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Co-directors Robert Manguso and Kathleen Yates discuss the ambitious idea behind TIDE, a project that aims to improve immunotherapy by systematically identifying the genes tumors use to evade the immune system. Through collaboration with Calico Life Sciences, the team has already probed the role of every gene in immunotherapy resistance across eight cancer models, and a cancer immunotherapy candidate that inhibits a target identified in a TIDE screen has already entered clinical trials.

Learn more about the inhibitor.

Learn more about TIDE, the project that identified the target.