharing-buttons"> <a href="https://www.facebook.com/sharer/sharer.php?u=/taxonomy/term/2311/feed&amp;title=" target="_blank" title="Share to Facebook" aria-label="Share to Facebook" class="social-sharing-buttons-button share-facebook" rel="noopener"> <svg aria-hidden="true" width="32px" height="32px" style="border-radius:100%;"> <use href="/modules/contrib/better_social_sharing_buttons/assets/dist/sprites/social-icons--no-color.svg#facebook" /> </svg> </a> <a href="https://twitter.com/intent/tweet?text=+/taxonomy/term/2311/feed" target="_blank" title="Share to X" aria-label="Share to X" class="social-sharing-buttons-button share-x" rel="noopener"> <svg aria-hidden="true" width="32px" height="32px" style="border-radius:100%;"> <use href="/modules/contrib/better_social_sharing_buttons/assets/dist/sprites/social-icons--no-color.svg#x" /> </svg> </a> <a href="mailto:?subject=&amp;body=/taxonomy/term/2311/feed" title="Share to Email" aria-label="Share to Email" class="social-sharing-buttons-button share-email" target="_blank" rel="noopener"> <svg aria-hidden="true" width="32px" height="32px" style="border-radius:100%;"> <use href="/modules/contrib/better_social_sharing_buttons/assets/dist/sprites/social-icons--no-color.svg#email" /> </svg> </a> </div> </div> <div class="block block-layout-builder block-field-blocknodelong-storyfield-content-paragraphs"> <div class="field field--name-field-content-paragraphs field--type-entity-reference-revisions field--label-hidden field__items"> <div class="field__item"> <div class="paragraph paragraph--type--text-with-sidebar text-with-sidebar"> <div class="field field--name-field-sidebar field--type-entity-reference-revisions field--label-hidden field__items"> <div class="field__item"> <div class="paragraph paragraph--type--sidebar-articles sidebar-articles"> <div class="sidebar-articles__col"> <div class="clearfix text-formatted field field--name-field-heading field--type-text field--label-hidden field__item"><p>Related News</p> </div> <div class="field field--name-field-content-reference field--type-entity-reference field--label-hidden field__items"> <div class="field__item"><article about="/news/scientists-reveal-cellular-changes-unique-early-alzheimers-disease" class="node"> <div class="field field--name-field-image field--type-entity-reference field--label-hidden field__item"><article class="media media--type-image media--view-mode-multiple-ct-sidebar-link-with-image"> <div class="field field--name-field-media-image field--type-image field--label-hidden field__item"> <a href="/news/scientists-reveal-cellular-changes-unique-early-alzheimers-disease"><picture> <source srcset="/files/styles/multiple_ct_sidebar_link_with_image_desktop_xl/public/longstory/24746155619_b586852fe9_o_main.png?h=035871dd&amp;itok=3nYqiEZV 1x" media="all and (min-width: 1921px)" type="image/png" width="104" height="104"> <source srcset="/files/styles/multiple_ct_sidebar_link_with_image_desktop_xl/public/longstory/24746155619_b586852fe9_o_main.png?h=035871dd&amp;itok=3nYqiEZV 1x" media="all and (min-width: 1601px) and (max-width: 1920px)" type="image/png" width="104" height="104"> <source srcset="/files/styles/multiple_ct_sidebar_link_with_image_desktop/public/longstory/24746155619_b586852fe9_o_main.png?h=035871dd&amp;itok=wU17IzF- 1x" media="all and (min-width: 1340px) and (max-width: 1600px)" type="image/png" width="87" height="104"> <source srcset="/files/styles/multiple_ct_sidebar_link_with_image_desktop/public/longstory/24746155619_b586852fe9_o_main.png?h=035871dd&amp;itok=wU17IzF- 1x" media="all and (min-width: 800px) and (max-width: 1339px)" type="image/png" width="87" height="104"> <source srcset="/files/styles/multiple_ct_sidebar_link_with_image_tablet/public/longstory/24746155619_b586852fe9_o_main.png?h=035871dd&amp;itok=03Z2hZpL 1x" media="all and (min-width: 540px) and (max-width: 799px)" type="image/png" width="285" height="186"> <source srcset="/files/styles/multiple_ct_sidebar_link_with_image_phone/public/longstory/24746155619_b586852fe9_o_main.png?h=035871dd&amp;itok=WE7B6Ds0 1x" media="all and (max-width: 539px)" type="image/png" width="220" height="186"> <img