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Genetic screens point to VPS4A and VPS4B as promising cancer drug targets

Ó³»­´«Ã½ scientists are using brain, kidney, and tumor organoids to gain new insights into disease mechanisms and therapeutic approaches.

Cancer cells that have lost a copy of a critical gene may be vulnerable to therapies that knock out the remaining copy

Study will help narrow down the list of targets for the next generation of cancer treatments

Cancer cells that cannot repair a certain form of DNA mutation become strongly dependent on single enzyme to survive, creating a new potential opportunity for drug development.

Compiled by Cancer Dependency Map group, tool lets researchers identify cancer vulnerabilities.

Cancer cells thrive despite harboring mutations that should kill them. By mapping the dependencies cancer cells rely on for survival, researchers hope to reveal new treatment opportunities.