Nodal morphogens.
Cold Spring Harb Perspect Biol
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| Abstract | Nodal signals belong to the TGF-beta superfamily and are essential for the induction of mesoderm and endoderm and the determination of the left-right axis. Nodal signals can act as morphogens-they have concentration-dependent effects and can act at a distance from their source of production. Nodal and its feedback inhibitor Lefty form an activator/inhibitor pair that behaves similarly to postulated reaction-diffusion models of tissue patterning. Nodal morphogen activity is also regulated by microRNAs, convertases, TGF-beta signals, coreceptors, and trafficking factors. This article describes how Nodal morphogens pattern embryonic fields and discusses how Nodal morphogen signaling is modulated. |
| Year of Publication | 2009
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| Journal | Cold Spring Harb Perspect Biol
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| Volume | 1
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| Issue | 5
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| Pages | a003459
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| Date Published | 2009 Nov
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| ISSN | 1943-0264
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| URL | |
| DOI | 10.1101/cshperspect.a003459
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| PubMed ID | 20066122
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| PubMed Central ID | PMC2773646
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| Grant list | R01 GM056211 / GM / NIGMS NIH HHS / United States
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