The Accelerating Medicines Partnership Type 2 Diabetes (AMP T2D) Knowledge Portal is an open-access web resource that aggregates, harmonizes, analyzes, and presents genetic associations and epigenomic annotations for type 2 diabetes, with the goal of helping researchers understand disease mechanisms and find new therapeutic targets. It is part of the Knowledge Portal Network (kp4cd.org), along with Portals for the genetics of heart disease, stroke, and sleep disorders. This introductory webinar explains the content of the Portals, focusing on the T2D Portal, and illustrates how to use the major interfaces and tools.