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      1. Disease areas ӳý brings people together to advance the understanding and treatment of disease.
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          • Cancer
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      2. Research areas Through programs spanning genetics, biology, artificial intelligence (AI), and therapeutic development, ӳý researchers are making discoveries that drive biomedical science forward.
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          • AI and machine learning
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      3. Technology areas Our researchers use their expertise in creating, adapting, and applying a variety of technologies to enable science here and beyond.
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          • Data sciences
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      4. Science
        1. Patient-partnered research Patients partner with our scientists to accelerate the pace of discovery and find better treatments.
        2. Partnering and licensing We work closely with pharmaceutical, biotech, and technology partners to accelerate the translation of our discoveries.
        3. Publications A catalog of scientific papers published by our members and staff scientists.
        4. Resources, services, and tools Key scientific datasets and computational tools developed by our scientists and their collaborators.
        5. Collaborations and consortia We join with institutions and scientists the world over to address foundational challenges in science and health.
  • Centers
      1. Carlos Slim Center for Health Research The Slim Center aims to bring the benefits of genomics-driven medicine to Latin America, gleaning new insights into diseases with relevance to the region.
      2. Gerstner Center for Cancer Diagnostics The Gerstner Center is developing next-generation diagnostic technology for cancer detection and tracking disease progression.
      3. Klarman Cell Observatory The Klarman Cell Observatory is systematically defining mammalian cellular circuits, how they work together to create tissues and organs, and are perturbed to cause disease.
      4. Merkin Institute for Transformative Technologies in Healthcare The Merkin Institute is supporting early-stage ideas aimed at advancing powerful technological approaches for improving how we understand and treat disease.
      5. Novo Nordisk Foundation Center for Genomic Mechanisms of Disease This center is developing new paradigms and technologies to scale the discovery of biological mechanisms of common, complex diseases, by facilitating close collaborations between the ӳý and the Danish research community.
      6. Eric and Wendy Schmidt Center The EWSC is catalyzing a new field of interdisciplinary research at the intersection of data science and life science, aimed at improving human health.
      7. Stanley Center for Psychiatric Research The Stanley Center aims to reduce the burden of serious mental illness by contributing new insights into pathogenesis, identifying biomarkers, and paving the way toward new treatments.
  • Education and outreach
      1. Art and science connection Explore the connection between art and science and how we bring together artists and ӳý scientists through our artist-in-residence program, gallery exhibitions, and ongoing public conversations.
      2. ӳý Discovery Center Visit our free public educational space that showcases how researchers at the ӳý and their colleagues around the world seek to understand and treat human disease.
      3. Learning resources Access free classroom materials and more for STEM educators, parents, students, tutors, and others.
      4. Public programs Discover remarkable stories of scientific progress, and explore the intersections of science, medicine, and society.
      5. Student opportunities Learn about ӳý's mentored research offerings for high school students, college students, and recent college graduates.
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      1. News and insights Learn about breakthroughs from ӳý scientists.
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  • Careers
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Lipotoxicity Induces Beta Cell Small Extracellular Vesicle-mediated β-cell Dysfunction in Male Mice.
Roy A, Hoff A, Her TK, et al. Lipotoxicity Induces Beta Cell Small Extracellular Vesicle-mediated β-cell Dysfunction in Male Mice. Endocrinology. 2025. doi:10.1210/endocr/bqaf067
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Pancreatic injury induces β-cell regeneration in axolotl.
Powell CJ, Singer HD, Juarez AR, et al. Pancreatic injury induces β-cell regeneration in axolotl. bioRxiv : the preprint server for biology. 2025. doi:10.1101/2025.01.23.634564
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Functional genomics of human skeletal development and the patterning of height heritability.
Richard D, Muthuirulan P, Young M, et al. Functional genomics of human skeletal development and the patterning of height heritability. Cell. 2024. doi:10.1016/j.cell.2024.10.040
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Loss of reduces adipogenesis and improves insulin sensitivity in mouse and human adipocytes.
Yu GZ, Krentz NAJ, Bentley L, et al. Loss of reduces adipogenesis and improves insulin sensitivity in mouse and human adipocytes. bioRxiv : the preprint server for biology. 2024. doi:10.1101/2024.07.30.605923
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Loss of reduces adipogenesis and improves insulin sensitivity in mouse and human adipocytes.
Yu GZ, Krentz NAJ, Bentley L, et al. Loss of reduces adipogenesis and improves insulin sensitivity in mouse and human adipocytes. bioRxiv : the preprint server for biology. 2024. doi:10.1101/2024.07.30.605923
Read more
Cardiorenal Outcomes in Middle-Aged and Older Adults With Type 1 and Type 2 Diabetes.
Ostrominski JW, Cho SMJ, Vaduganathan M, Honigberg MC. Cardiorenal Outcomes in Middle-Aged and Older Adults With Type 1 and Type 2 Diabetes. Journal of the American College of Cardiology. 2024. doi:10.1016/j.jacc.2024.06.024
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The role of accelerometer-derived sleep traits on glycated haemoglobin and glucose levels: a Mendelian randomization study.
Liu J, Richmond RC, Anderson EL, et al. The role of accelerometer-derived sleep traits on glycated haemoglobin and glucose levels: a Mendelian randomization study. Scientific reports. 2024;14(1):14962. doi:10.1038/s41598-024-58007-9
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Metabolic and inflammatory perturbation of diabetes associated gut dysbiosis in people living with and without HIV infection.
Luo K, Peters BA, Moon JY, et al. Metabolic and inflammatory perturbation of diabetes associated gut dysbiosis in people living with and without HIV infection. Genome medicine. 2024;16(1):59. doi:10.1186/s13073-024-01336-1
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Identification and Management of Atherosclerotic Cardiovascular Disease Risk in South Asian Populations in the U.S.
Agarwala A, Satish P, Rifai MA, et al. Identification and Management of Atherosclerotic Cardiovascular Disease Risk in South Asian Populations in the U.S. JACC. Advances. 2023;2(2). doi:10.1016/j.jacadv.2023.100258
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Long-term effects of COVID-19 on the endocrine system - a pilot case-control study.
Szczerbiński Łukasz, Okruszko MA, Szabłowski M, et al. Long-term effects of COVID-19 on the endocrine system - a pilot case-control study. Frontiers in endocrinology. 2023;14:1192174. doi:10.3389/fendo.2023.1192174
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In March of 2020, ӳý converted a clinical genetics processing lab into a large-scale COVID-19 testing facility in less than two weeks.

