Mutation

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Titan cells formation in Cryptococcus neoformans is finely tuned by environmental conditions and modulated by positive and negative genetic regulators.

Hommel B, Mukaremera L, Cordero RJB, et al. Titan cells formation in Cryptococcus neoformans is finely tuned by environmental conditions and modulated by positive and negative genetic regulators. PLoS Pathog. 2018;14(5):e1006982. doi:10.1371/journal.ppat.1006982

Phosphorylation of threonine residues on Shc promotes ligand binding and mediates crosstalk between MAPK and Akt pathways in breast cancer cells.

Suen KM, Lin CC, Seiler C, et al. Phosphorylation of threonine residues on Shc promotes ligand binding and mediates crosstalk between MAPK and Akt pathways in breast cancer cells. Int J Biochem Cell Biol. 2018;94:89-97. doi:10.1016/j.biocel.2017.11.014

Leukemia-specific delivery of mutant NOTCH1 targeted therapy.

Roti G, Qi J, Kitara S, et al. Leukemia-specific delivery of mutant NOTCH1 targeted therapy. J Exp Med. 2018;215(1):197-216. doi:10.1084/jem.20151778

Mutations in TAC1B: a Novel Genetic Determinant of Clinical Fluconazole Resistance in Candida auris.

Rybak JM, Muñoz JF, Barker KS, et al. Mutations in TAC1B: a Novel Genetic Determinant of Clinical Fluconazole Resistance in Candida auris. mBio. 2020;11(3). doi:10.1128/mBio.00365-20

Detection of Mutations in Barrett's Esophagus Before Progression to High-Grade Dysplasia or Adenocarcinoma.

Stachler MD, Camarda ND, Deitrick C, et al. Detection of Mutations in Barrett’s Esophagus Before Progression to High-Grade Dysplasia or Adenocarcinoma. Gastroenterology. 2018;155(1):156-167. doi:10.1053/j.gastro.2018.03.047

Enhancer signatures stratify and predict outcomes of non-functional pancreatic neuroendocrine tumors.

Cejas P, Drier Y, Dreijerink KMA, et al. Enhancer signatures stratify and predict outcomes of non-functional pancreatic neuroendocrine tumors. Nat Med. 2019;25(8):1260-1265. doi:10.1038/s41591-019-0493-4

Clinically relevant mutations in core metabolic genes confer antibiotic resistance.

Lopatkin AJ, Bening SC, Manson AL, et al. Clinically relevant mutations in core metabolic genes confer antibiotic resistance. Science. 2021;371(6531). doi:10.1126/science.aba0862

Molecular basis for the binding of SH3 ligands with non-peptide elements identified by combinatorial synthesis.

Feng S, Kapoor TM, Shirai F, Combs AP, Schreiber SL. Molecular basis for the binding of SH3 ligands with non-peptide elements identified by combinatorial synthesis. Chem Biol. 1996;3(8):661-70.

The mutational landscape of head and neck squamous cell carcinoma.

Stransky N, Egloff AM, Tward AD, et al. The mutational landscape of head and neck squamous cell carcinoma. Science. 2011;333(6046):1157-60. doi:10.1126/science.1208130

Mycobacterium tuberculosis Whole Genome Sequences From Southern India Suggest Novel Resistance Mechanisms and the Need for Region-Specific Diagnostics.

Manson AL, Abeel T, Galagan JE, et al. Mycobacterium tuberculosis Whole Genome Sequences From Southern India Suggest Novel Resistance Mechanisms and the Need for Region-Specific Diagnostics. Clin Infect Dis. 2017;64(11):1494-1501. doi:10.1093/cid/cix169

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