Phenotype

The Power of Sophisticated Phenotypic Screening and Modern Mechanism-of-Action Methods.

Wagner BK, Schreiber SL. The Power of Sophisticated Phenotypic Screening and Modern Mechanism-of-Action Methods. Cell Chem Biol. 2016;23(1):3-9. doi:10.1016/j.chembiol.2015.11.008

Leader of the pack: gene mapping in dogs and other model organisms.

Karlsson EK, Lindblad-Toh K. Leader of the pack: gene mapping in dogs and other model organisms. Nat Rev Genet. 2008;9(9):713-25. doi:10.1038/nrg2382

Curve-based multivariate distance matrix regression analysis: application to genetic association analyses involving repeated measures.

Salem RM, O’Connor DT, Schork NJ. Curve-based multivariate distance matrix regression analysis: application to genetic association analyses involving repeated measures. Physiol Genomics. 2010;42(2):236-47. doi:10.1152/physiolgenomics.00118.2009

Exome sequencing and directed clinical phenotyping diagnose cholesterol ester storage disease presenting as autosomal recessive hypercholesterolemia.

Stitziel NO, Fouchier SW, Sjouke B, et al. Exome sequencing and directed clinical phenotyping diagnose cholesterol ester storage disease presenting as autosomal recessive hypercholesterolemia. Arterioscler Thromb Vasc Biol. 2013;33(12):2909-14. doi:10.1161/ATVBAHA.113.302426

Association of low-frequency and rare coding-sequence variants with blood lipids and coronary heart disease in 56,000 whites and blacks.

Peloso GM, Auer PL, Bis JC, et al. Association of low-frequency and rare coding-sequence variants with blood lipids and coronary heart disease in 56,000 whites and blacks. Am J Hum Genet. 2014;94(2):223-32. doi:10.1016/j.ajhg.2014.01.009

Improved imputation quality of low-frequency and rare variants in European samples using the 'Genome of The Netherlands'.

Deelen P, Menelaou A, van Leeuwen EM, et al. Improved imputation quality of low-frequency and rare variants in European samples using the ’Genome of The Netherlands’. Eur J Hum Genet. 2014;22(11):1321-6. doi:10.1038/ejhg.2014.19

Structure, function and diversity of the healthy human microbiome.

Human Microbiome Project Consortium. Structure, function and diversity of the healthy human microbiome. Nature. 2012;486(7402):207-14. doi:10.1038/nature11234

Extracardiac control of embryonic cardiomyocyte proliferation and ventricular wall expansion.

Shen H, Cavallero S, Estrada KD, et al. Extracardiac control of embryonic cardiomyocyte proliferation and ventricular wall expansion. Cardiovasc Res. 2015;105(3):271-8. doi:10.1093/cvr/cvu269

Mixed model with correction for case-control ascertainment increases association power.

Hayeck TJ, Zaitlen NA, Loh PR, et al. Mixed model with correction for case-control ascertainment increases association power. Am J Hum Genet. 2015;96(5):720-30. doi:10.1016/j.ajhg.2015.03.004

Genetic variants primarily associated with type 2 diabetes are related to coronary artery disease risk.

Jansen H, Loley C, Lieb W, et al. Genetic variants primarily associated with type 2 diabetes are related to coronary artery disease risk. Atherosclerosis. 2015;241(2):419-26. doi:10.1016/j.atherosclerosis.2015.05.033

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