/ en /news/research-roundup-april-12-2019 <span class="field field--name-title field--type-string field--label-hidden"><h1>Research Roundup: April 12, 2019</h1> </span> <span class="field field--name-uid field--type-entity-reference field--label-hidden"> <span>By Tom Ulrich</span> </span> <span class="field field--name-created field--type-created field--label-hidden"><time datetime="2019-04-12T12:22:32-04:00" class="datetime">April 12, 2019</time> </span> <div class="hero-section container"> <div class="hero-section__row row"> <div class="hero-section__content hero-section__content_left col-6"> <div class="hero-section__breadcrumbs"> <div class="block block-layout-builder block-extra-field-blocknodenewsbreadcrumbs"> <nav class="breadcrumb" role="navigation" aria-labelledby="system-breadcrumb"> <h2 id="system-breadcrumb" class="visually-hidden">Breadcrumb</h2> <ol> <li> <a href="/">Home</a> </li> <li> <a href="/news">News</a> </li> </ol> </nav> </div> </div> <div class="hero-section__title"> <div class="block block-layout-builder block-field-blocknodenewstitle"> <span class="field field--name-title field--type-string field--label-hidden"><h1>Research Roundup: April 12, 2019</h1> </span> </div> </div> <div class="hero-section__description"> <div class="block block-layout-builder block-field-blocknodenewsbody"> <div class="clearfix text-formatted field field--name-body field--type-text-with-summary field--label-hidden field__item"><div class="summary-only"> <p><span id="docs-internal-guid-3fe5f155-7fff-e0f9-9ffb-9d189ac78a32">Molecular clues to microbes and multiple cancers.</span></p> </div> </div> </div> </div> <div class="hero-section__author"> <div class="block block-layout-builder block-extra-field-blocknodenewsextra-field-author-custom"> By Ó³»­´«Ã½ Communications </div> </div> <div class="hero-section__date"> <div class="block block-layout-builder block-field-blocknodenewscreated"> <span class="field field--name-created field--type-created field--label-hidden"><time datetime="2019-04-12T12:22:32-04:00" class="datetime">April 12, 2019</time> </span> </div> </div> </div> <div class="hero-section__right col-6"> <div class="hero-section__image"> <div class="block block-layout-builder block-field-blocknodenewsfield-image"> <div class="field field--name-field-image field--type-entity-reference field--label-hidden field__item"> <article class="media media--type-image media--view-mode-multiple-content-types-header"> <div class="field field--name-field-media-image field--type-image field--label-hidden field__item"> <picture> <source srcset="/files/styles/multiple_ct_header_desktop_xl/public/news/images/2019/RR5%20jacobs-day2-6.jpg?h=d3e04ee7&amp;itok=Ncg_3Ceu 1x" media="all and (min-width: 1921px)" type="image/jpeg" width="754" height="503"> <source srcset="/files/styles/multiple_ct_header_desktop_xl/public/news/images/2019/RR5%20jacobs-day2-6.jpg?h=d3e04ee7&amp;itok=Ncg_3Ceu 1x" media="all and (min-width: 1601px) and (max-width: 1920px)" type="image/jpeg" width="754" height="503"> <source srcset="/files/styles/multiple_ct_header_desktop/public/news/images/2019/RR5%20jacobs-day2-6.jpg?h=d3e04ee7&amp;itok=f5c-iarN 1x" media="all and (min-width: 1340px) and (max-width: 1600px)" type="image/jpeg" width="736" height="520"> <source srcset="/files/styles/multiple_ct_header_laptop/public/news/images/2019/RR5%20jacobs-day2-6.jpg?h=d3e04ee7&amp;itok=UZSzLyHJ 1x" media="all and (min-width: 800px) and (max-width: 1339px)" type="image/jpeg" width="641" height="451"> <source srcset="/files/styles/multiple_ct_header_tablet/public/news/images/2019/RR5%20jacobs-day2-6.jpg?h=d3e04ee7&amp;itok=dy9wqbrU 1x" media="all and (min-width: 540px) and (max-width: 799px)" type="image/jpeg" width="706" height="417"> <source srcset="/files/styles/multiple_ct_header_phone/public/news/images/2019/RR5%20jacobs-day2-6.jpg?h=d3e04ee7&amp;itok=ZmunmdGq 1x" media="all and (max-width: 539px)" type="image/jpeg" width="499" height="294"> <img loading="eager" width="499" height="294" src="/files/styles/multiple_ct_header_phone/public/news/images/2019/RR5%20jacobs-day2-6.jpg?h=d3e04ee7&amp;itok=ZmunmdGq" alt="Erik Jacobs" typeof="foaf:Image"> </picture> </div> <div class="media-caption"> <div class="media-caption__credit"> Credit: Erik Jacobs </div> <div class="media-caption__description"> </div> </div> </article> </div> </div> </div> </div> </div> </div> <div class="content-section content-section_with-sidebars container"> <div class="row"> <div class="content-section__left col-2"> <div class="block block-better-social-sharing-buttons block-social-sharing-buttons-block"> <div style="display: none"><link rel="preload" href="/modules/contrib/better_social_sharing_buttons/assets/dist/sprites/social-icons--no-color.svg" as="image" type="image/svg+xml" crossorigin="anonymous"></div> <div class="social-sharing-buttons"> <a href="https://www.facebook.com/sharer/sharer.php?u=/taxonomy/term/605/feed&amp;title=" target="_blank" title="Share to Facebook" aria-label="Share to Facebook" class="social-sharing-buttons-button share-facebook" rel="noopener"> <svg aria-hidden="true" width="32px" height="32px" style="border-radius:100%;"> <use href="/modules/contrib/better_social_sharing_buttons/assets/dist/sprites/social-icons--no-color.svg#facebook" /> </svg> </a> <a href="https://twitter.com/intent/tweet?text=+/taxonomy/term/605/feed" target="_blank" title="Share to X" aria-label="Share to X" class="social-sharing-buttons-button share-x" rel="noopener"> <svg aria-hidden="true" width="32px" height="32px" style="border-radius:100%;"> <use href="/modules/contrib/better_social_sharing_buttons/assets/dist/sprites/social-icons--no-color.svg#x" /> </svg> </a> <a href="mailto:?subject=&amp;body=/taxonomy/term/605/feed" title="Share to Email" aria-label="Share to Email" class="social-sharing-buttons-button share-email" target="_blank" rel="noopener"> <svg aria-hidden="true" width="32px" height="32px" style="border-radius:100%;"> <use href="/modules/contrib/better_social_sharing_buttons/assets/dist/sprites/social-icons--no-color.svg#email" /> </svg> </a> </div> </div> </div> <div class="content-section__main col-8"> <div class="block block-layout-builder block-field-blocknodenewsbody"> <div class="clearfix text-formatted field field--name-body field--type-text-with-summary field--label-hidden field__item"><p>Welcome to the April 12, 2019 installment of&nbsp;<a href="/search?keywords=research+roundup&amp;op=Search">Research Roundup</a>, a recurring snapshot of recent studies published by scientists at the Ó³»­´«Ã½ and their collaborators.</p> <h3>Clear view of cancer’s iron-dependent cell death</h3> <p dir="ltr"><span id="docs-internal-guid-6d4934a1-7fff-b791-e8ec-d6049fec4780">Clear-cell carcinomas (CCCs), which are often resistant to anti-cancer therapies, have a unique metabolic state that remains to be targeted therapeutically. A team led by postdoctoral scholar Yilong Zou and </span>core institute member <a href="/node/7596/">Stuart Schreiber</a> in the <a href="/node/12551/">Chemical Biology and Therapeutics Science Program</a> mined data from the Cancer Therapeutics Response Portal, and found that CCC cells are dependent upon glutathione peroxidase 4 (GPX4) and are prone to undergo ferroptosis, an iron-dependent, non-apoptotic cell death. By combining genome-wide CRISPR screening and lipidomic profiling, they discovered that GPX4-dependency in CCC cells is driven by the HIF-1/2α - HILPDA axis via enrichment of polyunsaturated lipids. Described in <em><a href="https://www.nature.com/articles/s41467-019-09277-9" target="_blank">Nature Communications</a></em>, the findings shed light on the ferroptosis pathway and suggest novel treatment avenues for CCC patients.</p> <h3>Mutations in microbes explain multi-drug resistance</h3> <p dir="ltr"><span id="docs-internal-guid-6d4934a1-7fff-b791-e8ec-d6049fec4780">Hospital-acquired infections are often antibiotic-resistant and difficult to control. Associate member Michael Gilmore, postdoctoral scholar Daria Van Tyne, group leader Abby Manson, institute scientist </span><a href="/node/7414">Ashlee Earl</a> and colleagues from the <a href="/node/8543">Infectious Disease and Microbiome Program</a> examined the genomes of archived Enterococcus faecalis bacteria, which caused one of the first sustained hospital outbreaks of a multidrug-resistant infection from the early- to mid-1980s. Reporting in <em><a href="https://stm.sciencemag.org/content/11/487/eaat8418" target="_blank">Science Translational Medicine</a></em>, the team identified mutations in the bacteria that emerged as they caused infections over four years. The mutations help explain how the microbes outsmart the immune system and resist treatment, and suggest new targets for the next generation of antibiotics. Read more in <em><a href="https://www.theatlantic.com/science/archive/2019/04/gut-bacteria-outbreak/586780/" target="_blank">The Atlantic</a></em> and <a href="https://www.genomeweb.com/sequencing/genomic-study-uncovers-human-bloodstream-infection-adaptations-historical-hospital#.XLCcNOtKhTZ" target="_blank">GenomeWeb</a>.</p> <h3>A vulnerability spanning many cancers</h3> <p dir="ltr"><span id="docs-internal-guid-6d4934a1-7fff-b791-e8ec-d6049fec4780">A large number of colorectal, gastric, ovarian, and endometrial cancers share a mutation pattern called microsatellite instability (MSI). Postdoctoral scholar Edmond Chan, research scientist Tsukasa Shibue, </span><a href="https://depmap.org/portal/depmap/" target="_blank">the Cancer Dependency Map (DepMap) project</a>’s associate director <a href="/node/9001/">Francisca Vazquez</a>, associate member Adam Bass of the <a href="/node/8529/">Cancer Program</a>, and other members of the DepMap team report in <em><a href="https://www.nature.com/articles/s41586-019-1102-x" target="_blank">Nature</a></em> that most MSI-harboring cell lines from these cancers depend on one gene, WRN, to survive and thrive — a discovery validated by <a href="https://www.nature.com/articles/s41586-019-1103-9" target="_blank">similar findings from the Wellcome Sanger Institute</a>. No drugs currently exist against this gene, but the two teams' data suggest that it should be an attractive target for therapeutic development. Learn more in <a href="/node/495166">a Ó³»­´«Ã½ news story</a>, <a href="https://www.fiercebiotech.com/research/using-crispr-to-identify-new-cancer-drug-target" target="_blank">FierceBiotech</a>, and <em><a href="https://www.nature.com/articles/d41586-019-01086-w" target="_blank">Nature News &amp; Views</a></em>.</p> <h3>Molecular clue to malignant brain tumor</h3> <p dir="ltr"><span id="docs-internal-guid-6d4934a1-7fff-b791-e8ec-d6049fec4780">Glioblastoma (GBM), a malignant brain tumor in adults, is one of the most aggressive cancers, with a median survival of around 15 months despite treatment. Tumor-associated macrophages (TAMs), a type of white blood cell, play an important role in the immune response to cancer ― the mechanism of which is not completely understood. A team led by associate member Francisco Quintana of the </span><a href="/node/8539">Metabolomics Platform</a> found that kynurenine, a metabolite produced by GBM cells, participates in the control of TAMs by activating AHR, a protein that controls gene expression. These findings, published in <em><a href="https://www.nature.com/articles/s41593-019-0370-y" target="_blank">Nature Neuroscience</a></em> confirm that AHR expression in TAMs regulates the immune response in GBM, suggesting &nbsp;a target for future therapeutic interventions.</p> <p><em>To learn more about research conducted at the Ó³»­´«Ã½, visit&nbsp;</em><a href="/publications"><em>broadinstitute.org/publications</em></a><em>, and keep an eye on&nbsp;</em><a href="/news"><em>broadinstitute.org/news</em></a><em>.