A perspective on stem cell modeling of amyotrophic lateral sclerosis.

Cell Cycle

Authors	A Sophie de Boer Kevin Eggan
Keywords	Humans Cell Differentiation Cell Culture Techniques DNA-Binding Proteins Induced Pluripotent Stem Cells Amyotrophic Lateral Sclerosis Superoxide Dismutase Astrocytes Microglia Superoxide Dismutase-1 Vesicular Transport Proteins RNA-Binding Protein FUS
Abstract	Amyotrophic lateral sclerosis is a complex neurodegenerative disease. Limitations in animal models have impeded progress in studying disease pathology and potential drug discovery. Here, we will review recent advances in the development of stem cell models for the study of ALS. Additionally, we will discuss the progress toward therapeutic development derived from these stem cell based assays.
Year of Publication	2015
Journal	Cell Cycle
Volume	14
Issue	23
Pages	3679-88
Date Published	2015
ISSN	1551-4005
URL
DOI	10.1080/15384101.2015.1093712
PubMed ID	26505672
PubMed Central ID	PMC4825790
Links
Grant list	R01NS089742 / NS / NINDS NIH HHS / United States RC2NS069395 / NS / NINDS NIH HHS / United States Howard Hughes Medical Institute / United States