Dissecting protein structure and function using directed evolution.
Nat Methods
| Authors | |
| Keywords | |
| Abstract | To characterize the contributions of individual amino acids to the structure or function of a protein, researchers have adopted directed evolution approaches, which use iterated cycles of mutagenesis and selection or screening to search vast areas of sequence space for sets of mutations that provide insights into the protein of interest. |
| Year of Publication | 2007
|
| Journal | Nat Methods
|
| Volume | 4
|
| Issue | 12
|
| Pages | 995-7
|
| Date Published | 2007 Dec
|
| ISSN | 1548-7105
|
| DOI | 10.1038/nmeth1207-995
|
| PubMed ID | 18049466
|
| PubMed Central ID | PMC4255555
|
| Links | |
| Grant list | Howard Hughes Medical Institute / United States
R01 GM065400 / GM / NIGMS NIH HHS / United States
|