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TYK2 protein-coding variants protect against rheumatoid arthritis and autoimmunity, with no evidence of major pleiotropic effects on non-autoimmune complex traits.

Diogo D, Bastarache L, Liao KP, et al. TYK2 protein-coding variants protect against rheumatoid arthritis and autoimmunity, with no evidence of major pleiotropic effects on non-autoimmune complex traits. PLoS One. 2015;10(4):e0122271. doi:10.1371/journal.pone.0122271

The receptor TREML4 amplifies TLR7-mediated signaling during antiviral responses and autoimmunity.

Ramirez-Ortiz ZG, Prasad A, Griffith JW, et al. The receptor TREML4 amplifies TLR7-mediated signaling during antiviral responses and autoimmunity. Nat Immunol. 2015;16(5):495-504. doi:10.1038/ni.3143

Genetic variants associated with autoimmunity drive NFκB signaling and responses to inflammatory stimuli.

Housley WJ, Fernandez SD, Vera K, et al. Genetic variants associated with autoimmunity drive NFκB signaling and responses to inflammatory stimuli. Sci Transl Med. 2015;7(291):291ra93. doi:10.1126/scitranslmed.aaa9223

Stable inhibitory activity of regulatory T cells requires the transcription factor Helios.

Kim HJ, Barnitz A, Kreslavsky T, et al. Stable inhibitory activity of regulatory T cells requires the transcription factor Helios. Science. 2015;350(6258):334-9. doi:10.1126/science.aad0616

Autoimmune diseases - connecting risk alleles with molecular traits of the immune system.

Gutierrez-Arcelus M, Rich SS, Raychaudhuri S. Autoimmune diseases - connecting risk alleles with molecular traits of the immune system. Nat Rev Genet. 2016;17(3):160-74. doi:10.1038/nrg.2015.33

Genetic dissection of lymphopenia from autoimmunity by introgression of mutated Ian5 gene onto the F344 rat.

Moralejo DH, Park HA, Speros SJ, et al. Genetic dissection of lymphopenia from autoimmunity by introgression of mutated Ian5 gene onto the F344 rat. J Autoimmun. 2003;21(4):315-24.