Ó³»´«Ã½ cancer research includes efforts to decipher the genetic and molecular landscape of a wide range of cancer and immune cells as well as equally systematic genome-wide approaches to interrogate the function of cancer genes and the vulnerabilities of tumors. In partnership with colleagues within academia and industry, Ó³»´«Ã½ cancer researchers develop breakthrough technologies to drive discoveries of new drug targets and potential therapies, and generate systematic strategies for predicting therapeutic combinations to combat resistance.
Project Achilles is a systematic effort aimed at identifying and cataloging genetic vulnerabilities across hundreds of genomically characterized cancer cell lines. The project uses a genome-wide shRNA library to silence individual genes and identify those genes that affect cell survival. Large-scale functional screening of cancer cell lines...