Epigenome-wide association studies without the need for cell-type composition.
Nat Methods
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Abstract | In epigenome-wide association studies, cell-type composition often differs between cases and controls, yielding associations that simply tag cell type rather than reveal fundamental biology. Current solutions require actual or estimated cell-type composition--information not easily obtainable for many samples of interest. We propose a method, FaST-LMM-EWASher, that automatically corrects for cell-type composition without the need for explicit knowledge of it, and then validate our method by comparison with the state-of-the-art approach. Corresponding software is available from . |
Year of Publication | 2014
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Journal | Nat Methods
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Volume | 11
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Issue | 3
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Pages | 309-11
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Date Published | 2014 Mar
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ISSN | 1548-7105
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URL | |
DOI | 10.1038/nmeth.2815
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PubMed ID | 24464286
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