Collaborative genome-wide association analysis supports a role for ANK3 and CACNA1C in bipolar disorder.

Nat Genet

Authors	Manuel Ferreira Michael O'Donovan Yan Meng Ian Jones Douglas Ruderfer Lisa Jones Jinbo Fan George Kirov Roy Perlis Elaine Green Jordan Smoller Detelina Grozeva Jennifer Stone Ivan Nikolov Kimberly Chambert Marian Hamshere Vishwajit Nimgaonkar Valentina Moskvina Michael Thase Sian Caesar Gary Sachs Jennifer Franklin Katherine Gordon-Smith Kristin Ardlie Stacey Gabriel Christine Fraser Brendan Blumenstiel Matthew DeFelice Gerome Breen Michael Gill Derek Morris Amanda Elkin Walter Muir Kevin McGhee Richard Williamson Donald MacIntyre Alan MacLean Clair St Michelle Robinson Margaret Van Beck Ana Pereira Radhika Kandaswamy Andrew McQuillin David Collier Nicholas Bass Allan Young Jacob Lawrence I Nicol Ferrier Adebayo Anjorin Anne Farmer David Curtis Edward Scolnick Peter McGuffin Mark Daly Aiden Corvin Peter Holmans Douglas Blackwood Hugh Gurling Michael Owen Shaun Purcell Pamela Sklar Nick Craddock Wellcome Trust Case Control Consortium
Keywords	Humans Genetic Predisposition to Disease Genome-Wide Association Study Polymorphism, Single Nucleotide Chromosomes, Human, Pair 12 Bipolar Disorder Chromosomes, Human, Pair 15 Calcium Channels, L-Type Chromosomes, Human, Pair 10 Logistic Models Ankyrins
Abstract	To identify susceptibility loci for bipolar disorder, we tested 1.8 million variants in 4,387 cases and 6,209 controls and identified a region of strong association (rs10994336, P = 9.1 x 10(-9)) in ANK3 (ankyrin G). We also found further support for the previously reported CACNA1C (alpha 1C subunit of the L-type voltage-gated calcium channel; combined P = 7.0 x 10(-8), rs1006737). Our results suggest that ion channelopathies may be involved in the pathogenesis of bipolar disorder.
Year of Publication	2008
Journal	Nat Genet
Volume	40
Issue	9
Pages	1056-8
Date Published	2008 Sep
ISSN	1061-4036
DOI	10.1038/ng.209
PubMed ID	18711365
PubMed Central ID	PMC2703780
Links
Grant list	G0701003 / Medical Research Council / United Kingdom G9309834 / Medical Research Council / United Kingdom R01 MH062137 / MH / NIMH NIH HHS / United States 082371 / Wellcome Trust / United Kingdom 077011 / Wellcome Trust / United Kingdom MH062137 / MH / NIMH NIH HHS / United States 076113 / Wellcome Trust / United Kingdom MH63420 / MH / NIMH NIH HHS / United States R01 MH067288 / MH / NIMH NIH HHS / United States G0500791 / Medical Research Council / United Kingdom G9623693N / Medical Research Council / United Kingdom Chief Scientist Office / United Kingdom R01 MH063420 / MH / NIMH NIH HHS / United States N01MH80001 / MH / NIMH NIH HHS / United States MH067288 / MH / NIMH NIH HHS / United States Wellcome Trust / United Kingdom R01 MH063445 / MH / NIMH NIH HHS / United States U54 RR020278 / RR / NCRR NIH HHS / United States MH063445 / MH / NIMH NIH HHS / United States