ӳ��ý

Kidney Disease

Inducible podocyte-specific deletion of CTCF drives progressive kidney disease and bone abnormalities.

Christov M, Clark AR, Corbin B, et al. Inducible podocyte-specific deletion of CTCF drives progressive kidney disease and bone abnormalities. JCI Insight. 2018;3(4). doi:10.1172/jci.insight.95091

GDC-0879, a BRAF Inhibitor, Protects Kidney Podocytes from Death.

Sieber J, Wieder N, Clark A, et al. GDC-0879, a BRAF Inhibitor, Protects Kidney Podocytes from Death. Cell Chem Biol. 2018;25(2):175-184.e4. doi:10.1016/j.chembiol.2017.11.006

A small-molecule inhibitor of TRPC5 ion channels suppresses progressive kidney disease in animal models.

Zhou Y, Castonguay P, Sidhom EH, et al. A small-molecule inhibitor of TRPC5 ion channels suppresses progressive kidney disease in animal models. Science. 2017;358(6368):1332-1336. doi:10.1126/science.aal4178

Lysine trimethylation regulates 78-kDa glucose-regulated protein proteostasis during endoplasmic reticulum stress.

Sieber J, Wieder N, Ostrosky-Frid M, et al. Lysine trimethylation regulates 78-kDa glucose-regulated protein proteostasis during endoplasmic reticulum stress. J Biol Chem. 2017;292(46):18878-18885. doi:10.1074/jbc.M117.797084