loading="eager" width="220" height="186" src="/files/styles/multiple_ct_sidebar_link_with_image_phone/public/longstory/24746155619_b586852fe9_o_main.png?h=035871dd&amp;itok=WE7B6Ds0" alt="A fluorescence microscopy image showing buildup of amyloid beta clusters among neurons in a mouse model of Alzheimer’s disease." title="A fluorescence microscopy image showing buildup of amyloid beta clusters among neurons in a mouse model of Alzheimer’s disease." typeof="foaf:Image"> </picture></a> </div> </article> </div> <div class="node__content"> <a href="/news/scientists-reveal-cellular-changes-unique-early-alzheimers-disease" class="node__title"><span class="field field--name-title field--type-string field--label-hidden">Scientists reveal cellular changes unique to early Alzheimer’s disease</span> </a> </div> </article> </div> <div class="field__item"><article about="/news/researchers-map-brain-cell-changes-alzheimers-disease" class="node"> <div class="field field--name-field-image field--type-entity-reference field--label-hidden field__item"><article class="media media--type-image media--view-mode-multiple-ct-sidebar-link-with-image"> <div class="field field--name-field-media-image field--type-image field--label-hidden field__item"> <a href="/news/researchers-map-brain-cell-changes-alzheimers-disease"><picture> <source srcset="/files/styles/multiple_ct_sidebar_link_with_image_desktop_xl/public/longstory/main_mAD-Figure-1_20221206-01.png?h=93c99ee8&amp;itok=YbcVyrou 1x" media="all and (min-width: 1921px)" type="image/png" width="104" height="104"> <source srcset="/files/styles/multiple_ct_sidebar_link_with_image_desktop_xl/public/longstory/main_mAD-Figure-1_20221206-01.png?h=93c99ee8&amp;itok=YbcVyrou 1x" media="all and (min-width: 1601px) and (max-width: 1920px)" type="image/png" width="104" height="104"> <source srcset="/files/styles/multiple_ct_sidebar_link_with_image_desktop/public/longstory/main_mAD-Figure-1_20221206-01.png?h=93c99ee8&amp;itok=_khBWxft 1x" media="all and (min-width: 1340px) and (max-width: 1600px)" type="image/png" width="87" height="104"> <source srcset="/files/styles/multiple_ct_sidebar_link_with_image_desktop/public/longstory/main_mAD-Figure-1_20221206-01.png?h=93c99ee8&amp;itok=_khBWxft 1x" media="all and (min-width: 800px) and (max-width: 1339px)" type="image/png" width="87" height="104"> <source srcset="/files/styles/multiple_ct_sidebar_link_with_image_tablet/public/longstory/main_mAD-Figure-1_20221206-01.png?h=93c99ee8&amp;itok=0DsI2w5k 1x" media="all and (min-width: 540px) and (max-width: 799px)" type="image/png" width="285" height="186"> <source srcset="/files/styles/multiple_ct_sidebar_link_with_image_phone/public/longstory/main_mAD-Figure-1_20221206-01.png?h=93c99ee8&amp;itok=rIgOybCw 1x" media="all and (max-width: 539px)" type="image/png" width="220" height="186"> <img loading="eager" width="220" height="186" src="/files/styles/multiple_ct_sidebar_link_with_image_phone/public/longstory/main_mAD-Figure-1_20221206-01.png?h=93c99ee8&amp;itok=rIgOybCw" alt="Fluorescence microscopy image of brain tissue from a mouse model of Alzheimer’s, showing tau tangles (red), amyloid plaques (white), RNA (green), and cell nuclei (blue)." title="Fluorescence microscopy image of brain tissue from a mouse model of Alzheimer’s, showing tau tangles (red), amyloid plaques (white), RNA (green), and cell nuclei (blue)." typeof="foaf:Image"> </picture></a> </div> </article> </div> <div class="node__content"> <a href="/news/researchers-map-brain-cell-changes-alzheimers-disease" class="node__title"><span class="field field--name-title field--type-string field--label-hidden">Researchers map brain cell changes in Alzheimer’s disease</span> </a> </div> </article> </div> </div> </div> </div> </div> </div> <div class="clearfix text-formatted field field--name-field-text field--type-text-long field--label-hidden field__item"><p>Since the 1990s, researchers have found several immune system molecules that act like “brakes” on immune responses, leading to a new class of cancer drugs. One of these “immune checkpoint” molecules, called Tim-3 has recently been linked to late-onset Alzheimer’s disease (AD), but its role in the brain was unknown until now. In a paper published in <a href="https://www.nature.com/articles/s41586-025-08852-z"><em>Nature</em></a>, researchers from Mass General Brigham and the ӳ����ý used preclinical models to uncover Tim-3’s role in microglia, the brain's resident immune cells, and have identified it as a promising therapeutic target for Alzheimer’s disease.