Unraveling the Functional Heterogeneity of Human Skin at Single-Cell Resolution.

Hematology/oncology clinics of North America
Authors
Keywords
Abstract

The skin consists of several cell populations, including epithelial, immune, and stromal cells. Recently, there has been a significant increase in single-cell RNA-sequencing studies, contributing to the development of a consensus Human Skin Cell Atlas. The aim is to understand skin biology better and identify potential therapeutic targets. The present review utilized previously published single-cell RNA-sequencing datasets to explore human skin's cellular and functional heterogeneity. Additionally, it summarizes the functional significance of newly identified cell subpopulations in processes such as wound healing and aging.

Year of Publication
2024
Journal
Hematology/oncology clinics of North America
Date Published
06/2024
ISSN
1558-1977
DOI
10.1016/j.hoc.2024.05.001
PubMed ID
38839486
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