Discovery and structure-activity relationships of small molecules that block the human immunoglobulin G-human neonatal Fc receptor (hIgG-hFcRn) protein-protein interaction.
Bioorg Med Chem Lett
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| Abstract | The neonatal Fc receptor, FcRn, prolongs the half-life of IgG in the serum and represents a potential therapeutic target for the treatment of autoimmune disease. Small molecules that block the protein-protein interactions of human IgG-human FcRn may lower pathogenic autoantibodies and provide effective treatment. A novel class of quinoxalines has been discovered as antagonists of the IgG:FcRn protein-protein interaction through optimization of a hit derived from a virtual ligand-based screen. |
| Year of Publication | 2013
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| Journal | Bioorg Med Chem Lett
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| Volume | 23
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| Issue | 5
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| Pages | 1253-6
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| Date Published | 2013 Mar 01
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| ISSN | 1464-3405
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| DOI | 10.1016/j.bmcl.2013.01.014
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| PubMed ID | 23375228
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