Intron retention is a source of neoepitopes in cancer.

Nat Biotechnol

Authors	Alicia Smart Claire Margolis Harold Pimentel Meng He Diana Miao Dennis Adeegbe Tim Fugmann Kwok-Kin Wong Eliezer Van Allen
Keywords	Humans Neoplasms RNA Computer Simulation Cell Line, Tumor Introns Models, Genetic Cancer Vaccines Epitopes Epitope Mapping
Abstract	We present an in silico approach to identifying neoepitopes derived from intron retention events in tumor transcriptomes. Using mass spectrometry immunopeptidome analysis, we show that retained intron neoepitopes are processed and presented on MHC I on the surface of cancer cell lines. RNA-derived neoepitopes should be considered for prospective personalized cancer vaccine development.
Year of Publication	2018
Journal	Nat Biotechnol
Volume	36
Issue	11
Pages	1056-1058
Date Published	2018 12
ISSN	1546-1696
DOI	10.1038/nbt.4239
PubMed ID	30114007
PubMed Central ID	PMC6226333
Links
Grant list	K08 CA188615 / CA / NCI NIH HHS / United States R01 CA166480 / CA / NCI NIH HHS / United States R01 CA227388 / CA / NCI NIH HHS / United States