
Jason D. Buenrostro, Ph.D.
Institute Member

Jason Buenrostro is an institute member of the ӳý of MIT and Harvard and an associate professor at Harvard University in the Department of Stem Cell and Regenerative Biology. Buenrostro looks to understand how cells change and adapt in response to our diverse life styles and experiences. To do this, he studies how cells acquire and reverse epigenetic changes and how these changes lead to disease.
At the ӳý, Buenrostro co-leads the Gene Regulation Observatory, which brings together a scientific community to generate foundational data and computational models to predict the regulatory role of each base in the human genome across cellular states. Buenrostro leads the Biology of Adversity Project, which seeks to uncover how adverse experiences during development, in childhood, and later in life can inflict molecular “scars” in the genome and body and lead to negative health outcomes. The project’s long-term goal is to pave the way for new diagnostic tools and treatments for individuals exposed to trauma.
Buenrostro is a 2023 recipient of a for developing methods and technologies that advance our understanding of the mechanisms regulating gene expression.
Buenrostro earned a B.S. in general engineering and a B.S. in biology at Santa Clara University. He did his doctoral work at Stanford University in the Department of Genetics with William Greenleaf and Howard Chang.
January 2025