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Covalent targeting of splicing in T cells.
Scott KA, Kojima H, Ropek N, et al. Covalent targeting of splicing in T cells. Cell chemical biology. 2024. doi:10.1016/j.chembiol.2024.10.010
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RPL22 is a tumor suppressor in MSI-high cancers and a splicing regulator of MDM4.
Weinstein HNW, Hu K, Fish L, et al. RPL22 is a tumor suppressor in MSI-high cancers and a splicing regulator of MDM4. Cell reports. 2024;43(8):114622. doi:10.1016/j.celrep.2024.114622
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RPL22 is a tumor suppressor in MSI-high cancers and a splicing regulator of MDM4.
Weinstein HNW, Hu K, Fish L, et al. RPL22 is a tumor suppressor in MSI-high cancers and a splicing regulator of MDM4. Cell reports. 2024;43(8):114622. doi:10.1016/j.celrep.2024.114622
Read more
Biosurfer for systematic tracking of regulatory mechanisms leading to protein isoform diversity.
Murali M, Saquing J, Lu S, et al. Biosurfer for systematic tracking of regulatory mechanisms leading to protein isoform diversity. bioRxiv : the preprint server for biology. 2024. doi:10.1101/2024.03.15.585320
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Genetic control of mRNA splicing as a potential mechanism for incomplete penetrance of rare coding variants.
Einson J, Glinos D, Boerwinkle E, et al. Genetic control of mRNA splicing as a potential mechanism for incomplete penetrance of rare coding variants. Genetics. 2023. doi:10.1093/genetics/iyad115
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Nova proteins direct synaptic integration of somatostatin interneurons through activity-dependent alternative splicing.
Ibrahim LA, Wamsley B, Alghamdi N, et al. Nova proteins direct synaptic integration of somatostatin interneurons through activity-dependent alternative splicing. eLife. 2023;12. doi:10.7554/eLife.86842
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Genetic analysis of isoform usage in the human anti-viral response reveals influenza-specific regulation of transcripts under balancing selection.
Ye CJ, Chen J, Villani AC, et al. Genetic analysis of isoform usage in the human anti-viral response reveals influenza-specific regulation of transcripts under balancing selection. Genome Res. 2018;28(12):1812-1825. doi:10.1101/gr.240390.118
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Rbfox1 Mediates Cell-type-Specific Splicing in Cortical Interneurons.
Wamsley B, Jaglin XH, Favuzzi E, et al. Rbfox1 Mediates Cell-type-Specific Splicing in Cortical Interneurons. Neuron. 2018;100(4):846-859.e7. doi:10.1016/j.neuron.2018.09.026
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Splicing modulation sensitizes chronic lymphocytic leukemia cells to venetoclax by remodeling mitochondrial apoptotic dependencies.
Hacken ET, Valentin R, Regis FFD, et al. Splicing modulation sensitizes chronic lymphocytic leukemia cells to venetoclax by remodeling mitochondrial apoptotic dependencies. JCI Insight. 2018;3(19). doi:10.1172/jci.insight.121438
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Integrative transcriptome analyses of the aging brain implicate altered splicing in Alzheimer's disease susceptibility.
Raj T, Li YI, Wong G, et al. Integrative transcriptome analyses of the aging brain implicate altered splicing in Alzheimer’s disease susceptibility. Nat Genet. 2018;50(11):1584-1592. doi:10.1038/s41588-018-0238-1
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In March of 2020, Ó³»­´«Ã½ converted a clinical genetics processing lab into a large-scale COVID-19 testing facility in less than two weeks.

We've screened more than 1,275 cancer cell lines as part of the Cancer Dependency Map (DepMap).

Ó³»­´«Ã½ Genomics Platform sequences a whole human genome every four minutes.

More than 11,000 individuals living with cancer in the United States and Canada have partnered with Count Me In to share their experiences and help accelerate cancer research.

The Drug Repurposing Hub is one of the most comprehensive and up-to-date biologically annotated collections of FDA-approved compounds in the world. Researchers anywhere can explore more than 6,000 drugs in the hub and search for possible new uses for them to jump-start new drug discovery.

In 2021, our sustainability efforts sent more than 80 percent of waste from the Genomics Platform to either a recycling facility or to an incineration plant that generates electricity.

Through Ó³»­´«Ã½'s Scientists in the Classroom program, Ó³»­´«Ã½ researchers visit every 8th grade classroom in Cambridge each year to talk about genetics and evolution.

Every summer, 18 high school students spend six weeks at Ó³»­´«Ã½ working side-by-side with mentors on cutting-edge research.

In November 2022, Ó³»­´«Ã½â€™s Genomics Platform sequenced its 500,000th whole human genome, a mere four years after sequencing its 100,000th.

By the end of 2022, Ó³»­´«Ã½â€™s COVID-19 testing lab had processed more than 37 million tests.

Working with Addgene, Ó³»­´«Ã½ has shared CRISPR genome-editing reagents with researchers at more than 3,200 institutions in 76 countries.

The NeuroGAP-Psychosis project, a collaboration between the Stanley Center for Psychiatric Research and Harvard T.H. Chan School of Public Health to study the genetics of severe mental illness, has recruited more than 42,000 participants in Ethiopia, Kenya, Uganda, and South Africa.

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