Dietary and metabolic control of stem cell function in physiology and cancer.
Cell Stem Cell
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| Abstract | Organismal diet has a profound impact on tissue homeostasis and health in mammals. Adult stem cells are a keystone of tissue homeostasis that alters tissue composition by balancing self-renewal and differentiation divisions. Because somatic stem cells may respond to shifts in organismal physiology to orchestrate tissue remodeling and some cancers are understood to arise from transformed stem cells, there is a likely possibility that organismal diet, stem cell function, and cancer initiation are interconnected. Here we will explore the emerging effects of diet on nutrient-sensing pathways active in mammalian tissue stem cells and their relevance to normal and cancerous growth. |
| Year of Publication | 2014
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| Journal | Cell Stem Cell
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| Volume | 14
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| Issue | 3
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| Pages | 292-305
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| Date Published | 2014 Mar 06
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| ISSN | 1875-9777
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| URL | |
| DOI | 10.1016/j.stem.2014.02.008
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| PubMed ID | 24607404
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| PubMed Central ID | PMC3992244
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| Grant list | R01 AI047389 / AI / NIAID NIH HHS / United States
R01 CA103866 / CA / NCI NIH HHS / United States
DK043351 / DK / NIDDK NIH HHS / United States
P30 DK043351 / DK / NIDDK NIH HHS / United States
K99 AG045144 / AG / NIA NIH HHS / United States
AI047389 / AI / NIAID NIH HHS / United States
CA103866 / CA / NCI NIH HHS / United States
AG045144 / AG / NIA NIH HHS / United States
R37 AI047389 / AI / NIAID NIH HHS / United States
R00 AG045144 / AG / NIA NIH HHS / United States
Howard Hughes Medical Institute / United States
CA129105 / CA / NCI NIH HHS / United States
R01 CA129105 / CA / NCI NIH HHS / United States
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