ӳ��ý

A split-Cas9 architecture for inducible genome editing and transcription modulation.

Zetsche B, Volz SE, Zhang F. A split-Cas9 architecture for inducible genome editing and transcription modulation. Nat Biotechnol. 2015;33(2):139-42. doi:10.1038/nbt.3149

CRISPR germline engineering--the community speaks.

Bosley KS, Botchan M, Bredenoord AL, et al. CRISPR germline engineering--the community speaks. Nat Biotechnol. 2015;33(5):478-86. doi:10.1038/nbt.3227

FTO Obesity Variant Circuitry and Adipocyte Browning in Humans.

Claussnitzer M, Dankel SN, Kim KH, et al. FTO Obesity Variant Circuitry and Adipocyte Browning in Humans. N Engl J Med. 2015;373(10):895-907. doi:10.1056/NEJMoa1502214

Cas9 gRNA engineering for genome editing, activation and repression.

Kiani S, Chavez A, Tuttle M, et al. Cas9 gRNA engineering for genome editing, activation and repression. Nat Methods. 2015;12(11):1051-4. doi:10.1038/nmeth.3580

Resources for the design of CRISPR gene editing experiments.

Graham DB, Root DE. Resources for the design of CRISPR gene editing experiments. Genome Biol. 2015;16:260. doi:10.1186/s13059-015-0823-x

Fusion of catalytically inactive Cas9 to FokI nuclease improves the specificity of genome modification.

Guilinger JP, Thompson DB, Liu DR. Fusion of catalytically inactive Cas9 to FokI nuclease improves the specificity of genome modification. Nat Biotechnol. 2014;32(6):577-82. doi:10.1038/nbt.2909