PC12 Cells

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AAK1 identified as an inhibitor of neuregulin-1/ErbB4-dependent neurotrophic factor signaling using integrative chemical genomics and proteomics.

Kuai L, Ong SE, Madison JM, et al. AAK1 identified as an inhibitor of neuregulin-1/ErbB4-dependent neurotrophic factor signaling using integrative chemical genomics and proteomics. Chem Biol. 2011;18(7):891-906. doi:10.1016/j.chembiol.2011.03.017

Small molecule microarrays enable the discovery of compounds that bind the Alzheimer's Aβ peptide and reduce its cytotoxicity.

Chen J, Armstrong AH, Koehler AN, Hecht MH. Small molecule microarrays enable the discovery of compounds that bind the Alzheimer’s Aβ peptide and reduce its cytotoxicity. J Am Chem Soc. 2010;132(47):17015-22. doi:10.1021/ja107552s

Oncogenic RIT1 mutations in lung adenocarcinoma.

Berger AH, Imielinski M, Duke F, et al. Oncogenic RIT1 mutations in lung adenocarcinoma. Oncogene. 2014;33(35):4418-23. doi:10.1038/onc.2013.581

Diversity synthesis of complex pyridines yields a probe of a neurotrophic signaling pathway.

Gray L, Wang X, Brown C, Kuai L, Schreiber SL. Diversity synthesis of complex pyridines yields a probe of a neurotrophic signaling pathway. Org Lett. 2008;10(13):2621-4. doi:10.1021/ol8004936

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