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Rapid and deep-scale ubiquitylation profiling for biology and translational research.

Udeshi ND, Mani DC, Satpathy S, et al. Rapid and deep-scale ubiquitylation profiling for biology and translational research. Nat Commun. 2020;11(1):359. doi:10.1038/s41467-019-14175-1

Localization and abundance analysis of human lncRNAs at single-cell and single-molecule resolution.

Cabili MN, Dunagin MC, McClanahan PD, et al. Localization and abundance analysis of human lncRNAs at single-cell and single-molecule resolution. Genome Biol. 2015;16:20. doi:10.1186/s13059-015-0586-4

TMT Labeling for the Masses: A Robust and Cost-efficient, In-solution Labeling Approach.

Zecha J, Satpathy S, Kanashova T, et al. TMT Labeling for the Masses: A Robust and Cost-efficient, In-solution Labeling Approach. Mol Cell Proteomics. 2019;18(7):1468-1478. doi:10.1074/mcp.TIR119.001385

Probing enzymatic activity inside living cells using a nanowire-cell "sandwich" assay.

Na YR, Kim SY, Gaublomme JT, et al. Probing enzymatic activity inside living cells using a nanowire-cell "sandwich" assay. Nano Lett. 2013;13(1):153-8. doi:10.1021/nl3037068

Rapid immunopurification of mitochondria for metabolite profiling and absolute quantification of matrix metabolites.

Chen WW, Freinkman E, Sabatini DM. Rapid immunopurification of mitochondria for metabolite profiling and absolute quantification of matrix metabolites. Nat Protoc. 2017;12(10):2215-2231. doi:10.1038/nprot.2017.104

Identification of a class of small molecule inhibitors of the sirtuin family of NAD-dependent deacetylases by phenotypic screening.

Grozinger CM, Chao ED, Blackwell HE, Moazed D, Schreiber SL. Identification of a class of small molecule inhibitors of the sirtuin family of NAD-dependent deacetylases by phenotypic screening. J Biol Chem. 2001;276(42):38837-43. doi:10.1074/jbc.M106779200

Identification of ATR-Chk1 pathway inhibitors that selectively target p53-deficient cells without directly suppressing ATR catalytic activity.

Kawasumi M, Bradner JE, Tolliday N, et al. Identification of ATR-Chk1 pathway inhibitors that selectively target p53-deficient cells without directly suppressing ATR catalytic activity. Cancer Res. 2014;74(24):7534-45. doi:10.1158/0008-5472.CAN-14-2650

Nuclear-Import Receptors Reverse Aberrant Phase Transitions of RNA-Binding Proteins with Prion-like Domains.

Guo L, Kim HJ, Wang H, et al. Nuclear-Import Receptors Reverse Aberrant Phase Transitions of RNA-Binding Proteins with Prion-like Domains. Cell. 2018;173(3):677-692.e20. doi:10.1016/j.cell.2018.03.002

Split--pool synthesis of 1,3-dioxanes leading to arrayed stock solutions of single compounds sufficient for multiple phenotypic and protein-binding assays.

Sternson SM, Louca JB, Wong JC, Schreiber SL. Split--pool synthesis of 1,3-dioxanes leading to arrayed stock solutions of single compounds sufficient for multiple phenotypic and protein-binding assays. J Am Chem Soc. 2001;123(8):1740-7.

High-affinity cooperative Ca binding by MICU1-MICU2 serves as an on-off switch for the uniporter.

Kamer KJ, Grabarek Z, Mootha VK. High-affinity cooperative Ca binding by MICU1-MICU2 serves as an on-off switch for the uniporter. EMBO Rep. 2017;18(8):1397-1411. doi:10.15252/embr.201643748