Creating Patient-Specific Neural Cells for the In Vitro Study of Brain Disorders.

Stem Cell Reports

Authors	Kristen Brennand M Carol Marchetto Nissim Benvenisty Oliver Brüstle Allison Ebert Juan Belmonte Ajamete Kaykas Madeline Lancaster Frederick Livesey Michael McConnell Ronald McKay Eric Morrow Alysson Muotri David Panchision Lee Rubin Akira Sawa Frank Soldner Hongjun Song Lorenz Studer Sally Temple Flora Vaccarino Jun Wu Pierre Vanderhaeghen Fred Gage Rudolf Jaenisch
Keywords	Humans Induced Pluripotent Stem Cells Precision Medicine Brain Brain Diseases Neurogenesis Drug Discovery Mosaicism
Abstract	As a group, we met to discuss the current challenges for creating meaningful patient-specific in vitro models to study brain disorders. Although the convergence of findings between laboratories and patient cohorts provided us confidence and optimism that hiPSC-based platforms will inform future drug discovery efforts, a number of critical technical challenges remain. This opinion piece outlines our collective views on the current state of hiPSC-based disease modeling and discusses what we see to be the critical objectives that must be addressed collectively as a field.
Year of Publication	2015
Journal	Stem Cell Reports
Volume	5
Issue	6
Pages	933-945
Date Published	2015 Dec 08
ISSN	2213-6711
DOI	10.1016/j.stemcr.2015.10.011
PubMed ID	26610635
PubMed Central ID	PMC4881284
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