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Gasdermin D deletion prevents liver injury and exacerbates extrahepatic damage in a murine model of alcohol-induced ACLF.

Ortega-Ribera M, Zhuang Y, Brezani V, et al. Gasdermin D deletion prevents liver injury and exacerbates extrahepatic damage in a murine model of alcohol-induced ACLF. eGastroenterology. 2025;3(1):e100151. doi:10.1136/egastro-2024-100151

Rare damaging CCR2 variants are associated with lower lifetime cardiovascular risk.

Georgakis MK, Malik R, Bounkari OE, et al. Rare damaging CCR2 variants are associated with lower lifetime cardiovascular risk. Genome medicine. 2025;17(1):27. doi:10.1186/s13073-025-01456-2

Decomposed interaction testing improves detection of genetic modifiers of the relationship of dietary omega-3 fatty acid intake and its plasma biomarkers with hsCRP in the UK Biobank.

Westerman KE, Patel CJ, Meigs JB, Chasman DI, Manning AK. Decomposed interaction testing improves detection of genetic modifiers of the relationship of dietary omega-3 fatty acid intake and its plasma biomarkers with hsCRP in the UK Biobank. Genes & nutrition. 2025;20(1):3. doi:10.1186/s12263-025-00765-w

Reverse transcriptase inhibitors diminish systemic proinflammatory responses to bacterial pathogens.

Hullahalli K, Dailey KG, Acbay R, Suzuki M, Balazs GI, Waldor MK. Reverse transcriptase inhibitors diminish systemic proinflammatory responses to bacterial pathogens. mBio. 2025:e0341224. doi:10.1128/mbio.03412-24

Adiposity, immunity, and inflammation: interrelationships in health and disease: a report from 24th Annual Harvard Nutrition Obesity Symposium, June 2023.

Burak MF, Stanley TL, Lawson EA, et al. Adiposity, immunity, and inflammation: interrelationships in health and disease: a report from 24th Annual Harvard Nutrition Obesity Symposium, June 2023. The American journal of clinical nutrition. 2024;120(1):257-268. doi:10.1016/j.ajcnut.2024.04.029

Type III interferons induce pyroptosis in gut epithelial cells and impair mucosal repair.

Jena KK, Mambu J, Boehmer D, et al. Type III interferons induce pyroptosis in gut epithelial cells and impair mucosal repair. Cell. 2024. doi:10.1016/j.cell.2024.10.010

Metatranscriptomics-guided discovery and characterization of a polyphenol-metabolizing gut microbial enzyme.

Bae M, Le C, Mehta RS, et al. Metatranscriptomics-guided discovery and characterization of a polyphenol-metabolizing gut microbial enzyme. Cell host & microbe. 2024. doi:10.1016/j.chom.2024.10.002

Vangl2 suppresses NF-κB signaling and ameliorates sepsis by targeting p65 for NDP52-mediated autophagic degradation.

Lu J, Zhang J, Jiang H, et al. Vangl2 suppresses NF-κB signaling and ameliorates sepsis by targeting p65 for NDP52-mediated autophagic degradation. eLife. 2024;12. doi:10.7554/eLife.87935

Vangl2 suppresses NF-κB signaling and ameliorates sepsis by targeting p65 for NDP52-mediated autophagic degradation.

Lu J, Zhang J, Jiang H, et al. Vangl2 suppresses NF-κB signaling and ameliorates sepsis by targeting p65 for NDP52-mediated autophagic degradation. eLife. 2024;12. doi:10.7554/eLife.87935

Vangl2 suppresses NF-κB signaling and ameliorates sepsis by targeting p65 for NDP52-mediated autophagic degradation.

Lu J, Zhang J, Jiang H, et al. Vangl2 suppresses NF-κB signaling and ameliorates sepsis by targeting p65 for NDP52-mediated autophagic degradation. eLife. 2024;12. doi:10.7554/eLife.87935