Gene discovery and polygenic prediction from a genome-wide association study of educational attainment in 1.1 million individuals.
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| Abstract | Here we conducted a large-scale genetic association analysis of educational attainment in a sample of approximately 1.1 million individuals and identify 1,271 independent genome-wide-significant SNPs. For the SNPs taken together, we found evidence of heterogeneous effects across environments. The SNPs implicate genes involved in brain-development processes and neuron-to-neuron communication. In a separate analysis of the X chromosome, we identify 10 independent genome-wide-significant SNPs and estimate a SNP heritability of around 0.3% in both men and women, consistent with partial dosage compensation. A joint (multi-phenotype) analysis of educational attainment and three related cognitive phenotypes generates polygenic scores that explain 11-13% of the variance in educational attainment and 7-10% of the variance in cognitive performance. This prediction accuracy substantially increases the utility of polygenic scores as tools in research. |
| Year of Publication | 2018
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| Journal | Nat Genet
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| Volume | 50
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| Issue | 8
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| Pages | 1112-1121
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| Date Published | 2018 07 23
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| ISSN | 1546-1718
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| DOI | 10.1038/s41588-018-0147-3
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| PubMed ID | 30038396
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| PubMed Central ID | PMC6393768
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| Grant list | BB/F022441/1 / BB_ / Biotechnology and Biological Sciences Research Council / United Kingdom
MC_UU_12015/1 / MRC_ / Medical Research Council / United Kingdom
MC_UU_12015/2 / MRC_ / Medical Research Council / United Kingdom
P2C HD047879 / HD / NICHD NIH HHS / United States
P30 AG010161 / AG / NIA NIH HHS / United States
G0600237 / MRC_ / Medical Research Council / United Kingdom
R01 AG055406 / AG / NIA NIH HHS / United States
G0901461 / MRC_ / Medical Research Council / United Kingdom
WT_ / Wellcome Trust / United Kingdom
P2C HD050924 / HD / NICHD NIH HHS / United States
R01 HD073342 / HD / NICHD NIH HHS / United States
MR/N01104X/2 / MRC_ / Medical Research Council / United Kingdom
G1001799 / MRC_ / Medical Research Council / United Kingdom
L30 MH104879 / MH / NIMH NIH HHS / United States
MC_UU_00007/10 / MRC_ / Medical Research Council / United Kingdom
G0100594 / MRC_ / Medical Research Council / United Kingdom
P2C HD066613 / HD / NICHD NIH HHS / United States
MC_UU_12013/4 / MRC_ / Medical Research Council / United Kingdom
P01 AG005842 / AG / NIA NIH HHS / United States
P30 AG012810 / AG / NIA NIH HHS / United States
R01 AG042568 / AG / NIA NIH HHS / United States
T32 AG000186 / AG / NIA NIH HHS / United States
BB/F019394/1 / BB_ / Biotechnology and Biological Sciences Research Council / United Kingdom
R01 AG015819 / AG / NIA NIH HHS / United States
647648 / ERC_ / European Research Council / International
MR/K026992/1 / MRC_ / Medical Research Council / United Kingdom
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