Dissecting evolution and disease using comparative vertebrate genomics.

Nat Rev Genet
Authors
Keywords
Abstract

With the generation of more than 100 sequenced vertebrate genomes in less than 25 years, the key question arises of how these resources can be used to inform new or ongoing projects. In the past, this diverse collection of sequences from human as well as model and non-model organisms has been used to annotate the human genome and to increase the understanding of human disease. In the future, comparative vertebrate genomics in conjunction with additional genomic resources will yield insights into the processes of genome function, evolution, speciation, selection and adaptation, as well as the quantification of species diversity. In this Review, we discuss how the genomics of non-human organisms can provide insights into vertebrate biology and how this can contribute to the understanding of human physiology and health.

Year of Publication
2017
Journal
Nat Rev Genet
Volume
18
Issue
10
Pages
624-636
Date Published
2017 10
ISSN
1471-0064
DOI
10.1038/nrg.2017.51
PubMed ID
28736437
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