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      5. Novo Nordisk Foundation Center for Genomic Mechanisms of Disease This center is developing new paradigms and technologies to scale the discovery of biological mechanisms of common, complex diseases, by facilitating close collaborations between the Ó³»­´«Ã½ and the Danish research community.
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      7. Stanley Center for Psychiatric Research The Stanley Center aims to reduce the burden of serious mental illness by contributing new insights into pathogenesis, identifying biomarkers, and paving the way toward new treatments.
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      1. Art and science connection Explore the connection between art and science and how we bring together artists and Ó³»­´«Ã½ scientists through our artist-in-residence program, gallery exhibitions, and ongoing public conversations.
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Identification of genes associated with dissociation of cognitive performance and neuropathological burden: Multistep analysis of genetic, epigenetic, and transcriptional data.
White CC, Yang HS, Yu L, et al. Identification of genes associated with dissociation of cognitive performance and neuropathological burden: Multistep analysis of genetic, epigenetic, and transcriptional data. PLoS Med. 2017;14(4):e1002287. doi:10.1371/journal.pmed.1002287
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The Genetics of Endophenotypes of Neurofunction to Understand Schizophrenia (GENUS) consortium: A collaborative cognitive and neuroimaging genetics project.
Blokland GAM, Del Re EC, Mesholam-Gately RI, et al. The Genetics of Endophenotypes of Neurofunction to Understand Schizophrenia (GENUS) consortium: A collaborative cognitive and neuroimaging genetics project. Schizophr Res. 2018;195:306-317. doi:10.1016/j.schres.2017.09.024
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First-episode psychosis patients display increased plasma IL-18 that correlates with cognitive dysfunction.
Orhan F, Fatouros-Bergman H, Schwieler L, et al. First-episode psychosis patients display increased plasma IL-18 that correlates with cognitive dysfunction. Schizophr Res. 2018;195:406-408. doi:10.1016/j.schres.2017.09.016
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Do glia drive synaptic and cognitive impairment in disease?
Chung WS, Welsh CA, Barres BA, Stevens B. Do glia drive synaptic and cognitive impairment in disease?. Nat Neurosci. 2015;18(11):1539-1545. doi:10.1038/nn.4142
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Neuropathologic features of TOMM40 '523 variant on late-life cognitive decline.
Yu L, Lutz MW, Farfel JM, et al. Neuropathologic features of TOMM40 ’523 variant on late-life cognitive decline. Alzheimers Dement. 2017;13(12):1380-1388. doi:10.1016/j.jalz.2017.05.002
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Genome-wide association study results for educational attainment aid in identifying genetic heterogeneity of schizophrenia.
Bansal V, Mitjans M, Burik CAP, et al. Genome-wide association study results for educational attainment aid in identifying genetic heterogeneity of schizophrenia. Nat Commun. 2018;9(1):3078. doi:10.1038/s41467-018-05510-z
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Targeted brain proteomics uncover multiple pathways to Alzheimer's dementia.
Yu L, Petyuk VA, Gaiteri C, et al. Targeted brain proteomics uncover multiple pathways to Alzheimer’s dementia. Ann Neurol. 2018;84(1):78-88. doi:10.1002/ana.25266
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Program to improve cognitive functioning in patients with schizophrenia: reflections.
Scolnick E. Program to improve cognitive functioning in patients with schizophrenia: reflections. Schizophr Res. 2004;72(1):75-7. doi:10.1016/j.schres.2004.09.005
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Histone acetylation: molecular mnemonics on the chromatin.
Gräff J, Tsai LH. Histone acetylation: molecular mnemonics on the chromatin. Nat Rev Neurosci. 2013;14(2):97-111. doi:10.1038/nrn3427
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A dietary regimen of caloric restriction or pharmacological activation of SIRT1 to delay the onset of neurodegeneration.
Gräff J, Kahn M, Samiei A, et al. A dietary regimen of caloric restriction or pharmacological activation of SIRT1 to delay the onset of neurodegeneration. J Neurosci. 2013;33(21):8951-60. doi:10.1523/JNEUROSCI.5657-12.2013
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In March of 2020, Ó³»­´«Ã½ converted a clinical genetics processing lab into a large-scale COVID-19 testing facility in less than two weeks.

We've screened more than 1,275 cancer cell lines as part of the Cancer Dependency Map (DepMap).

Ó³»­´«Ã½ Genomics Platform sequences a whole human genome every four minutes.

More than 11,000 individuals living with cancer in the United States and Canada have partnered with Count Me In to share their experiences and help accelerate cancer research.

The Drug Repurposing Hub is one of the most comprehensive and up-to-date biologically annotated collections of FDA-approved compounds in the world. Researchers anywhere can explore more than 6,000 drugs in the hub and search for possible new uses for them to jump-start new drug discovery.

In 2021, our sustainability efforts sent more than 80 percent of waste from the Genomics Platform to either a recycling facility or to an incineration plant that generates electricity.

Through Ó³»­´«Ã½'s Scientists in the Classroom program, Ó³»­´«Ã½ researchers visit every 8th grade classroom in Cambridge each year to talk about genetics and evolution.

Every summer, 18 high school students spend six weeks at Ó³»­´«Ã½ working side-by-side with mentors on cutting-edge research.

In November 2022, Ó³»­´«Ã½â€™s Genomics Platform sequenced its 500,000th whole human genome, a mere four years after sequencing its 100,000th.

By the end of 2022, Ó³»­´«Ã½â€™s COVID-19 testing lab had processed more than 37 million tests.

Working with Addgene, Ó³»­´«Ã½ has shared CRISPR genome-editing reagents with researchers at more than 3,200 institutions in 76 countries.

The NeuroGAP-Psychosis project, a collaboration between the Stanley Center for Psychiatric Research and Harvard T.H. Chan School of Public Health to study the genetics of severe mental illness, has recruited more than 42,000 participants in Ethiopia, Kenya, Uganda, and South Africa.

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