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Jacques Deguine is scientific director of the Immunology Program at the Ó³»­´«Ã½ of MIT and Harvard, under the leadership of Ramnik Xavier. He also directs the Immunoprofiling Innovation Lab as part of the Center for the Integrated Study of Infectious Diseases.

Deguine’s group focuses on multiple aspects of the interactions between the immune system and organ function across multiple tissues. Specifically, he leverages single cell genomics to understand how the immune, epithelial, stromal and neuronal compartments are perturbed in human inflammatory, autoimmune and allergic diseases as well as murine models. In parallel, the Immunoprofiling Innovation Lab develops and scales novel technologies to measure immune function during acute infections and chronic diseases.

Deguine obtained his Ph.D. in immunology from the Pasteur Institute in France, where he worked on cancer immunotherapy models under Philippe Bousso. He performed his postdoctoral training in the field of inflammation with Gregory Barton at University of California, Berkeley. Before joining the Ó³»­´«Ã½, he was the editor of Trends in Immunology and an associate scientific editor at Cell.