</em></p> </div> </div> <div class="block-node-broad-tags block block-layout-builder block-field-blocknodenewsfield-broad-tags"> <div class="block-node-broad-tags__row"> <div class="block-node-broad-tags__title">Tags:</div> <div class="field field--name-field-broad-tags field--type-entity-reference field--label-hidden field__items"> <div class="field__item"><a href="/broad-tags/cancer-program" hreflang="en">Cancer Program</a></div> <div class="field__item"><a href="/broad-tags/chemical-biology-and-therapeutics-science" hreflang="en">Chemical Biology and Therapeutics Science Program</a></div> <div class="field__item"><a href="/broad-tags/metabolomics-platform" hreflang="en">Metabolomics Platform</a></div> <div class="field__item"><a href="/broad-tags/infectious-disease-and-microbiome-0" hreflang="en">Infectious Disease and Microbiome Program</a></div> <div class="field__item"><a href="/broad-tags/schreiber-lab" hreflang="en">Schreiber Lab</a></div> <div class="field__item"><a href="/broad-tags/cancer" hreflang="en">Cancer</a></div> <div class="field__item"><a href="/broad-tags/stuart-schreiber" hreflang="en">Stuart Schreiber</a></div> <div class="field__item"><a href="/broad-tags/infectious-disease-and-microbiome" hreflang="en">Infectious Disease and Microbiome</a></div> </div> </div> </div> </div> <div class="content-section__right col-2"> <div class="block block-ctools block-entity-viewnode"> <article about="/news/research-roundup-april-12-2019" class="node node--type-news node--promoted node--view-mode-sidebar"> <div class="node__content"> <div class="sidebar-group"> <div class="sidebar-group__content"> <div class="block block-layout-builder block-field-blocknodenewsfield-news-extra-info"> <div class="clearfix text-formatted field field--name-field-news-extra-info field--type-text-long field--label-hidden field__item"><h2>Related People</h2> <p><a href="/node/7596/" target="_blank">Stuart Schreiber</a></p> <p dir="ltr"><span id="docs-internal-guid-5a13f6bc-7fff-a0d5-660f-f235d2d4cf9b"><a href="/node/7414" target="_blank">Ashlee Earl</a></span></p> <p dir="ltr"><span id="docs-internal-guid-5a13f6bc-7fff-a0d5-660f-f235d2d4cf9b"><a href="/node/9001/" target="_blank">Francisca Vazquez</a></span></p> <h2>Related Programs</h2> <p><a href="/node/8529/" target="_blank">Cancer Program</a></p> <p><a href="https://depmap.org/portal/" target="_blank">Cancer Dependency Map</a></p> <p><a href="/node/12551/" target="_blank">Chemical Biology and Therapeutics Science Program</a></p> <p><span id="docs-internal-guid-d325902e-7fff-72bc-d5ff-4a1567247717"><a href="/node/8543" target="_blank">Infectious Disease and Microbiome Program</a></span></p> <p><span id="docs-internal-guid-55c5badc-7fff-c400-6744-0ad65215e160"><a href="/node/8539" target="_blank">Metabolomics Platform</a></span></p> <h2>Related News</h2> <div><span id="docs-internal-guid-a576c0f8-7fff-cf3b-3c5f-bde51a405366"><a href="/node/495166" target="_blank">Loss of a DNA repair system creates a unique vulnerability in many cancer types</a></span></div> </div> </div> </div> </div> </div> </article> </div> </div> </div> </div> Fri, 12 Apr 2019 16:22:32 +0000 tulrich@broadinstitute.org 495886 at /scientific-community/software/malaria-therapeutics-response-portal-mtrp <span class="field field--name-title field--type-string field--label-hidden"><h1>Research Roundup: April 12, 2019</h1> </span> <span class="field field--name-uid field--type-entity-reference field--label-hidden"> <span>By Tom Ulrich</span> </span> <span class="field field--name-created field--type-created field--label-hidden"><time datetime="2019-04-12T12:22:32-04:00" class="datetime">April 12, 2019</time> </span> <div class="hero-section container"> <div class="hero-section__row row"> <div class="hero-section__content hero-section__content_left col-6"> <div class="hero-section__breadcrumbs"> <div class="block block-layout-builder block-extra-field-blocknodenewsbreadcrumbs"> <nav class="breadcrumb" role="navigation" aria-labelledby="system-breadcrumb"> <h2 id="system-breadcrumb" class="visually-hidden">Breadcrumb</h2> <ol> <li> <a href="/">Home</a> </li> <li> <a href="/news">News</a> </li> </ol> </nav> </div> </div> <div class="hero-section__title"> <div class="block block-layout-builder block-field-blocknodenewstitle"> <span class="field field--name-title field--type-string field--label-hidden"><h1>Research Roundup: April 12, 2019</h1> </span> </div> </div> <div class="hero-section__description"> <div class="block block-layout-builder block-field-blocknodenewsbody"> <div class="clearfix text-formatted field field--name-body field--type-text-with-summary field--label-hidden field__item"><div class="summary-only"> <p><span id="docs-internal-guid-3fe5f155-7fff-e0f9-9ffb-9d189ac78a32">Molecular clues to microbes and multiple cancers.</span></p> </div> </div> </div> </div> <div class="hero-section__author"> <div class="block block-layout-builder block-extra-field-blocknodenewsextra-field-author-custom"> By Ó³»­´«Ã½ Communications </div> </div> <div class="hero-section__date"> <div class="block block-layout-builder block-field-blocknodenewscreated"> <span class="field field--name-created field--type-created field--label-hidden"><time datetime="2019-04-12T12:22:32-04:00" class="datetime">April 12, 2019</time> </span> </div> </div> </div> <div class="hero-section__right col-6"> <div class="hero-section__image"> <div class="block block-layout-builder block-field-blocknodenewsfield-image"> <div class="field field--name-field-image field--type-entity-reference field--label-hidden field__item"> <article class="media media--type-image media--view-mode-multiple-content-types-header"> <div class="field field--name-field-media-image field--type-image field--label-hidden field__item"> <picture> <source srcset="/files/styles/multiple_ct_header_desktop_xl/public/news/images/2019/RR5%20jacobs-day2-6.jpg?h=d3e04ee7&amp;itok=Ncg_3Ceu 1x" media="all and (min-width: 1921px)" type="image/jpeg" width="754" height="503"> <source srcset="/files/styles/multiple_ct_header_desktop_xl/public/news/images/2019/RR5%20jacobs-day2-6.jpg?h=d3e04ee7&amp;itok=Ncg_3Ceu 1x" media="all and (min-width: 1601px) and (max-width: 1920px)" type="image/jpeg" width="754" height="503"> <source srcset="/files/styles/multiple_ct_header_desktop/public/news/images/2019/RR5%20jacobs-day2-6.jpg?h=d3e04ee7&amp;itok=f5c-iarN 1x" media="all and (min-width: 1340px) and (max-width: 1600px)" type="image/jpeg" width="736" height="520"> <source srcset="/files/styles/multiple_ct_header_laptop/public/news/images/2019/RR5%20jacobs-day2-6.jpg?h=d3e04ee7&amp;itok=UZSzLyHJ 1x" media="all and (min-width: 800px) and (max-width: 1339px)" type="image/jpeg" width="641" height="451"> <source srcset="/files/styles/multiple_ct_header_tablet/public/news/images/2019/RR5%20jacobs-day2-6.jpg?h=d3e04ee7&amp;itok=dy9wqbrU 1x" media="all and (min-width: 540px) and (max-width: 799px)" type="image/jpeg" width="706" height="417"> <source srcset="/files/styles/multiple_ct_header_phone/public/news/images/2019/RR5%20jacobs-day2-6.jpg?h=d3e04ee7&amp;itok=ZmunmdGq 1x" media="all and (max-width: 539px)" type="image/jpeg" width="499" height="294"> <img loading="eager" width="499" height="294" src="/files/styles/multiple_ct_header_phone/public/news/images/2019/RR5%20jacobs-day2-6.jpg?h=d3e04ee7&amp;itok=ZmunmdGq" alt="Erik Jacobs" typeof="foaf:Image"> </picture> </div> <div class="media-caption"> <div class="media-caption__credit"> Credit: Erik Jacobs </div> <div class="media-caption__description"> </div> </div> </article> </div> </div> </div> </div> </div> </div> <div class="content-section content-section_with-sidebars container"> <div class="row"> <div class="content-section__left col-2"> <div class="block block-better-social-sharing-buttons block-social-sharing-buttons-block"> <div style="display: none"><link rel="preload" href="/modules/contrib/better_social_sharing_buttons/assets/dist/sprites/social-icons--no-color.svg" as="image" type="image/svg+xml" crossorigin="anonymous"></div> <div class="social-sharing-buttons"> <a href="https://www.facebook.com/sharer/sharer.php?u=/taxonomy/term/605/feed&amp;title=" target="_blank" title="Share to Facebook" aria-label="Share to Facebook" class="social-sharing-buttons-button share-facebook" rel="noopener"> <svg aria-hidden="true" width="32px" height="32px" style="border-radius:100%;"> <use 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class="block block-layout-builder block-field-blocknodenewsbody"> <div class="clearfix text-formatted field field--name-body field--type-text-with-summary field--label-hidden field__item"><p>Welcome to the April 12, 2019 installment of&nbsp;<a href="/search?keywords=research+roundup&amp;op=Search">Research Roundup</a>, a recurring snapshot of recent studies published by scientists at the Ó³»­´«Ã½ and their collaborators.</p> <h3>Clear view of cancer’s iron-dependent cell death</h3> <p dir="ltr"><span id="docs-internal-guid-6d4934a1-7fff-b791-e8ec-d6049fec4780">Clear-cell carcinomas (CCCs), which are often resistant to anti-cancer therapies, have a unique metabolic state that remains to be targeted therapeutically. A team led by postdoctoral scholar Yilong Zou and </span>core institute member <a href="/node/7596/">Stuart Schreiber</a> in the <a href="/node/12551/">Chemical Biology and Therapeutics Science Program</a> mined data from the Cancer Therapeutics Response Portal, and found that CCC cells are dependent upon glutathione peroxidase 4 (GPX4) and are prone to undergo ferroptosis, an iron-dependent, non-apoptotic cell death. By combining genome-wide CRISPR screening and lipidomic profiling, they discovered that GPX4-dependency in CCC cells is driven by the HIF-1/2α - HILPDA axis via enrichment of polyunsaturated lipids. Described in <em><a href="https://www.nature.com/articles/s41467-019-09277-9" target="_blank">Nature Communications</a></em>, the findings shed light on the ferroptosis pathway and suggest novel treatment avenues for CCC patients.</p> <h3>Mutations in microbes explain multi-drug resistance</h3> <p dir="ltr"><span id="docs-internal-guid-6d4934a1-7fff-b791-e8ec-d6049fec4780">Hospital-acquired infections are often antibiotic-resistant and difficult to control. Associate member Michael Gilmore, postdoctoral scholar Daria Van Tyne, group leader Abby Manson, institute scientist </span><a href="/node/7414">Ashlee Earl</a> and colleagues from the <a href="/node/8543">Infectious Disease and Microbiome Program</a> examined the genomes of archived Enterococcus faecalis bacteria, which caused one of the first sustained hospital outbreaks of a multidrug-resistant infection from the early- to mid-1980s. Reporting in <em><a href="https://stm.sciencemag.org/content/11/487/eaat8418" target="_blank">Science Translational Medicine</a></em>, the team identified mutations in the bacteria that emerged as they caused infections over four years. The mutations help explain how the microbes outsmart the immune system and resist treatment, and suggest new targets for the next generation of antibiotics. Read more in <em><a href="https://www.theatlantic.com/science/archive/2019/04/gut-bacteria-outbreak/586780/" target="_blank">The Atlantic</a></em> and <a href="https://www.genomeweb.com/sequencing/genomic-study-uncovers-human-bloodstream-infection-adaptations-historical-hospital#.XLCcNOtKhTZ" target="_blank">GenomeWeb</a>.</p> <h3>A vulnerability spanning many cancers</h3> <p dir="ltr"><span id="docs-internal-guid-6d4934a1-7fff-b791-e8ec-d6049fec4780">A large number of colorectal, gastric, ovarian, and endometrial cancers share a mutation pattern called microsatellite instability (MSI). Postdoctoral scholar Edmond Chan, research scientist Tsukasa Shibue, </span><a href="https://depmap.org/portal/depmap/" target="_blank">the Cancer Dependency Map (DepMap) project</a>’s associate director <a href="/node/9001/">Francisca Vazquez</a>, associate member Adam Bass of the <a href="/node/8529/">Cancer Program</a>, and other members of the DepMap team report in <em><a href="https://www.nature.com/articles/s41586-019-1102-x" target="_blank">Nature</a></em> that most MSI-harboring cell lines from these cancers depend on one gene, WRN, to survive and thrive — a discovery validated by <a href="https://www.nature.com/articles/s41586-019-1103-9" target="_blank">similar findings from the Wellcome Sanger Institute</a>. No drugs currently exist against this gene, but the two teams' data suggest that it should be an attractive target for therapeutic development. Learn more in <a href="/node/495166">a Ó³»­´«Ã½ news story</a>, <a href="https://www.fiercebiotech.com/research/using-crispr-to-identify-new-cancer-drug-target" target="_blank">FierceBiotech</a>, and <em><a href="https://www.nature.com/articles/d41586-019-01086-w" target="_blank">Nature News &amp; Views</a></em>.