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      1. Carlos Slim Center for Health Research The Slim Center aims to bring the benefits of genomics-driven medicine to Latin America, gleaning new insights into diseases with relevance to the region.
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      5. Novo Nordisk Foundation Center for Genomic Mechanisms of Disease This center is developing new paradigms and technologies to scale the discovery of biological mechanisms of common, complex diseases, by facilitating close collaborations between the Ó³»­´«Ã½ and the Danish research community.
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      7. Stanley Center for Psychiatric Research The Stanley Center aims to reduce the burden of serious mental illness by contributing new insights into pathogenesis, identifying biomarkers, and paving the way toward new treatments.
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      1. Art and science connection Explore the connection between art and science and how we bring together artists and Ó³»­´«Ã½ scientists through our artist-in-residence program, gallery exhibitions, and ongoing public conversations.
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Therapeutic hypoxia for mitochondrial disease via enhancement of hemoglobin affinity and inhibition of HIF-2α.
Wang H, Miranda M, Marutani E, et al. Therapeutic hypoxia for mitochondrial disease via enhancement of hemoglobin affinity and inhibition of HIF-2α. The Journal of clinical investigation. 2024;134(23). doi:10.1172/JCI185569
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Stratified analysis identifies HIF-2 as a therapeutic target for highly immune-infiltrated melanomas.
Huang AY, Burke KP, Porter R, et al. Stratified analysis identifies HIF-2 as a therapeutic target for highly immune-infiltrated melanomas. bioRxiv : the preprint server for biology. 2024. doi:10.1101/2024.10.29.620300
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Stratified analysis identifies HIF-2 as a therapeutic target for highly immune-infiltrated melanomas.
Huang AY, Burke KP, Porter R, et al. Stratified analysis identifies HIF-2 as a therapeutic target for highly immune-infiltrated melanomas. bioRxiv : the preprint server for biology. 2024. doi:10.1101/2024.10.29.620300
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Total loss of gene function impairs neuroendocrine cancer cell fitness due to excessive HIF2α activity.
Abu-Remaileh M, Persky NS, Lee Y, Root DE, Kaelin WG. Total loss of gene function impairs neuroendocrine cancer cell fitness due to excessive HIF2α activity. Proceedings of the National Academy of Sciences of the United States of America. 2024;121(40):e2410356121. doi:10.1073/pnas.2410356121
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Integrative spatial analysis reveals a multi-layered organization of glioblastoma.
Greenwald AC, Darnell NG, Hoefflin R, et al. Integrative spatial analysis reveals a multi-layered organization of glioblastoma. Cell. 2024. doi:10.1016/j.cell.2024.03.029
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Hypoxia and intra-complex genetic suppressors rescue complex I mutants by a shared mechanism.
Meisel JD, Miranda M, Skinner OS, et al. Hypoxia and intra-complex genetic suppressors rescue complex I mutants by a shared mechanism. Cell. 2024. doi:10.1016/j.cell.2023.12.010
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Lipoylation is dependent on the ferredoxin FDX1 and dispensable under hypoxia in human cells.
Joshi PR, Sadre S, Guo XA, McCoy JG, Mootha VK. Lipoylation is dependent on the ferredoxin FDX1 and dispensable under hypoxia in human cells. The Journal of biological chemistry. 2023:105075. doi:10.1016/j.jbc.2023.105075
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The hypoxic burden of sleep apnoea predicts cardiovascular disease-related mortality: the Osteoporotic Fractures in Men Study and the Sleep Heart Health Study.
Azarbarzin A, Sands SA, Stone KL, et al. The hypoxic burden of sleep apnoea predicts cardiovascular disease-related mortality: the Osteoporotic Fractures in Men Study and the Sleep Heart Health Study. Eur Heart J. 2019;40(14):1149-1157. doi:10.1093/eurheartj/ehy624
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Hypoxia treatment reverses neurodegenerative disease in a mouse model of Leigh syndrome.
Ferrari M, Jain IH, Goldberger O, et al. Hypoxia treatment reverses neurodegenerative disease in a mouse model of Leigh syndrome. Proc Natl Acad Sci U S A. 2017;114(21):E4241-E4250. doi:10.1073/pnas.1621511114
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Hypoxia-Sensitive COMMD1 Integrates Signaling and Cellular Metabolism in Human Macrophages and Suppresses Osteoclastogenesis.
Murata K, Fang C, Terao C, et al. Hypoxia-Sensitive COMMD1 Integrates Signaling and Cellular Metabolism in Human Macrophages and Suppresses Osteoclastogenesis. Immunity. 2017;47(1):66-79.e5. doi:10.1016/j.immuni.2017.06.018
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In March of 2020, Ó³»­´«Ã½ converted a clinical genetics processing lab into a large-scale COVID-19 testing facility in less than two weeks.

We've screened more than 1,275 cancer cell lines as part of the Cancer Dependency Map (DepMap).

Ó³»­´«Ã½ Genomics Platform sequences a whole human genome every four minutes.

More than 11,000 individuals living with cancer in the United States and Canada have partnered with Count Me In to share their experiences and help accelerate cancer research.

The Drug Repurposing Hub is one of the most comprehensive and up-to-date biologically annotated collections of FDA-approved compounds in the world. Researchers anywhere can explore more than 6,000 drugs in the hub and search for possible new uses for them to jump-start new drug discovery.

In 2021, our sustainability efforts sent more than 80 percent of waste from the Genomics Platform to either a recycling facility or to an incineration plant that generates electricity.

Through Ó³»­´«Ã½'s Scientists in the Classroom program, Ó³»­´«Ã½ researchers visit every 8th grade classroom in Cambridge each year to talk about genetics and evolution.

Every summer, 18 high school students spend six weeks at Ó³»­´«Ã½ working side-by-side with mentors on cutting-edge research.

In November 2022, Ó³»­´«Ã½â€™s Genomics Platform sequenced its 500,000th whole human genome, a mere four years after sequencing its 100,000th.

By the end of 2022, Ó³»­´«Ã½â€™s COVID-19 testing lab had processed more than 37 million tests.

Working with Addgene, Ó³»­´«Ã½ has shared CRISPR genome-editing reagents with researchers at more than 3,200 institutions in 76 countries.

The NeuroGAP-Psychosis project, a collaboration between the Stanley Center for Psychiatric Research and Harvard T.H. Chan School of Public Health to study the genetics of severe mental illness, has recruited more than 42,000 participants in Ethiopia, Kenya, Uganda, and South Africa.

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