We've screened more than 1,275 cancer cell lines as part of the Cancer Dependency Map (DepMap).

ӳý Genomics Platform sequences a whole human genome every four minutes.

More than 11,000 individuals living with cancer in the United States and Canada have partnered with Count Me In to share their experiences and help accelerate cancer research.

The Drug Repurposing Hub is one of the most comprehensive and up-to-date biologically annotated collections of FDA-approved compounds in the world. Researchers anywhere can explore more than 6,000 drugs in the hub and search for possible new uses for them to jump-start new drug discovery.

In 2021, our sustainability efforts sent more than 80 percent of waste from the Genomics Platform to either a recycling facility or to an incineration plant that generates electricity.

Through ӳý's Scientists in the Classroom program, ӳý researchers visit every 8th grade classroom in Cambridge each year to talk about genetics and evolution.

Every summer, 18 high school students spend six weeks at ӳý working side-by-side with mentors on cutting-edge research.

In November 2022, ӳý’s Genomics Platform sequenced its 500,000th whole human genome, a mere four years after sequencing its 100,000th.

By the end of 2022, ӳý’s COVID-19 testing lab had processed more than 37 million tests.

Working with Addgene, ӳý has shared CRISPR genome-editing reagents with researchers at more than 3,200 institutions in 76 countries.

The NeuroGAP-Psychosis project, a collaboration between the Stanley Center for Psychiatric Research and Harvard T.H. Chan School of Public Health to study the genetics of severe mental illness, has recruited more than 42,000 participants in Ethiopia, Kenya, Uganda, and South Africa.

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