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IL-1β inflammatory response driven by primary breast cancer prevents metastasis-initiating cell colonization.

Castaño Z, San Juan BP, Spiegel A, et al. IL-1β inflammatory response driven by primary breast cancer prevents metastasis-initiating cell colonization. Nat Cell Biol. 2018;20(9):1084-1097. doi:10.1038/s41556-018-0173-5

Small-molecule enhancers of autophagy modulate cellular disease phenotypes suggested by human genetics.

Kuo SY, Castoreno AB, Aldrich LN, et al. Small-molecule enhancers of autophagy modulate cellular disease phenotypes suggested by human genetics. Proc Natl Acad Sci U S A. 2015;112(31):E4281-7. doi:10.1073/pnas.1512289112

Selective modulation of autophagy, innate immunity, and adaptive immunity by small molecules.

Shaw SY, Tran K, Castoreno AB, et al. Selective modulation of autophagy, innate immunity, and adaptive immunity by small molecules. ACS Chem Biol. 2013;8(12):2724-33. doi:10.1021/cb400352d

An Immunomodulatory Peptide Confers Protection in an Experimental Candidemia Murine Model.

Freitas CG, Lima SMF, Freire MS, et al. An Immunomodulatory Peptide Confers Protection in an Experimental Candidemia Murine Model. Antimicrob Agents Chemother. 2017;61(8). doi:10.1128/AAC.02518-16

Circadian clock protein BMAL1 regulates IL-1β in macrophages via NRF2.

Early JO, Menon D, Wyse CA, et al. Circadian clock protein BMAL1 regulates IL-1β in macrophages via NRF2. Proc Natl Acad Sci U S A. 2018;115(36):E8460-E8468. doi:10.1073/pnas.1800431115

Reactive astrocyte COX2-PGE2 production inhibits oligodendrocyte maturation in neonatal white matter injury.

Shiow LR, Favrais G, Schirmer L, et al. Reactive astrocyte COX2-PGE2 production inhibits oligodendrocyte maturation in neonatal white matter injury. Glia. 2017;65(12):2024-2037. doi:10.1002/glia.23212

BCG Vaccination Protects against Experimental Viral Infection in Humans through the Induction of Cytokines Associated with Trained Immunity.

Arts RJW, Moorlag SJCFM, Novakovic B, et al. BCG Vaccination Protects against Experimental Viral Infection in Humans through the Induction of Cytokines Associated with Trained Immunity. Cell Host Microbe. 2018;23(1):89-100.e5. doi:10.1016/j.chom.2017.12.010

GSDMD is critical for autoinflammatory pathology in a mouse model of Familial Mediterranean Fever.

Kanneganti A, Malireddi RKS, Saavedra PHV, et al. GSDMD is critical for autoinflammatory pathology in a mouse model of Familial Mediterranean Fever. J Exp Med. 2018;215(6):1519-1529. doi:10.1084/jem.20172060

Genome-wide siRNA screen for mediators of NF-κB activation.

Gewurz BE, Towfic F, Mar JC, et al. Genome-wide siRNA screen for mediators of NF-κB activation. Proc Natl Acad Sci U S A. 2012;109(7):2467-72. doi:10.1073/pnas.1120542109

IKKε-mediated tumorigenesis requires K63-linked polyubiquitination by a cIAP1/cIAP2/TRAF2 E3 ubiquitin ligase complex.

Zhou AY, Shen RR, Kim E, et al. IKKε-mediated tumorigenesis requires K63-linked polyubiquitination by a cIAP1/cIAP2/TRAF2 E3 ubiquitin ligase complex. Cell Rep. 2013;3(3):724-33. doi:10.1016/j.celrep.2013.01.031