Wong JC, Hong R, Schreiber SL. Structural biasing elements for in-cell histone deacetylase paralog selectivity. J Am Chem Soc. 2003;125(19):5586-7. doi:10.1021/ja0341440
Sanders BD, Jackson B, Brent M, et al. Identification and characterization of novel sirtuin inhibitor scaffolds. Bioorg Med Chem. 2009;17(19):7031-41. doi:10.1016/j.bmc.2009.07.073
Williams DR, Nag PP, Zorn N. Strategies for the synthesis of the novel antitumor agent peloruside A. Curr Opin Drug Discov Devel. 2008;11(2):251-71.
Johannessen L iv, Sundberg TB, O’Connell DJ, et al. Small-molecule studies identify CDK8 as a regulator of IL-10 in myeloid cells. Nat Chem Biol. 2017;13(10):1102-1108. doi:10.1038/nchembio.2458
Rohde JM, Brimacombe KR, Liu L, et al. Discovery and optimization of piperazine-1-thiourea-based human phosphoglycerate dehydrogenase inhibitors. Bioorg Med Chem. 2018;26(8):1727-1739. doi:10.1016/j.bmc.2018.02.016
Haggarty SJ, Koeller KM, Wong JC, Butcher RA, Schreiber SL. Multidimensional chemical genetic analysis of diversity-oriented synthesis-derived deacetylase inhibitors using cell-based assays. Chem Biol. 2003;10(5):383-96.
Patel V, Mazitschek R, Coleman B, et al. Identification and characterization of small molecule inhibitors of a class I histone deacetylase from Plasmodium falciparum. J Med Chem. 2009;52(8):2185-7. doi:10.1021/jm801654y
Gupta-Ostermann D, Wawer M, Wassermann AM, Bajorath J. Graph mining for SAR transfer series. J Chem Inf Model. 2012;52(4):935-42. doi:10.1021/ci300071y
Over B, McCarren P, Artursson P, et al. Impact of stereospecific intramolecular hydrogen bonding on cell permeability and physicochemical properties. J Med Chem. 2014;57(6):2746-54. doi:10.1021/jm500059t
Porto WF, Irazazabal L, Alves ESF, et al. In silico optimization of a guava antimicrobial peptide enables combinatorial exploration for peptide design. Nat Commun. 2018;9(1):1490. doi:10.1038/s41467-018-03746-3