</p> <h3>Molecular clue to malignant brain tumor</h3> <p dir="ltr"><span id="docs-internal-guid-6d4934a1-7fff-b791-e8ec-d6049fec4780">Glioblastoma (GBM), a malignant brain tumor in adults, is one of the most aggressive cancers, with a median survival of around 15 months despite treatment. Tumor-associated macrophages (TAMs), a type of white blood cell, play an important role in the immune response to cancer ― the mechanism of which is not completely understood. A team led by associate member Francisco Quintana of the </span><a href="/node/8539">Metabolomics Platform</a> found that kynurenine, a metabolite produced by GBM cells, participates in the control of TAMs by activating AHR, a protein that controls gene expression. These findings, published in <em><a href="https://www.nature.com/articles/s41593-019-0370-y" target="_blank">Nature Neuroscience</a></em> confirm that AHR expression in TAMs regulates the immune response in GBM, suggesting &nbsp;a target for future therapeutic interventions.</p> <p><em>To learn more about research conducted at the Ó³»­´«Ã½, visit&nbsp;</em><a href="/publications"><em>broadinstitute.org/publications</em></a><em>, and keep an eye on&nbsp;</em><a href="/news"><em>broadinstitute.org/news</em></a><em>.</em></p> </div> </div> <div class="block-node-broad-tags block block-layout-builder block-field-blocknodenewsfield-broad-tags"> <div class="block-node-broad-tags__row"> <div class="block-node-broad-tags__title">Tags:</div> <div class="field field--name-field-broad-tags field--type-entity-reference field--label-hidden field__items"> <div class="field__item"><a href="/broad-tags/cancer-program" hreflang="en">Cancer Program</a></div> <div class="field__item"><a href="/broad-tags/chemical-biology-and-therapeutics-science" hreflang="en">Chemical Biology and Therapeutics Science Program</a></div> <div class="field__item"><a href="/broad-tags/metabolomics-platform" hreflang="en">Metabolomics Platform</a></div> <div class="field__item"><a href="/broad-tags/infectious-disease-and-microbiome-0" hreflang="en">Infectious Disease and Microbiome Program</a></div> <div class="field__item"><a href="/broad-tags/schreiber-lab" hreflang="en">Schreiber Lab</a></div> <div class="field__item"><a href="/broad-tags/cancer" hreflang="en">Cancer</a></div> <div class="field__item"><a href="/broad-tags/stuart-schreiber" hreflang="en">Stuart Schreiber</a></div> <div class="field__item"><a href="/broad-tags/infectious-disease-and-microbiome" hreflang="en">Infectious Disease and Microbiome</a></div> </div> </div> </div> </div> <div class="content-section__right col-2"> <div class="block block-ctools block-entity-viewnode"> <article about="/news/research-roundup-april-12-2019" class="node node--type-news node--promoted node--view-mode-sidebar"> <div class="node__content"> <div class="sidebar-group"> <div class="sidebar-group__content"> <div class="block block-layout-builder block-field-blocknodenewsfield-news-extra-info"> <div class="clearfix text-formatted field field--name-field-news-extra-info field--type-text-long field--label-hidden field__item"><h2>Related People</h2> <p><a href="/node/7596/" target="_blank">Stuart Schreiber</a></p> <p dir="ltr"><span id="docs-internal-guid-5a13f6bc-7fff-a0d5-660f-f235d2d4cf9b"><a href="/node/7414" target="_blank">Ashlee Earl</a></span></p> <p dir="ltr"><span id="docs-internal-guid-5a13f6bc-7fff-a0d5-660f-f235d2d4cf9b"><a href="/node/9001/" target="_blank">Francisca Vazquez</a></span></p> <h2>Related Programs</h2> <p><a href="/node/8529/" target="_blank">Cancer Program</a></p> <p><a href="https://depmap.org/portal/" target="_blank">Cancer Dependency Map</a></p> <p><a href="/node/12551/" target="_blank">Chemical Biology and Therapeutics Science Program</a></p> <p><span id="docs-internal-guid-d325902e-7fff-72bc-d5ff-4a1567247717"><a href="/node/8543" target="_blank">Infectious Disease and Microbiome Program</a></span></p> <p><span id="docs-internal-guid-55c5badc-7fff-c400-6744-0ad65215e160"><a href="/node/8539" target="_blank">Metabolomics Platform</a></span></p> <h2>Related News</h2> <div><span id="docs-internal-guid-a576c0f8-7fff-cf3b-3c5f-bde51a405366"><a href="/node/495166" target="_blank">Loss of a DNA repair system creates a unique vulnerability in many cancer types</a></span></div> </div> </div> </div> </div> </div> </article> </div> </div> </div> </div> Thu, 04 May 2017 15:34:42 +0000 mnemchuk@broadinstitute.org 28606 at /scientific-community/data/molecular-library-program-mlp-profiling-data <span class="field field--name-title field--type-string field--label-hidden"><h1>Research Roundup: April 12, 2019</h1> </span> <span class="field field--name-uid field--type-entity-reference field--label-hidden"> <span>By Tom Ulrich</span> </span> <span class="field field--name-created field--type-created field--label-hidden"><time datetime="2019-04-12T12:22:32-04:00" class="datetime">April 12, 2019</time> </span> <div class="hero-section container"> <div class="hero-section__row row"> <div class="hero-section__content hero-section__content_left col-6"> <div class="hero-section__breadcrumbs"> <div class="block block-layout-builder block-extra-field-blocknodenewsbreadcrumbs"> <nav class="breadcrumb" role="navigation" aria-labelledby="system-breadcrumb"> <h2 id="system-breadcrumb" class="visually-hidden">Breadcrumb</h2> <ol> <li> <a href="/">Home</a> </li> <li> <a href="/news">News</a> </li> </ol> </nav> </div> </div> <div class="hero-section__title"> <div class="block block-layout-builder block-field-blocknodenewstitle"> <span class="field field--name-title field--type-string field--label-hidden"><h1>Research Roundup: April 12, 2019</h1> </span> </div> </div> <div class="hero-section__description"> <div class="block block-layout-builder block-field-blocknodenewsbody"> <div class="clearfix text-formatted field field--name-body field--type-text-with-summary field--label-hidden field__item"><div class="summary-only"> <p><span id="docs-internal-guid-3fe5f155-7fff-e0f9-9ffb-9d189ac78a32">Molecular clues to microbes and multiple cancers.</span></p> </div> </div> </div> </div> <div class="hero-section__author"> <div class="block block-layout-builder block-extra-field-blocknodenewsextra-field-author-custom"> By Ó³»­´«Ã½ Communications </div> </div> <div class="hero-section__date"> <div class="block block-layout-builder block-field-blocknodenewscreated"> <span class="field field--name-created field--type-created field--label-hidden"><time datetime="2019-04-12T12:22:32-04:00" class="datetime">April 12, 2019</time> </span> </div> </div> </div> <div class="hero-section__right col-6"> <div class="hero-section__image"> <div class="block block-layout-builder block-field-blocknodenewsfield-image"> <div class="field field--name-field-image field--type-entity-reference field--label-hidden field__item"> <article class="media media--type-image media--view-mode-multiple-content-types-header"> <div class="field field--name-field-media-image field--type-image field--label-hidden field__item"> <picture> <source srcset="/files/styles/multiple_ct_header_desktop_xl/public/news/images/2019/RR5%20jacobs-day2-6.jpg?h=d3e04ee7&amp;itok=Ncg_3Ceu 1x" media="all and (min-width: 1921px)" type="image/jpeg" width="754" height="503"> <source srcset="/files/styles/multiple_ct_header_desktop_xl/public/news/images/2019/RR5%20jacobs-day2-6.jpg?h=d3e04ee7&amp;itok=Ncg_3Ceu 1x" media="all and (min-width: 1601px) and (max-width: 1920px)" type="image/jpeg" width="754" height="503"> <source srcset="/files/styles/multiple_ct_header_desktop/public/news/images/2019/RR5%20jacobs-day2-6.jpg?h=d3e04ee7&amp;itok=f5c-iarN 1x" media="all and (min-width: 1340px) and (max-width: 1600px)" type="image/jpeg" width="736" height="520"> <source srcset="/files/styles/multiple_ct_header_laptop/public/news/images/2019/RR5%20jacobs-day2-6.jpg?h=d3e04ee7&amp;itok=UZSzLyHJ 1x" media="all and (min-width: 800px) and (max-width: 1339px)" type="image/jpeg" width="641" height="451"> <source srcset="/files/styles/multiple_ct_header_tablet/public/news/images/2019/RR5%20jacobs-day2-6.jpg?h=d3e04ee7&amp;itok=dy9wqbrU 1x" media="all and (min-width: 540px) and (max-width: 799px)" type="image/jpeg" width="706" height="417"> <source srcset="/files/styles/multiple_ct_header_phone/public/news/images/2019/RR5%20jacobs-day2-6.jpg?h=d3e04ee7&amp;itok=ZmunmdGq 1x" media="all and (max-width: 539px)" type="image/jpeg" width="499" height="294"> <img loading="eager" width="499" height="294" src="/files/styles/multiple_ct_header_phone/public/news/images/2019/RR5%20jacobs-day2-6.jpg?h=d3e04ee7&amp;itok=ZmunmdGq" alt="Erik Jacobs" typeof="foaf:Image"> </picture> </div> <div class="media-caption"> <div class="media-caption__credit"> Credit: Erik Jacobs </div> <div class="media-caption__description"> </div> </div> </article> </div> </div> </div> </div> </div> </div> <div class="content-section content-section_with-sidebars container"> <div class="row"> <div class="content-section__left col-2"> <div class="block block-better-social-sharing-buttons block-social-sharing-buttons-block"> <div style="display: none"><link rel="preload" href="/modules/contrib/better_social_sharing_buttons/assets/dist/sprites/social-icons--no-color.svg" as="image" type="image/svg+xml" crossorigin="anonymous"></div> <div class="social-sharing-buttons"> <a href="https://www.facebook.com/sharer/sharer.php?u=/taxonomy/term/605/feed&amp;title=" target="_blank" title="Share to Facebook" aria-label="Share to Facebook" class="social-sharing-buttons-button share-facebook" rel="noopener"> <svg aria-hidden="true" width="32px" height="32px" style="border-radius:100%;"> <use 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class="block block-layout-builder block-field-blocknodenewsbody"> <div class="clearfix text-formatted field field--name-body field--type-text-with-summary field--label-hidden field__item"><p>Welcome to the April 12, 2019 installment of&nbsp;<a href="/search?keywords=research+roundup&amp;op=Search">Research Roundup</a>, a recurring snapshot of recent studies published by scientists at the Ó³»­´«Ã½ and their collaborators.</p> <h3>Clear view of cancer’s iron-dependent cell death</h3> <p dir="ltr"><span id="docs-internal-guid-6d4934a1-7fff-b791-e8ec-d6049fec4780">Clear-cell carcinomas (CCCs), which are often resistant to anti-cancer therapies, have a unique metabolic state that remains to be targeted therapeutically. A team led by postdoctoral scholar Yilong Zou and </span>core institute member <a href="/node/7596/">Stuart Schreiber</a> in the <a href="/node/12551/">Chemical Biology and Therapeutics Science Program</a> mined data from the Cancer Therapeutics Response Portal, and found that CCC cells are dependent upon glutathione peroxidase 4 (GPX4) and are prone to undergo ferroptosis, an iron-dependent, non-apoptotic cell death. By combining genome-wide CRISPR screening and lipidomic profiling, they discovered that GPX4-dependency in CCC cells is driven by the HIF-1/2α - HILPDA axis via enrichment of polyunsaturated lipids. Described in <em><a href="https://www.nature.com/articles/s41467-019-09277-9" target="_blank">Nature Communications</a></em>, the findings shed light on the ferroptosis pathway and suggest novel treatment avenues for CCC patients.</p> <h3>Mutations in microbes explain multi-drug resistance</h3> <p dir="ltr"><span id="docs-internal-guid-6d4934a1-7fff-b791-e8ec-d6049fec4780">Hospital-acquired infections are often antibiotic-resistant and difficult to control. Associate member Michael Gilmore, postdoctoral scholar Daria Van Tyne, group leader Abby Manson, institute scientist </span><a href="/node/7414">Ashlee Earl</a> and colleagues from the <a href="/node/8543">Infectious Disease and Microbiome Program</a> examined the genomes of archived Enterococcus faecalis bacteria, which caused one of the first sustained hospital outbreaks of a multidrug-resistant infection from the early- to mid-1980s. Reporting in <em><a href="https://stm.sciencemag.org/content/11/487/eaat8418" target="_blank">Science Translational Medicine</a></em>, the team identified mutations in the bacteria that emerged as they caused infections over four years. The mutations help explain how the microbes outsmart the immune system and resist treatment, and suggest new targets for the next generation of antibiotics. Read more in <em><a href="https://www.theatlantic.com/science/archive/2019/04/gut-bacteria-outbreak/586780/" target="_blank">The Atlantic</a></em> and <a href="https://www.genomeweb.com/sequencing/genomic-study-uncovers-human-bloodstream-infection-adaptations-historical-hospital#.XLCcNOtKhTZ" target="_blank">GenomeWeb</a>.