Proteomics Platform

Proteomics

The Proteomics Platform provides best-in-class mass spectrometry-based proteomic technologies and analysis capabilities to the ӳý community and collaborators throughout the United States and beyond, with the goal of addressing important questions in biology, chemistry, and clinical sciences through intensive collaboration. We continue to adopt and pioneer development of cutting-edge sample processing, data collection, and data analysis technologies of greatest importance. 

Major areas of focus include:

Blog 02.13.2015
Dynamic profiling of the protein life cycle in response to pathogens

Cellular protein levels are dictated by the net balance of mRNA expression (the type of RNA that provides genetic information for proteins), protein synthesis, and protein degradation. While changes in protein levels are commonly inferred from measuring changes in mRNA levels (due to the difficulties involved in measuring protein levels), it’s not often clear whether determining RNA levels is actually a good proxy for measuring protein levels.

Proteomics Platform
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News 02.05.2015
Researchers find link between microbiome, type 1 diabetes

In one of the largest longitudinal studies of the microbiome to date, researchers from the ,  (MGH), and the  Study Group have identified a connection between changes in gut microbiota and the onset of type 1 diabetes (T1D). The study, which followed infants who were genetically predisposed to the condition, found that onset for those who developed the disease was preceded by a drop in microbial diversity – including a disproportional decrease in the number of species known to promote health in the gut. These findings, , could help pave the way for microbial-based diagnostic and therapeutic options for those with T1D.

Proteomics Platform
Infectious Disease and Microbiome Program
Diabetes
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