The CTD2 Dashboard is a web resource that links findings from Cancer Target Discovery and Development (CTD2) Network Centers, which collectively mine and functionally validate data from large-scale cancer genome characterization initiatives and advance them toward use in precision oncology. The Network developed the open-access CTD2 Dashboard as...
Identifying and Targeting Cancer Dependencies with Small Molecules
The Malaria Therapeutics Response Portal results from efforts to discover new antimalarial targets targeting multiple stages of Plasmodium parasites and acting by novel mechanisms of action. The data result from primary and secondary screens of a diverse collection of 100,000 compounds having three-dimensional topographic features derived from...
Using multiplex-cytological (MC) and gene-expression (GE) profiling assays, we assembled a reference dataset of profiles for structurally and stereochemically diverse diversity-oriented synthesis (DOS)-derived compounds (18,000-20,000), chemically diverse Molecular Libraries Program (MLP) compounds with biologically diverse performance identified...
The Cancer Therapeutics Response Portal (CTRP) links genetic, lineage, and other cellular features of cancer cell lines to small-molecule sensitivity with the goal of accelerating discovery of patient-matched cancer therapeutics. CTRP can be mined to develop insights into small-molecule mechanisms of action and novel therapeutic hypotheses, and...