</p> <h3>A vulnerability spanning many cancers</h3> <p dir="ltr"><span id="docs-internal-guid-6d4934a1-7fff-b791-e8ec-d6049fec4780">A large number of colorectal, gastric, ovarian, and endometrial cancers share a mutation pattern called microsatellite instability (MSI). Postdoctoral scholar Edmond Chan, research scientist Tsukasa Shibue, </span><a href="https://depmap.org/portal/depmap/" target="_blank">the Cancer Dependency Map (DepMap) project</a>’s associate director <a href="/node/9001/">Francisca Vazquez</a>, associate member Adam Bass of the <a href="/node/8529/">Cancer Program</a>, and other members of the DepMap team report in <em><a href="https://www.nature.com/articles/s41586-019-1102-x" target="_blank">Nature</a></em> that most MSI-harboring cell lines from these cancers depend on one gene, WRN, to survive and thrive — a discovery validated by <a href="https://www.nature.com/articles/s41586-019-1103-9" target="_blank">similar findings from the Wellcome Sanger Institute</a>. No drugs currently exist against this gene, but the two teams' data suggest that it should be an attractive target for therapeutic development. Learn more in <a href="/node/495166">a Ó³»­´«Ã½ news story</a>, <a href="https://www.fiercebiotech.com/research/using-crispr-to-identify-new-cancer-drug-target" target="_blank">FierceBiotech</a>, and <em><a href="https://www.nature.com/articles/d41586-019-01086-w" target="_blank">Nature News &amp; Views</a></em>.</p> <h3>Molecular clue to malignant brain tumor</h3> <p dir="ltr"><span id="docs-internal-guid-6d4934a1-7fff-b791-e8ec-d6049fec4780">Glioblastoma (GBM), a malignant brain tumor in adults, is one of the most aggressive cancers, with a median survival of around 15 months despite treatment. Tumor-associated macrophages (TAMs), a type of white blood cell, play an important role in the immune response to cancer ― the mechanism of which is not completely understood. A team led by associate member Francisco Quintana of the </span><a href="/node/8539">Metabolomics Platform</a> found that kynurenine, a metabolite produced by GBM cells, participates in the control of TAMs by activating AHR, a protein that controls gene expression. These findings, published in <em><a href="https://www.nature.com/articles/s41593-019-0370-y" target="_blank">Nature Neuroscience</a></em> confirm that AHR expression in TAMs regulates the immune response in GBM, suggesting &nbsp;a target for future therapeutic interventions.</p> <p><em>To learn more about research conducted at the Ó³»­´«Ã½, visit&nbsp;</em><a href="/publications"><em>broadinstitute.org/publications</em></a><em>, and keep an eye on&nbsp;</em><a href="/news"><em>broadinstitute.org/news</em></a><em>.</em></p> </div> </div> <div class="block-node-broad-tags block block-layout-builder block-field-blocknodenewsfield-broad-tags"> <div class="block-node-broad-tags__row"> <div class="block-node-broad-tags__title">Tags:</div> <div class="field field--name-field-broad-tags field--type-entity-reference field--label-hidden field__items"> <div class="field__item"><a href="/broad-tags/cancer-program" hreflang="en">Cancer Program</a></div> <div class="field__item"><a href="/broad-tags/chemical-biology-and-therapeutics-science" hreflang="en">Chemical Biology and Therapeutics Science Program</a></div> <div class="field__item"><a href="/broad-tags/metabolomics-platform" hreflang="en">Metabolomics Platform</a></div> <div class="field__item"><a href="/broad-tags/infectious-disease-and-microbiome-0" hreflang="en">Infectious Disease and Microbiome Program</a></div> <div class="field__item"><a href="/broad-tags/schreiber-lab" hreflang="en">Schreiber Lab</a></div> <div class="field__item"><a href="/broad-tags/cancer" hreflang="en">Cancer</a></div> <div class="field__item"><a href="/broad-tags/stuart-schreiber" hreflang="en">Stuart Schreiber</a></div> <div class="field__item"><a href="/broad-tags/infectious-disease-and-microbiome" hreflang="en">Infectious Disease and Microbiome</a></div> </div> </div> </div> </div> <div class="content-section__right col-2"> <div class="block block-ctools block-entity-viewnode"> <article about="/news/research-roundup-april-12-2019" class="node node--type-news node--promoted node--view-mode-sidebar"> <div class="node__content"> <div class="sidebar-group"> <div class="sidebar-group__content"> <div class="block block-layout-builder block-field-blocknodenewsfield-news-extra-info"> <div class="clearfix text-formatted field field--name-field-news-extra-info field--type-text-long field--label-hidden field__item"><h2>Related People</h2> <p><a href="/node/7596/" target="_blank">Stuart Schreiber</a></p> <p dir="ltr"><span id="docs-internal-guid-5a13f6bc-7fff-a0d5-660f-f235d2d4cf9b"><a href="/node/7414" target="_blank">Ashlee Earl</a></span></p> <p dir="ltr"><span id="docs-internal-guid-5a13f6bc-7fff-a0d5-660f-f235d2d4cf9b"><a href="/node/9001/" target="_blank">Francisca Vazquez</a></span></p> <h2>Related Programs</h2> <p><a href="/node/8529/" target="_blank">Cancer Program</a></p> <p><a href="https://depmap.org/portal/" target="_blank">Cancer Dependency Map</a></p> <p><a href="/node/12551/" target="_blank">Chemical Biology and Therapeutics Science Program</a></p> <p><span id="docs-internal-guid-d325902e-7fff-72bc-d5ff-4a1567247717"><a href="/node/8543" target="_blank">Infectious Disease and Microbiome Program</a></span></p> <p><span id="docs-internal-guid-55c5badc-7fff-c400-6744-0ad65215e160"><a href="/node/8539" target="_blank">Metabolomics Platform</a></span></p> <h2>Related News</h2> <div><span id="docs-internal-guid-a576c0f8-7fff-cf3b-3c5f-bde51a405366"><a href="/node/495166" target="_blank">Loss of a DNA repair system creates a unique vulnerability in many cancer types</a></span></div> </div> </div> </div> </div> </div> </article> </div> </div> </div> </div> Wed, 03 May 2017 21:37:56 +0000 mnemchuk@broadinstitute.org 28286 at /news/broad-researchers-join-signing-21st-century-cures-act <span class="field field--name-title field--type-string field--label-hidden"><h1>Research Roundup: April 12, 2019</h1> </span> <span class="field field--name-uid field--type-entity-reference field--label-hidden"> <span>By Tom Ulrich</span> </span> <span class="field field--name-created field--type-created field--label-hidden"><time datetime="2019-04-12T12:22:32-04:00" class="datetime">April 12, 2019</time> </span> <div class="hero-section container"> <div class="hero-section__row row"> <div class="hero-section__content hero-section__content_left col-6"> <div class="hero-section__breadcrumbs"> <div class="block block-layout-builder block-extra-field-blocknodenewsbreadcrumbs"> <nav class="breadcrumb" role="navigation" aria-labelledby="system-breadcrumb"> <h2 id="system-breadcrumb" class="visually-hidden">Breadcrumb</h2> <ol> <li> <a href="/">Home</a> </li> <li> <a href="/news">News</a> </li> </ol> </nav> </div> </div> <div class="hero-section__title"> <div class="block block-layout-builder block-field-blocknodenewstitle"> <span class="field field--name-title field--type-string field--label-hidden"><h1>Research Roundup: April 12, 2019</h1> </span> </div> </div> <div class="hero-section__description"> <div class="block block-layout-builder block-field-blocknodenewsbody"> <div class="clearfix text-formatted field field--name-body field--type-text-with-summary field--label-hidden field__item"><div class="summary-only"> <p><span id="docs-internal-guid-3fe5f155-7fff-e0f9-9ffb-9d189ac78a32">Molecular clues to microbes and multiple cancers.</span></p> </div> </div> </div> </div> <div class="hero-section__author"> <div class="block block-layout-builder block-extra-field-blocknodenewsextra-field-author-custom"> By Ó³»­´«Ã½ Communications </div> </div> <div class="hero-section__date"> <div class="block block-layout-builder block-field-blocknodenewscreated"> <span class="field field--name-created field--type-created field--label-hidden"><time datetime="2019-04-12T12:22:32-04:00" class="datetime">April 12, 2019</time> </span> </div> </div> </div> <div class="hero-section__right col-6"> <div class="hero-section__image"> <div class="block block-layout-builder block-field-blocknodenewsfield-image"> <div class="field field--name-field-image field--type-entity-reference field--label-hidden field__item"> <article class="media media--type-image media--view-mode-multiple-content-types-header"> <div class="field field--name-field-media-image field--type-image field--label-hidden field__item"> <picture> <source srcset="/files/styles/multiple_ct_header_desktop_xl/public/news/images/2019/RR5%20jacobs-day2-6.jpg?h=d3e04ee7&amp;itok=Ncg_3Ceu 1x" media="all and (min-width: 1921px)" type="image/jpeg" width="754" height="503"> <source srcset="/files/styles/multiple_ct_header_desktop_xl/public/news/images/2019/RR5%20jacobs-day2-6.jpg?h=d3e04ee7&amp;itok=Ncg_3Ceu 1x" media="all and (min-width: 1601px) and (max-width: 1920px)" type="image/jpeg" width="754" height="503"> <source srcset="/files/styles/multiple_ct_header_desktop/public/news/images/2019/RR5%20jacobs-day2-6.jpg?h=d3e04ee7&amp;itok=f5c-iarN 1x" media="all and (min-width: 1340px) and (max-width: 1600px)" type="image/jpeg" width="736" height="520"> <source srcset="/files/styles/multiple_ct_header_laptop/public/news/images/2019/RR5%20jacobs-day2-6.jpg?h=d3e04ee7&amp;itok=UZSzLyHJ 1x" media="all and (min-width: 800px) and (max-width: 1339px)" type="image/jpeg" width="641" height="451"> <source srcset="/files/styles/multiple_ct_header_tablet/public/news/images/2019/RR5%20jacobs-day2-6.jpg?h=d3e04ee7&amp;itok=dy9wqbrU 1x" media="all and (min-width: 540px) and (max-width: 799px)" type="image/jpeg" width="706" height="417"> <source srcset="/files/styles/multiple_ct_header_phone/public/news/images/2019/RR5%20jacobs-day2-6.jpg?h=d3e04ee7&amp;itok=ZmunmdGq 1x" media="all and (max-width: 539px)" type="image/jpeg" width="499" height="294"> <img loading="eager" width="499" height="294" src="/files/styles/multiple_ct_header_phone/public/news/images/2019/RR5%20jacobs-day2-6.jpg?h=d3e04ee7&amp;itok=ZmunmdGq" alt="Erik Jacobs" typeof="foaf:Image"> </picture> </div> <div class="media-caption"> <div class="media-caption__credit"> Credit: Erik Jacobs </div> <div class="media-caption__description"> </div> </div> </article> </div> </div> </div> </div> </div> </div> <div class="content-section content-section_with-sidebars container"> <div class="row"> <div class="content-section__left col-2"> <div class="block block-better-social-sharing-buttons block-social-sharing-buttons-block"> <div style="display: none"><link rel="preload" href="/modules/contrib/better_social_sharing_buttons/assets/dist/sprites/social-icons--no-color.svg" as="image" type="image/svg+xml" crossorigin="anonymous"></div> <div class="social-sharing-buttons"> <a href="https://www.facebook.com/sharer/sharer.php?u=/taxonomy/term/605/feed&amp;title=" target="_blank" title="Share to Facebook" aria-label="Share to Facebook" class="social-sharing-buttons-button share-facebook" rel="noopener"> <svg aria-hidden="true" width="32px" height="32px" style="border-radius:100%;"> <use 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class="block block-layout-builder block-field-blocknodenewsbody"> <div class="clearfix text-formatted field field--name-body field--type-text-with-summary field--label-hidden field__item"><p>Welcome to the April 12, 2019 installment of&nbsp;<a href="/search?keywords=research+roundup&amp;op=Search">Research Roundup</a>, a recurring snapshot of recent studies published by scientists at the Ó³»­´«Ã½ and their collaborators.</p> <h3>Clear view of cancer’s iron-dependent cell death</h3> <p dir="ltr"><span id="docs-internal-guid-6d4934a1-7fff-b791-e8ec-d6049fec4780">Clear-cell carcinomas (CCCs), which are often resistant to anti-cancer therapies, have a unique metabolic state that remains to be targeted therapeutically. A team led by postdoctoral scholar Yilong Zou and </span>core institute member <a href="/node/7596/">Stuart Schreiber</a> in the <a href="/node/12551/">Chemical Biology and Therapeutics Science Program</a> mined data from the Cancer Therapeutics Response Portal, and found that CCC cells are dependent upon glutathione peroxidase 4 (GPX4) and are prone to undergo ferroptosis, an iron-dependent, non-apoptotic cell death. By combining genome-wide CRISPR screening and lipidomic profiling, they discovered that GPX4-dependency in CCC cells is driven by the HIF-1/2α - HILPDA axis via enrichment of polyunsaturated lipids. Described in <em><a href="https://www.nature.com/articles/s41467-019-09277-9" target="_blank">Nature Communications</a></em>, the findings shed light on the ferroptosis pathway and suggest novel treatment avenues for CCC patients.