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It can take a year or more for a chemical library to be screened in cells, a delay that often slows chemists’ access to biological data that could help them plan their synthesis efforts. In the  last week, a team led by Stuart Schreiber and Zarko Boskovic, of Ó³»­´«Ã½â€™s Center for the Science of Therapeutics and Harvard University’s Department of Chemistry and Chemical Biology, shares an approach for screening newly synthesized compounds’ biological activity in near real-time. Combining chemical synthesis and cell painting, the approach could make the library design process more nimble, reveal how certain synthesis steps impact molecules’ biological activities, and accelerate drug candidate discovery.