High Prevalence of Carbapenem-resistant in Fecal and Water Samples in Dhaka, Bangladesh.

Open forum infectious diseases
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Keywords
Abstract

We evaluated (Kp) gut carriage in healthy, unrelated adults and children living in separate households in Dhaka, Bangladesh. Average Kp prevalence in stool samples ranged from 61% in young children (15/25) to 81% in adults (21/26), with significantly higher abundance in adults ( = .03, -test). Kp was also prevalent in household water (64%, 21/33) and standing water (85%, 23/27). The presence of Kp in household water was not strongly linked to stool Kp abundance among household members. Antimicrobial resistance was notable: 9% (6/69) of stool and 16% (7/44) of water isolates exhibited multidrug resistance. Carbapenem resistance was observed in 12% of stool isolates (8/69) and 14% of water isolates (6/44). These findings underscore the commonality of Kp in human and environmental reservoirs in Dhaka, Bangladesh, and highlight the emergence of drug-resistant Kp beyond healthcare settings.

Year of Publication
2024
Journal
Open forum infectious diseases
Volume
11
Issue
11
Pages
ofae612
Date Published
11/2024
ISSN
2328-8957
DOI
10.1093/ofid/ofae612
PubMed ID
39494455
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