</p> <h3>Mutations in microbes explain multi-drug resistance</h3> <p dir="ltr"><span id="docs-internal-guid-6d4934a1-7fff-b791-e8ec-d6049fec4780">Hospital-acquired infections are often antibiotic-resistant and difficult to control. Associate member Michael Gilmore, postdoctoral scholar Daria Van Tyne, group leader Abby Manson, institute scientist </span><a href="/node/7414">Ashlee Earl</a> and colleagues from the <a href="/node/8543">Infectious Disease and Microbiome Program</a> examined the genomes of archived Enterococcus faecalis bacteria, which caused one of the first sustained hospital outbreaks of a multidrug-resistant infection from the early- to mid-1980s. Reporting in <em><a href="https://stm.sciencemag.org/content/11/487/eaat8418" target="_blank">Science Translational Medicine</a></em>, the team identified mutations in the bacteria that emerged as they caused infections over four years. The mutations help explain how the microbes outsmart the immune system and resist treatment, and suggest new targets for the next generation of antibiotics. Read more in <em><a href="https://www.theatlantic.com/science/archive/2019/04/gut-bacteria-outbreak/586780/" target="_blank">The Atlantic</a></em> and <a href="https://www.genomeweb.com/sequencing/genomic-study-uncovers-human-bloodstream-infection-adaptations-historical-hospital#.XLCcNOtKhTZ" target="_blank">GenomeWeb</a>.</p> <h3>A vulnerability spanning many cancers</h3> <p dir="ltr"><span id="docs-internal-guid-6d4934a1-7fff-b791-e8ec-d6049fec4780">A large number of colorectal, gastric, ovarian, and endometrial cancers share a mutation pattern called microsatellite instability (MSI). Postdoctoral scholar Edmond Chan, research scientist Tsukasa Shibue, </span><a href="https://depmap.org/portal/depmap/" target="_blank">the Cancer Dependency Map (DepMap) project</a>’s associate director <a href="/node/9001/">Francisca Vazquez</a>, associate member Adam Bass of the <a href="/node/8529/">Cancer Program</a>, and other members of the DepMap team report in <em><a href="https://www.nature.com/articles/s41586-019-1102-x" target="_blank">Nature</a></em> that most MSI-harboring cell lines from these cancers depend on one gene, WRN, to survive and thrive — a discovery validated by <a href="https://www.nature.com/articles/s41586-019-1103-9" target="_blank">similar findings from the Wellcome Sanger Institute</a>. No drugs currently exist against this gene, but the two teams' data suggest that it should be an attractive target for therapeutic development. Learn more in <a href="/node/495166">a Ó³»­´«Ã½ news story</a>, <a href="https://www.fiercebiotech.com/research/using-crispr-to-identify-new-cancer-drug-target" target="_blank">FierceBiotech</a>, and <em><a href="https://www.nature.com/articles/d41586-019-01086-w" target="_blank">Nature News &amp; Views</a></em>.</p> <h3>Molecular clue to malignant brain tumor</h3> <p dir="ltr"><span id="docs-internal-guid-6d4934a1-7fff-b791-e8ec-d6049fec4780">Glioblastoma (GBM), a malignant brain tumor in adults, is one of the most aggressive cancers, with a median survival of around 15 months despite treatment. Tumor-associated macrophages (TAMs), a type of white blood cell, play an important role in the immune response to cancer ― the mechanism of which is not completely understood. A team led by associate member Francisco Quintana of the </span><a href="/node/8539">Metabolomics Platform</a> found that kynurenine, a metabolite produced by GBM cells, participates in the control of TAMs by activating AHR, a protein that controls gene expression. These findings, published in <em><a href="https://www.nature.com/articles/s41593-019-0370-y" target="_blank">Nature Neuroscience</a></em> confirm that AHR expression in TAMs regulates the immune response in GBM, suggesting &nbsp;a target for future therapeutic interventions.</p> <p><em>To learn more about research conducted at the Ó³»­´«Ã½, visit&nbsp;</em><a href="/publications"><em>broadinstitute.org/publications</em></a><em>, and keep an eye on&nbsp;</em><a href="/news"><em>broadinstitute.org/news</em></a><em>.</em></p> </div> </div> <div class="block-node-broad-tags block block-layout-builder block-field-blocknodenewsfield-broad-tags"> <div class="block-node-broad-tags__row"> <div class="block-node-broad-tags__title">Tags:</div> <div class="field field--name-field-broad-tags field--type-entity-reference field--label-hidden field__items"> <div class="field__item"><a href="/broad-tags/cancer-program" hreflang="en">Cancer Program</a></div> <div class="field__item"><a href="/broad-tags/chemical-biology-and-therapeutics-science" hreflang="en">Chemical Biology and Therapeutics Science Program</a></div> <div class="field__item"><a href="/broad-tags/metabolomics-platform" hreflang="en">Metabolomics Platform</a></div> <div class="field__item"><a href="/broad-tags/infectious-disease-and-microbiome-0" hreflang="en">Infectious Disease and Microbiome Program</a></div> <div class="field__item"><a href="/broad-tags/schreiber-lab" hreflang="en">Schreiber Lab</a></div> <div class="field__item"><a href="/broad-tags/cancer" hreflang="en">Cancer</a></div> <div class="field__item"><a href="/broad-tags/stuart-schreiber" hreflang="en">Stuart Schreiber</a></div> <div class="field__item"><a href="/broad-tags/infectious-disease-and-microbiome" hreflang="en">Infectious Disease and Microbiome</a></div> </div> </div> </div> </div> <div class="content-section__right col-2"> <div class="block block-ctools block-entity-viewnode"> <article about="/news/research-roundup-april-12-2019" class="node node--type-news node--promoted node--view-mode-sidebar"> <div class="node__content"> <div class="sidebar-group"> <div class="sidebar-group__content"> <div class="block block-layout-builder block-field-blocknodenewsfield-news-extra-info"> <div class="clearfix text-formatted field field--name-field-news-extra-info field--type-text-long field--label-hidden field__item"><h2>Related People</h2> <p><a href="/node/7596/" target="_blank">Stuart Schreiber</a></p> <p dir="ltr"><span id="docs-internal-guid-5a13f6bc-7fff-a0d5-660f-f235d2d4cf9b"><a href="/node/7414" target="_blank">Ashlee Earl</a></span></p> <p dir="ltr"><span id="docs-internal-guid-5a13f6bc-7fff-a0d5-660f-f235d2d4cf9b"><a href="/node/9001/" target="_blank">Francisca Vazquez</a></span></p> <h2>Related Programs</h2> <p><a href="/node/8529/" target="_blank">Cancer Program</a></p> <p><a href="https://depmap.org/portal/" target="_blank">Cancer Dependency Map</a></p> <p><a href="/node/12551/" target="_blank">Chemical Biology and Therapeutics Science Program</a></p> <p><span id="docs-internal-guid-d325902e-7fff-72bc-d5ff-4a1567247717"><a href="/node/8543" target="_blank">Infectious Disease and Microbiome Program</a></span></p> <p><span id="docs-internal-guid-55c5badc-7fff-c400-6744-0ad65215e160"><a href="/node/8539" target="_blank">Metabolomics Platform</a></span></p> <h2>Related News</h2> <div><span id="docs-internal-guid-a576c0f8-7fff-cf3b-3c5f-bde51a405366"><a href="/node/495166" target="_blank">Loss of a DNA repair system creates a unique vulnerability in many cancer types</a></span></div> </div> </div> </div> </div> </div> </article> </div> </div> </div> </div> Thu, 15 Dec 2016 19:42:29 +0000 lgirard@broadinstitute.org 13871 at /news/chemistry-based-approach-reveals-new-target-fight-against-malaria <span class="field field--name-title field--type-string field--label-hidden"><h1>Research Roundup: April 12, 2019</h1> </span> <span class="field field--name-uid field--type-entity-reference field--label-hidden"> <span>By Tom Ulrich</span> </span> <span class="field field--name-created field--type-created field--label-hidden"><time datetime="2019-04-12T12:22:32-04:00" class="datetime">April 12, 2019</time> </span> <div class="hero-section container"> <div class="hero-section__row row"> <div class="hero-section__content hero-section__content_left col-6"> <div class="hero-section__breadcrumbs"> <div class="block block-layout-builder block-extra-field-blocknodenewsbreadcrumbs"> <nav class="breadcrumb" role="navigation" aria-labelledby="system-breadcrumb"> <h2 id="system-breadcrumb" class="visually-hidden">Breadcrumb</h2> <ol> <li> <a href="/">Home</a> </li> <li> <a href="/news">News</a> </li> </ol> </nav> </div> </div> <div class="hero-section__title"> <div class="block block-layout-builder block-field-blocknodenewstitle"> <span class="field field--name-title field--type-string field--label-hidden"><h1>Research Roundup: April 12, 2019</h1> </span> </div> </div> <div class="hero-section__description"> <div class="block block-layout-builder block-field-blocknodenewsbody"> <div class="clearfix text-formatted field field--name-body field--type-text-with-summary field--label-hidden field__item"><div class="summary-only"> <p><span id="docs-internal-guid-3fe5f155-7fff-e0f9-9ffb-9d189ac78a32">Molecular clues to microbes and multiple cancers.</span></p> </div> </div> </div> </div> <div class="hero-section__author"> <div class="block block-layout-builder block-extra-field-blocknodenewsextra-field-author-custom"> By Ó³»­´«Ã½ Communications </div> </div> <div class="hero-section__date"> <div class="block block-layout-builder block-field-blocknodenewscreated"> <span class="field field--name-created field--type-created field--label-hidden"><time datetime="2019-04-12T12:22:32-04:00" class="datetime">April 12, 2019</time> </span> </div> </div> </div> <div class="hero-section__right col-6"> <div class="hero-section__image"> <div class="block block-layout-builder block-field-blocknodenewsfield-image"> <div class="field field--name-field-image field--type-entity-reference field--label-hidden field__item"> <article class="media media--type-image media--view-mode-multiple-content-types-header"> <div class="field field--name-field-media-image field--type-image field--label-hidden field__item"> <picture> <source srcset="/files/styles/multiple_ct_header_desktop_xl/public/news/images/2019/RR5%20jacobs-day2-6.jpg?h=d3e04ee7&amp;itok=Ncg_3Ceu 1x" media="all and (min-width: 1921px)" type="image/jpeg" width="754" height="503"> <source srcset="/files/styles/multiple_ct_header_desktop_xl/public/news/images/2019/RR5%20jacobs-day2-6.jpg?h=d3e04ee7&amp;itok=Ncg_3Ceu 1x" media="all and (min-width: 1601px) and (max-width: 1920px)" type="image/jpeg" width="754" height="503"> <source srcset="/files/styles/multiple_ct_header_desktop/public/news/images/2019/RR5%20jacobs-day2-6.jpg?h=d3e04ee7&amp;itok=f5c-iarN 1x" media="all and (min-width: 1340px) and (max-width: 1600px)" type="image/jpeg" width="736" height="520"> <source srcset="/files/styles/multiple_ct_header_laptop/public/news/images/2019/RR5%20jacobs-day2-6.jpg?h=d3e04ee7&amp;itok=UZSzLyHJ 1x" media="all and (min-width: 800px) and (max-width: 1339px)" type="image/jpeg" width="641" height="451"> <source srcset="/files/styles/multiple_ct_header_tablet/public/news/images/2019/RR5%20jacobs-day2-6.jpg?h=d3e04ee7&amp;itok=dy9wqbrU 1x" media="all and (min-width: 540px) and (max-width: 799px)" type="image/jpeg" width="706" height="417"> <source srcset="/files/styles/multiple_ct_header_phone/public/news/images/2019/RR5%20jacobs-day2-6.jpg?h=d3e04ee7&amp;itok=ZmunmdGq 1x" media="all and (max-width: 539px)" type="image/jpeg" width="499" height="294"> <img loading="eager" width="499" height="294" src="/files/styles/multiple_ct_header_phone/public/news/images/2019/RR5%20jacobs-day2-6.jpg?h=d3e04ee7&amp;itok=ZmunmdGq" alt="Erik Jacobs" typeof="foaf:Image"> </picture> </div> <div class="media-caption"> <div class="media-caption__credit"> Credit: Erik Jacobs </div> <div class="media-caption__description"> </div> </div> </article> </div> </div> </div> </div> </div> </div> <div class="content-section content-section_with-sidebars container"> <div class="row"> <div class="content-section__left col-2"> <div class="block block-better-social-sharing-buttons block-social-sharing-buttons-block"> <div style="display: none"><link rel="preload" href="/modules/contrib/better_social_sharing_buttons/assets/dist/sprites/social-icons--no-color.svg" as="image" type="image/svg+xml" crossorigin="anonymous"></div> <div class="social-sharing-buttons"> <a href="https://www.facebook.com/sharer/sharer.php?u=/taxonomy/term/605/feed&amp;title=" target="_blank" title="Share to Facebook" aria-label="Share to Facebook" class="social-sharing-buttons-button share-facebook" rel="noopener"> <svg aria-hidden="true" width="32px" height="32px" style="border-radius:100%;"> <use 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class="block block-layout-builder block-field-blocknodenewsbody"> <div class="clearfix text-formatted field field--name-body field--type-text-with-summary field--label-hidden field__item"><p>Welcome to the April 12, 2019 installment of&nbsp;<a href="/search?keywords=research+roundup&amp;op=Search">Research Roundup</a>, a recurring snapshot of recent studies published by scientists at the Ó³»­´«Ã½ and their collaborators.