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A team led by researchers from the Ó³»­´«Ã½ of MIT and Harvard, the National Institutes of Health, and Vanderbilt University Medical Center has used base editing, a recently developed form of gene editing, to rescue disease symptoms and lifespan in mice that have Hutchinson-Gilford progeria syndrome.

Co-senior authors on the study include David Liu, director of the Merkin Institute of Transformative Technologies in Healthcare at the Ó³»­´«Ã½, professor at Harvard University, and investigator with the Howard Hughes Medical Institute, Francis Collins, director of the National Institutes of Health and senior investigator at the National Human Genome Research Institute, and Jonathan Brown, assistant professor of medicine in the Division of Cardiovascular Medicine at Vanderbilt University Medical Center.

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Paper cited:
Koblan LW, Erdos MR, et al. Nature. Online January 6, 2021. DOI: 10.1038/s41586-020-03086-7