Ng PY, Tang Y, Knosp WM, Stadler S, Shaw JT. Synthesis of diverse lactam carboxamides leading to the discovery of a new transcription-factor inhibitor. Angew Chem Int Ed Engl. 2007;46(28):5352-5. doi:10.1002/anie.200700762
Dančík V, Carrel H, Bodycombe NE, et al. Connecting Small Molecules with Similar Assay Performance Profiles Leads to New Biological Hypotheses. J Biomol Screen. 2014;19(5):771-81. doi:10.1177/1087057113520226
Gutierrez-Arcelus M, Rich SS, Raychaudhuri S. Autoimmune diseases - connecting risk alleles with molecular traits of the immune system. Nat Rev Genet. 2016;17(3):160-74. doi:10.1038/nrg.2015.33
Lawrence MS, Phillips KJ, Liu DR. Supercharging proteins can impart unusual resilience. J Am Chem Soc. 2007;129(33):10110-2. doi:10.1021/ja071641y
Tolliday N, Clemons PA, Ferraiolo P, et al. Small molecules, big players: the National Cancer Institute’s Initiative for Chemical Genetics. Cancer Res. 2006;66(18):8935-42. doi:10.1158/0008-5472.CAN-06-2552
Nishimasu H, Ran A, Hsu PD, et al. Crystal structure of Cas9 in complex with guide RNA and target DNA. Cell. 2014;156(5):935-49. doi:10.1016/j.cell.2014.02.001
Reis SA, Ghosh B, Hendricks A, et al. Light-controlled modulation of gene expression by chemical optoepigenetic probes. Nat Chem Biol. 2016;12(5):317-23. doi:10.1038/nchembio.2042
Luo M, Lin H, Fischbach MA, Liu DR, Walsh CT, Groves JT. Enzymatic tailoring of enterobactin alters membrane partitioning and iron acquisition. ACS Chem Biol. 2006;1(1):29-32. doi:10.1021/cb0500034
Ng PY, Masse CE, Shaw JT. Cycloaddition reactions of imines with 3-thiosuccinic anhydrides: synthesis of the tricyclic core of martinellic acid. Org Lett. 2006;8(18):3999-4002. doi:10.1021/ol061473z
Schaffer AE, Eggens VRC, Çağlayan AO, et al. CLP1 founder mutation links tRNA splicing and maturation to cerebellar development and neurodegeneration. Cell. 2014;157(3):651-63. doi:10.1016/j.cell.2014.03.049