</p> <h3>Clear view of cancer’s iron-dependent cell death</h3> <p dir="ltr"><span id="docs-internal-guid-6d4934a1-7fff-b791-e8ec-d6049fec4780">Clear-cell carcinomas (CCCs), which are often resistant to anti-cancer therapies, have a unique metabolic state that remains to be targeted therapeutically. A team led by postdoctoral scholar Yilong Zou and </span>core institute member <a href="/node/7596/">Stuart Schreiber</a> in the <a href="/node/12551/">Chemical Biology and Therapeutics Science Program</a> mined data from the Cancer Therapeutics Response Portal, and found that CCC cells are dependent upon glutathione peroxidase 4 (GPX4) and are prone to undergo ferroptosis, an iron-dependent, non-apoptotic cell death. By combining genome-wide CRISPR screening and lipidomic profiling, they discovered that GPX4-dependency in CCC cells is driven by the HIF-1/2α - HILPDA axis via enrichment of polyunsaturated lipids. Described in <em><a href="https://www.nature.com/articles/s41467-019-09277-9" target="_blank">Nature Communications</a></em>, the findings shed light on the ferroptosis pathway and suggest novel treatment avenues for CCC patients.</p> <h3>Mutations in microbes explain multi-drug resistance</h3> <p dir="ltr"><span id="docs-internal-guid-6d4934a1-7fff-b791-e8ec-d6049fec4780">Hospital-acquired infections are often antibiotic-resistant and difficult to control. Associate member Michael Gilmore, postdoctoral scholar Daria Van Tyne, group leader Abby Manson, institute scientist </span><a href="/node/7414">Ashlee Earl</a> and colleagues from the <a href="/node/8543">Infectious Disease and Microbiome Program</a> examined the genomes of archived Enterococcus faecalis bacteria, which caused one of the first sustained hospital outbreaks of a multidrug-resistant infection from the early- to mid-1980s. Reporting in <em><a href="https://stm.sciencemag.org/content/11/487/eaat8418" target="_blank">Science Translational Medicine</a></em>, the team identified mutations in the bacteria that emerged as they caused infections over four years. The mutations help explain how the microbes outsmart the immune system and resist treatment, and suggest new targets for the next generation of antibiotics. Read more in <em><a href="https://www.theatlantic.com/science/archive/2019/04/gut-bacteria-outbreak/586780/" target="_blank">The Atlantic</a></em> and <a href="https://www.genomeweb.com/sequencing/genomic-study-uncovers-human-bloodstream-infection-adaptations-historical-hospital#.XLCcNOtKhTZ" target="_blank">GenomeWeb</a>.</p> <h3>A vulnerability spanning many cancers</h3> <p dir="ltr"><span id="docs-internal-guid-6d4934a1-7fff-b791-e8ec-d6049fec4780">A large number of colorectal, gastric, ovarian, and endometrial cancers share a mutation pattern called microsatellite instability (MSI). Postdoctoral scholar Edmond Chan, research scientist Tsukasa Shibue, </span><a href="https://depmap.org/portal/depmap/" target="_blank">the Cancer Dependency Map (DepMap) project</a>’s associate director <a href="/node/9001/">Francisca Vazquez</a>, associate member Adam Bass of the <a href="/node/8529/">Cancer Program</a>, and other members of the DepMap team report in <em><a href="https://www.nature.com/articles/s41586-019-1102-x" target="_blank">Nature</a></em> that most MSI-harboring cell lines from these cancers depend on one gene, WRN, to survive and thrive — a discovery validated by <a href="https://www.nature.com/articles/s41586-019-1103-9" target="_blank">similar findings from the Wellcome Sanger Institute</a>. No drugs currently exist against this gene, but the two teams' data suggest that it should be an attractive target for therapeutic development. Learn more in <a href="/node/495166">a Ó³»­´«Ã½ news story</a>, <a href="https://www.fiercebiotech.com/research/using-crispr-to-identify-new-cancer-drug-target" target="_blank">FierceBiotech</a>, and <em><a href="https://www.nature.com/articles/d41586-019-01086-w" target="_blank">Nature News &amp; Views</a></em>.</p> <h3>Molecular clue to malignant brain tumor</h3> <p dir="ltr"><span id="docs-internal-guid-6d4934a1-7fff-b791-e8ec-d6049fec4780">Glioblastoma (GBM), a malignant brain tumor in adults, is one of the most aggressive cancers, with a median survival of around 15 months despite treatment. Tumor-associated macrophages (TAMs), a type of white blood cell, play an important role in the immune response to cancer ― the mechanism of which is not completely understood. A team led by associate member Francisco Quintana of the </span><a href="/node/8539">Metabolomics Platform</a> found that kynurenine, a metabolite produced by GBM cells, participates in the control of TAMs by activating AHR, a protein that controls gene expression. These findings, published in <em><a href="https://www.nature.com/articles/s41593-019-0370-y" target="_blank">Nature Neuroscience</a></em> confirm that AHR expression in TAMs regulates the immune response in GBM, suggesting &nbsp;a target for future therapeutic interventions.</p> <p><em>To learn more about research conducted at the Ó³»­´«Ã½, visit&nbsp;</em><a href="/publications"><em>broadinstitute.org/publications</em></a><em>, and keep an eye on&nbsp;</em><a href="/news"><em>broadinstitute.org/news</em></a><em>.</em></p> </div> </div> <div class="block-node-broad-tags block block-layout-builder block-field-blocknodenewsfield-broad-tags"> <div class="block-node-broad-tags__row"> <div class="block-node-broad-tags__title">Tags:</div> <div class="field field--name-field-broad-tags field--type-entity-reference field--label-hidden field__items"> <div class="field__item"><a href="/broad-tags/cancer-program" hreflang="en">Cancer Program</a></div> <div class="field__item"><a href="/broad-tags/chemical-biology-and-therapeutics-science" hreflang="en">Chemical Biology and Therapeutics Science Program</a></div> <div class="field__item"><a href="/broad-tags/metabolomics-platform" hreflang="en">Metabolomics Platform</a></div> <div class="field__item"><a href="/broad-tags/infectious-disease-and-microbiome-0" hreflang="en">Infectious Disease and Microbiome Program</a></div> <div class="field__item"><a href="/broad-tags/schreiber-lab" hreflang="en">Schreiber Lab</a></div> <div class="field__item"><a href="/broad-tags/cancer" hreflang="en">Cancer</a></div> <div class="field__item"><a href="/broad-tags/stuart-schreiber" hreflang="en">Stuart Schreiber</a></div> <div class="field__item"><a href="/broad-tags/infectious-disease-and-microbiome" hreflang="en">Infectious Disease and Microbiome</a></div> </div> </div> </div> </div> <div class="content-section__right col-2"> <div class="block block-ctools block-entity-viewnode"> <article about="/news/research-roundup-april-12-2019" class="node node--type-news node--promoted node--view-mode-sidebar"> <div class="node__content"> <div class="sidebar-group"> <div class="sidebar-group__content"> <div class="block block-layout-builder block-field-blocknodenewsfield-news-extra-info"> <div class="clearfix text-formatted field field--name-field-news-extra-info field--type-text-long field--label-hidden field__item"><h2>Related People</h2> <p><a href="/node/7596/" target="_blank">Stuart Schreiber</a></p> <p dir="ltr"><span id="docs-internal-guid-5a13f6bc-7fff-a0d5-660f-f235d2d4cf9b"><a href="/node/7414" target="_blank">Ashlee Earl</a></span></p> <p dir="ltr"><span id="docs-internal-guid-5a13f6bc-7fff-a0d5-660f-f235d2d4cf9b"><a href="/node/9001/" target="_blank">Francisca Vazquez</a></span></p> <h2>Related Programs</h2> <p><a href="/node/8529/" target="_blank">Cancer Program</a></p> <p><a href="https://depmap.org/portal/" target="_blank">Cancer Dependency Map</a></p> <p><a href="/node/12551/" target="_blank">Chemical Biology and Therapeutics Science Program</a></p> <p><span id="docs-internal-guid-d325902e-7fff-72bc-d5ff-4a1567247717"><a href="/node/8543" target="_blank">Infectious Disease and Microbiome Program</a></span></p> <p><span id="docs-internal-guid-55c5badc-7fff-c400-6744-0ad65215e160"><a href="/node/8539" target="_blank">Metabolomics Platform</a></span></p> <h2>Related News</h2> <div><span id="docs-internal-guid-a576c0f8-7fff-cf3b-3c5f-bde51a405366"><a href="/node/495166" target="_blank">Loss of a DNA repair system creates a unique vulnerability in many cancer types</a></span></div> </div> </div> </div> </div> </div> </article> </div> </div> </div> </div> Wed, 07 Sep 2016 19:54:25 +0000 veronica@broadinstitute.org 10901 at /news/new-approach-speeds-chemical-library-screens <span class="field field--name-title field--type-string field--label-hidden"><h1>Research Roundup: April 12, 2019</h1> </span> <span class="field field--name-uid field--type-entity-reference field--label-hidden"> <span>By Tom Ulrich</span> </span> <span class="field field--name-created field--type-created field--label-hidden"><time datetime="2019-04-12T12:22:32-04:00" class="datetime">April 12, 2019</time> </span> <div class="hero-section container"> <div class="hero-section__row row"> <div class="hero-section__content hero-section__content_left col-6"> <div class="hero-section__breadcrumbs"> <div class="block block-layout-builder block-extra-field-blocknodenewsbreadcrumbs"> <nav class="breadcrumb" role="navigation" aria-labelledby="system-breadcrumb"> <h2 id="system-breadcrumb" class="visually-hidden">Breadcrumb</h2> <ol> <li> <a href="/">Home</a> </li> <li> <a href="/news">News</a> </li> </ol> </nav> </div> </div> <div class="hero-section__title"> <div class="block block-layout-builder block-field-blocknodenewstitle"> <span class="field field--name-title field--type-string field--label-hidden"><h1>Research Roundup: April 12, 2019</h1> </span> </div> </div> <div class="hero-section__description"> <div class="block block-layout-builder block-field-blocknodenewsbody"> <div class="clearfix text-formatted field field--name-body field--type-text-with-summary field--label-hidden field__item"><div class="summary-only"> <p><span id="docs-internal-guid-3fe5f155-7fff-e0f9-9ffb-9d189ac78a32">Molecular clues to microbes and multiple cancers.