</p> <p>“Immune checkpoint inhibitors have revolutionized cancer immunotherapy, and it is exciting that we might be able to repurpose them to treat Alzheimer’s disease,” said senior author <a href="/bios/vijay-k-kuchroo">Vijay Kuchroo</a>&nbsp;of the Gene Lay Institute of Immunology and Inflammation at Brigham and Women’s Hospital and Massachusetts General Hospital, founding members of the Mass General Brigham healthcare system. Kuchroo is also an institute member at the ӳ����ý. “Microglia are pivotal in neuroinflammation and neurodegeneration, and therapeutic targeting of Tim-3 in microglia may alter them to an optimal state to fight the disease pathology in AD."</p> <p>Using a mouse model of AD, the Kuchroo lab together with Oleg Butovsky lab, at the Ann Romney Center for Neurologic Diseases at BWH, determined that Tim-3 is only expressed in microglia in the central nervous system, where it helps the cells maintain a healthy state of homeostasis. Tim-3 can also, however, prevent the brain from effectively clearing out the toxic plaques that accumulate during AD. The researchers found that deleting Tim-3 helped kickstart plaque removal by prompting the microglia to eat up more of the plaques, while also producing anti-inflammatory proteins to reduce neuroinflammation, and limiting cognitive impairment.<br> &nbsp;<br> Over a half-dozen clinical trials are currently testing therapeutics that target Tim-3 to treat patients with immunotherapy-resistant cancers. According to the authors, the new study highlights the therapeutic potential of adapting these treatments to enhance plaque clearance and mitigate neurodegeneration in Alzheimer’s disease.</p> <p><em><a href="https://www.massgeneralbrigham.org/en/about/newsroom/press-releases/potential-alzheimers-target-in-brain-immune-cells" target="_blank">Adapted from a Mass General Brigham story</a>.</em></p> </div> </div> </div> <div class="field__item"> <div class="paragraph paragraph--type--table-outro paragraph--view-mode--default"> <div class="field field--name-field-paragraph field--type-entity-reference-revisions field--label-hidden field__items"> <div class="field__item"> <div class="paragraph paragraph--type--table-outro-row paragraph--view-mode--default"> <div class="clearfix text-formatted field field--name-field-heading field--type-text field--label-hidden field__item"><p>Funding</p> </div> <div class="clearfix text-formatted field field--name-field-text field--type-text-long field--label-hidden field__item"><p>This work was supported by the National Institutes of Health, Cure Alzheimer’s Fund, and the BrightFocus Foundation.</p> </div> </div> </div> <div class="field__item"> <div class="paragraph paragraph--type--table-outro-row paragraph--view-mode--default"> <div class="clearfix text-formatted field field--name-field-heading field--type-text field--label-hidden field__item"><p>Paper cited</p> </div> <div class="clearfix text-formatted field field--name-field-text field--type-text-long field--label-hidden field__item"><p>Kimura, K, et al. “<a href="https://www.nature.com/articles/s41586-025-08852-z">Tim-3 immune checkpoint regulates microglial function and Alzheimer's disease</a>” <em>Nature. </em>Online April 9, 2025.<em>&nbsp;</em>DOI: 10.1038/s41586-025-08852-z</p> </div> </div> </div> </div> </div> </div> </div> </div> </div> </div> <div class="content-section container"> <div class="content-section__main"> <div class="block-node-broad-tags block block-layout-builder block-field-blocknodelong-storyfield-broad-tags"> <div class="block-node-broad-tags__row"> <div class="block-node-broad-tags__title">Tags:</div> <div class="field field--name-field-broad-tags field--type-entity-reference field--label-hidden field__items"> <div class="field__item"><a href="/broad-tags/neurodegeneration" hreflang="en">Neurodegeneration</a></div> </div> </div> </div> </div> </div> Thu, 28 Sep 2023 15:00:00 +0000 adicorat 5555746 at