Proteogenomic data and resources for pan-cancer analysis.
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| Abstract | The National Cancer Institute's Clinical Proteomic Tumor Analysis Consortium (CPTAC) investigates tumors from a proteogenomic perspective, creating rich multi-omics datasets connecting genomic aberrations to cancer phenotypes. To facilitate pan-cancer investigations, we have generated harmonized genomic, transcriptomic, proteomic, and clinical data for >1000 tumors in 10 cohorts to create a cohesive and powerful dataset for scientific discovery. We outline efforts by the CPTAC pan-cancer working group in data harmonization, data dissemination, and computational resources for aiding biological discoveries. We also discuss challenges for multi-omics data integration and analysis, specifically the unique challenges of working with both nucleotide sequencing and mass spectrometry proteomics data. |
| Year of Publication | 2023
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| Journal | Cancer cell
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| Volume | 41
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| Issue | 8
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| Pages | 1397-1406
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| Date Published | 08/2023
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| ISSN | 1878-3686
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| DOI | 10.1016/j.ccell.2023.06.009
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| PubMed ID | 37582339
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