Diversity-oriented synthesis of 13- to 18-membered macrolactams via ring-closing metathesis.
J Org Chem
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| Abstract | An efficient build/couple/pair approach to diversity-oriented synthesis was employed to access several structurally complex macrolactams. In this paper, we describe the successful evaluation of ring-closing metathesis toward the systematic generation of skeletal diversity. By appropriately varying the nature and chain length of the alkenol fragment, a diverse collection of 13- to 18-membered macrolactams were obtained. |
| Year of Publication | 2011
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| Journal | J Org Chem
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| Volume | 76
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| Issue | 19
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| Pages | 8042-8
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| Date Published | 2011 Oct 07
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| ISSN | 1520-6904
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| DOI | 10.1021/jo2011957
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| PubMed ID | 21875084
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| PubMed Central ID | PMC4284946
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| Grant list | P50 GM069721 / GM / NIGMS NIH HHS / United States
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