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Cancer is caused by a series of mutations that are acquired, in many cases, over many years. But in the beginning, the initiating mutations can lead to a pre-malignant lesion (such as a polyp in the colon) before causing full-fledged disease.

In this 2017 Midsummer Nights' Science talk, Benjamin Ebert will discusses his lab's work in learning about these pre-malignancies, their clinical consequences, and how to detect them — raising the question of whether clinicians could use this information to prevent the development of some cancers.