SMAD4 represses FOSL1 expression and pancreatic cancer metastatic colonization.

Cell Rep

Authors	Chao Dai Jonathan Rennhack Taylor Arnoff Maneesha Thaker Scott Younger John Doench August Huang Annan Yang Andrew Aguirre Belinda Wang Evan Mun Joyce O'Connell Ying Huang Katherine Labella Jessica Talamas Ji Li Nina Ilic Justin Hwang Andrew Hong Andrew Giacomelli Ole Gjoerup David Root William Hahn
Abstract	Metastasis is a complex and poorly understood process. In pancreatic cancer, loss of the transforming growth factor (TGF)-β/BMP effector SMAD4 is correlated with changes in altered histopathological transitions, metastatic disease, and poor prognosis. In this study, we use isogenic cancer cell lines to identify SMAD4 regulated genes that contribute to the development of metastatic colonization. We perform an in vivo screen identifying FOSL1 as both a SMAD4 target and sufficient to drive colonization to the lung. The targeting of these genes early in treatment may provide a therapeutic benefit.
Year of Publication	2021
Journal	Cell Rep
Volume	36
Issue	4
Pages	109443
Date Published	2021 Jul 27
ISSN	2211-1247
DOI	10.1016/j.celrep.2021.109443
PubMed ID	34320363
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