</span></p> </div> </div> </div> </div> <div class="hero-section__author"> <div class="block block-layout-builder block-extra-field-blocknodenewsextra-field-author-custom"> By Ó³»­´«Ã½ Communications </div> </div> <div class="hero-section__date"> <div class="block block-layout-builder block-field-blocknodenewscreated"> <span class="field field--name-created field--type-created field--label-hidden"><time datetime="2019-04-12T12:22:32-04:00" class="datetime">April 12, 2019</time> </span> </div> </div> </div> <div class="hero-section__right col-6"> <div class="hero-section__image"> <div class="block block-layout-builder block-field-blocknodenewsfield-image"> <div class="field field--name-field-image field--type-entity-reference field--label-hidden field__item"> <article class="media media--type-image media--view-mode-multiple-content-types-header"> <div class="field field--name-field-media-image field--type-image field--label-hidden field__item"> <picture> <source srcset="/files/styles/multiple_ct_header_desktop_xl/public/news/images/2019/RR5%20jacobs-day2-6.jpg?h=d3e04ee7&amp;itok=Ncg_3Ceu 1x" media="all and (min-width: 1921px)" type="image/jpeg" width="754" height="503"> <source srcset="/files/styles/multiple_ct_header_desktop_xl/public/news/images/2019/RR5%20jacobs-day2-6.jpg?h=d3e04ee7&amp;itok=Ncg_3Ceu 1x" media="all and (min-width: 1601px) and (max-width: 1920px)" type="image/jpeg" width="754" height="503"> <source srcset="/files/styles/multiple_ct_header_desktop/public/news/images/2019/RR5%20jacobs-day2-6.jpg?h=d3e04ee7&amp;itok=f5c-iarN 1x" media="all and (min-width: 1340px) and (max-width: 1600px)" type="image/jpeg" width="736" height="520"> <source srcset="/files/styles/multiple_ct_header_laptop/public/news/images/2019/RR5%20jacobs-day2-6.jpg?h=d3e04ee7&amp;itok=UZSzLyHJ 1x" media="all and (min-width: 800px) and (max-width: 1339px)" type="image/jpeg" width="641" height="451"> <source srcset="/files/styles/multiple_ct_header_tablet/public/news/images/2019/RR5%20jacobs-day2-6.jpg?h=d3e04ee7&amp;itok=dy9wqbrU 1x" media="all and (min-width: 540px) and (max-width: 799px)" type="image/jpeg" width="706" height="417"> <source srcset="/files/styles/multiple_ct_header_phone/public/news/images/2019/RR5%20jacobs-day2-6.jpg?h=d3e04ee7&amp;itok=ZmunmdGq 1x" media="all and (max-width: 539px)" type="image/jpeg" width="499" height="294"> <img loading="eager" width="499" height="294" src="/files/styles/multiple_ct_header_phone/public/news/images/2019/RR5%20jacobs-day2-6.jpg?h=d3e04ee7&amp;itok=ZmunmdGq" alt="Erik Jacobs" typeof="foaf:Image"> </picture> </div> <div class="media-caption"> <div class="media-caption__credit"> Credit: Erik Jacobs </div> <div class="media-caption__description"> </div> </div> </article> </div> </div> </div> </div> </div> </div> <div class="content-section content-section_with-sidebars container"> <div class="row"> <div class="content-section__left col-2"> <div class="block block-better-social-sharing-buttons block-social-sharing-buttons-block"> <div style="display: none"><link rel="preload" href="/modules/contrib/better_social_sharing_buttons/assets/dist/sprites/social-icons--no-color.svg" as="image" type="image/svg+xml" crossorigin="anonymous"></div> <div class="social-sharing-buttons"> <a href="https://www.facebook.com/sharer/sharer.php?u=/taxonomy/term/605/feed&amp;title=" target="_blank" title="Share to Facebook" aria-label="Share to Facebook" class="social-sharing-buttons-button share-facebook" rel="noopener"> <svg aria-hidden="true" width="32px" height="32px" style="border-radius:100%;"> <use 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class="block block-layout-builder block-field-blocknodenewsbody"> <div class="clearfix text-formatted field field--name-body field--type-text-with-summary field--label-hidden field__item"><p>Welcome to the April 12, 2019 installment of&nbsp;<a href="/search?keywords=research+roundup&amp;op=Search">Research Roundup</a>, a recurring snapshot of recent studies published by scientists at the Ó³»­´«Ã½ and their collaborators.</p> <h3>Clear view of cancer’s iron-dependent cell death</h3> <p dir="ltr"><span id="docs-internal-guid-6d4934a1-7fff-b791-e8ec-d6049fec4780">Clear-cell carcinomas (CCCs), which are often resistant to anti-cancer therapies, have a unique metabolic state that remains to be targeted therapeutically. A team led by postdoctoral scholar Yilong Zou and </span>core institute member <a href="/node/7596/">Stuart Schreiber</a> in the <a href="/node/12551/">Chemical Biology and Therapeutics Science Program</a> mined data from the Cancer Therapeutics Response Portal, and found that CCC cells are dependent upon glutathione peroxidase 4 (GPX4) and are prone to undergo ferroptosis, an iron-dependent, non-apoptotic cell death. By combining genome-wide CRISPR screening and lipidomic profiling, they discovered that GPX4-dependency in CCC cells is driven by the HIF-1/2α - HILPDA axis via enrichment of polyunsaturated lipids. Described in <em><a href="https://www.nature.com/articles/s41467-019-09277-9" target="_blank">Nature Communications</a></em>, the findings shed light on the ferroptosis pathway and suggest novel treatment avenues for CCC patients.</p> <h3>Mutations in microbes explain multi-drug resistance</h3> <p dir="ltr"><span id="docs-internal-guid-6d4934a1-7fff-b791-e8ec-d6049fec4780">Hospital-acquired infections are often antibiotic-resistant and difficult to control. Associate member Michael Gilmore, postdoctoral scholar Daria Van Tyne, group leader Abby Manson, institute scientist </span><a href="/node/7414">Ashlee Earl</a> and colleagues from the <a href="/node/8543">Infectious Disease and Microbiome Program</a> examined the genomes of archived Enterococcus faecalis bacteria, which caused one of the first sustained hospital outbreaks of a multidrug-resistant infection from the early- to mid-1980s. Reporting in <em><a href="https://stm.sciencemag.org/content/11/487/eaat8418" target="_blank">Science Translational Medicine</a></em>, the team identified mutations in the bacteria that emerged as they caused infections over four years. The mutations help explain how the microbes outsmart the immune system and resist treatment, and suggest new targets for the next generation of antibiotics. Read more in <em><a href="https://www.theatlantic.com/science/archive/2019/04/gut-bacteria-outbreak/586780/" target="_blank">The Atlantic</a></em> and <a href="https://www.genomeweb.com/sequencing/genomic-study-uncovers-human-bloodstream-infection-adaptations-historical-hospital#.XLCcNOtKhTZ" target="_blank">GenomeWeb</a>.</p> <h3>A vulnerability spanning many cancers</h3> <p dir="ltr"><span id="docs-internal-guid-6d4934a1-7fff-b791-e8ec-d6049fec4780">A large number of colorectal, gastric, ovarian, and endometrial cancers share a mutation pattern called microsatellite instability (MSI). Postdoctoral scholar Edmond Chan, research scientist Tsukasa Shibue, </span><a href="https://depmap.org/portal/depmap/" target="_blank">the Cancer Dependency Map (DepMap) project</a>’s associate director <a href="/node/9001/">Francisca Vazquez</a>, associate member Adam Bass of the <a href="/node/8529/">Cancer Program</a>, and other members of the DepMap team report in <em><a href="https://www.nature.com/articles/s41586-019-1102-x" target="_blank">Nature</a></em> that most MSI-harboring cell lines from these cancers depend on one gene, WRN, to survive and thrive — a discovery validated by <a href="https://www.nature.com/articles/s41586-019-1103-9" target="_blank">similar findings from the Wellcome Sanger Institute</a>. No drugs currently exist against this gene, but the two teams' data suggest that it should be an attractive target for therapeutic development. Learn more in <a href="/node/495166">a Ó³»­´«Ã½ news story</a>, <a href="https://www.fiercebiotech.com/research/using-crispr-to-identify-new-cancer-drug-target" target="_blank">FierceBiotech</a>, and <em><a href="https://www.nature.com/articles/d41586-019-01086-w" target="_blank">Nature News &amp; Views</a></em>.</p> <h3>Molecular clue to malignant brain tumor</h3> <p dir="ltr"><span id="docs-internal-guid-6d4934a1-7fff-b791-e8ec-d6049fec4780">Glioblastoma (GBM), a malignant brain tumor in adults, is one of the most aggressive cancers, with a median survival of around 15 months despite treatment. Tumor-associated macrophages (TAMs), a type of white blood cell, play an important role in the immune response to cancer ― the mechanism of which is not completely understood. A team led by associate member Francisco Quintana of the </span><a href="/node/8539">Metabolomics Platform</a> found that kynurenine, a metabolite produced by GBM cells, participates in the control of TAMs by activating AHR, a protein that controls gene expression. These findings, published in <em><a href="https://www.nature.com/articles/s41593-019-0370-y" target="_blank">Nature Neuroscience</a></em> confirm that AHR expression in TAMs regulates the immune response in GBM, suggesting &nbsp;a target for future therapeutic interventions.</p> <p><em>To learn more about research conducted at the Ó³»­´«Ã½, visit&nbsp;</em><a href="/publications"><em>broadinstitute.org/publications</em></a><em>, and keep an eye on&nbsp;</em><a href="/news"><em>broadinstitute.org/news</em></a><em>.</em></p> </div> </div> <div class="block-node-broad-tags block block-layout-builder block-field-blocknodenewsfield-broad-tags"> <div class="block-node-broad-tags__row"> <div class="block-node-broad-tags__title">Tags:</div> <div class="field field--name-field-broad-tags field--type-entity-reference field--label-hidden field__items"> <div class="field__item"><a href="/broad-tags/cancer-program" hreflang="en">Cancer Program</a></div> <div class="field__item"><a href="/broad-tags/chemical-biology-and-therapeutics-science" hreflang="en">Chemical Biology and Therapeutics Science Program</a></div> <div class="field__item"><a href="/broad-tags/metabolomics-platform" hreflang="en">Metabolomics Platform</a></div> <div class="field__item"><a href="/broad-tags/infectious-disease-and-microbiome-0" hreflang="en">Infectious Disease and Microbiome Program</a></div> <div class="field__item"><a href="/broad-tags/schreiber-lab" hreflang="en">Schreiber Lab</a></div> <div class="field__item"><a href="/broad-tags/cancer" hreflang="en">Cancer</a></div> <div class="field__item"><a href="/broad-tags/stuart-schreiber" hreflang="en">Stuart Schreiber</a></div> <div class="field__item"><a href="/broad-tags/infectious-disease-and-microbiome" hreflang="en">Infectious Disease and Microbiome</a></div> </div> </div> </div> </div> <div class="content-section__right col-2"> <div class="block block-ctools block-entity-viewnode"> <article about="/news/research-roundup-april-12-2019" class="node node--type-news node--promoted node--view-mode-sidebar"> <div class="node__content"> <div class="sidebar-group"> <div class="sidebar-group__content"> <div class="block block-layout-builder block-field-blocknodenewsfield-news-extra-info"> <div class="clearfix text-formatted field field--name-field-news-extra-info field--type-text-long field--label-hidden field__item"><h2>Related People</h2> <p><a href="/node/7596/" target="_blank">Stuart Schreiber</a></p> <p dir="ltr"><span id="docs-internal-guid-5a13f6bc-7fff-a0d5-660f-f235d2d4cf9b"><a href="/node/7414" target="_blank">Ashlee Earl</a></span></p> <p dir="ltr"><span id="docs-internal-guid-5a13f6bc-7fff-a0d5-660f-f235d2d4cf9b"><a href="/node/9001/" target="_blank">Francisca Vazquez</a></span></p> <h2>Related Programs</h2> <p><a href="/node/8529/" target="_blank">Cancer Program</a></p> <p><a href="https://depmap.org/portal/" target="_blank">Cancer Dependency Map</a></p> <p><a href="/node/12551/" target="_blank">Chemical Biology and Therapeutics Science Program</a></p> <p><span id="docs-internal-guid-d325902e-7fff-72bc-d5ff-4a1567247717"><a href="/node/8543" target="_blank">Infectious Disease and Microbiome Program</a></span></p> <p><span id="docs-internal-guid-55c5badc-7fff-c400-6744-0ad65215e160"><a href="/node/8539" target="_blank">Metabolomics Platform</a></span></p> <h2>Related News</h2> <div><span id="docs-internal-guid-a576c0f8-7fff-cf3b-3c5f-bde51a405366"><a href="/node/495166" target="_blank">Loss of a DNA repair system creates a unique vulnerability in many cancer types</a></span></div> </div> </div> </div> </div> </div> </article> </div> </div> </div> </div> Mon, 18 Jul 2016 16:40:52 +0000 veronica@broadinstitute.org 8896 at /scientific-community/software/cancer-therapeutics-response-portal <span class="field field--name-title field--type-string field--label-hidden"><h1>Research Roundup: April 12, 2019</h1> </span> <span class="field field--name-uid field--type-entity-reference field--label-hidden"> <span>By Tom Ulrich</span> </span> <span class="field field--name-created field--type-created field--label-hidden"><time datetime="2019-04-12T12:22:32-04:00" class="datetime">April 12, 2019</time> </span> <div class="hero-section container"> <div class="hero-section__row row"> <div class="hero-section__content hero-section__content_left col-6"> <div class="hero-section__breadcrumbs"> <div class="block block-layout-builder block-extra-field-blocknodenewsbreadcrumbs"> <nav class="breadcrumb" role="navigation" aria-labelledby="system-breadcrumb"> <h2 id="system-breadcrumb" class="visually-hidden">Breadcrumb</h2> <ol> <li> <a href="/">Home</a> </li> <li> <a href="/news">News</a> </li> </ol> </nav> </div> </div> <div class="hero-section__title"> <div class="block block-layout-builder block-field-blocknodenewstitle"> <span class="field field--name-title field--type-string field--label-hidden"><h1>Research Roundup: April 12, 2019</h1> </span> </div> </div> <div class="hero-section__description"> <div class="block block-layout-builder block-field-blocknodenewsbody"> <div class="clearfix text-formatted field field--name-body field--type-text-with-summary field--label-hidden field__item"><div class="summary-only"> <p><span id="docs-internal-guid-3fe5f155-7fff-e0f9-9ffb-9d189ac78a32">Molecular clues to microbes and multiple cancers.