Assessing G1-to-S-phase progression after genotoxic stress.
Methods Mol Biol
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| Abstract | Maintenance of genomic integrity is critical for the survival of organisms. Thus, mammalian cells employ a complex DNA damage response that can sense and repair DNA damage. One important aspect of the cellular DNA damage response is the activation of checkpoints that result in cell cycle arrest. In this chapter we present methods for the induction of genotoxic stress. Additionally, we describe methods for studying the progression of cells from G(1) to S phase after genotoxic stress. |
| Year of Publication | 2011
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| Journal | Methods Mol Biol
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| Volume | 782
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| Pages | 221-30
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| Date Published | 2011
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| ISSN | 1940-6029
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| DOI | 10.1007/978-1-61779-273-1_16
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| PubMed ID | 21870295
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| PubMed Central ID | PMC3645480
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| Grant list | R01 GM065814 / GM / NIGMS NIH HHS / United States
R01 GM 65814 / GM / NIGMS NIH HHS / United States
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