Epigenetic and Oncogenic Inhibitors Cooperatively Drive Differentiation and Kill KRAS-Mutant Colorectal Cancers.
Cancer discovery
| Authors | |
| Abstract | Combined EZH2 and RAS pathway inhibitors kill KRAS-mutant colorectal cancer cells and promote durable tumor regression in vivo. These agents function by cooperatively suppressing the WNT pathway, driving differentiation, and epigenetically reprogramming cells to permit the induction of apoptotic signals, which then kill these more differentiated tumor cells. |
| Year of Publication | 2024
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| Journal | Cancer discovery
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| Volume | 14
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| Issue | 12
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| Pages | 2430-2449
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| Date Published | 12/2024
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| ISSN | 2159-8290
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| DOI | 10.1158/2159-8290.CD-23-0866
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| PubMed ID | 39121480
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| Links |