Cellular and transcriptional diversity over the course of human lactation.
Proc Natl Acad Sci U S A
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| Abstract | SignificanceHuman breast milk is the nutritional food source evolved specifically to meet the needs of infants, but much remains to be learned about its composition and changes over the course of lactation. Our description of the cellular components of breast milk, their associations with maternal-infant dyad metadata, and quantification of alterations at the gene and pathway levels provide a longitudinal picture of human breast milk cells across lactational time. These results pave the way for improved therapeutic support of healthy lactation and milk production. |
| Year of Publication | 2022
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| Journal | Proc Natl Acad Sci U S A
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| Volume | 119
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| Issue | 15
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| Pages | e2121720119
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| Date Published | 2022 Apr 12
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| ISSN | 1091-6490
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| DOI | 10.1073/pnas.2121720119
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| PubMed ID | 35377806
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| Grant list | F32-AI136459 / GF / NIH HHS / United States
P30-CA14051 / GF / NIH HHS / United States
1122374 / National Science Foundation (NSF)
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