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Evan Macosko is a core institute member at the Ó³»­´«Ã½ of MIT and Harvard, and an associate professor in the Departments of Psychiatry and Neurobiology at Harvard Medical School. He and his lab invent and apply genomics technology to the study of brain diseases, most especially schizophrenia and Parkinson’s disease. Areas of technological focus include developing genomics approaches to measuring gene expression within cells from intact tissue sections, quantifying synaptic connections, and detecting molecular interactions within cells. Macosko began his work in this field as a postdoctoral fellow with the development of Drop-seq, a foundational technique for performing high-throughput single-cell gene expression analysis. His own group has built upon this work to invent Slide-seq and Slide-tags, technologies that enable genomics measurements of single cells at high spatial resolution. The lab has applied these approaches to discover new brain cell types, characterize cellular responses to psychological stress, and identify disease-vulnerable neurons in neurodegenerative disease.

Macosko received an A.B. in chemistry from Harvard College, his M.D. from Weill Cornell Medical College, and a Ph.D. from The Rockefeller University. He is a practicing adult psychiatrist, completing residency training in psychiatry at McLean and Massachusetts General Hospitals. He is a recipient of a Pew Scholars Award, a Merkin Institute Fellowship, and is the co-director of the Ó³»­´«Ã½'s Center for Human Brain Cell Variation.

Photo credit: Juliana Sohn