</span></p> </div> </div> </div> </div> <div class="hero-section__author"> <div class="block block-layout-builder block-extra-field-blocknodenewsextra-field-author-custom"> By Ó³»­´«Ã½ Communications </div> </div> <div class="hero-section__date"> <div class="block block-layout-builder block-field-blocknodenewscreated"> <span class="field field--name-created field--type-created field--label-hidden"><time datetime="2019-04-12T12:22:32-04:00" class="datetime">April 12, 2019</time> </span> </div> </div> </div> <div class="hero-section__right col-6"> <div class="hero-section__image"> <div class="block block-layout-builder block-field-blocknodenewsfield-image"> <div class="field field--name-field-image field--type-entity-reference field--label-hidden field__item"> <article class="media media--type-image media--view-mode-multiple-content-types-header"> <div class="field field--name-field-media-image field--type-image field--label-hidden field__item"> <picture> <source srcset="/files/styles/multiple_ct_header_desktop_xl/public/news/images/2019/RR5%20jacobs-day2-6.jpg?h=d3e04ee7&amp;itok=Ncg_3Ceu 1x" media="all and (min-width: 1921px)" type="image/jpeg" width="754" height="503"> <source srcset="/files/styles/multiple_ct_header_desktop_xl/public/news/images/2019/RR5%20jacobs-day2-6.jpg?h=d3e04ee7&amp;itok=Ncg_3Ceu 1x" media="all and (min-width: 1601px) and (max-width: 1920px)" type="image/jpeg" width="754" height="503"> <source srcset="/files/styles/multiple_ct_header_desktop/public/news/images/2019/RR5%20jacobs-day2-6.jpg?h=d3e04ee7&amp;itok=f5c-iarN 1x" media="all and (min-width: 1340px) and (max-width: 1600px)" type="image/jpeg" width="736" height="520"> <source srcset="/files/styles/multiple_ct_header_laptop/public/news/images/2019/RR5%20jacobs-day2-6.jpg?h=d3e04ee7&amp;itok=UZSzLyHJ 1x" media="all and (min-width: 800px) and (max-width: 1339px)" type="image/jpeg" width="641" height="451"> <source srcset="/files/styles/multiple_ct_header_tablet/public/news/images/2019/RR5%20jacobs-day2-6.jpg?h=d3e04ee7&amp;itok=dy9wqbrU 1x" media="all and (min-width: 540px) and (max-width: 799px)" type="image/jpeg" width="706" height="417"> <source srcset="/files/styles/multiple_ct_header_phone/public/news/images/2019/RR5%20jacobs-day2-6.jpg?h=d3e04ee7&amp;itok=ZmunmdGq 1x" media="all and (max-width: 539px)" type="image/jpeg" width="499" height="294"> <img loading="eager" width="499" height="294" src="/files/styles/multiple_ct_header_phone/public/news/images/2019/RR5%20jacobs-day2-6.jpg?h=d3e04ee7&amp;itok=ZmunmdGq" alt="Erik Jacobs" typeof="foaf:Image"> </picture> </div> <div class="media-caption"> <div class="media-caption__credit"> Credit: Erik Jacobs </div> <div class="media-caption__description"> </div> </div> </article> </div> </div> </div> </div> </div> </div> <div class="content-section content-section_with-sidebars container"> <div class="row"> <div class="content-section__left col-2"> <div class="block block-better-social-sharing-buttons block-social-sharing-buttons-block"> <div style="display: none"><link rel="preload" href="/modules/contrib/better_social_sharing_buttons/assets/dist/sprites/social-icons--no-color.svg" as="image" type="image/svg+xml" crossorigin="anonymous"></div> <div class="social-sharing-buttons"> <a href="https://www.facebook.com/sharer/sharer.php?u=/taxonomy/term/605/feed&amp;title=" target="_blank" title="Share to Facebook" aria-label="Share to Facebook" class="social-sharing-buttons-button share-facebook" rel="noopener"> <svg aria-hidden="true" width="32px" height="32px" style="border-radius:100%;"> <use 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class="block block-layout-builder block-field-blocknodenewsbody"> <div class="clearfix text-formatted field field--name-body field--type-text-with-summary field--label-hidden field__item"><p>Welcome to the April 12, 2019 installment of&nbsp;<a href="/search?keywords=research+roundup&amp;op=Search">Research Roundup</a>, a recurring snapshot of recent studies published by scientists at the Ó³»­´«Ã½ and their collaborators.</p> <h3>Clear view of cancer’s iron-dependent cell death</h3> <p dir="ltr"><span id="docs-internal-guid-6d4934a1-7fff-b791-e8ec-d6049fec4780">Clear-cell carcinomas (CCCs), which are often resistant to anti-cancer therapies, have a unique metabolic state that remains to be targeted therapeutically. A team led by postdoctoral scholar Yilong Zou and </span>core institute member <a href="/node/7596/">Stuart Schreiber</a> in the <a href="/node/12551/">Chemical Biology and Therapeutics Science Program</a> mined data from the Cancer Therapeutics Response Portal, and found that CCC cells are dependent upon glutathione peroxidase 4 (GPX4) and are prone to undergo ferroptosis, an iron-dependent, non-apoptotic cell death. By combining genome-wide CRISPR screening and lipidomic profiling, they discovered that GPX4-dependency in CCC cells is driven by the HIF-1/2α - HILPDA axis via enrichment of polyunsaturated lipids. Described in <em><a href="https://www.nature.com/articles/s41467-019-09277-9" target="_blank">Nature Communications</a></em>, the findings shed light on the ferroptosis pathway and suggest novel treatment avenues for CCC patients.</p> <h3>Mutations in microbes explain multi-drug resistance</h3> <p dir="ltr"><span id="docs-internal-guid-6d4934a1-7fff-b791-e8ec-d6049fec4780">Hospital-acquired infections are often antibiotic-resistant and difficult to control. Associate member Michael Gilmore, postdoctoral scholar Daria Van Tyne, group leader Abby Manson, institute scientist </span><a href="/node/7414">Ashlee Earl</a> and colleagues from the <a href="/node/8543">Infectious Disease and Microbiome Program</a> examined the genomes of archived Enterococcus faecalis bacteria, which caused one of the first sustained hospital outbreaks of a multidrug-resistant infection from the early- to mid-1980s. Reporting in <em><a href="https://stm.sciencemag.org/content/11/487/eaat8418" target="_blank">Science Translational Medicine</a></em>, the team identified mutations in the bacteria that emerged as they caused infections over four years. The mutations help explain how the microbes outsmart the immune system and resist treatment, and suggest new targets for the next generation of antibiotics. Read more in <em><a href="https://www.theatlantic.com/science/archive/2019/04/gut-bacteria-outbreak/586780/" target="_blank">The Atlantic</a></em> and <a href="https://www.genomeweb.com/sequencing/genomic-study-uncovers-human-bloodstream-infection-adaptations-historical-hospital#.XLCcNOtKhTZ" target="_blank">GenomeWeb</a>.</p> <h3>A vulnerability spanning many cancers</h3> <p dir="ltr"><span id="docs-internal-guid-6d4934a1-7fff-b791-e8ec-d6049fec4780">A large number of colorectal, gastric, ovarian, and endometrial cancers share a mutation pattern called microsatellite instability (MSI). Postdoctoral scholar Edmond Chan, research scientist Tsukasa Shibue, </span><a href="https://depmap.org/portal/depmap/" target="_blank">the Cancer Dependency Map (DepMap) project</a>’s associate director <a href="/node/9001/">Francisca Vazquez</a>, associate member Adam Bass of the <a href="/node/8529/">Cancer Program</a>, and other members of the DepMap team report in <em><a href="https://www.nature.com/articles/s41586-019-1102-x" target="_blank">Nature</a></em> that most MSI-harboring cell lines from these cancers depend on one gene, WRN, to survive and thrive — a discovery validated by <a href="https://www.nature.com/articles/s41586-019-1103-9" target="_blank">similar findings from the Wellcome Sanger Institute</a>. No drugs currently exist against this gene, but the two teams' data suggest that it should be an attractive target for therapeutic development. Learn more in <a href="/node/495166">a Ó³»­´«Ã½ news story</a>, <a href="https://www.fiercebiotech.com/research/using-crispr-to-identify-new-cancer-drug-target" target="_blank">FierceBiotech</a>, and <em><a href="https://www.nature.com/articles/d41586-019-01086-w" target="_blank">Nature News &amp; Views</a></em>.</p> <h3>Molecular clue to malignant brain tumor</h3> <p dir="ltr"><span id="docs-internal-guid-6d4934a1-7fff-b791-e8ec-d6049fec4780">Glioblastoma (GBM), a malignant brain tumor in adults, is one of the most aggressive cancers, with a median survival of around 15 months despite treatment. Tumor-associated macrophages (TAMs), a type of white blood cell, play an important role in the immune response to cancer ― the mechanism of which is not completely understood. A team led by associate member Francisco Quintana of the </span><a href="/node/8539">Metabolomics Platform</a> found that kynurenine, a metabolite produced by GBM cells, participates in the control of TAMs by activating AHR, a protein that controls gene expression. These findings, published in <em><a href="https://www.nature.com/articles/s41593-019-0370-y" target="_blank">Nature Neuroscience</a></em> confirm that AHR expression in TAMs regulates the immune response in GBM, suggesting &nbsp;a target for future therapeutic interventions.</p> <p><em>To learn more about research conducted at the Ó³»­´«Ã½, visit&nbsp;</em><a href="/publications"><em>broadinstitute.org/publications</em></a><em>, and keep an eye on&nbsp;</em><a href="/news"><em>broadinstitute.org/news</em></a><em>.</em></p> </div> </div> <div class="block-node-broad-tags block block-layout-builder block-field-blocknodenewsfield-broad-tags"> <div class="block-node-broad-tags__row"> <div class="block-node-broad-tags__title">Tags:</div> <div class="field field--name-field-broad-tags field--type-entity-reference field--label-hidden field__items"> <div class="field__item"><a href="/broad-tags/cancer-program" hreflang="en">Cancer Program</a></div> <div class="field__item"><a href="/broad-tags/chemical-biology-and-therapeutics-science" hreflang="en">Chemical Biology and Therapeutics Science Program</a></div> <div class="field__item"><a href="/broad-tags/metabolomics-platform" hreflang="en">Metabolomics Platform</a></div> <div class="field__item"><a href="/broad-tags/infectious-disease-and-microbiome-0" hreflang="en">Infectious Disease and Microbiome Program</a></div> <div class="field__item"><a href="/broad-tags/schreiber-lab" hreflang="en">Schreiber Lab</a></div> <div class="field__item"><a href="/broad-tags/cancer" hreflang="en">Cancer</a></div> <div class="field__item"><a href="/broad-tags/stuart-schreiber" hreflang="en">Stuart Schreiber</a></div> <div class="field__item"><a href="/broad-tags/infectious-disease-and-microbiome" hreflang="en">Infectious Disease and Microbiome</a></div> </div> </div> </div> </div> <div class="content-section__right col-2"> <div class="block block-ctools block-entity-viewnode"> <article about="/news/research-roundup-april-12-2019" class="node node--type-news node--promoted node--view-mode-sidebar"> <div class="node__content"> <div class="sidebar-group"> <div class="sidebar-group__content"> <div class="block block-layout-builder block-field-blocknodenewsfield-news-extra-info"> <div class="clearfix text-formatted field field--name-field-news-extra-info field--type-text-long field--label-hidden field__item"><h2>Related People</h2> <p><a href="/node/7596/" target="_blank">Stuart Schreiber</a></p> <p dir="ltr"><span id="docs-internal-guid-5a13f6bc-7fff-a0d5-660f-f235d2d4cf9b"><a href="/node/7414" target="_blank">Ashlee Earl</a></span></p> <p dir="ltr"><span id="docs-internal-guid-5a13f6bc-7fff-a0d5-660f-f235d2d4cf9b"><a href="/node/9001/" target="_blank">Francisca Vazquez</a></span></p> <h2>Related Programs</h2> <p><a href="/node/8529/" target="_blank">Cancer Program</a></p> <p><a href="https://depmap.org/portal/" target="_blank">Cancer Dependency Map</a></p> <p><a href="/node/12551/" target="_blank">Chemical Biology and Therapeutics Science Program</a></p> <p><span id="docs-internal-guid-d325902e-7fff-72bc-d5ff-4a1567247717"><a href="/node/8543" target="_blank">Infectious Disease and Microbiome Program</a></span></p> <p><span id="docs-internal-guid-55c5badc-7fff-c400-6744-0ad65215e160"><a href="/node/8539" target="_blank">Metabolomics Platform</a></span></p> <h2>Related News</h2> <div><span id="docs-internal-guid-a576c0f8-7fff-cf3b-3c5f-bde51a405366"><a href="/node/495166" target="_blank">Loss of a DNA repair system creates a unique vulnerability in many cancer types</a></span></div> </div> </div> </div> </div> </div> </article> </div> </div> </div> </div> Mon, 22 Jul 2013 18:48:17 +0000 bistline@broadinstitute.org 5157 at